Recombinant tissue plasminogen activator increases blood-brain barrier disruption in acute ischemic stroke: An MR imaging permeability study

American Journal of Neuroradiology

Volumn 30, Issue 10, 2009, Pages 1864-1869

  Kassner, Andrea ^a,c   Roberts, T P L ^b   Moran, B ^c   Silver, F L ^d   Mikulis, D J ^c,d  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^c UNIVERSITY OF TORONTO   (Canada)

^d TORONTO WESTERN HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALTEPLASE; GADODIAMIDE; GADOLINIUM PENTETATE;

ACUTE DISEASE; ADULT; AGED; ARTICLE; BLEEDING TENDENCY; BLOOD BRAIN BARRIER; BRAIN ANGIOGRAPHY; BRAIN HEMORRHAGE; BRAIN ISCHEMIA; CEREBROVASCULAR ACCIDENT; CLINICAL ARTICLE; CLINICAL PROTOCOL; COMPUTER ASSISTED TOMOGRAPHY; CONTRAST ENHANCEMENT; DIFFUSION WEIGHTED IMAGING; FEMALE; HEMORRHAGIC TRANSFORMATION; HUMAN; IMAGING SYSTEM; MAGNETIC RESONANCE ANGIOGRAPHY; MALE; NATIONAL INSTITUTES OF HEALTH STROKE SCALE; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; PERFUSION WEIGHTED IMAGING; PREDICTION; QUANTITATIVE ANALYSIS; RECEIVER OPERATING CHARACTERISTIC; RISK; STATISTICAL SIGNIFICANCE; STROKE; TREATMENT OUTCOME;

ACUTE DISEASE; ADULT; AGED; AGED, 80 AND OVER; BLOOD-BRAIN BARRIER; BRAIN ISCHEMIA; FEMALE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; PREDICTIVE VALUE OF TESTS; RECOMBINANT PROTEINS; RISK FACTORS; ROC CURVE; SENSITIVITY AND SPECIFICITY; STROKE; TISSUE PLASMINOGEN ACTIVATOR;

EID: 71449102812     PISSN: 01956108     EISSN: None     Source Type: Journal    
DOI: 10.3174/ajnr.A1774     Document Type: Article

References (30)

1. del Zoppo G, von Kummer R, Hamann GF. Ischaemic damage of brain microvessels: inherent risks for thrombolytic treatment in stroke. J Neurol Neurosurg Psychiatry 1998;65:1-9
2. Smith W, Sung G, Starkman S, et al. Safety and efficacy of mechanical embolectomy in acute ischemic stroke: results of the MERCI trial. Stroke 2005;36:1432-1438 (Pubitemid 40967507)
3. Lyden P, Zivin JA. Hemorrhagic transformation after cerebral ischemia: mechanisms and incidence. Cerebrovasc Brain Met Rev 1993;5:1-16
4. Intracerebral hemorrhage after intravenous t-PA therapy for ischemic stroke: The NINDS tPA Stroke Study Group. Stroke 1997;28:2109-2118
5. Larrue V, von Kummer R, del Zoppo G, et al. Hemorrhagic transformation in acute ischemic stroke: potential contributing factors in the European Cooperative Acute Stroke Study. Stroke 1997;28:957-960 (Pubitemid 27209140)
6. Toni D, Fiorelli M, Bastianello S, et al. Hemorrhagic transformation of brain infarct: predictability in the first 5 hours from stroke onset and influence on clinical outcome. Neurology 1996;46:41-45
7. Hacke W, Kaste M, Fieschi C, et al. Intravenous thrombolysis with recombinant tissue plasminogen activator for acute hemispheric stroke: The European Cooperative Acute Stroke Study (ECASS). JAMA 1995;274:1017-1025
8. Hacke W, Kaste M, Fieschi C, et al. Randomised double-blind placebo-controlled trial of thrombolytic therapy with intravenous alteplase in acute ischaemic stroke (ECASS II). Lancet 1998;352:1245-1251 (Pubitemid 28470336)
9. Jaillard A, Cornu C, Durieux A, et al. Hemorrhagic transformation in acute ischemic stroke: The MAST-E study. Stroke 1999;30:1326-1332 (Pubitemid 29296057)
10. Thrombolytic therapy with streptokinase in acute ischemic stroke: The Multicenter Acute Stroke Trial Europe Study Group. N Engl J Med 1996;335:145-150
11. Hacke W, Kaste M, Bluhmki E, et al. Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. N Engl J Med 2008;359:1317-1329
12. Baron J, von Kummer R, del Zoppo GJ. Treatment of acute ischemic stroke: challenging the concept of a rigid and universal time window. Stroke 1999;30:180-182
13. Furlan A, Higashida R, Wechsler L, et al. Intra-arterial prourokinase for acute ischemic stroke: The PROACT II study - A randomized clinical trial. Prolyse in Acute Cerebral Thromboembolism. JAMA 1999;282:2003-2011
14. Hacke W, Albers G, Al-Rawi Y, et al. The desmoteplase in acute ischemic stroke trial (DIAS): a phase II MRI-based 9-hour window acute thrombolysis trial with intravenous desmoteplase. Stroke 2006;36:66-73 (Pubitemid 40054177)
15. Rowley H. Successful patient selection with DWPW-MRI for IV treatment with desmoteplase at 3-9 hours: DIAS and DEDAS trial results. In: Proceedings of the American Society of Neuroradiology, Toronto, Ontario, Canada, May 21-27, 2005
16. Kassner A, Roberts T, Taylor K, et al. Prediction of hemorrhage in acute ischemic stroke using permeability MR imaging. AJNR Am J Neuroradiol 2005;26:2213-2217
17. Periaswamy S. General-Purpose Medical Image Registration [PhD dissertation]. Hanover, NH: Dartmouth College; 2003
18. Roberts H, Roberts TPL, Brasch RC, et al. Quantitative measurement of microvascular permeability in human brain tumors achieved using dynamic contrast-enhanced MR imaging: correlation with histologic grade. AJNR Am J Neuroradiol 2000;21:891-899 (Pubitemid 30262836)
19. 14C-sucrose in areas of blood-brain opening. Magn Reson Med 2003;50:283-292
20. Stejskal E. Spin diffusion measurements: spin echoes in the presence of a time-dependent field gradient. J Chem Phys 1965;42:288-292
21. R Development Core Team. R: A Language and Environment for Statistical Computing. Vienna, Austria: R Foundation for Statistical Computing; 2007
22. Cao Y, Brown SL, Knight RA, et al. Effect of intravascular-to- extravascular water exchange on the determination of blood-to-tissue transfer constant by magnetic resonance imaging. Magn Reson Med 2005;53:282-293 (Pubitemid 40171042)
23. Lin K, Kazmi KS, Law M, et al. Measuring elevated microvascular permeability and predicting hemorrhagic transformation in acute ischemic stroke using first-pass dynamic perfusion CT imaging. AJNR Am J Neuroradiol 2007;28:1292-1298 (Pubitemid 47309661)
24. Bisdas S, Hartel M, Cheong LH, et al. Prediction of subsequent hemorrhage in acute ischemic stroke using permeability CT imaging and a distributed parameter tracer kinetic model. J Neuroradiol 2007;34:101-108 (Pubitemid 46770846)
25. Dankbaar JW, Hom J, Schneider T, et al. Dynamic perfusion CT assessment of the blood-brain barrier permeability: first pass versus delayed acquisition. AJNR Am J Neuroradiol 2008;29:1671-1676
26. Rosell A, Ortega-Aznar A, Alvarez-Sabin J, et al. Increased brain expression of matrix metalloproteinase-9 after ischemic and hemorrhagic human stroke. Stroke 2006;37:1399-1406 (Pubitemid 44305716)
27. Castellanos M, Leira R, Serena J, et al. Plasma metalloproteinase-9 concentration predicts hemorrhagic transformation in acute ischemic stroke. Stroke 2003;34:40-46 (Pubitemid 36070797)
28. Montaner J, Molina CA, Monasterio J, et al. Matrix metalloproteinase-9 pretreatment level predicts intracranial hemorrhagic complications after thrombolysis in human stroke. Circulation 2003;107:598-603 (Pubitemid 36176811)
29. Kastrup A, Gröschel K, Ringer TM, et al. Early disruption of the blood-brain barrier after thrombolytic therapy predicts hemorrhage in patients with acute stroke. Stroke 2008;39:2385-2387
30. Nyormoi O, Mills L, Bar-Eli M. An MMP-2/MMP-9 inhibitor, 5a, enhances apoptosis induced by ligands of the TNF receptor superfamily in cancer cells. Cell Death Differ 2003;10:558-569 (Pubitemid 36656645)