Production of lovastatin examined by an integrated approach based on chemometrics and DOSY-NMR

Biotechnology and Bioengineering

Volumn 80, Issue 5, 2002, Pages 589-593

  Bradamante, Silvia ^a   Barenghi, Livia ^a   Beretta, Giangiacomo ^b   Bonfa', Maria ^c   Rollini, Manuela ^b   Manzoni, Matilde ^b  

^a CNR   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c UNIVERSITY OF MILANO BICOCCA   (Italy)

Author keywords

Decision tree algorithm; DOSY NMR spectroscopy; Fermentation; Lovastatin

Indexed keywords

ALGORITHMS; DRUG PRODUCTS; FERMENTATION; FUNGI; METABOLITES; NUCLEAR MAGNETIC RESONANCE;

CHEMOMETRICS;

BIOTECHNOLOGY;

MEVINOLIN;

ALGORITHM; ARTICLE; ASPERGILLUS TERREUS; BIOPROCESS; DRUG MANUFACTURE; FERMENTATION; METABOLITE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; ASPERGILLUS; BIOLOGICAL MODEL; BIOSYNTHESIS; CHEMICAL MODEL; CLASSIFICATION; CLUSTER ANALYSIS; COMBINATORIAL CHEMISTRY; COMPARATIVE STUDY; DECISION TREE; EVALUATION; ISOLATION AND PURIFICATION; METABOLISM; METHODOLOGY; MICROBIOLOGY; QUALITY CONTROL; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; SPECIES DIFFERENCE; STATISTICS; VALIDATION STUDY;

ASPERGILLUS; ASPERGILLUS TERREUS;

ALGORITHMS; ASPERGILLUS; CLUSTER ANALYSIS; COMBINATORIAL CHEMISTRY TECHNIQUES; DECISION TREES; INDUSTRIAL MICROBIOLOGY; LOVASTATIN; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, BIOLOGICAL; MODELS, CHEMICAL; QUALITY CONTROL; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SPECIES SPECIFICITY; STATISTICS;

EID: 0037027823     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/bit.10418     Document Type: Article

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