Lovastatin and (+)-geodin formation by Aspergillus terreus ATCC 20542 in a batch culture with the simultaneous use of lactose and glycerol as carbon sources

Engineering in Life Sciences

Volumn 11, Issue 3, 2011, Pages 272-282

  Bizukojc, Marcin ^a   Pecyna, Marta ^a  

^a LODZ UNIVERSITY OF TECHNOLOGY   (Poland)

Author keywords

(+) Geodin; Batch process kinetics; Glycerol; Lactose; Lovastatin

Indexed keywords

(+)-GEODIN; ASPERGILLUS TERREUS ATCC 20542; BATCH CULTURE; BATCH PROCESS; CARBON SOURCE; FORMATION RATES; LACTOSE; LOVASTATIN; POLYKETIDE METABOLITES; SIMULTANEOUS USE; SOLE CARBON SOURCE;

ASPERGILLUS; BATCH CELL CULTURE; BATCH DATA PROCESSING; BIOCHEMISTRY; BIOSYNTHESIS; KETONES; MIXTURES; SUGARS;

GLYCEROL;

CARBON; GEODIN; GLYCEROL; LACTOSE; MEVINOLIN; NITROGEN; POLYKETIDE; UNCLASSIFIED DRUG;

ALCOHOL; BIOTECHNOLOGY; CARBON; CONCENTRATION (COMPOSITION); DRUG; EXPERIMENTAL STUDY; FUNGUS; METABOLITE; REACTION KINETICS; SUGAR;

ARTICLE; ASPERGILLUS TERREUS; BACTERIAL STRAIN; BIOMASS; BIOSYNTHESIS; CARBON SOURCE; CONTROLLED STUDY; DRUG SYNTHESIS; FED BATCH CULTURE; FUNGUS CULTURE; NONHUMAN; VOLUMETRY;

ASPERGILLUS TERREUS ATCC 20542;

EID: 79958773886     PISSN: 16180240     EISSN: 16182863     Source Type: Journal    
DOI: 10.1002/elsc.201000179     Document Type: Article

References (38)

1. Casas Lopez, J. L., Sanchez Perez, J. A., Fernandez Sevilla, J. M., Acien Fernandez, F. G. et al., Production of lovastatin by Aspergillus terreus: effects of C:N ratio and the principal nutrients on growth and metabolite production. Enzyme Microb. Technol. 2003, 33, 270-277.
2. Szakacs, G., Morovjan, G., Tengerdy, R. P., Production of lovastatin by a wild strain of Aspergillus terreus. Biotechnol. Lett. 1998, 20, 411-415.
3. Kumar, M.S., Jana, S. K., Senthil, V., Shashanka, V. et al., Repeated fed-batch process for improving lovastatin production. Process Biochem. 2000, 36, 363-368.
4. Hajjaj, H., Niederberger, P., Duboc, P., Lovastatin biosynthesis by Aspergillus terreus in a chemically defined medium. Appl. Environ. Microbiol. 2001, 67, 2596-2602.
5. Lai, L.-S., Pan, C.-C., Tzeng, B.-K., The influence of medium design on lovastatin production and pellet formation with a high producing mutant of Aspergillus terreus in submerged culture. Process Biochem. 2003, 38, 1317-1326.
6. Casas Lopez, J. L., Sanchez Perez, J. A., Fernandez Sevilla, J. M., Acien Fernandez, F. G. et al., Fermentation optimization for the production of lovastatin by Aspergillus terreus; use of response surface methodology. J. Chem. Technol. Biotechnol. 2004, 79, 1119-1126.
7. Bizukojc, M., Pawlowska, B., Ledakowicz, S., Supplementation of the cultivation media with B-group vitamins enhances lovastatin biosynthesis by Aspergillus terreus. J. Biotechnol. 2007, 127, 258-268.
8. Bizukojc, M., Ledakowicz, S., Biosynthesis of lovastatin and (+)-geodin by Aspergillus terreus in batch and fed-batch culture in the stirred tank bioreactor. Biochem. Eng. J. 2008, 42, 198-207.
9. Lai, L.-S., Hung, C. S., Lo, C. C., Effects of lactose and glucose on production of itaconic acid and lovastatin by Aspergillus terreus ATCC 20542. J. Biosci. Bioeng. 2007, 104, 9-13.
10. Lai, L.-S., Tsai, T-H., Wang, T. C., Cheng, T. Y., The influence of culturing environments on lovastatin production by Aspergillus terreus in submerged cultures. Enzyme Microb. Technol. 2005, 36, 737-748.
11. Casas Lopez, J. L., Sanchez Perez, J. A., Fernandez Sevilla, J. M., Rodriguez Porcel, E. M., Chisti, Y., Pellet morphology, culture rheology and lovastatin production in cultures of Aspergillus terreus. J. Biotechnol. 2005, 116, 61-77.
12. Rodriguez Porcel, E. M., Casas Lopez, J. L., Sanchez Perez, J. A., Fernandez Sevilla, J. M. et al., Aspergillus terreus broth rheology, oxygen transfer, and lovastatin production in a gas-agitated slurry reactor. Ind. Eng. Chem. Res. 2006, 45, 4837-4843.
13. Manzoni, M., Rollini, M., Bergomi, S., Cavazzoni, V., Production and purification of statins from Aspergillus terreus strains. Biotechnol. Tech. 1998, 12, 529-532.
14. Bradamante, S., Barenghi, L., Berreta, G., Bonfa, M. et al., Production of lovastatin examined by an integrated approach based on chemometrics and DOSY-NMR. Biotechnol. Bioeng. 2002, 80, 589-593.
15. Barios-Gonzalez, J., Miranda, R. U., Biotechnological production and applications of statins. Appl. Microbiol. Biotechnol. 2010, 85, 869-883.
16. Musial, I., Rymowicz, W., Biodiesel by-products used as substrates for oxalic acid production by Aspergillus niger. In: Aggelis, G. (Ed.), Microbial Conversions of Raw Glycerol, Nova Science Publishers, New York 2009, pp. 31-40.
17. Andre, A., Diamantopoulu, P., Philippoussis, A., Sarris, D. et al., Biotechnological conversions of bio-diesel derived waste glycerol into added-value compounds by higher fungi: production of biomass, single cell oil and oxalic acid. Ind. Crops. Prod. 2010, 31, 407-416.
18. Papanikolaou, S., Aggelis, G., Biotechnological valorization of biodiesel derived glycerol waste through production of single cell oil and citric acid by Yarrowia lipolytica. Lipid Technol. 2009, 21, 83-87.
19. Rywinska, A., Rymowicz, W., Zarowska, B., Wojtatowicz, M., Biosynthesis of citric acid from glycerol by acetate mutants of Yarrowia lipolytica in fed-batch fermentation. Food Technol. Biotechnol. 2009, 47, 1-6.
20. Rymowicz, W., Fatykhova, A. R., Kamzolova, S. V., Rywinska, A., Morgunov, I. G., Citric acid production from glycerol-containing waste of biodiesel industry by Yarrowia lipolytica in batch, repeated batch, and cell recycle regimes. Appl. Microbiol. Biotechnol. 2010, 87, 971-979.
21. Fakas, S., Papanikolaou, S., Batsosa, A., Galiotou-Panayotoua, M. et al., Evaluating renewable carbon sources as substrates for single cell oil production by Cunninghamella echinulata and Mortierella isabellina. Biomass Bioenergy 2009, 33, 573-580.
22. Biebl, H., Marten, S., Fermentation of 1, 3-propanediol: use of cosubstrates. Appl. Microbiol. Biotechnol. 1995, 44, 14-19.
23. Barbirato, F., Camarasa-Claret, C., Grivet, J. P., Bories, A., Glycerol fermentation by a new 1, 3-propanediol-producing microorganism: Enterobacter agglomerans. Appl. Microbiol. Biotechnol. 1995, 43, 786-793.
24. Biebl, H., Zeng, A.-P., Menzel, K., Deckwer, W.-D., Fermentation of glycerol to 1, 3-propanediol and 2, 3-butanediol by Klebsiella pneumoniae. Appl. Microbiol. Biotechnol. 1998, 50, 24-29.
25. Zeng, A.-P., Biebl, H., Bulk chemicals from biotechnology: the case of 1, 3-propanediol production and the new trends. Adv. Biochem. Eng. Biotechnol. 2002, 74, 239-259.
26. Xiu, Z.-L., Zeng, A.-P., Present state and perspective of downstream processing of biologically produced 1, 3-propanediol and 2, 3-butanediol. Appl. Microbiol. Biotechnol. 2008, 78, 917-926.
27. Hargreaves, J., Park, J., Ghisalberti, E. L., Sivasithamparam, K. et al., New chlorinated diphenyl ethers from an Aspergillus species. J. Nat. Prod. 2002, 65, 7-10.
28. Askenazi, M., Driggers, E., Holtzman, D. A., Norman, T. C. et al., Integrating transcriptional and metabolite profiles to direct the engineering of lovastatin producing fungal strains. Nat. Biotechnol. 2003, 21, 50-156.
29. Couch, R. D., Gaucher, M., Rational elimination of Aspergillus terreus sulochrin production. J. Biotechnol. 2004, 108, 171-178.
30. Bizukojc, M., Ledakowicz, S., Simultaneous biosynthesis of (+)-geodin by a lovastatin-producing fungus Aspergillus terreus. J. Biotechnol. 2007, 132, 453-460.
31. Pecyna, M., Bizukojc, M., Lovastatin biosynthesis by Aspergillus terreus with the simultaneous use of lactose and glycerol in a discontinuous fed-batch culture. J. Biotechnol. 2011, 151, 77-86.
32. Bizukojc, M., Ledakowicz, S., A macrokinetic modelling of the biosynthesis of lovastatin by Aspergillus terreus. J. Biotechnol. 2007, 130, 422-435.
33. Liu, G., Xu, Z., Cen, P., A morphologically structured model for mycelial growth and secondary metabolite formation. Chin. J. Chem. Eng. 2000, 8, 46-51.
34. Bizukojc, M., Ledakowicz, S., The morphological and physiological evolution of Aspergillus terreus mycelium in the submerged culture and its relation to the formation of secondary metabolites. World J. Microbiol. Biotechnol. 2010, 26, 41-54.
35. Makri, A., Fakas, S., Aggelis, G., Metabolic activities of biotechnological interest in Yarrowia lipolytica grown on glycerol in repeated batch cultures. Biores. Technol. 2010, 101, 2351-2358.
36. Papanikolaou, S., Munigilia, L., Chevalot, I., Aggelis, G., Marc, I., Yarrowia lipolytica as a potential producer of citric acid from raw glycerol. J. Appl. Microbiol. 2002, 92, 737-744.
37. Bizukojc, M., Biosynthesis of polyketide compounds by Aspergillus terreus (in Polish), DSc thesis, Technical University of Lodz, 2009.
38. Seiboth, B., Pakdaman, B. S., Hartl, L., Kubicek, C. P., Lactose metabolism in filamentous fungi: how to deal with an unknown substrate. Fungal Biol. Rev. 2007, 21, 42-48.