The MRI-measured arterial input function resulting from a bolus injection of Gd-DTPA in a rat model of stroke slightly underestimates that of Gd-[ 14C]DTPA and marginally overestimates the blood-to-brain influx rate constant determined by Patlak plots

Magnetic Resonance in Medicine

Volumn 63, Issue 6, 2010, Pages 1502-1509

  Nagaraja, Tavarekere N ^a   Karki, Kishor ^a   Ewing, James R ^a,b   Divine, George W ^a   Fenstermacher, Joseph D ^a   Patlak, Clifford S ^c   Knight, Robert A ^a,b  

^a HENRY FORD HOSPITAL   (United States)

^b OAKLAND UNIVERSITY   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Blood brain barrier; Cerebral ischemia; Magnetic resonance contrast agents; Population averaged AIF; Reference tissue model

Indexed keywords

BRAIN; GADOLINIUM; MAGNETIC RESONANCE; RATE CONSTANTS; RATS; TISSUE;

BLOOD-BRAIN BARRIER; CEREBRAL ISCHEMIA; MAGNETIC RESONANCE CONTRAST AGENTS; POPULATION-AVERAGED AIF; REFERENCE TISSUE MODEL;

BLOOD;

GADOLINIUM PENTETATE; PENTETIC ACID GADOLINIUM C 14; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTERIAL BLOOD; ARTICLE; BLOOD BRAIN BARRIER; CONTROLLED STUDY; DISEASE MODEL; MALE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; RAT; REFERENCE VALUE; STROKE; ANIMAL; BLOOD; CEREBROVASCULAR ACCIDENT; HUMAN; INTRAARTERIAL DRUG ADMINISTRATION; PATHOPHYSIOLOGY; RADIOGRAPHY;

ANIMALS; BLOOD-BRAIN BARRIER; DISEASE MODELS, ANIMAL; GADOLINIUM DTPA; HUMANS; INJECTIONS, INTRA-ARTERIAL; MAGNETIC RESONANCE IMAGING; RATS; STROKE;

EID: 77952722665     PISSN: 07403194     EISSN: 15222594     Source Type: Journal    
DOI: 10.1002/mrm.22339     Document Type: Article

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