Transient fecal shedding and limited animal-to-animal transmission of Clostridium difficile by naturally infected finishing feedlot cattle

Applied and Environmental Microbiology

Volumn 77, Issue 10, 2011, Pages 3391-3397

  Rodriguez Palacios, Alexander ^a   Pickworth, Carrie ^a   Loerch, Steve ^a   LeJeune, Jeffrey T ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CLOSTRIDIUM DIFFICILE; CONFIDENCE INTERVAL; ENZYME LINKED IMMUNOSORBENT ASSAY; FEEDLOT CATTLES; FOOD CONTAMINATION; MEAT PROCESSING PLANTS; ODDS RATIOS; PREDISPOSING FACTORS; RESPIRATORY DISEASE; SPATIOTEMPORAL ANALYSIS; STANDARD DEVIATION; TOXIGENIC; TOXIN GENES;

CLOSTRIDIUM; GENES; HARVESTING; PULMONARY DISEASES;

ANIMALS;

BACTERIAL TOXIN;

ANTIMICROBIAL ACTIVITY; ASSAY; BACTERIAL DISEASE; CATTLE; DISEASE TRANSMISSION; ENDEMIC SPECIES; ENZYME ACTIVITY; EXPERIMENTAL STUDY; FECAL COLIFORM; HARVESTING; IDENTIFICATION METHOD; INFECTIOUS DISEASE; POLLUTION EFFECT; POLYMERASE CHAIN REACTION; RESPIRATORY DISEASE; RISK FACTOR; SPATIOTEMPORAL ANALYSIS; TOXIN;

ANIMAL; ANIMAL DISEASE; ARTICLE; BACTERIAL SHEDDING; BACTERIUM IDENTIFICATION; BIOSYNTHESIS; CATTLE; CLASSIFICATION; CLOSTRIDIUM DIFFICILE; CLOSTRIDIUM INFECTION; DISEASE TRANSMISSION; ENZYME LINKED IMMUNOSORBENT ASSAY; FECES; GENETICS; HETEROZYGOTE; ISOLATION AND PURIFICATION; MICROBIOLOGY; POLYMERASE CHAIN REACTION; RIBOTYPING;

ANIMALS; BACTERIAL SHEDDING; BACTERIAL TOXINS; BACTERIAL TYPING TECHNIQUES; CARRIER STATE; CATTLE; CLOSTRIDIUM DIFFICILE; CLOSTRIDIUM INFECTIONS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FECES; POLYMERASE CHAIN REACTION; RIBOTYPING;

ANIMALIA; BOS; BOVINAE; CLOSTRIDIUM DIFFICILE;

EID: 79958228235     PISSN: 00992240     EISSN: 10985336     Source Type: Journal    
DOI: 10.1128/AEM.02736-10     Document Type: Article

References (49)

1. Ackermann, G., D. Adler, and A. C. Rodloff. 2003. In vitro activity of linezolid against Clostridium difficile. J. Antimicrob. Chemother. 51:743-745.
2. al Saif, N., and J. S. Brazier. 1996. The distribution of Clostridium difficile in the environment of South Wales. J. Med. Microbiol. 45:133-137.
3. Arroyo, L. G., et al. 2005. Use of a selective enrichment broth to recover Clostridium difficile from stool swabs stored under different conditions. J. Clin. Microbiol. 43:5341-5343.
4. Bakri, M. M., D. J. Brown, J. P. Butcher, and A. D. Sutherland. 2009. Clostridium difficile in ready-to-eat salads, Scotland. Emerg. Infect. Dis. 15: 817-18.
5. Bell, N., N. Schuurman, and S. M. Hameed. 2008. Are injuries spatially related? Join-count spatial autocorrelation for small-area injury analysis. Injury Prev. 14:346-353.
6. Bidet, P., F. Barbut, V. Lalande, B. Burghoffer, and J. C. Petit. 1999. Development of a new PCR-ribotyping method for Clostridium difficile based on ribosomal RNA gene sequencing. FEMS Microbiol. Lett. 175:261-266.
7. Brown, L. D., T. T. Cai, and A. DasGupta. 2001. Interval estimation for a binomial proportion. Stat. Sci. 16:101-117.
8. Centers for Disease Control and Prevention. 2008. Surveillance for community-associated Clostridium difficile-Connecticut, 2006. MMWR Morb. Mortal. Wkly. Rep. 57:340-343.
9. Chowell, G., J. M. Hyman, L. M. A. Bettencourt, C. Castillo-Chavez, and H. Nishiura. 2009. The effective reproduction number as a prelude to statistical estimation of time-dependent epidemic trends, p. 103-121. In G. Chowell, J. M. Hayman, L. M. A. Bettencourt, and C. Castillo-Chavez (ed.), Mathematical and statistical estimation approaches in epidemiology. Springer, Dordrecht, Netherlands.
10. Clooten, J., S. Kruth, L. Arroyo, and J. S. Weese. 2008. Prevalence and risk factors for Clostridium difficile colonization in dogs and cats hospitalized in an intensive care unit. Vet. Microbiol. 129:209-214.
11. Clopper, C. J., and E. S. Pearson. 1934. The use of confidence or fiducial limits illustrated in the case of the binomial. Biometrika 26:404-413.
12. Debast, S. B., et al. 2009. Clostridium difficile PCR ribotype 078 toxinotype V found in diarrhoeal pigs identical to isolates from affected humans. Environ. Microbiol. 11:505-511.
13. Dohoo, I., W. Martin, and H. Stryhn. 2003. Cohort studies, p. 69, 151-162. In S. M. McPike (ed.), Veterinary epidemiologic research. AVC, Inc., Charlottetown, Prince Edward Island, Canada.
14. Dubberke, E. R., and A. I. Wertheimer. 2009. Review of current literature on the economic burden of Clostridium difficile infection. Infect. Control Hosp. Epidemiol. 30:57-66.
15. Elder, R. O., et al. 2000. Correlation of enterohemorrhagic Escherichia coli O157 prevalence in feces, hides, and carcasses of beef cattle during processing. Proc. Natl. Acad. Sci. U. S. A. 97:2999-3003.
16. Fedorko, D. P., and E. C. Williams. 1997. Use of cycloserine-cefoxitinfructose agar and L-proline-aminopeptidase (PRO discs) in the rapid identification of Clostridium difficile. J. Clin. Microbiol. 35:1258-1259.
17. French, E., A. Rodriguez-Palacios, and J. T. LeJeune. 2010. Enteric bacterial pathogens with zoonotic potential isolated from farm-raised deer. Foodborne Pathog. Dis. 7:1031-1037.
18. Garcia, A., et al. 2000. Evaluation of four rapid methods for the investigation of the toxigenic capacity of Clostridium difficile strains isolated in a selective medium. Enferm. Infecc. Microbiol. Clin. 18:109-112.
19. Gill, C. O. 2007. Microbiological conditions of meats from large game animals and birds. Meat Sci. 77:149-160.
20. Hecht, D. W., and D. Citron. 2007. Standard M11-A7. Methods for antimicrobial susceptibility testing of anaerobic bacteria, 7th ed. Clinical Laboratory Standards Institute, Wayne, PA.
21. Iizuka, M., et al. 2004. Elemental diet modulates the growth of Clostridium difficile in the gut flora. Aliment. Pharmacol. Ther. 20(Suppl. 1):151-157.
22. Jhung, M. A., et al. 2008. Toxinotype V Clostridium difficile in humans and food animals. Emerg. Infect. Dis. 14:1039-1045.
23. Jones, R. N., S. Kohno, Y. Ono, J. E. Ross, and K. Yanagihara. 2009. ZAAPS International Surveillance Program (2007) for linezolid resistance: results from 5591 Gram-positive clinical isolates in 23 countries. Diagn. Microbiol. Infect. Dis. 64:191-201.
24. Keel, K., J. S. Brazier, K. W. Post, S. Weese, and J. G. Songer. 2007. Prevalence of PCR ribotypes among Clostridium difficile isolates from pigs, calves, and other species. J. Clin. Microbiol. 45:1963-1964.
25. Lawley, T. D., et al. 2009. Antibiotic treatment of Clostridium difficile carrier mice triggers a supershedder state, spore-mediated transmission, and severe disease in immunocompromised hosts. Infect. Immun. 77:3661-3669.
26. Lemee, L., et al. 2004. Multiplex PCR targeting tpi (triose phosphate isomerase), tcdA (toxin A), and tcdB (toxin B) genes for toxigenic culture of Clostridium difficile. J. Clin. Microbiol. 42:5710-5714.
27. Limbago, B. M., et al. 2009. Clostridium difficile strains from communityassociated infections. J. Clin. Microbiol. 47:3004-3007.
28. McFarland, L. V. 2008. Update on the changing epidemiology of Clostridium difficile-associated disease. Nat. Clin. Pract. Gastroenterol. Hepatol. 5:40-48.
29. Metcalf, D. S., M. C. Costa, W. M. Dew, and J. S. Weese. 2010. Clostridium difficile in vegetables, Canada. Lett. Appl. Microbiol. 51:600-602.
30. Nagy, E., and M. J. Dowzicky. 2010. In vitro activity of tigecycline and comparators against a European compilation of anaerobes collected as part of the Tigecycline Evaluation and Surveillance Trial (TEST). Scand. J. Infect. Dis. 42:33-38.
31. National Research Council. 2000. Nutrient requirements of beef cattle, 7th rev. ed. National Academy of Sciences, Washington, DC.
32. Norman, K. N., et al. 2009. Varied prevalence of Clostridium difficile in an integrated swine operation. Anaerobe 15:256-260.
33. Oliver, S. P., D. A. Patel, T. R. Callaway, and M. E. Torrence. 2009. ASAS centennial paper: developments and future outlook for preharvest food safety. J. Anim. Sci. 87:419-437.
34. Persson, S., M. Torpdahl, and K. E. Olsen. 2008. New multiplex PCR method for the detection of Clostridium difficile toxin A (tcdA) and toxin B (tcdB) and the binary toxin (cdtA/cdtB) genes applied to a Danish strain collection. Clin. Microbiol. Infect. 14:1057-1064.
35. Petrie, A., and P. Watson. 1999. Statistics for veterinary and animal sciences, 1st ed. Blackwell Science, Oxford, United Kingdom.
36. Rodriguez-Palacios, A., et al. 2009. Possible seasonality of Clostridium difficile in retail meat, Canada. Emerg. Infect. Dis. 15:802-805.
37. Rodriguez-Palacios, A., R. J. Reid-Smith, H. R. Staempfli, and J. S. Weese. 2010. Clostridium difficile survives minimal temperature recommended for cooking ground meats. Anaerobe 16:540-542.
38. Rodriguez-Palacios, A., H. R. Staempfli, T. Duffield, and J. S. Weese. 2007. Clostridium difficile in retail ground meat, Canada. Emerg. Infect. Dis. 13: 485-87.
39. Rodriguez-Palacios, A., et al. 2006. Clostridium difficile PCR ribotypes in calves, Canada. Emerg. Infect. Dis. 12:1730-1736.
40. Rodriguez-Palacios, A., H. R. Stampfli, M. Stalker, T. Duffield, and J. S. Weese. 2007. Natural and experimental infection of neonatal calves with Clostridium difficile. Vet. Microbiol. 124:166-172.
41. Rupnik, M. 2007. Is Clostridium difficile-associated infection a potentially zoonotic and foodborne disease? Clin. Microbiol. Infect. 13:457-459.
42. Rupnik, M., A. Widmer, O. Zimmermann, C. Eckert, and F. Barbut. 2008. Clostridium difficile toxinotype V, ribotype 078, in animals and humans. J. Clin. Microbiol. 46:2146.
43. Sathish, S., and K. Swaminathan. 2008. Molecular characterization of the diversity of Clostridium chauvoei isolates collected from two bovine slaughterhouses: analysis of cross-contamination. Anaerobe 14:190-199.
44. Songer, J. G., et al. 2009. Clostridium difficile in retail meat products, U.S.A., 2007. Emerg. Infect. Dis. 15:819-821.
45. Spigaglia, P., and P. Mastrantonio. 2002. Molecular analysis of the pathogenicity locus and polymorphism in the putative negative regulator of toxin production (TcdC) among Clostridium difficile clinical isolates. J. Clin. Microbiol. 40:3470-3475.
46. Thonnard, J., F. Carreer, V. Avesani, and M. Delmee. 1996. Toxin A detection on Clostridium difficile colonies from 24-h cultures. Clin. Microbiol. Infect. :50-54.
47. Turcsan, J., L. Varga, Z. Turcsan, J. Szigeti, and L. Farkas. 2001. Occurrence of anaerobic bacterial, clostridial, and Clostridium perfringens spores in raw goose livers from a poultry processing plant in Hungary. J. Food Prot. 64:1252-1254.
48. Vengust, M., L. G. Arroyo, J. S. Weese, H. R. Baird, and J. D. Baird. 2003. Preliminary evidence for dormant clostridial spores in equine skeletal muscle. Equine Vet. J. 35:514-516.
49. Yates, W. D. 1982. A review of infectious bovine rhinotracheitis, shipping fever pneumonia and viral-bacterial synergism in respiratory disease of cattle. Can. J. Comp. Med. 46:225-263