Structural effects of the L145Q, V157F, and R282W cancer-associated mutations in the p53 DNA-binding core domain

Biochemistry

Volumn 50, Issue 23, 2011, Pages 5345-5353

  Calhoun, Sara ^a   Daggett, Valerie ^a  

^a University of Washington   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER-ASSOCIATED MUTATIONS; CELL-CYCLE ARREST; DNA-BINDING; DYNAMIC EFFECTS; HUMAN CANCER; MOLECULAR DYNAMICS SIMULATIONS; MUTANT SIMULATIONS; P53 FUNCTION; PHYSIOLOGICAL TEMPERATURE; SHEET STRUCTURE; SIGNALING PATHWAYS; STRUCTURAL CHANGE; STRUCTURAL EFFECT; TUMOR SUPPRESSORS; WILD TYPES; WILD-TYPE PROTEINS;

CELL DEATH; DISEASES; DYES; GENES; MOLECULAR DYNAMICS; TRANSCRIPTION; TRANSCRIPTION FACTORS;

DNA;

DNA; PROTEIN P53;

APOPTOSIS; ARTICLE; BETA SHEET; CELL CYCLE ARREST; GENE MUTATION; GENE REARRANGEMENT; GENE STRUCTURE; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DNA BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN STABILITY; PROTEIN STRUCTURE;

BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DNA; HUMANS; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; MUTATION; NEOPLASMS; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR SUPPRESSOR PROTEIN P53;

EID: 79958837494     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi200192j     Document Type: Article

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