ICV STZ induced impairment in memory and neuronal mitochondrial function: A protective role of nicotinic receptor

Behavioural Brain Research

Volumn 224, Issue 1, 2011, Pages 50-57

  Saxena, Gunjan ^a   Patro, Ishan K ^b   Nath, Chandishwar ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

^b JIWAJI UNIVERSITY   (India)

Author keywords

Memory impairment; Mitochondria; Neurodegeneration; Nicotinic receptor; Streptozotocin

Indexed keywords

CALCIUM ION; CARBACHOL; CASPASE 3; DONEPEZIL; GLUTATHIONE; MALONALDEHYDE; MUSCARINIC RECEPTOR; NICOTINE; NICOTINIC RECEPTOR; REACTIVE OXYGEN METABOLITE; STREPTOZOCIN; TACRINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL FUNCTION; CONTROLLED STUDY; ENZYME ACTIVITY; GLUCOSE BLOOD LEVEL; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; LOCOMOTION; MALE; MAZE TEST; MEMORY DISORDER; MITOCHONDRION; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; PROTEIN FUNCTION; RAT; SPATIAL MEMORY;

ANALYSIS OF VARIANCE; ANIMALS; BLOOD GLUCOSE; BRAIN; CALCIUM; CASPASE 3; CELL DEATH; CHOLINESTERASE INHIBITORS; DISEASE MODELS, ANIMAL; GLUTATHIONE; INDANS; INJECTIONS, INTRAVENTRICULAR; MALE; MALONDIALDEHYDE; MAZE LEARNING; MEMORY DISORDERS; MITOCHONDRIA; MOTOR ACTIVITY; NEURONS; NICOTINE; PIPERIDINES; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; RECEPTORS, NICOTINIC; STREPTOZOCIN; TACRINE;

EID: 79958833489     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2011.04.039     Document Type: Article

References (59)

1. Blockland A. Acetylcholine, a neurotransmitter for learning and memory. Brain Res 1996, 21:285-300.
2. Pritchard A.L., Harris J., Pritchard C.W., Coates J., Haque S., Holder R., et al. Role of 5HT2A and 5HT2C polymorphisms in behavioral and psychological symptoms of Alzheimers disease. Neurobiol Ageing 2008, 29:341-347.
3. 2+ homeostasis. Brain Res 2007, 1143:11-21.
4. Kristensen M. Neurotransmitters in Alzheimer's disease. Ugeskr Laeger 1990, 152:2165-2168.
5. Perry E., Walker M., Grace J. Acetylcholine in mind: a neurotransmitter correlate of consciousnessŽ. Trends Neurosci 1999, 22:273-280.
6. Saxena G., Singh S.P., Agrawal R., Nath C. Effect of donepezil and tacrine on oxidative stress in intracerebral streptozotocin-induced model of dementia in mice. Eur J Pharmacol 2008, 581:283-289.
7. Lin M.T., Beal M.F. Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature 2006, 443:787-795.
8. Annunziato L., Amoroso S., Pannaccione A., Cataldi M., Pignataro G., D'Alessio A., et al. Apoptosis induced in neuronal cells by oxidative stress: role played by caspases and intracellular calcium ions. Toxicol Lett 2003, 139:125-133.
9. Sheehan J.P., Russel H., Swerdlow, Scott W., Miller R.E., Davis J.K., et al. Calcium homeostasis and reactive oxygen species production in cells transformed by mitochondria from individuals with sporadic Alzheimer's disease. J Neurosci 1997, 17:4612-4622.
10. LeBlanc A.C. The role of apoptotic pathways in Alzheimer's disease neurodegeneration and cell death. Curr Alzheimer Res 2005, 2:389-402.
11. Coleman P.D., Yao P.J. Synaptic slaughter in Alzheimer's disease. Neurobiol Aging 2003, 24:1023-1027.
12. Masliah E., Crews L., Hansen L. Synaptic remodeling during aging and in Alzheimer's disease. J Alzheimers Dis 2006, 9:91-99.
13. Louneva N., Cohen J.W., Han L.-Y., Talbot K., Wilson R.S., Bennett D.A., et al. Caspase-3 is enriched in postsynaptic densities and increased in Alzheimer's disease. Am J Pathol 2008, 173:1488-1495.
14. Chung C.W., Song Y.H., Kim I.K., Yoon W.J., Ryu B.R., Jo D.G., et al. Proapoptotic effects of tau cleavage product generated by caspase-3. Neurobiol Dis 2001, 8:162-172.
15. Gamblin T.C., Chen F., Zambrano A., Abraha A., Lagalwar S., Guillozet A.L., et al. Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease. Proc Natl Acad Sci USA 2003, 100:10032-10037.
16. Fasulo L., Ugolini G., Cattaneo A. Apoptotic effect of caspase-3 cleaved tau in hippocampal neurons and its potentiation by tau FTDP-mutation N279K. J Alzheimers Dis 2005, 7:3-13.
17. Zhao M., Su J., Head E., Cotman C.W. Accumulation of caspase cleaved amyloid precursor protein represents an early neurodegenerative event in aging and in Alzheimer's disease. Neurobiol Dis 2003, 14:391-403.
18. Engidawork E., Gulesserian T., Yoo B.C., Cairns N., Lubec G. Alteration of caspases and apoptosis-related proteins in brains of patients with Alzheimer's disease. Biochem Biophys Res Commun 2001, 281:84-93.
19. Giacobini E. New trends in cholinergic therapy for Alzheimer's disease: nicotin agonists or cholinesterase inhibitors. Prog Brain Res 1996, 13:655-670.
20. Kedar N.P., Cole W.C., Prasad K.C. Risk factors for Alzheimer's disease: role of multiple antioxidants, non-steroidal anti-inflammatory and cholinergic agents alone or in combination in prevention and treatment. J Am Coll Nutr 2002, 21:506-522.
21. Sharma M., Gupta Y.K. Effect of chronic treatment of melatonin on learning, memory and oxidative deficiencies induced by intracerebroventricular streptozotocin in rats. Pharmacol Biochem Behav 2001, 70:325-331.
22. Saxena G., Bharti S., Kamat P.K., Sharma S., Nath C. Melatonin alleviates memory deficits and neuronal degeneration induced by intracerebroventricular administration of streptozotocin in rats. Pharmacol Biochem Behav 2010, 94:397-403.
23. Kosasa T., Kuriya Y., Matsui K., Yamanishi Y. Inhibitory effects of donepezil hydrochloride E2020 on cholinesterase activity in brain and peripheral tissues of young and aged rats. Eur J Pharmacol 1999, 386:7-13.
24. Sprick U., Sprick C. Subcutaneous injection of carbachol enhances brain graft-induced recovery of memory-function by circumventing the blood-brain barrier. Behav Brain Res 1991, 43:175-183.
25. Addy N., Levin E.D. Nicotine interactions with haloperidol, clozapine and risperidone and working memory function in rats. Neuropsychopharmacology 2002, 27:534-541.
26. Saxena G., Singh S.P., Pal R., Singh S., Pratap R., Nath C. Gugulipid, an extract of Commiphora whighitii with lipid-lowering properties, has protective effects against streptozotocin-induced memory deficits in mice. Pharmacol Biochem Behav 2007, 86:797-805.
27. Tota S., Kamat P.K., Awasthi H., Singh N., Raghubir R., Nath C., et al. Candesartan improves memory decline in mice: involvement of AT1 receptors in memory deficit induced by intracerebral streptozotocin. Behav Brain Res 2009, 199:235-240.
28. Qi D., Zhu Y., Wen L., Liu Q., Qiao H. Ginsenoside Rg1 restores the impairment of learning induced by chronic morphine administration in rats. J Psychopharmacol 2008, 23:74-83.
29. Chen D., Wu C.F., Shi B., Xu Y.M. Tamoxifen and toremifen impair retrieval, but not acquisition of spatial information processing in mice. Pharmacol Biochem Behav 2002, 72:417-421.
30. Edwards J.A., Brimijoin S. Divergent regulation of acetylcholinesterase and butyrylcholinesterase in tissues of the rat. J Neurochem 1982, 38:1393-1403.
31. Glowinski J., Iversen L.L. Regional studies of catecholamines in the rat brain: I. The disposition of [3H] norepinephrine, [3H] dopamine and [3H] DOPA in various regions of the brain. J Neurochem 1966, 13:655-670.
32. Ellman G.L. Tissue sulphydryl groups. Arch Biochem Biophys 1959, 82:70-77.
33. Colado M.I., O'shea E., Granados R., Misra A., Murray T.K., Green A.R. A study of the neurotoxic effect of MDMA ('ecstasy') on 5-HT neurons in the brains of mothers and neonates following administration of the drug during pregnancy. Br J Pharmacol 1997, 121:827-833.
34. Partridge R.S., Monroe S.M., Parks J.K., Johnson K., Parker W.D., Eaton G.R., et al. Spin trapping of azidyl and hydroxyl radicals in azide-inhibited rat brain submitochondrial particles. Arch Biochem Biophys 1994, 310:210-217.
35. Kamat P.K., Tota S., Saxena G., Shukla R., Nath C. Okadaic acid (ICV) induced memory impairment in rats: a suitable experimental model to test anti-dementia activity. Brain Res 2010, 1309:66-74.
36. Myhre O., Andersen J.M., Aarnes H., Fonnum F. Evaluation of the probes 2′,7′-dichlorofluorescin diacetate, luminol, and lucigenin as indicators of reactive species formation. Biochem Pharmacol 2003, 65:1575-1582.
37. 2+ indicators with greatly improved fluorescence properties. J Biol Chem 1985, 260:3440-3450.
38. Nath R., McGinnis K., Dutta S., Shivers B., Wang K.K. Inhibition of p38 kinase mimics survival signal-linked protection against apoptosis in rat cerebellar granule neurons. Cell Mol Biol Lett 2001, 6:173-184.
39. Rathore P., Dohare P., Varma S., Ray A., Sharma U., Jaganathanan N.R., et al. Curcuma oil: reduces early accumulation of oxidative product and is anti-apoptogenic in transient focal ischemia in rat brain. Neurochem Res 2008, 33:1672-1682.
40. Tota S., Awasthi H., Kamat P.K., Nath C., Hanif K. Protective effect of quercetin against intracerebral streptozotocin induced reduction in cerebral blood flow and impairment of memory in mice. Behav Brain Res 2010, 209:73-79.
41. Awasthi H., Tota S., Hanif K., Nath C., Shukla R. Protective effect of curcumin against intracerebral streptozotocin induced impairment in memory and cerebral blood flow. Life Sci 2010, 86:87-94.
42. Lannert H., Hoyer S. Intracerebroventricular administration of streptozotocin causes long-term diminutions in learning and memory abilities and in cerebral energy metabolism in adult rats. Behav Neurosci 1998, 112:1199-1208.
43. Zeevalk G.D., Bernard L.P., Niklas W.J. Role of oxidative stress and the glutathione system in loss of dopamine due to impairment of energy metabolism. J Neurochem 1998, 70:1421-1430.
44. Guela C. Abnormalities of neural circuitry in Alzheimer's disease. Neurology 1998, 51:S18-S29.
45. Blass J.P., Gibson G.E. Cerebrometabolic aspects of delirium in relationship with dementia. Dement Geriatr Cogn Disord 1999, 10:335-338.
46. Castellani R., Hirai K., Aliev G., Drew K.L., Nunomura A., Takeda A., et al. Role of mitochondrial dysfunction in Alzheimer's disease. J Neurosci Res 2002, 70:357-360.
47. Reddy P.H. Amyloid precursor protein mediated free radicals and oxidative damage: implications for the development and progression of Alzheimers disease. J Neurochem 2006, 96:1-13.
48. Singh R.P., Sharad S., Kapur S. Free radicals and oxidative stress in neurodegenerative diseases: relevance of dietary antioxidants. J Indian Acad Clin Med 2004, 5:219.
49. Mattson M.P., Keller J.N., Begley J.G. Evidence for synaptic apoptosis. Exp Neurol 1999, 153:35-48.
50. Cantoni O., Sestili F., Cattabeni F., Bellomo G., Pou S., Cohen M., et al. Quin-2 prevents hydrogenperoxide induced DNA breakage and cytotoxicity. Eur J Biochem 1989, 182:209-212.
51. Wang G.J., Thayer S.A. NMDA-induced calcium loads recycle across the mitochondrial inner membrane of hippocampal neurons in culture. J Neurophysiol 2002, 87:740-749.
52. Duchen M.R. Contributions of mitochondria to animal physiology: from homeostatic sensor to calcium signalling and cell death. J Physiol (Lond) 1999, 516:1-17.
53. Orrenius S., Burkitt M.J., Kass G.E., Dybukt G.M., Nicotera P. Calcium ions and oxidative injury. Ann Neurol 1992, 32:33-42.
54. Akasofu S., Kosasa T., Kimura M., Kubota A. Protective effect of donepezil in a primary culture of rat cortical neurons exposed to oxygen-glucose deprivation. Eur J Pharmacol 2006, 472:57-63.
55. Takada Y., Yonezawa A., Kume T., Katsuki H., Kaneko S., Sugimoto H., et al. Nicotinic acetylcholine receptor-mediated neuroprotection by donepezil against glutamate neurotoxicity in rat cortical neurons. J Pharmacol Exp Ther 2009, 306:772-777.
56. Guo Q., Sopher B.L., Furukawa K., Pham D.G., Robinson N., Martin G.M., et al. Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid β peptide. J Neurosci 1997, 17:4212-4222.
57. Tang D., Kidd V.J. Cleavage of DFF-45/ICAD by multiple caspases is essential for its function during apoptosis. J Biol Chem 1998, 273:28549-28552.
58. Yang L., He H.-Y., Zhang X.J. Increased expression of intranuclear AChE involved in apoptosis of SK-N-SH cells. Neurosci Res 2002, 42:261-268.
59. Liu Q., Zhao B. Nicotine attenuates β-amyloid peptide-induced neurotoxicity, free radical and calcium accumulation in hippocampal neuronal cultures. Br J Pharmacol 2004, 141:746-754.