Transgenic mice expressing mutant (N279K) human tau show mutation dependent cognitive deficits without neurofibrillary tangle formation

FEBS Letters

Volumn 579, Issue 25, 2005, Pages 5704-5712

  Taniguchi, Taizo ^a,b   Doe, Nobutaka ^c   Matsuyama, Shogo ^d   Kitamura, Yoshihisa ^b   Mori, Hiroshi ^e   Saito, Naoaki ^a   Tanaka, Chikako ^a  

^a KOBE UNIVERSITY   (Japan)

^b Behavioral and Medical Sciences Research Consortium   (Japan)

^c KWANSEI GAKUIN UNIVERSITY   (Japan)

^d KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^e OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Animal models; Behavioral analysis; FTDP 17; Tau

Indexed keywords

MUTANT PROTEIN; TAU PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOSOMAL DOMINANT DISORDER; BRAIN DISEASE; COGNITIVE DEFECT; CONTROLLED STUDY; FRONTOTEMPORAL DEMENTIA AND PARKINSONISM LINKED TO CHROMOSOME 17; GENE MUTATION; HISTOLOGY; HYPERACTIVITY; LEARNING; LOCOMOTION; MALE; MOUSE; NEUROFIBRILLARY TANGLE; NONHUMAN; OPEN FIELD BEHAVIOR; OPEN FIELD TEST; PREPULSE INHIBITION; PRIORITY JOURNAL; REARING; STATISTICAL SIGNIFICANCE; TRANSGENIC MOUSE;

ALZHEIMER DISEASE; ANIMALS; ASPARAGINE; AVOIDANCE LEARNING; CHROMOSOMES, HUMAN, PAIR 17; COGNITION DISORDERS; DISEASE MODELS, ANIMAL; HIPPOCAMPUS; HUMANS; LYSINE; MAZE LEARNING; MICE; MICE, TRANSGENIC; MUTATION, MISSENSE; NERVE TISSUE PROTEINS; NEUROFIBRILLARY TANGLES; PHOSPHORYLATION; TAU PROTEINS;

ANIMALIA; MUS MUSCULUS;

EID: 26844479213     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2005.09.047     Document Type: Article

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