A unified magnetic resonance imaging pharmacokinetic theory: Intravascular and extracellular contrast reagents

Magnetic Resonance in Medicine

Volumn 54, Issue 6, 2005, Pages 1351-1359

  Li, Xin ^a   Rooney, William D ^a   Springer Jr , Charles S ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

DCE MRI; Longitudinal relaxation; Pharmacokinetics; Shutter speed; Water exchange

Indexed keywords

MAGNETIC RESONANCE IMAGING; MOLECULES; PHARMACOKINETICS; RATE CONSTANTS; TISSUE;

DCE-MRI; EXCHANGE KINETICS; FIRST-ORDER RATE CONSTANTS; HIGH MAGNETIC FIELDS; LONGITUDINAL RELAXATION; SHUTTER SPEED; THE STANDARD MODEL; WATER EXCHANGE;

REAGENTS;

CONTRAST MEDIUM;

ARTICLE; BLOOD VESSEL; CONCENTRATION RESPONSE; CONTRAST ENHANCEMENT; ENDOTHELIUM CELL; EQUILIBRIUM CONSTANT; EXTRACELLULAR SPACE; HUMAN; ISOTHERM; MAGNETIC FIELD; NUCLEAR MAGNETIC RESONANCE IMAGING; THEORETICAL MODEL; TIME;

EID: 28444450138     PISSN: 07403194     EISSN: None     Source Type: Journal    
DOI: 10.1002/mrm.20684     Document Type: Article

References (22)

1. Choyke PL, Dwyer AJ, Knopp MV. Functional tumor imaging with dynamic contrast-enhanced magnetic resonance imaging. J Magn Reson Imaging 2003;17:509-520.
2. Landis CS, Li X, Telang FW, Coderre JA, Micca PL, Rooney WD, Latour LL, Vetek G, Palyka I, Springer CS. Determination of the MRI contrast agent concentration time course in vivo following bolus injection: effect of equilibrium transcytolemmal water exchange. Magn Reson Med 2000;44:563-574.
3. Landis CS, Li X, Telang FW, Molina PE, Palyka I, Vetek G, Springer CS. Equilibrium transcytolemmal water-exchange kinetics in skeletal muscle in vivo. Magn Reson Med 1999;42:467-478.
4. Yankeelov TE, Rooney WD, Li X, Springer CS. Variation of the relaxographic "shutter-speed" for transcytolemmal water exchange affects the CR bolus-tracking curve shape. Magn Reson Med 2003;50:1151-1169.
5. Zhou R, Pickup S, Yankeelov TE, Springer CS, Glickson JD. Simultaneous measurement of arterial input function and tumor pharmacokinetics in mice by dynamic contrast enhanced imaging: effects of transcytolemmal water exchange. Magn Reson Med 2004;52:248-257.
6. 1, relaxivity in brain tissue in vivo is lower than in saline. Magn Reson Med 2005;53:35-40.
7. Li X, Huang W, Yankeelov TE, Tudorica A, Rooney WD, Springer CS. Shutter-speed analysis of contrast reagent bolus-tracking data: preliminary observations in benign and malignant breast disease. Magn Reson Med 2005;53:724-729.
8. Yankeelov TE, Rooney WD, Huang W, Dyke JP, Li X, Tudorica A, Lee J-H, Koutcher JA, Springer CS. Evidence for shutter-speed variation in CR bolus-tracking studies of human pathology. NMR Biomed 2005;18: 173-185.
9. 1H exchange: an estimate of the error introduced in MRI by assuming the fast exchange limit in bolus tracking. Magn Reson Med 2004;51:816-827.
10. 1,-weighted MRI. Magn Reson Med 2002;47: 601-606.
11. Larsson HBW, Stubgaard M. Frederiksen JL, Jensen M, Henriksen O, Paulson OB. Quantitation of blood-brain barrier defect by magnetic resonance imaging and gadolinium-DTPA in patients with multiple sclerosis and brain tumors. Magn Reson Med 1990;16:117-131.
12. Tofts PS, Kermode AG. Measurement of the blood-brain barrier permeability and leakage space using dynamic: MR imaging: 1. Fundamental concepts. Magn Reson Med 1991;17:357-367.
13. Furman-Haran E, Margalit R, Grobgeld D, Degani H. Dynamic contrast-enhanced magnetic resonance imaging reveals stress-induced angiogenesis in MCF7 human breast tumors. Proc Natl Acad Sci USA 1996; 93:6247-6251.
14. Tofts PS. Modeling tracer kinetics in dynamic Gd-DTPA imaging. J Magn Reson Imaging 1997;7:91-101.
15. 2* relaxivity due to blood volume magnetic susceptibility: using BALD to calibrate BOLD. In: Proceedings of the 11th Annual Meeting of ISMRM, Toronto, Canada, 2003. p 214.
16. Rooney WD, Li X, Telang FW, Taylor M, Coyle P, Springer CS. First pass bolus-tracking measurement of transendothelial water exchange in healthy controls. In: Proceedings of the 12th Annual Meeting of ISMRM, Kyoto, 2004. p 1390.
17. Spencer RGS, Fishbein KW. Measurement of spin-lattice relaxation times and concentrations in systems with chemical exchange using the one-pulse sequence: breakdown of the Ernst model for partial saturation in nuclear magnetic resonance spectroscopy. J Magn Reson 2000; 142:120-135.
18. Cao Y, Brown SL, Knight RA, Fenstermacher JD, Ewing JR. Effect of intravascular-to-extravascular water exchange on the determination of blood-to-tissue transfer constant by magnetic resonance imaging. Magn Reson Med 2005;53:282-293.
19. Rooney WD, Telang FW, Springer CS. Quantitative 4T determination of normal human brain vascular properties suggests CR transport across BBB. In: Proceedings of the 10th Annual Meeting of ISMRM, Honolulu, 2002.p 1314.
20. 1,-weighted dynamic contrast-enhanced MRI. In: Tofts PS, editor. Quantitative MRI of the brain: measuring changes caused by disease. Chichester: Wiley, 2003. p 348.
21. Labadie C, Lee J-H, Vetek G, Springer CS. Relaxographic imaging. J Magn Reson B 1994;105:99-112.
22. Tanny SR, Pickering M, Springer CS. Increasing the time resolution of dynamic nuclear magnetic resonance spectroscopy through the use of lanthanide shift reagents. J Am Chem Soc 1973;95:6227-6232. 1360-1368