Assessment of Mitochondrial Respiratory Complex Function in Vitro and in Vivo

Drug-Induced Mitochondrial Dysfunction

Volumn , Issue , 2008, Pages 383-395

  Birch Machin, Mark A ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

Linked assay spectrophotometric measurement; Mitochondrial respiratory complex function assessment; Mitochondrial ROSs and mitochondria targeted probe molecules

Indexed keywords

EID: 79958766883     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9780470372531.ch15     Document Type: Chapter

References (35)

1. Birch-Machin MA, Briggs H, Saborido AA, Bindoff LA, Turnbull DM. An evaluation of the measurement of the activities of complexes I-IV in the respiratory chain of human skeletal muscle mitochondria. Biochem Med Metab Biol. 1994;51:35-42.
2. Rustin, P, Chretien D, Bourgeron T, et al. Biochemical and molecular investigations in respiratory chain deficiencies. Clin Chim Acta. 1994;228(1):35-51.
3. Sottocasa GL, Kuylenstierna B, Ernster L, Bergstrand A. An electron transport system associated with the outer membrane of liver mitochondria. J Cell Biol. 1967;32:415-438.
4. Chretien D, Slama A, Munnich A, Rotig A, Rustin P. Revisiting pitfalls, problems and tentative solutions for assaying mitochondrial respiratory chain complex III in human samples. Curr Med Chem. 2004;11:233-239.
5. Zheng X, Shoffner JM, Voljavec AS, Wallace DC. Evaluation of procedures for assaying oxidative phosphorylation: enzyme activities in mitochondrial myopathy muscle biopsies. Biochim Biophys Acta. 1990;1019:1-10.
6. Birch-Machin MA, Howell N, Turnbull DM. Defects at coupling site II. Methods Toxicol. 1993;2:324-336.
7. Chretien D, Gallego J, Barrientos A, et al. Biochemical parameters for the diagnosis of mitochondrial respiratory chain deficiency in humans, and their lack of age-related changes. Biochem J. 1998;329:249-254.
8. Taylor RW, Birch-Machin MA, Bartlett K, Turnbull DM. Succinate-cytochrome c reductase: assesssment of its value in the investigation of defects of the respiratory chain. Biochim Biophys Acta. 1993;1181:261-265.
9. Birch-Machin MA, Singh-Kler R, Turnbull DM. Study of skeletal muscle dysfunction. In Mitochondrial Dysfunction (LH Lash, DP Jones, eds). San Diego, CA: Academic Press; 1993:51-69.
10. Taylor RW, Birch-Machin MA, Bartlett K, Lowerson SA, Turnbull DM. The control of mitochondrial oxidations by complex III in rat muscle and liver mitochondria:implications for our understanding of mitochondrial cytopathies in man. J Biol Chem. 1994;269(5):3523-3528.
11. Chan K, Truong D, Shangari N, O'Brien PJ. Drug-induced mitochondrial toxicity. Expert Opin Drug Metab Toxicol. 2005;1(4):655-669.
12. Chernyak BV, Izyumov DS, Lyamzaev KG, et al. Production of reactive oxygen species in mitochondria of HeLa cells under oxidative stress. Biochim Biophys Acta. 2006;1757(5-6):525-534.
13. Marsden JR, Coburn PR, Marks J, Shuster S. Measurement of the response of psoriasis to short-term application of anthralin. Br J Dermatol. 1983;109:209-218.
14. McGill A, Frank A, Emmett N, et al. The antipsoriatic drug anthralin accumulates in keratinocyte mitochondria, dissipates mitochondrial membrane potential, and induces apoptosis through a pathway dependent on respiratory competent mitochondria. FASEB J. 2005;19:1012-1014.
15. Fuchs J, Nitschmann WH, Packer L. The antipsoriatic compound anthralin influences bioenergetic parameters and redox properties of energy transducing membranes. J Invest Dermatol. 1990;94:71-76.
16. Pelicano H, Feng L, Zhou Y, Hileman EO, Keating MJ, Huang P. Inhibition of mitochondrial respiration: a novel strategy to enhance drug-induced apoptosis in human leukemia cells by a reactive oxygen species-mediated mechanism. J Biol Chem. 2003;278:37832-37839.
17. Meyer T, Nindl I, Schmook T, et al. Induction of apoptosis by Toll-like receptor-7 agonist in tissue cultures. Br J Dermatol. 2003;149(suppl 66):9-14.
18. Schon M, Bong AB, Drewniok C, et al. Tumor-selective induction of apoptosis and the small-molecule immune response modifier imiquimod. J Natl Cancer Inst. 2003;95(15):1138-1149.
19. Dummer R, Urosevic M, Kempf W, et al. Imiquimod in basal cell carcinoma: how does it work? Br J Dermatol. 2003;149(suppl 66):57-58.
20. Schon MP, Wienrich BG, Drewniok C, et al. Death receptor-independent apoptosis in malignant melanoma induced by the small-molecule immune response modifier imiquimod. J Invest Dermatol. 2004;122(5):1266-1276.
21. Berman B, Sullivan T, De Araujo T, et al. Expression of Fas-receptor on basal cell carcinomas after treatment with imiquimod 5% cream or vehicle. Br J Dermatol. 2003;149(suppl 66):59-61.
22. Vidal D, Matias-Guiu X, Alomar A. Efficacy of imiquimod for the expression of Bcl-2, Ki67, p53 and basal cell carcinoma apoptosis. Br J Dermatol. 2004;151(3):656-662.
23. Urosevic M, Maier T, Benninghoff B, et al. Mechanisms underlying imiquimodinduced regression of basal cell carcinoma in vivo. Arch Dermatol. 2003;139(10):1325-1332.
24. Lysa B, Tartler U,Wolf R, et al. Gene expression in actinic keratoses: pharmacological modulation by imiquimod. Br J Dermatol. 2004;151(6):1150-1159.
25. Aitken G, Henderson JR, Chang S-C, McNeil C, Birch-Machin MA. Direct monitoring of UV-induced free radical generation in HaCaT keratinocytes. Clin Exp Dermatol. 2007;32:722-727.
26. Aitken G, Henderson JR, Chang S-C, McNeil C, Birch-Machin MA. Direct real-time electrochemical measurement and flow cytometry of UVA induced oxidative stress and its perturbation by mitochondrial electron transport chain inhibitors. Br J Dermatol. 2005;152:830.
27. Birch-Machin MA. The role of mitochondria in ageing and carcinogenesis. Clin Exp Dermatol. 2006 Jun;31(4):548-552.
28. Durham SE, Krishnan KJ, Betts J, Birch-Machin MA. Mitochondrial DNA damage in non-melanoma skin cancer. Br J Cancer. 2003;88:90-95.
29. Zini R, Morin C, Bertelli A, Bertelli AA, Tilement JP. Effects of resveratrol on the rat brain respiratory chain. Drugs Exp Clin Res. 1999;25(2-3):87-97.
30. Lagouge M, Argmann C, Gerhart-Hines Z, et al. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell. 2006;127(6):1109-1122.
31. Sareen D, van Ginkel PR, Takach JC, et al. Mitochondria as the primary target of resveratrol-induced apoptosis in human retinoblastoma cells. Invest Ophthalmol Vis Sci. 2006;47(9):3708-3716.
32. Murphy MP. Investigating mitochondrial radical production using targeted probes. Biochem Soc Trans. 2004;32:1011-1014.
33. Echtay KS, Murphy MP, Smith RA, Talbot DA, Brand MD. Superoxide activates mitochondrial uncoupling protein 2 from the matrix side. J Biol Chem. 2002;277:47129-47135.
34. St-Pierre J, Buckingham JA, Roebuck SJ, Brand MD. Topology of superoxide production from different sites in the mitochondrial electron transport chain. J Biol Chem 2002;277:44784-44790.
35. O'Malley Y, Fink BD, Ross NC, Prisinzano TE, Sivitz WI. Reactive oxygen and targeted antioxidant administration in endothelial cell mitochondria. J Biol Chem. 2006;281(52):39766-39775.