MRI and quantitative autoradiographic studies following bolus injections of unlabeled and 14C-labeled gadolinium-diethylenetriaminepentaacetic acid in a rat model of stroke yield similar distribution volumes and blood-to-brain influx rate constants

NMR in Biomedicine

Volumn 24, Issue 5, 2011, Pages 547-558

  Nagaraja, Tavarekere N ^a   Ewing, James R ^a,b   Karki, Kishor ^a,b   Jacobs, Paul E ^c   Divine, George W ^a   Fenstermacher, Joseph D ^a   Patlak, Clifford S ^d   Knight, Robert A ^a,b  

^a HENRY FORD HOSPITAL   (United States)

^b OAKLAND UNIVERSITY   (United States)

^c MICHIGAN STATE UNIVERSITY   (United States)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Arterial input function; Blood brain barrier; Cerebral blood flow; Cerebral ischemia; DCE MRI; Magnetic resonance contrast agents; Neurovascular unit; Patlak plot

Indexed keywords

ARTERIAL INPUT FUNCTION; BLOOD-BRAIN BARRIER; CEREBRAL BLOOD FLOW; CEREBRAL ISCHEMIA; DCE-MRI; MAGNETIC RESONANCE CONTRAST AGENTS; NEUROVASCULAR UNIT; PATLAK PLOT;

AMINO ACIDS; BLOOD; BLOOD VESSELS; GADOLINIUM; MAGNETIC RESONANCE; RADIOGRAPHY; RATE CONSTANTS; RATS; SUGAR (SUCROSE); TISSUE;

BRAIN;

2 AMINO 2 METHYLPROPIONIC ACID; CARBON 14; GADOLINIUM; PENTETATE CALCIUM; SUCROSE; TRACER;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BRAIN REGION; DISTRIBUTION VOLUME; ISOTOPE LABELING; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; REPERFUSION; STROKE;

ANIMALS; AUTORADIOGRAPHY; BLOOD-BRAIN BARRIER; BRAIN; CARBON ISOTOPES; DISEASE MODELS, ANIMAL; GADOLINIUM DTPA; INJECTIONS; KINETICS; MAGNETIC RESONANCE IMAGING; MALE; RATS; RATS, WISTAR; STAINING AND LABELING; STROKE;

RATTUS; RATTUS NORVEGICUS;

EID: 79958785737     PISSN: 09523480     EISSN: 10991492     Source Type: Journal    
DOI: 10.1002/nbm.1625     Document Type: Article

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