Estimating blood and brain concentrations and blood-to-brain influx by magnetic resonance imaging with step-down infusion of Gd-DTPA in focal transient cerebral ischemia and confirmation by quantitative autoradiography with Gd-[14C]DTPA

Journal of Cerebral Blood Flow and Metabolism

Volumn 29, Issue 5, 2009, Pages 1048-1058

  Knight, Robert A ^a,b   Karki, Kishor ^a,b   Ewing, James R ^a,b   Divine, George W ^a   Fenstermacher, Joseph D ^a   Patlak, Clifford S ^c   Nagaraja, Tavarekere N ^a  

^a HENRY FORD HOSPITAL   (United States)

^b OAKLAND UNIVERSITY   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Arterial input function; Bloodbrain barrier; Magnetic resonance contrast agents; Patlak plot; Rat; Stroke

Indexed keywords

GADOLINIUM PENTETATE; GADOLINIUM PENTETATE CARBON 14; UNCLASSIFIED DRUG; CARBON; CONTRAST MEDIUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BLOOD BRAIN BARRIER; BLOOD SAMPLING; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; MALE; NEUROIMAGING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; RAT; TRANSIENT ISCHEMIC ATTACK; ANIMAL; BLOOD; BRAIN; CEREBRAL ARTERY DISEASE; DISEASE MODEL; INTRAVENOUS DRUG ADMINISTRATION; METABOLISM; PATHOLOGY; SCINTISCANNING; WISTAR RAT;

ANIMALS; AUTORADIOGRAPHY; BLOOD-BRAIN BARRIER; BRAIN; CARBON RADIOISOTOPES; CONTRAST MEDIA; DISEASE MODELS, ANIMAL; GADOLINIUM DTPA; INFARCTION, MIDDLE CEREBRAL ARTERY; INFUSIONS, INTRAVENOUS; MAGNETIC RESONANCE IMAGING; MALE; RATS; RATS, WISTAR;

EID: 65549119704     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1038/jcbfm.2009.20     Document Type: Article

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