Lysozyme transgenic goats' milk influences gastrointestinal morphology in young pigs

Journal of Nutrition

Volumn 138, Issue 5, 2008, Pages 921-926

  Brundige, Dottie R ^a   Maga, Elizabeth A ^a   Klasing, Kirk C ^a   Murray, James D ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LYSOZYME;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL COUNT; BACTERIAL GROWTH; BLOOD ANALYSIS; CONTROLLED STUDY; DIET; ENTEROBACTER INFECTION; ENZYME ACTIVITY; ESCHERICHIA COLI; FOOD INTAKE; GASTROINTESTINAL TRACT FUNCTION; GENETIC ENGINEERING; GOAT; HISTOLOGY; ILEUM; INTESTINE ABSORPTION; MILK; MORPHOLOGY; NONHUMAN; PROTEIN EXPRESSION; SWINE; TRANSGENICS; WEIGHT GAIN; ANIMAL; BLOOD; DUODENUM; ENTEROPATHOGENIC ESCHERICHIA COLI; ENZYMOLOGY; FEMALE; GASTROINTESTINAL TRACT; GENE EXPRESSION; GENETICS; GROWTH, DEVELOPMENT AND AGING; HUMAN; MALE; METABOLISM; MICROBIOLOGY; PHYSIOLOGY; TRANSGENIC ANIMAL;

BACTERIA (MICROORGANISMS); CAPRA HIRCUS; ESCHERICHIA COLI; SUIDAE;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; COLONY COUNT, MICROBIAL; DIET; DUODENUM; ENTEROPATHOGENIC ESCHERICHIA COLI; FEMALE; GASTROINTESTINAL TRACT; GENE EXPRESSION; GOATS; HUMANS; MALE; MILK; MURAMIDASE; SWINE;

EID: 42449129106     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.1093/jn/138.5.921     Document Type: Article

References (43)

1. Work Group on Breastfeeding. Breastfeeding and the use of human milk. American Academy of Pediatrics. Pediatrics. 1997;100:1035-9.
2. Schack-Nielsen L, Michaelsen KF. Advances in our understanding of the biology of human milk and its effects on the offspring. J Nutr. 2007;137:S503-10.
3. Oddy WH. The impact of breastmilk on infant and child health. Breastfeed Rev. 2002;10:5-18.
4. Lonnerdal B. Nutritional and physiologic significance of human milk proteins. Am J Clin Nutr. 2003;77:S1537-43.
5. Ellison RT III, Giehl TJ. Killing of gram-negative bacteria by lactoferrin and lysozyme. J Clin Invest. 1991;88:1080-91.
6. Blake CC, Johnson LN, Mair GA, North AC, Phillips DC, Sarma VR. Crystallographic studies of the activity of hen egg-white lysozyme. Proc R Soc Lond B Biol Sci. 1967;167:378-88.
7. Hughey VL, Johnson EA. Antimicrobial activity of lysozyme against bacteria involved in food spoilage and food-borne disease. Appl Environ Microbiol. 1987;53:2165-70.
8. Hughey VL, Wilger PA, Johnson EA. Antibacterial activity of hen egg white lysozyme against Listeria monocytogenes Scott A in foods. Appl Environ Microbiol. 1989;55:631-8.
9. Masschalck B, Michiels CW. Antimicrobial properties of lysozyme in relation to foodborne vegetative bacteria. Crit Rev Microbiol. 2003;29:191-214.
10. Touch V, Hayakawa S, Fukada K, Aratani Y, Sun Y. Preparation of antimicrobial reduced lysozyme compatible in food applications. J Agric Food Chem. 2003;51:5154-61.
11. Maga EA, Cullor JS, Smith W, Anderson GB, Murray JD. Human lysozyme expressed in the mammary gland of transgenic dairy goats can inhibit the growth of bacteria that cause mastitis and the cold-spoilage of milk. Foodborne Pathog Dis. 2006;3:384-92.
12. Wharton BA, Balmer SE, Scott PH. Faecal flora in the newborn. Effect of lactoferrin and related nutrients. Adv Exp Med Biol. 1994;357:91-8.
13. Solis B, Samartin S, Gomez S, Nova E, de la Rosa B, Marcos A. Probiotics as a help in children suffering from malnutrition and diarrhoea. Eur J Clin Nutr. 2002;56 Suppl 3:S57-9.
14. Schiffrin EJ, Blum S. Interactions between the microbiota and the intestinal mucosa. Eur J Clin Nutr. 2002;56 Suppl 3:S60-4.
15. Brandenburg K, Koch MH, Seydel U. Biophysical characterisation of lysozyme binding to LPS Re and lipid A. Eur J Biochem. 1998;258:686-95.
16. Ginsburg I. Role of lipoteichoic acid in infection and inflammation. Lancet Infect Dis. 2002;2:171-9.
17. Takada K, Ohno N, Yadomae T. Lysozyme regulates LPS-induced interleukin-6 release in mice. Circ Shock. 1994;44:169-74.
18. Takada K, Ohno N, Yadomae T. Binding of lysozyme to lipopolysaccharide suppresses tumor necrosis factor production in vivo. Infect Immun. 1994;62:1171-5.
19. Nathan C. Points of control in inflammation. Nature. 2002;420:846-52.
20. Fagundes-Neto U, Scaletsky IC. The gut at war: the consequences of enteropathogenic Escherichia coli infection as a factor of diarrhea and malnutrition. Sao Paulo Med J. 2000;118:21-9.
21. Lunn PG. The impact of infection and nutrition on gut function and growth in childhood. Proc Nutr Soc. 2000;59:147-54.
22. Chandan RC, Parry RM Jr, Shahani KM. Lysozyme, lipase, and ribonuclease in milk of various species. J Dairy Sci. 1968;51:606-7.
23. Maga EA, Walker RL, Anderson GB, Murray JD. Consumption of milk from transgenic goats expressing human lysozyme in the mammary gland results in the modulation of intestinal microflora. Transgenic Res. 2006;15:515-9.
24. Miller ER, Ullrey DE. The pig as a model for human nutrition. Annu Rev Nutr. 1987;7:361-82.
25. Blachier F, Vaugelade P, Robert V, Kibangou B, Canonne-Hergaux F, Delpal S, Bureau F, Blottiere H, Bougle D. Comparative capacities of the pig colon and duodenum for luminal iron absorption. Can J Physiol Pharmacol. 2007;85:185-92.
26. Domeneghini C, Di Giancamillo A, Arrighi S, Bosi G. Gut-trophic feed additives and their effects upon the gut structure and intestinal metabolism. State of the art in the pig, and perspectives towards humans. Histol Histopathol. 2006;21:273-83.
27. Zhu C, Harel J, Jacques M, Desautels C, Donnenberg MS, Beaudry M, Fairbrother JM. Virulence properties and attaching-effacing activity of Escherichia coli O45 from swine postweaning diarrhea. Infect Immun. 1994;62:4153-9.
28. Girard F, Oswald IP, Taranu I, Helie P, Appleyard GD, Harel J, Fairbrother JM. Host immune status influences the development of attaching and effacing lesions in weaned pigs. Infect Immun. 2005;73:5514-23.
29. Humphrey BD, Huang N, Klasing KC. Rice expressing lactoferrin and lysozyme has antibiotic-like properties when fed to chicks. J Nutr. 2002;132:1214-8.
30. Thymann T, Sorensen KU, Hedemann MS, Elnif J, Jensen BB, Banga-Mboko H, Leser TD, Sangild PT. Antimicrobial treatment reduces intestinal microflora and improves protein digestive capacity without changes in villous structure in weanling pigs. Br J Nutr. 2007;97:1128-37.
31. Cromwell GL. Why and how antibiotics are used in swine production. Anim Biotechnol. 2002;13:7-27.
32. Schwarz S, Kehrenberg C, Walsh TR. Use of antimicrobial agents in veterinary medicine and food animal production. Int J Antimicrob Agents. 2001;17:431-7.
33. Roura E, Homedes J, Klasing KC. Prevention of immunologic stress contributes to the growth-permitting ability of dietary antibiotics in chicks. J Nutr. 1992;122:2383-90.
34. Penders J, Thijs C, Vink C, Stelma FF, Snijders B, Kummeling I, van den Brandt PA, Stobberingh EE. Factors influencing the composition of the intestinal microbiota in early infancy. Pediatrics. 2006;118:511-21.
35. Edwards CA, Parrett AM. Intestinal flora during the first months of life: new perspectives. Br J Nutr. 2002;88 Suppl 1:S11-8.
36. Mackie RI, Sghir A, Gaskins HR. Developmental microbial ecology of the neonatal gastrointestinal tract. Am J Clin Nutr. 1999;69:S1035-45.
37. Valentiner-Branth P, Steinsland H, Fischer TK, Perch M, Scheutz F, Dias F, Aaby P, Molbak K, Sommerfelt H. Cohort study of Guinean children: incidence, pathogenicity, conferred protection, and attributable risk for enteropathogens during the first 2 years of life. J Clin Microbiol. 2003;41:4238-45.
38. Quiroga M, Oviedo P, Chinen I, Pegels E, Husulak E, Binztein N, Rivas M, Schiavoni L, Vergara M. Asymptomatic infections by diarrheagenic Escherichia coli in children from Misiones, Argentina, during the first twenty months of their lives. Rev Inst Med Trop Sao Paulo. 2000;42:9-15.
39. Long K, Vasquez-Garibay E, Mathewson J, de la Cabada J, DuPont H. The impact of infant feeding patterns on infection and diarrheal disease due to enterotoxigenic Escherichia coli. Salud Publica Mex. 1999;41:263-70.
40. Golding J, Emmett PM, Rogers IS. Gastroenteritis, diarrhoea and breast feeding. Early Hum Dev. 1997;49 Suppl:S83-103.
41. Thorn CE. Normal hematology of the pig. In: Feldman BF, Zinkl JG, Jain NC, editors. Schalm's veterinary hematology. 5th ed. Baltimore: Lippencott Williams & Wilkins; 2000. p. 1089-95.
42. Thapar N, Sanderson IR. Diarrhoea in children: an interface between developing and developed countries. Lancet. 2004;363:641-53.
43. Scaletsky IC, Pedroso MZ, Fagundes-Neto U. Attaching and effacing enteropathogenic Escherichia coli O18ab invades epithelial cells and causes persistent diarrhea. Infect Immun. 1996;64:4876-81.