Current status of transgenic animal research for human health applications

Acta Scientiae Veterinariae

Volumn 38, Issue SUPPL. 2, 2010, Pages

  Murray, James D ^a   Mohamad Fauzi, Nuradilla ^a   Cooper, Caitlin A ^a   Maga, Elizabeth A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Applications; Genetic engineering; Livestock; Transgenic

Indexed keywords

ANIMALIA; CAPRA HIRCUS; LENTIVIRUS;

EID: 79958756195     PISSN: 16780345     EISSN: 16799216     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Bender B., Bodrogi L., Mayer B., Schneider Z., Zhao Y., Hammarström L., Eggen A., Kacskovics I. & Bosze Z. 2007. Position independent and copy-number-related expression of the bovine neonatal Fc receptor alpha-chain in transgenic mice carrying a 102 kb BAC genomic fragment. Transgenic Research. 16: 613-627.
2. Bertolini L.R., Bertolini M., Maga E.A., Madden K.R. & Murray J.D. 2009. Increased gene targeting in Ku70 and Xrcc4 transiently deficient human somatic cells. Molecular Biotechnology. 41: 106-114.
3. Bosch P., Hodges C.A. & Stice S.L. 2004. Generation of transgenic livestock by somatic nuclear transfer. Biotechnología Aplicada. 21: 128-136.
4. Brundige D.R., Maga E.A., Klasing K.C. & Murray J.D. 2008. Lysozyme transgenic goats' milk influences gastrointestinal morphology in young pigs. Journal Nutrition 138: 921-926.
5. Clark J. & Whitelaw B. 2003. A future for transgenic livestock. Nature Review Genetics. 4: 825-833.
6. Du S.J., Gong Z., Fletcher G., Shears M., King M.J., Idler D.R. & Hew C.L. 1992. Growth enhancement in transgenic Atlantic salmon by the use of an "all fish" chimeric growth hormone gene construct. Biotechnology. 10: 176-181.
7. Edmunds T., Van Patten S.M., Pollock J., Hanson E., Bernasconi R., Higgins E., Manavalan P., Ziomek C., Meade H., McPherson J.M. & Cole E.S. 1998. Transgenically produced human antithrombin: structural and functional comparison to human plasma-derived antithrombin. Blood. 91: 4561-4571.
8. Fahrenkrug S.C., Blake A., Carlson D.F., Doran T., Van Eenennaam A., Faber D., Galli C., Gao Q., Hackett P.B., Li N., Maga E.A., Muir W.M., Murray J.D., Shi D., Stotish R., Sullivan E., Taylor J.F., Walton M., Wheeler M., Whitelaw B. & Glenn B.P. 2010. Precision genetics for complex objectives in nimal agriculture. Journal Animal Science. [in press].
9. Freitas V.J., Serova I.A., Andreeva L.E., Dvoryanchikov G.A., Lopes E.S. Jr., Teixeira D.I., Dias L.P., Avelar S.R., Moura R.R., Melo L.M., Pereira A.F., Cajazeiras J.B., Andrade M.L., Almeida K.C., Sousa F.C., Carvalho A.C. & Serov O.L. 2007. Production of transgenic goat (Capra hircus) with human Granulocyte Colony Stimulating Factor (hG-CSF) gene in Brazil. Anais da Academia Brasileira de Ciências. 79: 585-592.
10. Garcia-Otin A. & Guillou F. 2006. Mammalian genome targeting using site-specific recombinases. Frontiers in Bioscience. 11: 1108-1136.
11. Golovan S.P., Meidinger R.G., Ajakaiye A., Cottrill M., Wiederkehr M.Z., Barney D.J., Plante C., Pollard J.W., Fan M.Z., Hayes M.A., Laursen J., Hjorth J.P., Hacker R.R., Phillips J.P. & Forsberg C.W. 2001. Pigs expressing salivary phytase produce lowphosphorus manure. Nature Biotechnology. 19: 741-745.
12. Hammer R.E., Pursel V.G., Rexroad Jr., C.E., Wall R.J., Bolt D.J., Ebert K.M., Palmiter R.D. & Brinster R.L. 1985. Production of transgenic rabbits, heep and pigs by microinjection. Nature. 315: 680-683.
13. Harrison S.J., Guidolin A., Faast R., Crocker L.A., Giannakis C., D'Apice A.J., Nottle M.B. & Lyons I. 2002. Efficient generation of á(1,3) galactosyltransferase knockout porcine fetal fibroblasts for nuclear transfer. Transgenic Research. 11: 143-150.
14. Huang Y.J., Huang Y., Baldassarre H., Wang B., Lazaris A., Leduc M., Bilodeau A.S., Bellemare A., Côté M., Herskovits P., Touati M., Turcotte C., Valeanu L., Lemée N., Wilgus H., Bégin I., Bhatia B., Rao K., Neveu N., Brochu E., Pierson J., Hockley D.K., Cerasoli D.M., Lenz D.E., Karatzas C.N. & Langermann S. 2007. Recombinant human butyrylcholinesterase from milk of transgenic animals to protect against organophosphate poisoning. Proceeding ational Academy Science USA. 104: 13603-13068.
15. Ivics Z., Li M.A., Mátés L., Boeke J.D., Nagy A., Bradley A. & Izsvák Z. 2009. Transposon-mediated genome manipulation in vertebrates. Nature Methods. 6: 415-422.
16. Kandavelou K., Ramalingam S., London V., Mani M., Wu J., Alexeev V., Civin C.I. & Chandrasegaran S. 2009. Targeted manipulation of mammalian genomes using zinc-finger nucleases. Biochemical Biophysical Research Communication. 388: 56-61.
17. Kuroiwa Y., Kasinathan P., Sathiyaseelan T., Jiao J.A., Matsushita H., Sathiyaseelan J., Wu H., Mellquist J., Hammitt M., Koster J., Kamoda S., Tachibana K., Ishida I. & Robl J.M. 2009. Antigen-specific human polyclonal antibodies from hyperimmunized cattle. Nature Biotechnology. 27: 173-181.
18. Lai L, Kang J.X, Li R., Wang J., Witt W.T., Yong H.Y., Hao Y., Wax D.M., Murphy C.N., Rieke A., Samuel M., Linville M.L., Korte S.W., Evans R.W., Starzl T.E., Prather R.S. & Dai Y. 2006. Generation of cloned transgenic pigs rich in omega-3 fatty acids. Nature Biotechnology. 24: 435-436.
19. Laible G. 2009. Enhancing livestock through genetic engineering - Recent advances and future prospects. Compendium Immunology Microbiology Infectious Disease. 32: 123-137.
20. Laible G. & Alonso-Gonzalez L. 2009. Gene targeting from laboratory to livestock: Current status and emerging concepts. Biotechnology Journal. 4: 1278-1292.
21. Lillico S.G., Sherman A., McGrew M.J., Robertson C.D., Smith J., Haslam C., Barnard P., Radcliffe P.A., Mitrophanous K.A., Elliot E.A. & Sang H.M. 2007. Oviduct-specific expression of two therapeutic proteins in transgenic hens. Proceeding National Academy Science USA. 104: 1771-1776.
22. Maga E.A., Cullor J.S., Smith W., Anderson G.B. & Murray J.D. 2006. Human lysozyme expressed in the mammary gland of transgenic dairy goats can inhibit the growth of bacteria that cause mastitis and the cold-spoilage of milk. Foodborne Pathogens and Disease. 3: 384-392.
23. Maga E.A., Shoemaker C.F., Rowe J.D., BonDurant R.H., Anderson G.B. & Murray J.D. 2006. Production and processing of milk from transgenic goats expressing human lysozyme in the mammary gland. Journal Dairy Science. 89: 518-524.
24. Mansour S.L., Thomas K.R. & Capecchi M.R. 1988. Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: A general strategy for targeting mutations to non-selectable genes. Nature. 336: 348-52.
25. Marques M.M., Thomson A.J., McCreath K.J. & McWhir J. 2006. Conventional gene targeting protocols lead to loss of targeted cells when applied to a silent gene locus in primary fibroblasts. Journal Biotechnology. 125: 185-193.
26. Murray J.D., Nancarrow C.D., Marshall J.T., Hazelton I.G. & Ward K.A. 1989. The production of transgenic Merino sheep by microinjection of ovine metallothionein ovine growth hormone fusion genes. Reproduction Fertility and Development. 1: 147-155.
27. Murray J.D. & Maga E.A. 2010. Is there a risk from not using GE animals? Transgenic Research. 19: 357-361.
28. Phelps C.J., Koike C., Vaught T.D., Boone J., Wells K.D., Chen S.H., Ball S., Specht S.M., Polejaeva I.A., Monahan J.A., Jobst P.M., Sharma S.B., Lamborn A.E., Garst A.S., Moore M., Demetris A.J., Rudert W.A., Bottino R., Bertera S., Trucco M., Starzl T.E., Dai Y. & Ayares D.L. 2003. Production f alpha 1,3-galactosyltransferase-deficient pigs. Science. 299: 411-414.
29. Reh W.A., Maga E.A., Collette N.M.B., Moyer A., Conrad-Brink J.S., Taylor S.J., DePeters E.J., Oppenheim S., Rowe J.D., BonDurant R.H., Anderson G.B. & Murray J.D. 2004. Using a stearoyl-CoA desaturase transgene to alter milk fatty acid composition. Journal Dairy Science. 87: 3510-3514.
30. Schultz B.R. & Chamberlain J.S. 2008. Recombinant adeno-associated virus transduction and integration. Molecular Therapy. 16: 1189-1199.
31. Simons J.P., Wilmut I., Clark A.J., Archibald A.L., Bishop J.O. & Lathe R. 1988. Gene transfer into sheep. Nature Biotechnology. 6: 179-183.
32. Stanford W.L., Cohn J.B. & Cordes S.P. 2001. Gene-trap mutagenesis: past, present and beyond. Nature Review Genetics. 2: 756-768.
33. Tai H.C., Ezzelarab M., Hara H., Ayares D. & Cooper D.K. 2007. Progress in xenotransplantation following the introduction of geneknockout technology. Transplant International. 20: 107-117.
34. Vasquez K.M., Marburger K., Intody Z. & Wilson J.H. 2001. Manipulating the mammalian genome by homologous recombination. Proceeding National Academy Science USA. 98: 8403-8410.
35. Wall R.J., Laible G., Maga E.A., Seidel Jr. G. & Whitelaw B. 2009. Animal Productivity and Genetic Diversity: Cloned and Transgenic Animals. Animal Agriculture's Future through Biotechnology, Part 8. Council for Agriculture Science and Technology, Issue Paper Number 43 August 2009.
36. Wheeler M.B., Bleck G.T. & Donovan S.M. 2001. Transgenic alteration of sow milk to improve piglet growth and health. Reproduction. 58: 313-324.
37. Whitelaw C.B.A., Lilico S.G. & King T. 2008. Production of transgenic farm animals by viral vector-mediated gene transfer. Reproduction in Domestic Animal. 43(2): 355-358.
38. Williams D. 2003. Sows' ears, silk purses and goats' milk: new production methods and medical applications for silk. Medical Device Technology. 14: 9-11.
39. Yan Z., Sun X. & Engelhardt J.F. 2009. Progress and prospects: techniques for site-directed mutagenesis in animal models. Gene Therapy. 16: 581-588.