Repeated fed-batch process for improving lovastatin production

Process Biochemistry

Volumn 36, Issue 4, 2000, Pages 363-368

  Kumar, M Sitaram ^a   Jana, Swapan K ^a   Senthil, V ^a   Shashanka, V ^a   Kumar, S Vijay ^a   Sadhukhan, A K ^a  

^a DR REDDY S RESEARCH FOUNDATION   (India)

Author keywords

Aspergillus terreus; Fed batch process; Lovastatin; Oxygen transfer; Submerged cultivation; Volumetric productivity

Indexed keywords

MEVINOLIN;

ARTICLE; ASPERGILLUS TERREUS; BIOREACTOR; COST EFFECTIVENESS ANALYSIS; DRUG MANUFACTURE; FUNGUS CULTURE; NONHUMAN; OXYGEN CONSUMPTION; VOLUMETRY;

EID: 0033735694     PISSN: 13595113     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0032-9592(00)00222-3     Document Type: Article

References (15)

1. Mevinolin: A highly potent competitive inhibitor of hydroxymethyl glutaryl-coenzyme A reductase and a cholesterol-lowering agent
2. Induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human firboblasts incubated with copactin (ML-236 B), a competitive inhibitor of the reductase
3. Production of lovastatin, an inhibitor of cholesterol accumulation in humans
4. Colorimetric method for determination of sugars and related substances
5. Competitive inhibition of 3-hydroxy-3-methyl glutaryl coenzyme A reductase by ML-236 A and ML-236 B fungal metabolites having hypocholesterolemic activity
6. ML-236 A, ML-236 B and ML-236 C, new inhibitors of cholesterogenesis produced by Penicillium citrinum
7. Monacolin K, a new hypocholesterolemic agent produced by a Monascus spp.
8. Use of DNS reagent for determination of reducing sugar
9. Use of the Plackett and Burman technique in a discovery program for new natural products
10. Increased lovastatin formation by Aspergillus terreus using repeated fed-batch process
11. Regeneration of Aspergillus nidulans protoplasts
12. A rapid technique for screening of lovastatin producing strains of Aspergillus terreus by agar plug and Neurospora crassa bioassay
13. Kinetic analysis of the reaction catalyzed by rat-liver 3-hydroxy-3-methylglutaryl coenzyme A reductase using two specific inhibitor
14. New development in lipid lowering therapy: The role of inhibitors of hydroxymethyl glutaryl co-enzyme A reductase
15. Mutants of a lovastatin hyper producing Aspergillus terreus deficient in the production of sulochrin