P301S mutant human tau transgenic mice manifest early symptoms of human tauopathies with dementia and altered sensorimotor gating

PLoS ONE

Volumn 6, Issue 6, 2011, Pages

  Takeuchi, Hiroki ^a,b   Iba, Michiyo ^c   Inoue, Haruhisa ^b,d   Higuchi, Makoto ^e   Takao, Keizo ^f   Tsukita, Kayoko ^b   Karatsu, Yoshiko ^b   Iwamoto, Yumiko ^b   Miyakawa, Tsuyoshi ^g   Suhara, Tetsuya ^e   Trojanowski, John Q ^c   Lee, Virginia M Y ^c   Takahashi, Ryosuke ^a  

^a KYOTO UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

^d JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^e NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

^f NATIONAL INSTITUTE FOR PHYSIOLOGICAL SCIENCES   (Japan)

^g FUJITA HEALTH UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

TAU PROTEIN;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ANXIETY DISORDER; ARTICLE; BEHAVIOR DISORDER; CONTROLLED STUDY; DEMENTIA; FEAR; FEMALE; FORCED SWIMMING TEST; HOPELESSNESS; HOT PLATE TEST; HYPERACTIVITY; LIGHT DARK CYCLE; LOCOMOTION; MAZE TEST; MILD COGNITIVE IMPAIRMENT; MOTOR COORDINATION; MOUSE; MUSCLE STRENGTH; NEUROLOGIC EXAMINATION; NONHUMAN; OPEN FIELD TEST; PREPULSE INHIBITION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REFERENCE MEMORY; ROTAROD TEST; SENSORY GATING; SOCIAL INTERACTION; SPATIAL MEMORY; STARTLE REFLEX; SYMPTOM; TASK PERFORMANCE; TAUOPATHY; VISUAL ACUITY; WORKING MEMORY; ANIMAL; DISEASE MODEL; GENETICS; HUMAN; PATHOLOGY; TRANSGENIC MOUSE;

ANIMALIA; MUS MUSCULUS;

ANIMALS; DEMENTIA; DISEASE MODELS, ANIMAL; HUMANS; MAZE LEARNING; MICE; MICE, TRANSGENIC; SENSORY GATING; TAU PROTEINS;

EID: 79958829010     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0021050     Document Type: Article

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