Acute blood-brain barrier opening in experimentally induced focal cerebral ischemia is preferentially identified by quantitative magnetization transfer imaging

Magnetic Resonance in Medicine

Volumn 54, Issue 4, 2005, Pages 822-832

  Knight, Robert A ^a,b   Nagesh, Vijaya ^c   Nagaraja, Tavarekere N ^a   Ewing, James R ^a,b   Whitton, Polly A ^a   Bershad, Eric ^a   Fagan, Susan C ^d,e   Fenstermacher, Joseph D ^a  

^a HENRY FORD HEALTH SCIENCES CENTER   (United States)

^b OAKLAND UNIVERSITY   (United States)

^c UNIVERSITY OF MICHIGAN   (United States)

^d UNIVERSITY OF GEORGIA   (United States)

^e MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

Gd DTPA; Hemorrhagic transformation; Magnetization transfer; MRI; rt PA; Stroke

Indexed keywords

AMINO ACIDS; BRAIN; MAGNETIC RESONANCE IMAGING; MAGNETIZATION; RADIOGRAPHY; SURFACE DIFFUSION;

AMINOISOBUTYRIC ACID; APPARENT DIFFUSION COEFFICIENT; DIETHYLENETRIAMINE PENTA-ACETIC ACIDS; FOCAL CEREBRAL ISCHEMIAS; GD-DTPA; HEMORRHAGIC TRANSFORMATION; MAGNETIZATION TRANSFER; STROKE;

BLOOD;

2 AMINO 2 METHYLPROPIONIC ACID; ALTEPLASE; CARBON 14; GADOLINIUM PENTETATE; WATER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BLOOD BRAIN BARRIER; BRAIN BLOOD FLOW; BRAIN EDEMA; BRAIN HEMORRHAGE; BRAIN ISCHEMIA; CAUDATE NUCLEUS; CONTROLLED STUDY; DIFFUSION COEFFICIENT; HISTOPATHOLOGY; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PREOPTIC AREA; PUTAMEN; QUANTITATIVE DIAGNOSIS; RAT; STROKE;

EID: 26844465371     PISSN: 07403194     EISSN: None     Source Type: Journal    
DOI: 10.1002/mrm.20630     Document Type: Article

References (40)

1. The NINDS t-PA Stroke Study Group. Intracerebral hemorrhage after intravenous t-PA therapy for ischemic stroke. Stroke 1997;28:2109-2118.
2. Dijkhuizen RM, Asahi M, Wu O, Rosen BR, Lo EH. Delayed rt-PA treatment in a rat embolic stroke model: diagnosis and prognosis of ischemic injury and hemorrhagic transformation with magnetic resonance imaging. J Cereb Blood Flow Metab 2001;21:964-971.
3. Dijkhuizen RM, Asahi M, Wu O, Rosen BR, Lo EH. Rapid breakdown of microvascular barriers and subsequent hemorrhagic transformation after delayed recombinant tissue plasminogen activator treatment in a rat embolic stroke model. Stroke 2002;33:2100-2104.
4. Neumann-Haefelin C, Grinker G, Uhlenkuken U, Pillekamp F, Hossmann, K.-A., Hoehn M. Prediction of hemorrhagic transformation after thrombolytic therapy of clot embolism: an MRI investigation in rat brain. Stroke 2002;33:1392-1398.
5. Jiang Q, Zhang RL, Zhang ZG, Knight RA, Ewing JR, Ding GL, Lu M, Arniego P, Zhang L, Hu J, Li QJ, Chopp M. Magnetic resonance imaging characterization of hemorrhagic transformation of embolic stroke in the rat. J Cereb Metab Blood Flow 2002;22:559-568.
6. Bryan RN, Levy LM, Whitlow WD, Killian JM, Preziosi TJ, Rosario JA. Diagnosis of acute cerebral infarction: comparison of CT and MR imaging. Am J Neuroradiol 1991;12:611-620.
7. Gilligan AK, Markus R, Read S, Srikanth V, Hirano T, Fitt G, Arenas M, Chambers BR, Davis SM, Donnan GA. Baseline blood pressure but not early computed tomography changes predicts major hemorrhage after streptokinase in acute ischemic stroke. Stroke 2002;33:2236-2242.
8. Patel SC, Levine SR, Tilley BC, Grotta JC, Lu M, Frankel M, Haley ECJ, Brott TG, Broderick JP, Horowitz S, Lyden PD, Lewandowski CA, Marler JR, Welch KMA. Lack of clinical significance of early ischemic changes on computed tomography in acute stroke. J Am Med Assoc 2001;286:2830-2838.
9. Hayman LA, Evans RA, Bastion FO, Hinck VC. Delayed high dose contrast CT: identifying patients at risk of massive hemorrhagic infarction. Am J Roentgenol 1981;136:1151-1159.
10. Chen H, Chopp M, Zhang ZG, Garcia JH. The effect of hypothermia on transient middle cerebral artery occlusion in the rat. J Cereb Blood Flow Metab 1992;12:621-628.
11. Knight RA, Barker PB, Fagan SC, Li Y, Jacobs MA, Welch KMA. Prediction of impending hemorrhagic transformation in ischemic stroke using magnetic resonance imaging in rats. Stroke 1998;29:144-151.
12. Fagan SC, Nagaraja TN, Fenstermacher JD, Zheng J, Johnson M, Knight RA. Hemorrhagic transformation is related to the duration of occlusion and treatment with tissue plasminogen activator in a non-embolic stroke model. Neurol Res 2003;25:377-382.
13. Fagan SC, Garcia JH. Hemorrhagic transformation in focal cerebral ischemia: Influence of time to artery reopening and tissue plasminogen activator. Pharmacotherapy 1999;19:139-42.
14. Look DC, Locker DR. Time saving in measurement of NMR and EPR relaxation times. Rev Sci Instrum 1970;41:250-251.
15. 14C-sucrose in areas of blood-brain opening. Magn Reson Med 2003;50:283-292.
16. Le Bihan D, Breton E, Lallemand D, Grenier P, Cabanis E, Laval-Jeantet MMR. imaging of intravoxel incoherent motions: application to diffusion and perfusion in neurologic disorders. Radiology 1986;161:401-407.
17. Ewing JR, Wei L, Knight RA, Pawa S, Nagaraja TN, Brusca T, Divine GW, Fenstermacher JD. Direct comparison of local cerebral blood flow rates measured by MRI arterial spin-tagging and quantitative autoradiography in a rat model of experimental cerebral ischemia. J Cereb Blood Flow Metab 2003;23:198-209.
18. Ewing JR, Jiang Q, Boska M, Brown S, Zhang ZG, Nelson J, Welch KMA. PIPS: A fast and accurate estimate of the magnetization forward transfer rate between free and bound proton pools - Demonstration in two models of pathology in rat brain. In: Proceedings of the 4th Annual Meeting of ISMRM, New York, 1996: p. 1660.
19. Edzes HT, Samulski ET. The measurement of cross-relaxation effects in the proton NMR spin-lattice relaxation of water in biological systems: hydrated collagen and muscle. J Magn Reson 1977;31:207-229.
20. Wolff SD, Balaban RS. Magnetization transfer contrast (MTC) and tissue water proton relaxation in vivo. Magn Reson Med 1989;10:135-144.
21. Blasberg RG, Fenstermacher JD, Patlak CS. Transport of a-aminoisobutyric acid across brain capillary and cellular membranes. J Cereb Blood Flow Metab 1983;3:8-32.
22. Patlak CS, Blasberg RG, Fenstermacher JD. Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. J Cereb Blood Flow Metab 1983;3:1-7.
23. Windham JP, Abd-Allah DA, Riemann DA, Froelich JW, Haggar AM. Eigenimage filtering in MR imaging. J Comp Assist Tomogr 1988;12: 1-9.
24. Bezdek J. A convergence theorem for the fuzzy clustering algorithm. IEEE Trans Pattern Anal Mach Intel 1980;2:1-8.
25. Ball G, Hall D. ISODATA, A novel method of data analysis and pattern classification. Stanford Research Institute, Menlo Park, 1965; Apr.
26. Ball GH, Hall DJA. Clustering technique for summarizing multivariate data. Behav Sci 1967;12:153-155.
27. Osborne KA, Shigenko T, Balarsky AM, Ford I, McCulloch J, Teasdale GM, Graham DI. Quantitative assessment of early brain damage in a rat model of focal ischemia. J Neural Neurosurg Psychiatry 1987;50:402-410.
28. Duverger D, MacKenzie ET. The quantification of cerebral infarction following focal ischemia in the rat: influence of strain, arterial pressure, blood glucose concentration, and age. J Cereb Blood Flow Metab 1988; 8:449-461.
29. Swanson RA, Morton MT, Tsao-Wu G, Savalos RA, Davidson C, Sharp FRA. semiautomated method for measuring brain infarct volume. J Cereb Blood Flow Metab 1990;10:290-293.
30. Knight RA, Nagaraja TN, Ewing JR, Nagesh V, Whitton P, Bershad E, Fagan SC, Fenstermacher JD. Quantitation and localization of blood- to-brain influx by MRI and quantitative autoradiography in a model of transient focal ishemia. Magn Reson Med 2005;54:813-821.
31. Kamijyo Y, Garcia JH, Cooper J. Temporary regional cerebral ischemia in the cat. A model of hemorrhagic and subcortical infarction. J Neuropath Exp Neural 1977;36:338-350.
32. Garcia JH, Lowry SL, Briggs L, Mitchem HL, Morawetz R, Halsey JH, Conger KA. Brain capillaries expand and rupture in areas of ischemia and reperfusion., in Cerebrovascular Diseases, M. Reivich and H. H. Hurtig, Eds. Raven Press: New York, 1983; p. 169-182.
33. Hamann GF, Okada Y, Fitridge R, del Zoppo GJ. Microvascular basal lamina antigens disappear during cerebral ischemia and reperfusion. Stroke 1995;26:2120-2126.
34. Hamann GF, Okada Y, del Zoppo GJ. Hemorrhagic transformation and microvascular integrity during focal cerebral ischemia/reperfusion. J Cereb Blood Flow Metab 1996;16:1373-1378.
35. Jacobs MA, Zhang ZG, Knight RA, Soltanian-Zadeh H, Goussev AV, Peck DJ, Chopp MA. model for multiparametric MRI tissue characterization in experimental cerebral ischemia with histological validation in rat: part 1. Stroke 2001;32:943-949.
36. Schlaug G, Benfield A, Baird AE, B, S, Lovblad KO, Parker RA, Edelman RR, Warach S. The ischemic penumbra: operationally denned by diffusion and perfusion MRI. Neurology 1999;53:1528-1537.
37. Dijkhuizen RM, Nicolay K. Magnetic resonance imaging in experimental models of brain disorders. J Cereb Blood Flow Metab 2003;23:1383-1402.
38. Gingrich MB, Traynelis SF. Serine proteases and brain damage - is there a link? Trends Neurosci 2000;23.
39. Ewing J, Jiang Q, Boska M, Zhang Z, Brown S, Li G, Divine G, Chopp MT. 1 and magnetization transfer at 7 Tesla in acute ischemic infarct in the rat. Magn Reson Med 1999;41:696-705.
40. Henkelman RM, Huang X, Xiang QS, Stanisz GJ, Swanson SD, Bronskill MJ. Quantitative interpretation of magnetization transfer. Magn Reson Med 1993;29:759-766.