Consumption of a plant sterol-based spread derived from rice bran oil is effective at reducing plasma lipid levels in mildly hypercholesterolaemic individuals

British Journal of Nutrition

Volumn 105, Issue 12, 2011, Pages 1808-1818

  Eady, Sarah ^a   Wallace, Alison ^a   Willis, Jinny ^b   Scott, Russell ^b   Frampton, Chris ^c  

^a THE NEW ZEALAND INSTITUTE FOR PLANT AND FOOD RESEARCH LIMITED   (New Zealand)

^b CHRISTCHURCH HOSPITAL   (New Zealand)

^c UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

Cholesterol; Lipoproteins; Plant sterols

Indexed keywords

CHOLESTEROL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PHYTOSTEROL; SUNFLOWER OIL; TRIACYLGLYCEROL; VEGETABLE OIL;

ADULT; AGED; ARTICLE; BLOOD SAMPLING; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIET SUPPLEMENTATION; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; FEMALE; FOOD INTAKE; HUMAN; HYPERCHOLESTEROLEMIA; LIPID ANALYSIS; LIPID BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; RANDOMIZED CONTROLLED TRIAL; RICE BRAN; TREATMENT DURATION; TRIACYLGLYCEROL BLOOD LEVEL;

HELIANTHUS;

EID: 79958770764     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114510005519     Document Type: Article

References (53)

1. National Heart, Lung and Blood Institute (NHLBI) (2002) National Cholesterol Education Programme (National Cholesterol Education Programme) Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation 106, 3143-3421.
2. Executive summary of The Third Report of the National Cholesterol Education Programme (National Cholesterol Education Programme) (2001) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 285, 2486-2497.
3. Plat J & Mensink RP (2005) Plant stanol and sterol esters in the control of blood cholesterol levels. Mechanism and safety aspects. Am J Cardiol 96, 15D-22D. (Pubitemid 40898165)
4. Law M (2000) Plant sterol and stanol spreads and health. BMJ 320, 861-864.
5. Piironen V, Lindsay DG & Miettienen TA (2000) Plant sterols: biosynthesis, biological function and their importance to human nutrition. J Sci Food Agric 80, 939-966. (Pubitemid 30319392)
6. Devaraj S & Jialal I (2006) The role of dietary supplementation with plant sterols and stanols in the prevention of cardiovascular disease. Nutr Rev 647, 348-354. (Pubitemid 44124979)
7. Fernandes P & Cabral JMS (2006) Plant sterols: applications and recovery methods. Bioresour Technol. http://www. eslevier.com
8. Salo P & Wester I (2005) Low fat formulations of plant stanols and sterols. Am J Cardiol 96, 51D-54D. (Pubitemid 40898171)
9. Katan MB, Grundy SM, Jones P, et al. (2003) Efficacy and safety of plant stanols and sterols in the management of blood cholesterol levels. Mayo Clin Proc 78, 965-978. (Pubitemid 36936128)
10. St-Onge MP & Jones PJH (2003) Plant sterols and human lipid metabolism: efficacy, safety and novel foods. Lipids 384, 367-375.
11. AbuMweis SS, Barake R & Jones PJH (2008) Plant sterols/ stanols as cholesterol lowering agents: a meta-analysis of randomised controlled trials. Food Nutr Res 52. http:// www.foodandnutritionresearch.net
12. Qureshi AA, Sami SA & Khan FA (2002) Effects of stabilized rice bran, its soluble and fibre fractions on blood glucose levels and serum lipid parameters in humans with diabetes mellitus types I and II. J Nutr Biochem 13, 175-187. (Pubitemid 34226694)
13. Wilson TA, Nicolosi RJ, Woolfrey B, et al. (2007) Rice bran oil and oryzanol reduce plasma lipid and lipoprotein cholesterol concentrations and aortic cholesterol ester accumulation to a greater extent than ferulic acid in hypercholesterolemic hamsters. J Nutr Biochem 18, 105-112. (Pubitemid 46048986)
14. Lee J-W, Lee S-W, Kim M-K, et al. (2005) Beneficial effect of the unsaponifiable matter from rice bran oil on oxidative stress in vitro compared with a-tocopherol. J Sci Food Agric 85, 493-498. (Pubitemid 40199000)
15. Most MM, Tulley R, Morales S, et al. (2005) Rice bran oil, not fibre, lowers cholesterol in humans. Am J Clin Nutr 81, 64-68. (Pubitemid 43073376)
16. Cicero AFG & Gaddi A (2001) Rice bran oil and g-oryzanol in the treatment of hyperlipoproteinaemias and other conditions. Phyto Res 15, 227-289.
17. Friedweld WT, Levy RT & Fredrickson DS (1972) Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 18, 499-502.
18. Lesperence L (2009) The Concise New Zealand Food Composition Tables, 8th ed. Wellington/Palmerston North: New Zealand Institute for Plant and Food Research/Ministry of Health. http://www.crop.cri.nz/home/products.services/ nutrition/foodcompsitiondata/consise8ed.pdf
19. Ostlund RE (2007) Plant sterols, cholesterol absorption and healthy diets. Lipids 42, 41-45.
20. De Deckere EAM & Korver O (1996) Minor constituents of rice bran oil as functional foods. Nutr Rev 11, s120-s133.
21. Jeppesen J, Hein HO, Suadicani P, et al. (1997) Relation of high TG-low HDL cholesterol and LDL cholesterol to the incidence of ischemic heart disease: an eight year follow up in the Copenhagen Male Study. Arterioscler Thromb Vasc Biol 17, 1114-1120. (Pubitemid 27260331)
22. Derdemezis CS, Filippatos TD, Mikhailidis DP, et al. (2010) Review Article: effects of plant sterols and stanols beyond low density lipoprotein cholesterol lowering. J Cardiovasc Pharmacol Ther 15, 120-134.
23. Racette SB, Lin X, Lefevre M, et al. (2010) Dose effects of dietary phytosterols on cholesterol metabolism: a controlled feeding study. Am J Clin Nutr 91, 32-38.
24. Escurriol V, Cofan M, Serra M, et al. (2009) Serum sterol responses to increasing plant sterol intake from natural foods in the Mediterranean diet. Eur J Nutr 48, 373-382.
25. Gerber A, Evers T, Haverkamp H, et al. (2006) Cost-benefit analysis of a plant sterol containing low fat spread for cholesterol reduction. Eur J Health Econom 7, 247-254.
26. Wiboonsirikul J, Kimura Y, Kanaya Y, et al. (2008) Production and characterisation of functional substances from a by-product of rice bran oil and protein production by compressed hot water treatment. Biosci Biotechnol Biochem 722, 384-392. (Pubitemid 351353672)
27. Sugano M & Tsuji E (1997) Rice bran oil and cholesterol metabolism. J Nutr 127, 521-524.
28. Godber JS, Xu Z, Hegsted M, et al. (2002) Rice bran and rice bran oil in functional foods development. Louisiana Agricultural Magazine 454, 9-10. (Pubitemid 36657500)
29. Jariwalla RJ (2001) Rice bran products: phytonutrients with potential applications in preventative and clinical medicine. Drugs Exp Clin Res 27, 17-26. (Pubitemid 32215892)
30. Lichtenstein AH & Deckelbaum RJ (2001) Stanol/sterol ester containing foods and blood cholesterol levels. Circulation 103, 1177-1179.
31. De Jong N, Zuur A, Wolfs MC, et al. (2007) Exposure and effectiveness of phytosterol/stanol-enriched spreads. Eur J Clin Nutr 61, 1407-1415.
32. Ostlund RE (2002) Plant sterols in human nutrition. Ann Rev Nutr 22, 533-549.
33. Westrate J & Meijer GW (1998) Plant sterol enriched spreads and reduction of plasma total and LDL cholesterol concentrations in normocholesterolemic and mildly hypercholesterolaemic subjects. Eur J Clin Nutr 52, 334-343. (Pubitemid 28230699)
34. Hendricks HF, Westrate JA, van Vliet T, et al. (1999) Spreads enriched with three different levels of vegetable oil sterols and the degree of cholesterol lowering in normocholesterolaemic and mildly hypercholesterolaemic subjects. Eur J Clin Nutr 534, 319-327. (Pubitemid 29164264)
35. Maki C, Davidson MH, Umporowicz DM, et al. (2001) Lipid responses to plant-sterol enriched reduced fat spreads incorporated into a National Cholesterol Education Program Step 1 diet. Am J Clin Nutr 74, 33-43. (Pubitemid 32574909)
36. Mensink RP & Katan MB (1992) Effect of dietary fatty acids on serum lipids and lipoproteins. A meta-analysis of 27 trials. Arterioscler Thromb 12, 911-919.
37. Hu FB, Manson JE & Willet WC (2001) Types of dietary fat and risk of coronary heart disease: a critical review. J Am Coll Nutr 20, 5-19. (Pubitemid 32244959)
38. Gibson RS (2005) Measuring food consumption of individuals. In Principles of Nutritional Assessment, pp. 41-50. Oxford: Oxford University Press.
39. Sacks FM & Campos H (2006) Polyunsaturated fatty acids, inflammation and cardiovascular disease: time to widen our view of the mechanisms. J Clin Endocrinol Metab 91, 398-400. (Pubitemid 43236900)
40. Gardner CD & Kraemer HC (1995) Monosaturated versus polyunsaturated dietary fat and serum lipids: a meta analysis. Arterioscler Thromb Vasc Biol 15, 1917-1927.
41. Beglinger C & Degen L (2004) Fat in the intestine as a regulator of appetite - role of CCK. Physiol Behav 83, 617-621. (Pubitemid 40038512)
42. Soupas L, Juntunen L, Lampi AM, et al. (2004) Effects of sterol structure, temperature and lipid medium on phytosterol oxidation. J Agric Food Chem 52, 6485-6491.
43. Knopp RH, Paramsothy P, Retzlaff BM, et al. (2005) Gender differences in lipoprotein metabolism and dietary response: basis in hormonal differences and implications for cardiovascular disease. Curr Atheroscler Rep 7, 472-479. (Pubitemid 43033774)
44. Knopp RH, Paramsothy P, Retzlaff BM, et al. (2006) Sex differences in lipoprotein metabolism and dietary response: basis in hormonal differences and implications for cardiovascular disease. Curr Atheroscler Rep 8, 452-459. (Pubitemid 44742140)
45. Lapointe A, Balk EM & Lictehnstein AH (2006) Gender differences in plasma lipid response to dietary fat. Nutr Rev 64, 234-249. (Pubitemid 43953287)
46. Jones PJH, MacDougall DE, Ntanios F, et al. (1997) Dietary phytosterols as cholesterol lowering agents in humans. Can J Physiol Pharmacol 75, 217-227. (Pubitemid 27255000)
47. Micallef MA & Manohar L (2008) The lipid lowering effects of phytosterols and (n-3) polyunsaturated fatty acids are synergistic and complementary in hypolipidaemic men and women. J Nutr 138, 1086-1090.
48. Bonanome A & Grundy SM (1988) Effect of dietary stearic acid on plasma on cholesterol and lipoprotein levels. N Engl J Med 318, 1244-1248.
49. O'Dea K, Traianedes K, Chisholm K, et al. (1990) Cholesterol lowering effect of a low fat diet containing both lean beef is reversed by the addition of beef fat.AmJClinNutr 52, 491-494.
50. Gylling H, Hallikainen M, Nissinen MJ, et al. (2010) Very high plant stanol intake and serum plant stanols and non-cholesterol sterols. Euro J Nutr 49, 111-117.
51. Nguyen TT (1999) The cholesterol lowering action of plant stanol esters. J Nutr 129, 2109-2112.
52. Plat J, Nichols JA & Mensink RP (2005) Plant Sterols and stanols: effects on mixed micellar composition and LXR (target gene) activation. J Lipid Res 46, 2468-2476. (Pubitemid 41532535)
53. Grandjean PW & Alhassan S (2006) Essential laboratory methods for blood lipid and lipoprotein analysis. In Lipid Metabolism and Health, pp. 117-142 [RJ Moffat and B Stamford, editors]. Boca Raton, FL: CRC Press.