메뉴 건너뛰기




Volumn 42, Issue 8, 2003, Pages 2483-2485

Efficient visible light induced nuclease activity of a ternary mono-1,10-phenanthroline copper(II) complex containing 2-(methylthio)ethylsalicylaldimine

Author keywords

[No Author keywords available]

Indexed keywords

1,10 PHENANTHROLINE COPPER; 2 (METHYLTHIO)ETHYLSALICYLALDIMINE; COPPER ACETATE; DIMETHYL SULFOXIDE; DOUBLE STRANDED DNA; HYDROGEN PEROXIDE; LIGAND; METHANOL; NUCLEASE; PROPIONIC ACID DERIVATIVE; SALICYLIC ACID DERIVATIVE; SCHIFF BASE; THIOLACTIC ACID; UNCLASSIFIED DRUG;

EID: 0037460004     PISSN: 00201669     EISSN: None     Source Type: Journal    
DOI: 10.1021/ic026241k     Document Type: Conference Paper
Times cited : (79)

References (28)
  • 4
  • 17
    • 0347226854 scopus 로고    scopus 로고
    • note
    • 2, DMF, and MeOH; less soluble in water. CAUTION! Perchlorate salts of metal complexes containing organic ligands are potentially explosive. Single crystals of 1, suitable for X-ray analysis, were obtained on slow evaporation of an aqueous methanolic solution of 1.
  • 18
    • 0345965625 scopus 로고    scopus 로고
    • note
    • 2]/3. Intensity data for a crystal of dimensions 0.35 × 0.30 × 0.20 mm were obtained from a Bruker SMART APEX CCD diffractometer, equipped with a fine focus 1.75 kW sealed tube Mo Kα X-ray source, with increasing ω (width of 0.3°/frame) at a scan speed of 18 s/frame. The SMART software was used for data acquisition and the SAINT software for data reduction. Absorption corrections were made on the intensity data. The structure was solved and refined with the SHELX program. There was one lattice methanol molecule in the crystallographic asymmetric unit containing two independent molecules of 1.
  • 21
    • 0347857023 scopus 로고    scopus 로고
    • note
    • 3, 90 μM) prior to the addition of the complex. The visible light used was commercial flourescent lamps (4 × 40 W) in the laboratory for inhibition reactions, and the reaction duration was 15 min prior to incubation in the dark chamber at 37 °C followed by electrophoresis. The UV light used has a monochromatic wavelength of λ = 312 nm. Eppendorf and glass vials were used for the UV and visible light irradiations, respectively.
  • 24
    • 0346596979 scopus 로고    scopus 로고
    • note
    • Under similar rection conditions with a 5 min exposure time, the extent of DNA cleavage observed with monochromatic radiation of 436 and 532 nm is ∼30 and ∼35%, respectively. More exposure time (∼10 min) is required for observing significant cleavage (∼65%) using visible radiation.
  • 25
    • 0347226855 scopus 로고    scopus 로고
    • note
    • The true identity of the oxidizing species is presently unknown. It may be free hydroxyl radical or a copper-based oxo or hydroxo species (refs 3a,b).
  • 28
    • 0347857019 scopus 로고    scopus 로고
    • note
    • 4, where HL′ is a ONO-donor Schiff base, do not show any photonuclease activity under similar reaction conditions.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.