Lovastatin biosynthesis by Aspergillus terreus with the simultaneous use of lactose and glycerol in a discontinuous fed-batch culture

Journal of Biotechnology

Volumn 151, Issue 1, 2011, Pages 77-86

  Pecyna, Marta ^a   Bizukojc, Marcin ^a  

^a LODZ UNIVERSITY OF TECHNOLOGY   (Poland)

Author keywords

(+) Geodin; Fed batch culture; Glycerol; Kinetics; Lactose; Lovastatin

Indexed keywords

(+)-GEODIN; ASPERGILLUS TERREUS; CARBON SUBSTRATES; CULTIVATION MEDIA; FED-BATCH CULTURES; FUNGAL ACTIVITY; INITIAL STAGES; LACTOSE; LOVASTATIN; LOVASTATIN PRODUCTION; POLYKETIDE METABOLITES; POLYKETIDES; PRODUCT FORMATION; SIMULTANEOUS USE; YIELD COEFFICIENT;

BATCH CELL CULTURE; BIOCHEMISTRY; BIOSYNTHESIS; GLYCEROL; SUBSTRATES;

SUGARS;

GEODIN; GLYCEROL; LACTOSE; MEVINOLIN; POLYKETIDE; UNCLASSIFIED DRUG;

ARTICLE; ASPERGILLUS TERREUS; BATCH PROCESS; CARBON SOURCE; CONCENTRATION (PARAMETERS); FED BATCH CULTURE; FED BATCH REACTOR; METABOLITE; NONHUMAN; PRIORITY JOURNAL;

ASPERGILLUS; BENZOFURANS; BIOMASS; BIOREACTORS; BIOTECHNOLOGY; FERMENTATION; GLYCEROL; KINETICS; LACTOSE; LOVASTATIN;

ASPERGILLUS TERREUS;

EID: 78650677059     PISSN: 01681656     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jbiotec.2010.10.079     Document Type: Article

References (23)

1. Alberts A.W., Chen J., Kuron G., Hunt V., Huff J., Hoffman C., Rothrock J., Lopez M., Joshua H., Harris E., Patchett A., Monaghan R., Currie S., Stapley E., Albers-Schonberg G., Hensens O., Hirshfield J., Hoogsteen K., Liesch J., Springer J. Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol lowering agent. Proc. Natl. Acad. Sci. U.S.A. 1980, 77:3957-3961.
2. Askenazi M., Driggers E., Holtzman D.A., Norman T.C., Iverson S., Zimmer D., Boers M.-E., Blomquist P.R., Martinez E.J., Monreal A.W., Feibelman T.P., Mayorga M.E., Maxon M.E., Sykes K., Tobin J.V., Cordero E., Salama S., Trueheart J., Royer J.C., Madden K.T. Integrating transcriptional and metabolite profiles to direct the engineering of lovastatin producing fungal strains. Nat. Biotechnol. 2003, 21:150-156.
3. Barios-Gonzalez J., Miranda R.U. Biotechnological production and applications of statins. Appl. Microbiol. Biotechnol. 2010, 85:869-883.
4. Bizukojc M., Ledakowicz S. A macrokinetic modelling of the biosynthesis of lovastatin by Aspergillus terreus. J. Biotechnol. 2007, 130:422-435.
5. Bizukojc M., Ledakowicz S. Simultaneous biosynthesis of (+)-geodin by a lovastatin producing fungus Aspergillus terreus in batch and fed-batch culture in the stirred tank bioreactors. J. Biotechnol. 2007, 132:453-460.
6. Bizukojc M., Ledakowicz S. Biosynthesis of lovastatin and (+)-geodin by Aspergillus terreus in batch and fed-batch culture in the stirred tank bioreactor. Biochem. Eng. J. 2008, 42:198-207.
7. Bizukojc M., Pawłowska B., Ledakowicz S. Supplementation of the cultivation media with B-group vitamins enhances lovastatin biosynthesis by Aspergillus terreus. J. Biotechnol. 2007, 127:258-268.
8. Bradamante S., Barenghi L., Beretta G., Bonfa M., Rollini M., Manzoni M. Production of lovastatin examined by an integrated approach based on chemometrics and DOSY-NMR. Biotechnol. Bioeng. 2002, 80:589-593.
9. Casas Lopez J.L., Sanchez Perez J.A., Fernandez Sevilla J.M., Acien Fernandez F.G., Molina Grima E., Chisti Y. Production of lovastatin by Aspergillus terreus: effects of C:N ratio and the principal nutrients on growth and metabolite production. Enzyme Microb. Technol. 2003, 33:270-277.
10. Casas Lopez J.L., Sanchez Perez J.A., Fernandez Sevilla J.M., Acien Fernandez F.G., Molina Grima E.M., Chisti Y. Fermentation optimization for the production of lovastatin by Aspergillus terreus: use of response surface methodology. J. Chem. Technol. Biotechnol. 2004, 79:1119-1126.
11. Couch R.D., Gaucher M. Rational elimination of Aspergillus terreus sulochrin production. J. Biotechnol. 2004, 108:171-178.
12. Hajjaj H., Niederberger P., Duboc P. Lovastatin biosynthesis by Aspergillus terreus in a chemically defined medium. Appl. Environ. Microbiol. 2001, 67:2596-2602.
13. Jia Z., Zhang X., Zhao Y., Cao X. Enhancement of lovastatin production by supplementing polyketide antibiotics to the submerged culture of Aspergillus terreus. Appl. Biochem. Biotechnol. 2010, 160:2014-2025.
14. Kumar M.S., Jana S.K., Senthil V., Shashanka V., Vijay- Kumar S., Sadhukhan A.K. Repeated fed-batch process for improving lovastatin production. Process Biochem. 2000, 36:363-368.
15. Lai L.-S., Pan C.-C., Tzeng B.-K. Medium optimization for lovastatin production by Aspergillus terreus in submerged cultures. J. Chin. Inst. Chem. Eng. 2002, 33:517-527.
16. Manzoni M., Rollini M., Bergomi S., Cavazzoni V. Production and purification of statins from Aspergillus terreus strains. Biotechnol. Tech. 1998, 12:529-532.
17. Monaghan, R.L., Alberts, A.W., Hoffman, C.H., Albers-Schonberg, G., 1980. Hypocholesterolemic fermentation products and process of preparation. United States Patent 4, 231, 938.
18. Novak N., Gerdin S., Berovic M. Increased lovastatin formation by Aspergillus terreus using repeated fed-batch process. Biotechnol. Lett. 1997, 19:947-948.
19. Rodriguez Porcel E.M., Casas Lopez J.L., Sanchez Perez J.A., Chisti Y. Enhanced production of lovastatin in a bubble column by Aspergillus terreus using a two-stage feeding strategy. J. Chem. Technol. Biotechnol. 2007, 82:58-64.
20. Rodriguez Porcel E.M., Casas Lopez J.L., Sanchez Perez J.A., Chisti Y. Lovastatin production in a two-stage feeding operation. J. Chem. Technol. Biotechnol. 2008, 83:1236-1243.
21. Seiboth B., Pakdaman B.S., Hartl L., Kubicek C.P. Lactose metabolism in filamentous fungi: how to deal with an unknown substrate. Fungal Biol. Rev. 2007, 21:42-48.
22. Szakacs G., Morovjan G., Tengerdy R.P. Production of lovastatin by a wild strain of Aspergillus terreus. Biotechnol. Lett. 1998, 20:411-415.
23. Vinci V.A., Hoerner T.D., Coffman A.D., Schimmel T.G., Dabora R.L., Kirkepar A.C., Ruby C.L., Stieber R.W. Mutants of a lovastatin-hyperproducing Aspergillus terreus deficient in the production of sulochrin. J. Ind. Microbiol. 1991, 8:113-120.