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Volumn 7, Issue 6, 2011, Pages 332-342

Risk factors for and management of cognitive dysfunction in multiple sclerosis

Author keywords

[No Author keywords available]

Indexed keywords

3,4 DIAMINOPYRIDINE; 4 AMINOPYRIDINE; AMANTADINE; AMPHETAMINE; BRAIN DERIVED NEUROTROPHIC FACTOR; DONEPEZIL; HLA DR15 ANTIGEN; METHYLPHENIDATE; MODAFINIL; RIVASTIGMINE;

EID: 79958223011     PISSN: 17594758     EISSN: 17594766     Source Type: Journal    
DOI: 10.1038/nrneurol.2011.61     Document Type: Review
Times cited : (320)

References (159)
  • 1
    • 33749059726 scopus 로고    scopus 로고
    • The neurobiology of multiple sclerosis: Genes, inflammation, and neurodegeneration
    • DOI 10.1016/j.neuron.2006.09.011, PII S0896627306007161
    • Hauser, S. L., Oksenberg, J. R., Hauser, S. L. & Oksenberg, J. R. The neurobiology of multiple sclerosis: genes, inflammation, and neurodegeneration. Neuron 52, 61-76 (2006). (Pubitemid 44466355)
    • (2006) Neuron , vol.52 , Issue.1 , pp. 61-76
    • Hauser, S.L.1    Oksenberg, J.R.2
  • 3
    • 0025731153 scopus 로고
    • Cognitive dysfunction in multiple sclerosis. I. Frequency, patterns, and prediction
    • Rao, S. M., Leo, G. J., Bernardin, L. & Unverzagt, F. Cognitive dysfunction in multiple sclerosis. I. Frequency, patterns, and prediction. Neurology 41, 685-691 (1991).
    • (1991) Neurology , vol.41 , pp. 685-691
    • Rao, S.M.1    Leo, G.J.2    Bernardin, L.3    Unverzagt, F.4
  • 4
    • 0027418515 scopus 로고
    • Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. I. Clinical results of a multicenter, randomized, double-blind, placebo-controlled trial
    • [No authors listed]. The IFNB Multiple Sclerosis Study Group
    • [No authors listed] Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. I. Clinical results of a multicenter, randomized, double-blind, placebo-controlled trial. The IFNB Multiple Sclerosis Study Group. Neurology 43, 655-661 (1993).
    • (1993) Neurology , vol.43 , pp. 655-661
  • 5
    • 0029311748 scopus 로고
    • A phase III trial of intramuscular recombinant interferon beta as treatment for exascerbating-remitting multiple sclerosis: Design and conduct of study and baseline characteristics of patients
    • Jacobs, L. D., et al. A phase III trial of intramuscular recombinant interferon beta as treatment for exascerbating-remitting multiple sclerosis: design and conduct of study and baseline characteristics of patients. Mult. Scler. 1, 118-135 (1995).
    • (1995) Mult. Scler. , vol.1 , pp. 118-135
    • Jacobs, L.D.1
  • 6
    • 6844254570 scopus 로고    scopus 로고
    • Extended use of glatiramer acetate (Copaxone) is well tolerated and maintains its clinical effect on multiple sclerosis relapse rate and degree of disability
    • Copolymer 1 Multiple Sclerosis Study Group
    • Johnson, K. P., et al. Extended use of glatiramer acetate (Copaxone) is well tolerated and maintains its clinical effect on multiple sclerosis relapse rate and degree of disability. Copolymer 1 Multiple Sclerosis Study Group. Neurology 50, 701-708 (1998).
    • (1998) Neurology , vol.50 , pp. 701-708
    • Johnson, K.P.1
  • 7
    • 33646844323 scopus 로고    scopus 로고
    • Multiple sclerosis-related cognitive changes: A review of cross-sectional and longitudinal studies
    • DOI 10.1016/j.jns.2005.08.019, PII S0022510X06000979
    • Amato, M. P., Zipoli, V. & Portaccio, E. Multiple-sclerosis related cognitive changes: a review of cross-sectional and longitudinal studies. J. Neurol. Sci. 245, 41-46 (2006). (Pubitemid 43775956)
    • (2006) Journal of the Neurological Sciences , vol.245 , Issue.1-2 , pp. 41-46
    • Amato, M.P.1    Zipoli, V.2    Portaccio, E.3
  • 9
    • 55549127927 scopus 로고    scopus 로고
    • Cognitive impairment in multiple sclerosis
    • Chiaravalloti, N. D. & DeLuca, J. Cognitive impairment in multiple sclerosis. Lancet Neurol. 7, 1139-1151 (2008).
    • (2008) Lancet Neurol. , vol.7 , pp. 1139-1151
    • Chiaravalloti, N.D.1    De Luca, J.2
  • 10
    • 58149090341 scopus 로고    scopus 로고
    • Cognitive impairment in multiple sclerosis
    • Patti, F. Cognitive impairment in multiple sclerosis. Mult. Scler. 15, 2-8 (2009).
    • (2009) Mult. Scler. , vol.15 , pp. 2-8
    • Patti, F.1
  • 11
    • 67649311963 scopus 로고    scopus 로고
    • Cognitive impairment and its relation with disease measures in mildly disabled patients with relapsing-remitting multiple sclerosis: Baseline results from the Cognitive Impairment in Multiple Sclerosis (COGIMUS) study
    • Patti, F., et al. Cognitive impairment and its relation with disease measures in mildly disabled patients with relapsing-remitting multiple sclerosis: baseline results from the Cognitive Impairment in Multiple Sclerosis (COGIMUS) study. Mult. Scler. 15, 779-788 (2009).
    • (2009) Mult. Scler. , vol.15 , pp. 779-788
    • Patti, F.1
  • 17
    • 0033651677 scopus 로고    scopus 로고
    • Information processing efficiency in patients with multiple sclerosis
    • Archibald, C. J. & Fisk, J. D. Information processing efficiency in patients with multiple sclerosis. J. Clin. Exp. Neuropsychol. 22, 686-701 (2000).
    • (2000) J. Clin. Exp. Neuropsychol. , vol.22 , pp. 686-701
    • Archibald, C.J.1    Fisk, J.D.2
  • 20
    • 47249154403 scopus 로고    scopus 로고
    • The relationship between cognitive deficits and everyday functional activities in multiple sclerosis
    • DOI 10.1037/0894-4105.22.4.442, PII S0894410508600480
    • Kalmar, J. H., Gaudino, E. A., Moore, N. B., Halper, J. & Deluca, J. The relationship between cognitive deficits and everyday functional activities in multiple sclerosis. Neuropsychology 22, 442-449 (2008). (Pubitemid 351992891)
    • (2008) Neuropsychology , vol.22 , Issue.4 , pp. 442-449
    • Kalmar, J.H.1    Gaudino, E.A.2    Moore, N.B.3    Halper, J.4    DeLuca, J.5
  • 21
    • 0032918643 scopus 로고    scopus 로고
    • Multiple sclerosis: A preliminary study of selected variables affecting rehabilitation outcome
    • Langdon, D. W. & Thompson, A. J. Multiple sclerosis: a preliminary study of selected variables affecting rehabilitation outcome. Mult. Scler. 5, 94-100 (1999). (Pubitemid 29186826)
    • (1999) Multiple Sclerosis , vol.5 , Issue.2 , pp. 94-100
    • Langdon, D.W.1    Thompson, A.J.2
  • 22
    • 0025777432 scopus 로고
    • Cognitive dysfunction in multiple sclerosis. II. Impact on employment and social functioning
    • Rao, S. M., et al. Cognitive dysfunction in multiple sclerosis. II. Impact on employment and social functioning. Neurology 41, 692-696 (1991).
    • (1991) Neurology , vol.41 , pp. 692-696
    • Rao, S.M.1
  • 24
    • 0016177104 scopus 로고
    • Evaluating storage, retention, and retrieval in disordered memory and learning
    • Buschke, F. & Fuld, P. A. Evaluating storage, retention, and retrieval in disordered memory and learning. Neurology 24, 1019-1025 (1974).
    • (1974) Neurology , vol.24 , pp. 1019-1025
    • Buschke, F.1    Fuld, P.A.2
  • 25
    • 0014399636 scopus 로고
    • And psychometric study of a patient with memory disturbances
    • Barbizet, J. & Cany, E. Clinical and psychometric study of a patient with memory disturbances. Int. J. Neurol. 7, 44-54 (1968).
    • (1968) Int. J. Neurol. , vol.7 , pp. 44-54
    • Barbizet, J.1    Clinical, C.E.2
  • 28
    • 0017615754 scopus 로고
    • Paced auditory serial addition task: A measure of recovery from concussion
    • Gronwall, D. M. A. Paced auditory serial addition task: a measure of recovery from concussion. Percept. Mot. Skills 44, 367-373 (1977). (Pubitemid 8087310)
    • (1977) Perceptual and Motor Skills , vol.44 , Issue.2 , pp. 367-373
    • Gronwall, D.M.A.1
  • 35
    • 33645867091 scopus 로고    scopus 로고
    • Cognitive impairment in patients with multiple sclerosis using the Brief Repeatable Battery-Neuropsychology test
    • Sepulcre, J., et al. Cognitive impairment in patients with multiple sclerosis using the Brief Repeatable Battery-Neuropsychology test. Mult. Scler. 12, 187-195 (2006).
    • (2006) Mult. Scler. , vol.12 , pp. 187-195
    • Sepulcre, J.1
  • 36
    • 77952825584 scopus 로고    scopus 로고
    • Reliability, practice effects, and change indices for Raos Brief Repeatable Battery
    • Portaccio, E., et al. Reliability, practice effects, and change indices for Raos Brief Repeatable Battery. Mult. Scler. 16, 611617 (2010).
    • (2010) Mult. Scler. , vol.16 , pp. 611-617
    • Portaccio, E.1
  • 37
    • 0025186932 scopus 로고
    • Guidelines for neuropsychological research in multiple sclerosis
    • Peyser, J. M., Rao, S. M., LaRocca, N. G. & Kaplan, E. Guidelines for neuropsychological research in multiple sclerosis. Arch. Neurol. 47, 94-97 (1990). (Pubitemid 20024163)
    • (1990) Archives of Neurology , vol.47 , Issue.1 , pp. 94-97
    • Peyser, J.M.1    Rao, S.M.2    LaRocca, N.3    Kaplan, E.4
  • 38
    • 0030055207 scopus 로고    scopus 로고
    • Revision of the brief visuospatial memory test: Studies of normal performance, reliability, and, validity
    • DOI 10.1037/1040-3590.8.2.145
    • Benedict, R. H. B., Schretlen, D., Groninger, L., Dobraski, M. & Shpritz, B. Revision of the Brief Visuospatial Memory Test: studies of normal performance, reliability, and validity. Psychol. Assess. 8, 145-153 (1996). (Pubitemid 26236038)
    • (1996) Psychological Assessment , vol.8 , Issue.2 , pp. 145-153
    • Benedict, R.H.B.1    Groninger, L.2    Schretlen, D.3    Dobraski, M.4    Shpritz, B.5
  • 43
    • 69149086791 scopus 로고    scopus 로고
    • Sensitivity of conventional memory tests in multiple sclerosis: Comparing the Rao Brief Repeatable Neuropsychological Battery and the Minimal Assessment of Cognitive Function in MS
    • Strober, L., et al. Sensitivity of conventional memory tests in multiple sclerosis: comparing the Rao Brief Repeatable Neuropsychological Battery and the Minimal Assessment of Cognitive Function in MS. Mult. Scler. 15, 1077-1084 (2009).
    • (2009) Mult. Scler. , vol.15 , pp. 1077-1084
    • Strober, L.1
  • 44
    • 42449120553 scopus 로고    scopus 로고
    • Influence of recruitment and participation bias in neuropsychological research among MS patients
    • DOI 10.1017/S1355617708080624, PII S1355617708080624
    • Duquin, J. A., Parmenter, B. A. & Benedict, R. H. B. Influence of recruitment and participation bias on neuropsychological research among MS patients. J. Int. Neuropsychol. Soc. 14, 494-498 (2008). (Pubitemid 351560445)
    • (2008) Journal of the International Neuropsychological Society , vol.14 , Issue.3 , pp. 494-498
    • Duquin, J.A.1    Parmenter, B.A.2    Benedict, R.H.B.3
  • 45
    • 33847073785 scopus 로고    scopus 로고
    • Validity of the Wisconsin Card Sorting and Delis-Kaplan Executive Function System (DKEFS) Sorting Tests in multiple sclerosis
    • Parmenter, B. A., et al. Validity of the Wisconsin Card Sorting and Delis-Kaplan Executive Function System (DKEFS) Sorting Tests in multiple sclerosis. J. Clin. Exp. Neuropsychol. 29, 215-223 (2007).
    • (2007) J. Clin. Exp. Neuropsychol. , vol.29 , pp. 215-223
    • Parmenter, B.A.1
  • 46
    • 27744477639 scopus 로고    scopus 로고
    • Effects of using same- versus alternate-form memory tests during short-interval repeated assessments in multiple sclerosis
    • DOI 10.1017/S1355617705050782, PII S1355617705050782
    • Benedict, R. H. B. Effects of using same vs alternate form memory tests in short-interval, repeated assessment in multiple sclerosis. J. Int. Neuropsychol. Soc. 11, 727-736 (2005). (Pubitemid 41631486)
    • (2005) Journal of the International Neuropsychological Society , vol.11 , Issue.6 , pp. 727-736
    • Benedict, R.H.B.1
  • 53
    • 77149155676 scopus 로고    scopus 로고
    • The utility of regression-based norms in interpreting the minimal assessment of cognitive function in multiple sclerosis (MACFIMS)
    • Parmenter, B. A., Testa, S. M., Schretlen, D. J., Weinstock-Guttman, B. & Benedict, R. H. The utility of regression-based norms in interpreting the minimal assessment of cognitive function in multiple sclerosis (MACFIMS). J. Int. Neuropsychol. Soc. 16, 616 (2010).
    • (2010) J. Int. Neuropsychol. Soc. , vol.16 , pp. 6-16
    • Parmenter, B.A.1    Testa, S.M.2    Schretlen, D.J.3    Weinstock-Guttman, B.4    Benedict, R.H.5
  • 54
    • 33846555710 scopus 로고    scopus 로고
    • Screening for cognitive impairment in multiple sclerosis using the Symbol Digit Modalities Test
    • DOI 10.1177/1352458506070750
    • Parmenter, B. A., Weinstock-Guttman, B., Garg, N., Munschauer, F. & Benedict, R. H. B. Screening for cognitive impairment in MS using the Symbol Digit Modalities Test. Mult. Scler. 13, 52-57 (2007). (Pubitemid 46152761)
    • (2007) Multiple Sclerosis , vol.13 , Issue.1 , pp. 52-57
    • Parmenter, B.A.1    Weinstock-Guttman, B.2    Garg, N.3    Munschauer, F.4    Benedict, R.H.B.5
  • 56
  • 61
    • 2942643975 scopus 로고    scopus 로고
    • Correlating brain atrophy with cognitive dysfunction, mood disturbances, and personality disorder in multiple sclerosis
    • Benedict, R. H. B., Carone, D. & Bakshi, R. Correlating brain atrophy with cognitive dysfunction, mood disturbances, and personality disorder in multiple sclerosis. J. Neuroimaging 14 (Suppl. 3), 36S-45S (2004). (Pubitemid 38781410)
    • (2004) Journal of Neuroimaging , vol.14 , Issue.SUPPL. 3
    • Benedict, R.H.B.1    Carone, D.A.2    Bakshi, R.3
  • 62
    • 1042302759 scopus 로고    scopus 로고
    • Prediction of neuropsychological impairment in multiple sclerosis: Comparison of conventional magnetic resonance imaging measures of atrophy and lesion burden
    • DOI 10.1001/archneur.61.2.226
    • Benedict, R. H. B., et al. Prediction of neuropsychological impairment in multiple sclerosis: comparison of conventional magnetic resonance imaging measures of atrophy and lesion burden. Arch. Neurol. 61, 226-230 (2004). (Pubitemid 38197556)
    • (2004) Archives of Neurology , vol.61 , Issue.2 , pp. 226-230
    • Benedict, R.H.B.1    Weinstock-Guttman, B.2    Fishman, I.3    Sharma, J.4    Tjoa, C.W.5    Bakshi, R.6
  • 63
    • 76449087199 scopus 로고    scopus 로고
    • Psychometrics and normative data for the Multiple Sclerosis Functional Composite: Replacing the PASAT with the Symbol Digit Modalities Test
    • Drake, A. S., et al. Psychometrics and normative data for the Multiple Sclerosis Functional Composite: replacing the PASAT with the Symbol Digit Modalities Test. Mult. Scler. 16, 228237 (2010).
    • (2010) Mult. Scler. , vol.16 , pp. 228-237
    • Drake, A.S.1
  • 64
    • 0032837796 scopus 로고    scopus 로고
    • The multiple sclerosis functional composite measure (MSFC): An integrated approach to MS clinical outcome assessment
    • Fischer, J. S., Rudick, R. A., Cutter, G. R. & Reingold, S. C. The Multiple Sclerosis Functional Composite Measure (MSFC): an integrated approach to MS clinical outcome assessment. National MS Society Clinical Outcomes Assessment Task Force. Mult. Scler. 5, 244-250 (1999). (Pubitemid 29405620)
    • (1999) Multiple Sclerosis , vol.5 , Issue.4 , pp. 244-250
    • Fischer, J.S.1    Rudick, R.A.2    Cutter, G.R.3    Reingold, S.C.4
  • 65
    • 34447257357 scopus 로고    scopus 로고
    • PASAT in detecting cognitive impairment in relapsing-remitting MS
    • Rosti, E., Hamalainen, P., Koivisto, K. & Hokkanen, L. PASAT in detecting cognitive impairment in relapsing-remitting MS. Appl. Neuropsychol. 14, 101-112 (2007). (Pubitemid 47041910)
    • (2007) Applied Neuropsychology , vol.14 , Issue.2 , pp. 101-112
    • Rosti, E.1    Hamalainen, P.2    Koivisto, K.3    Hokkanen, L.4
  • 66
    • 0029395655 scopus 로고
    • The brief repeatable battery of neuropsychological tests for multiple sclerosis: A preliminary serial study
    • Bever, C., Grattan, L., Panitch, H. S. & Johnson, K. P. The brief repeatable battery of neuropsychological tests for multiple sclerosis: a preliminary serial study. Mult. Scler. 1, 165-169 (1995).
    • (1995) Mult. Scler. , vol.1 , pp. 165-169
    • Bever, C.1    Grattan, L.2    Panitch, H.S.3    Johnson, K.P.4
  • 67
    • 54449101658 scopus 로고    scopus 로고
    • Repeated assessment of neuropsychological deficits in multiple sclerosis using the Symbol Digit Modalities Test and the MS Neuropsychological Screening Questionnaire
    • Benedict, R. H. B., et al. Repeated assessment of neuropsychological deficits in multiple sclerosis using the Symbol Digit Modalities Test and the MS Neuropsychological Screening Questionnaire. Mult. Scler. 14, 940-946 (2008).
    • (2008) Mult. Scler. , vol.14 , pp. 940-946
    • Benedict, R.H.B.1
  • 68
    • 78449297684 scopus 로고    scopus 로고
    • Evaluation of the symbol digit modalities test (SDMT) and MS neuropsychological screening questionnaire (MSNQ) in natalizumab-treated MS patients over 48 weeks
    • Morrow, S. A., et al. Evaluation of the symbol digit modalities test (SDMT) and MS neuropsychological screening questionnaire (MSNQ) in natalizumab-treated MS patients over 48 weeks. Mult. Scler. 16, 13851392 (2010).
    • (2010) Mult. Scler. , vol.16 , pp. 1385-1392
    • Morrow, S.A.1
  • 69
    • 80054742853 scopus 로고    scopus 로고
    • Effects of acute relapses on neuropsychological status in multiple sclerosis patients
    • doi:10.1007/s00415-011-5975-5973
    • Morrow, S. A., Jurgensen, S., Forrestal, F. & Benedict, R. H. B. Effects of acute relapses on neuropsychological status in multiple sclerosis patients. J. Neurol. doi:10.1007/s00415-011-5975-5973.
    • J. Neurol.
    • Morrow, S.A.1    Jurgensen, S.2    Forrestal, F.3    Benedict, R.H.B.4
  • 70
    • 77957913088 scopus 로고    scopus 로고
    • Predicting loss of employment over three years in multiple sclerosis: Clinically meaningful cognitive decline
    • Morrow, S. A., et al. Predicting loss of employment over three years in multiple sclerosis: clinically meaningful cognitive decline. Clinical Neuropsychologist 24, 11311145 (2010).
    • (2010) Clinical Neuropsychologist , vol.24 , pp. 1131-1145
    • Morrow, S.A.1
  • 71
    • 72949097178 scopus 로고    scopus 로고
    • Cognitive aging in patients with multiple sclerosis: A cross-sectional analysis of speeded processing
    • Bodling, A. M., Denney, D. R. & Lynch, S. G. Cognitive aging in patients with multiple sclerosis: a cross-sectional analysis of speeded processing. Arch. Clin. Neuropsychol. 24, 761-767 (2009).
    • (2009) Arch. Clin. Neuropsychol. , vol.24 , pp. 761-767
    • Bodling, A.M.1    Denney, D.R.2    Lynch, S.G.3
  • 72
    • 0034798404 scopus 로고    scopus 로고
    • Cognitive dysfunction in early-onset multiple sclerosis: A reappraisal after 10 years
    • Amato, M. P., Ponziani, G., Siracusa, G. & Sorbi, S. Cognitive dysfunction in early-onset multiple sclerosis: a reappraisal after 10 years. Arch. Neurol. 58, 1602-1606 (2001). (Pubitemid 32963224)
    • (2001) Archives of Neurology , vol.58 , Issue.10 , pp. 1602-1606
    • Amato, M.P.1    Ponziani, G.2    Siracusa, G.3    Sorbi, S.4
  • 73
    • 77957933856 scopus 로고    scopus 로고
    • Cognitive and psychosocial features in childhood and juvenile MS: Two-year follow-up
    • Amato, M. P., et al. Cognitive and psychosocial features in childhood and juvenile MS: two-year follow-up. Neurology 75, 11341140 (2010).
    • (2010) Neurology , vol.75 , pp. 1134-1140
    • Amato, M.P.1
  • 74
    • 0037851026 scopus 로고    scopus 로고
    • Sex differences in cognitive impairment in multiple sclerosis
    • DOI 10.1076/clin.16.4.472.13904
    • Beatty, W. W. & Aupperle, R. L. Sex differences in cognitive impairment in multiple sclerosis. Clin. Neuropsychol. 16, 472-480 (2002). (Pubitemid 36605802)
    • (2002) Clinical Neuropsychologist , vol.16 , Issue.4 , pp. 472-480
    • Beatty, W.W.1    Aupperle, R.L.2
  • 76
    • 33646685266 scopus 로고    scopus 로고
    • Does multiple sclerosis-associated disability differ between races?
    • 1235
    • Marrie, R. A., Cutter, G., Tyry, T., Vollmer, T. & Campagnolo, D. Does multiple sclerosis-associated disability differ between races? Neurology 66, 12351240 (1235).
    • Neurology , vol.66 , pp. 1235-1240
    • Marrie, R.A.1    Cutter, G.2    Tyry, T.3    Vollmer, T.4    Campagnolo, D.5
  • 77
    • 51349169159 scopus 로고    scopus 로고
    • Depression in multiple sclerosis: Review and theoretical proposal
    • Arnett, P. A., Barwick, F. H. & Beeney, J. E. Depression in multiple sclerosis: review and theoretical proposal. J. Int. Neuropsychol. Soc. 14, 691-724 (2008).
    • (2008) J. Int. Neuropsychol. Soc. , vol.14 , pp. 691-724
    • Arnett, P.A.1    Barwick, F.H.2    Beeney, J.E.3
  • 78
    • 69549114866 scopus 로고    scopus 로고
    • Subjective fatigue is not associated with cognitive impairment in multiple sclerosis: Cross-sectional and longitudinal analysis
    • Morrow, S. A., Weinstock-Guttman, B., Munschauer, F., Hojnacki, D. & Benedict, R. H. B. Subjective fatigue is not associated with cognitive impairment in multiple sclerosis: cross-sectional and longitudinal analysis. Mult. Scler. 15, 998-1005 (2009).
    • (2009) Mult. Scler. , Issue.15 , pp. 998-1005
    • Morrow, S.A.1    Weinstock-Guttman, B.2    Munschauer, F.3    Hojnacki, D.4    Benedict, R.H.B.5
  • 81
    • 0029090569 scopus 로고
    • Brain MRI correlates of cognitive impairment in primary and secondary progressive multiple sclerosis
    • Comi, G., et al. Brain MRI correlates of cognitive impairment in primary and secondary progressive multiple sclerosis. J. Neurol. Sci. 132, 222-227 (1995).
    • (1995) J. Neurol. Sci. , vol.132 , pp. 222-227
    • Comi, G.1
  • 82
    • 0028102659 scopus 로고
    • Influence of clinical variables on neuropsychological performance in multiple sclerosis
    • Filippi, M., et al. Influence of clinical variables on neuropsychological performance in multiple sclerosis. Eur. Neurol. 34, 324-328 (1994).
    • (1994) Eur. Neurol. , vol.34 , pp. 324-328
    • Filippi, M.1
  • 83
    • 54849431166 scopus 로고    scopus 로고
    • Gray matter atrophy in multiple sclerosis: A longitudinal study
    • Fisher, E., Lee, J. C., Nakamura, K. & Rudick, R. A. Gray matter atrophy in multiple sclerosis: a longitudinal study. Ann. Neurol. 64, 255-265 (2008).
    • (2008) Ann. Neurol. , vol.64 , pp. 255-265
    • Fisher, E.1    Lee, J.C.2    Nakamura, K.3    Rudick, R.A.4
  • 84
    • 34250672398 scopus 로고    scopus 로고
    • Smoking is a risk factor for multiple sclerosis: A metanalysis
    • DOI 10.1177/1352458506073501
    • Hawkes, C. H. Smoking is a risk factor for multiple sclerosis: a metanalysis. Mult. Scler. 13, 610-615 (2007). (Pubitemid 46939526)
    • (2007) Multiple Sclerosis , vol.13 , Issue.5 , pp. 610-615
    • Hawkes, C.H.1
  • 85
    • 67349263039 scopus 로고    scopus 로고
    • Smoking is associated with progressive disease course and increased progression in clinical disability in a prospective cohort of people with multiple sclerosis
    • Pittas, F., et al. Smoking is associated with progressive disease course and increased progression in clinical disability in a prospective cohort of people with multiple sclerosis. J. Neurol. 256, 577-585 (2009).
    • (2009) J. Neurol. , vol.256 , pp. 577-585
    • Pittas, F.1
  • 86
    • 70349107686 scopus 로고    scopus 로고
    • Multiple sclerosis with predominant, severe cognitive impairment
    • Staff, N. P., Lucchinetti, C. F. & Keegan, B. M. Multiple sclerosis with predominant, severe cognitive impairment. Arch. Neurol. 66, 1139-1143 (2009).
    • (2009) Arch. Neurol. , vol.66 , pp. 1139-1143
    • Staff, N.P.1    Lucchinetti, C.F.2    Keegan, B.M.3
  • 87
    • 48449087313 scopus 로고    scopus 로고
    • Multiple sclerosis and cannabis: A cognitive and psychiatric study
    • Ghaffar, O. & Feinstein, A. Multiple sclerosis and cannabis: a cognitive and psychiatric study. Neurology 71, 164-169 (2008).
    • (2008) Neurology , vol.71 , pp. 164-169
    • Ghaffar, O.1    Feinstein, A.2
  • 88
    • 33645886064 scopus 로고    scopus 로고
    • Neuropsychological deficits in long-term frequent cannabis users
    • DOI 10.1212/01.wnl.0000201279.83203.c6, PII 0000611420060314000025
    • Messinis, L., Kyprianidou, A., Malefaki, S. & Papathanasopoulos, P. Neuropsychological deficits in long-term frequent cannabis users. Neurology 66, 737-739 (2006). (Pubitemid 43739832)
    • (2006) Neurology , vol.66 , Issue.5 , pp. 737-739
    • Messinis, L.1    Kyprianidou, A.2    Malefaki, S.3    Papathanasopoulos, P.4
  • 89
    • 34247544366 scopus 로고    scopus 로고
    • Personality and medical illness burden among older adults in primary care
    • DOI 10.1097/PSY.0b013e3180313975, PII 0000684220070400000009
    • Chapman, B. P., Lyness, J. M. & Duberstein, P. Personality and medical illness burden among older adults in primary care. Psychosom. Med. 69, 277-282 (2007). (Pubitemid 46653081)
    • (2007) Psychosomatic Medicine , vol.69 , Issue.3 , pp. 277-282
    • Chapman, B.P.1    Lyness, J.M.2    Duberstein, P.3
  • 90
    • 79551627849 scopus 로고    scopus 로고
    • The NEO-FFI in multiple sclerosis: Internal consistency, factorial validity, and correspondence between self and informant reports
    • Schwartz, E. S., Chapman, B. P., Duberstein, P. R., Weinstock-Guttman, B. & Benedict, R. H. The NEO-FFI in multiple sclerosis: internal consistency, factorial validity, and correspondence between self and informant reports. Assessment 18, 3949 (2011).
    • (2011) Assessment , vol.18 , pp. 39-49
    • Schwartz, E.S.1    Chapman, B.P.2    Duberstein, P.R.3    Weinstock-Guttman, B.4    Benedict, R.H.5
  • 92
    • 0034575124 scopus 로고    scopus 로고
    • Apolipoprotein E: Far more than a lipid transport protein
    • Mahley, R. W. & Rall, S. C. Jr. Apolipoprotein E: far more than a lipid transport protein. Annu.Rev. Genomics Hum. Genet. 1, 507-537 (2000).
    • (2000) Annu.Rev. Genomics Hum. Genet. , vol.1 , pp. 507-537
    • Mahley, R.W.1    Rall Jr., S.C.2
  • 95
    • 78651291539 scopus 로고    scopus 로고
    • APOE 4-positive multiple sclerosis patients develop more gray matter and whole brain atrophy. A 4-year longitudinal study using the 15-year disease onset model
    • Horáková, D., et al. APOE 4-positive multiple sclerosis patients develop more gray matter and whole brain atrophy. a 4-year longitudinal study using the 15-year disease onset model. Fol. Biol. Praha 56, 242251 (2010).
    • (2010) Fol. Biol. Praha , vol.56 , pp. 242-251
    • Horáková, D.1
  • 96
    • 85047684775 scopus 로고    scopus 로고
    • APOE 4 and cognitive dysfunction in multiple sclerosis: A review
    • Ghaffar, O. & Feinstein, A. APOE ?4 and cognitive dysfunction in multiple sclerosis: a review. J. Neuropsychiatry Clin. Neurosci. 22, 155165 (2010).
    • (2010) J. Neuropsychiatry Clin. Neurosci. , vol.22 , pp. 155-165
    • Ghaffar, O.1    Feinstein, A.2
  • 98
    • 59349097653 scopus 로고    scopus 로고
    • An APOA1 promoter polymorphism is associated with cognitive performance in patients with multiple sclerosis
    • Koutsis, G., et al. An APOA1 promoter polymorphism is associated with cognitive performance in patients with multiple sclerosis. Mult. Scler. 15, 174-179 (2009).
    • (2009) Mult. Scler. , vol.15 , pp. 174-179
    • Koutsis, G.1
  • 99
    • 33847196388 scopus 로고    scopus 로고
    • APOE 4 is associated with impaired verbal learning in patients with MS
    • Koutsis, G., et al. APOE ?4 is associated with impaired verbal learning in patients with MS. Neurology 68, 546-549 (2007).
    • (2007) Neurology , vol.68 , pp. 546-549
    • Koutsis, G.1
  • 100
    • 33846530125 scopus 로고    scopus 로고
    • Cognitive impairment in patients with multiple sclerosis: Association with the APOE gene and promoter polymorphisms
    • DOI 10.1177/1352458506070682
    • Parmenter, B. A., Denney, D. R., Lynch, S. G., Middleton, L. S. & Harlan, L. M. Cognitive impairment in patients with multiple sclerosis: association with the APOE gene and promoter polymorphisms. Mult. Scler. 13, 25-32 (2007). (Pubitemid 46152758)
    • (2007) Multiple Sclerosis , vol.13 , Issue.1 , pp. 25-32
    • Parmenter, B.A.1    Denney, D.R.2    Lynch, S.G.3    Middleton, L.S.4    Harlan, L.M.5
  • 102
    • 77952478035 scopus 로고    scopus 로고
    • APOE 4 and the cognitive genetics of multiple sclerosis
    • Ghaffar, O., Reis, M., Pennell, N., OConnor, P. & Feinstein, A. APOE 4 and the cognitive genetics of multiple sclerosis. Neurology 74, 16111618 (2010).
    • (2010) Neurology , vol.74 , pp. 1611-1618
    • Ghaffar, O.1    Reis, M.2    Pennell, N.3    Oconnor, P.4    Feinstein, A.5
  • 103
    • 72849129081 scopus 로고    scopus 로고
    • ApolipoproteinE epsilon 4 allele is not associated with disease course and severity in multiple sclerosis
    • Portaccio, E., et al. ApolipoproteinE epsilon 4 allele is not associated with disease course and severity in multiple sclerosis. Acta Neurol. Scand. 120, 439-441 (2009).
    • (2009) Acta Neurol. Scand. , vol.120 , pp. 439-441
    • Portaccio, E.1
  • 104
    • 70349673166 scopus 로고    scopus 로고
    • Apolipoprotein genotype does not influence MS severity, cognition, or brain atrophy
    • van der Walt, A., et al. Apolipoprotein genotype does not influence MS severity, cognition, or brain atrophy. Neurology 73, 1018-1025 (2009).
    • (2009) Neurology , vol.73 , pp. 1018-1025
    • Van Der Walt, A.1
  • 105
    • 77956333737 scopus 로고    scopus 로고
    • Multiple sclerosis susceptibility-associated SNPs do not influence disease severity measures in a cohort of Australian MS patients
    • Jensen, C. J., et al. Multiple sclerosis susceptibility-associated SNPs do not influence disease severity measures in a cohort of Australian MS patients. PLoS ONE 5, e10003 (2010).
    • (2010) PLoS ONE , vol.5
    • Jensen, C.J.1
  • 107
    • 78650574794 scopus 로고    scopus 로고
    • The rs2030324 SNP of brain derived neurotrophic factor (BDNF) is associated with visual cognitive processing in multiple sclerosis
    • Weinstock-Guttman, B., et al. The rs2030324 SNP of brain derived neurotrophic factor (BDNF) is associated with visual cognitive processing in multiple sclerosis. Pathophysiology 18, 4352 (2010).
    • (2010) Pathophysiology , vol.18 , pp. 43-52
    • Weinstock-Guttman, B.1
  • 108
    • 74449090368 scopus 로고    scopus 로고
    • The effects of BDNF Val66Met polymorphism on brain function in controls and patients with multiple sclerosis: An imaging genetic study
    • Cerasa, A., et al. The effects of BDNF Val66Met polymorphism on brain function in controls and patients with multiple sclerosis: an imaging genetic study. Behav. Brain Res. 207, 377386 (2010).
    • (2010) Behav. Brain Res. , vol.207 , pp. 377-386
    • Cerasa, A.1
  • 109
    • 45549092100 scopus 로고    scopus 로고
    • The genetics of multiple sclerosis: SNPs to pathways to pathogenesis
    • DOI 10.1038/nrg2395, PII NRG2395
    • Oksenberg, J. R., Baranzini, S. E., Sawcer, S. & Hauser, S. L. The genetics of multiple sclerosis: SNPs to pathways to pathogenesis. Nat. Rev. Genet. 9, 516-526 (2008). (Pubitemid 351861542)
    • (2008) Nature Reviews Genetics , vol.9 , Issue.7 , pp. 516-526
    • Oksenberg, J.R.1    Baranzini, S.E.2    Sawcer, S.3    Hauser, S.L.4
  • 111
    • 0034099319 scopus 로고    scopus 로고
    • Intraventricular CSF pulsation artifact on fast fluid-attenuated inversion-recovery MR images: Analysis of 100 consecutive normal studies
    • Bakshi, R., Caruthers, S. D., Janardhan, V. & Wasay, M. Intraventricular CSF pulsation artifact on fast fluid-attenuated inversion-recovery MR images: analysis of 100 consecutive normal studies. AJNR Am. J. Neuroradiol. 21, 503-508 (2000). (Pubitemid 30149342)
    • (2000) American Journal of Neuroradiology , vol.21 , Issue.3 , pp. 503-508
    • Bakshi, R.1    Caruthers, S.D.2    Janardhan, V.3    Wasay, M.4
  • 112
    • 0035004650 scopus 로고    scopus 로고
    • Fluid-attenuated inversion recovery magnetic resonance imaging detects cortical and juxtacortical multiple sclerosis lesions
    • Bakshi, R., Ariyaratana, S., Benedict, R. H. & Jacobs, L. Fluid-attenuated inversion recovery magnetic resonance imaging detects cortical and juxtacortical multiple sclerosis lesions. Arch. Neurol. 58, 742-748 (2001). (Pubitemid 32423046)
    • (2001) Archives of Neurology , vol.58 , Issue.5 , pp. 742-748
    • Bakshi, R.1    Ariyaratana, S.2    Benedict, R.H.B.3    Jacobs, L.4
  • 114
    • 2542418047 scopus 로고    scopus 로고
    • Role of MRI in multiple sclerosis I: Inflammation and lesions
    • d505-999
    • Zivadinov, R. & Bakshi, R. Role of MRI in multiple sclerosis I: inflammation and lesions. Front. Biosci. 9, 665-683 (2004). (Pubitemid 39043742)
    • (2004) Frontiers in Bioscience , vol.9 , pp. 665-683
    • Zivadinov, R.1    Bakshi, R.2
  • 115
    • 0024563870 scopus 로고
    • Correlation of magnetic resonance imaging with neuropsychological testing in multiple sclerosis
    • Rao, S. M., Leo, G. J., Haughton, V. M., Aubin-Faubert, P. S. & Bernardin, L. Correlation of magnetic resonance imaging with neuropsychological testing in multiple sclerosis. Neurology 39, 161-166 (1989). (Pubitemid 19059298)
    • (1989) Neurology , vol.39 , Issue.2 , pp. 161-166
    • Rao, S.M.1    Leo, G.J.2    Haughton, V.M.3    St. Aubtin-Faubert, P.4    Bernardin, L.5
  • 116
    • 20744442122 scopus 로고    scopus 로고
    • Intracortical lesions in multiple sclerosis: Improved detection with 3D double inversion-recovery MR imaging
    • DOI 10.1148/radiol.2361040450
    • Geurts, J. J., et al. Intracortical lesions in multiple sclerosis: improved detection with 3D double inversion-recovery MR imaging. Radiology 236, 254-260 (2005). (Pubitemid 40853320)
    • (2005) Radiology , vol.236 , Issue.1 , pp. 254-260
    • Geurts, J.J.G.1    Pouwels, P.J.W.2    Uitdehaag, B.M.J.3    Polman, C.H.4    Barkhof, F.5    Castelijns, J.A.6
  • 117
    • 16844364980 scopus 로고    scopus 로고
    • Cortical lesions in multiple sclerosis: Combined postmortem MR imaging and histopathology
    • Geurts, J. J., et al. Cortical lesions in multiple sclerosis: combined postmortem MR imaging and histopathology. AJNR Am. J. Neuroradiol. 26, 572-527 (2005).
    • (2005) AJNR Am. J. Neuroradiol. , vol.26 , pp. 572-527
    • Geurts, J.J.1
  • 118
    • 77957565209 scopus 로고    scopus 로고
    • T1 cortical hypointensities and their association with cognitive disability in multiple sclerosis
    • Bagnato, F., et al. T1 cortical hypointensities and their association with cognitive disability in multiple sclerosis. Mult. Scler. 16, 12031212 (2010).
    • (2010) Mult. Scler. , vol.16 , pp. 1203-1212
    • Bagnato, F.1
  • 119
    • 66149183024 scopus 로고    scopus 로고
    • Accumulation of cortical lesions in MS: Relation with cognitive impairment
    • Roosendaal, S. D., et al. Accumulation of cortical lesions in MS: relation with cognitive impairment. Mult. Scler. 15, 708-714 (2009).
    • (2009) Mult. Scler. , vol.15 , pp. 708-714
    • Roosendaal, S.D.1
  • 122
    • 0032796747 scopus 로고    scopus 로고
    • Axonal pathology in multiple sclerosis: Relationship to neurologic disability
    • DOI 10.1097/00019052-199906000-00008
    • Trapp, B. D., Ransohoff, R. & Rudick, R. Axonal pathology in multiple sclerosis: relationship to neurologic disability. Curr. Opin. Neurol. 12, 295-302 (1999). (Pubitemid 29378163)
    • (1999) Current Opinion in Neurology , vol.12 , Issue.3 , pp. 295-302
    • Trapp, B.D.1    Ransohoff, R.2    Rudick, R.3
  • 123
    • 0034842126 scopus 로고    scopus 로고
    • Transected neurites, apoptotic neurons, and reduced inflammation in cortical multiple sclerosis lesions
    • DOI 10.1002/ana.1123
    • Peterson, J. W., Bö, L., Mörk, S., Chang, A. & Trapp, B. D. Transected neurites, apoptotic neurons, and reduced inflammation in cortical multiple sclerosis lesions. Ann. Neurol. 50, 389-400 (2001). (Pubitemid 32848742)
    • (2001) Annals of Neurology , vol.50 , Issue.3 , pp. 389-400
    • Peterson, J.W.1    Bo, L.2    Mork, S.3    Chang, A.4    Trapp, B.D.5
  • 127
    • 0037196878 scopus 로고    scopus 로고
    • Cognitive dysfunction in patients with mildly disabling relapsing-remitting multiple sclerosis: An exploratory study with diffusion tensor MR imaging
    • PII S0022510X01006906
    • Rovaris, M., et al. Cognitive dysfunction in patients with mildly disabling relapsing-remitting multiple sclerosis: an exploratory study with diffusion tensor MR imaging. J. Neurol. Sci. 195, 103-109 (2002). (Pubitemid 34202286)
    • (2002) Journal of the Neurological Sciences , vol.195 , Issue.2 , pp. 103-109
    • Rovaris, M.1    Iannucci, G.2    Falautano, M.3    Possa, F.4    Martinelli, V.5    Comi, G.6    Filippi, M.7
  • 128
    • 0033544320 scopus 로고    scopus 로고
    • Use of the brain parenchymal fraction to measure whole brain atrophy in relapsing-remitting MS
    • Rudick, R. A., Fisher, E., Lee, J. C., Simon, J. & Jacobs, L. Use of the brain parenchymal fraction to measure whole brain atrophy in relapsing-remitting MS. Multiple Sclerosis Collaborative Research Group. Neurology 53, 1698-1704 (1999). (Pubitemid 29530342)
    • (1999) Neurology , vol.53 , Issue.8 , pp. 1698-1704
    • Rudick, R.A.1    Fisher, E.2    Lee, J.-C.3    Simon, J.4    Jacobs, L.5
  • 130
    • 34548713551 scopus 로고    scopus 로고
    • Thalamic atrophy and cognition in multiple sclerosis
    • Houtchens, M. K., et al. Thalamic atrophy and cognition in multiple sclerosis. Neurology 69, 113-123 (2007).
    • (2007) Neurology , vol.69 , pp. 113-123
    • Houtchens, M.K.1
  • 132
    • 77956302460 scopus 로고    scopus 로고
    • Hippocampal atrophy in relapsing-remitting and primary progressive MS: A comparative study
    • Anderson, V. M., et al. Hippocampal atrophy in relapsing-remitting and primary progressive MS: a comparative study. Mult. Scler. 16, 10831090 (2010).
    • (2010) Mult. Scler. , vol.16 , pp. 1083-1090
    • Anderson, V.M.1
  • 134
    • 1342309509 scopus 로고    scopus 로고
    • Structural brain abnormalities in multiple sclerosis patients with major depression
    • Feinstein, A., et al. Structural brain abnormalities in multiple sclerosis patients with major depression. Neurology 62, 586-590 (2004). (Pubitemid 38252800)
    • (2004) Neurology , vol.62 , Issue.4 , pp. 586-590
    • Feinstein, A.1    Roy, P.2    Lobaugh, N.3    Feinstein, K.4    O'Connor, P.5    Black, S.6
  • 136
    • 33747591635 scopus 로고    scopus 로고
    • Cognitive reserve and Alzheimer disease
    • DOI 10.1097/00002093-200607001-00010, PII 0000209320060700100010
    • Stern, Y. Cognitive reserve and Alzheimer disease. Alzheimer Dis. Assoc. Disord. 20, S69-S74 (2006). (Pubitemid 44265854)
    • (2006) Alzheimer Disease and Associated Disorders , vol.20 , Issue.SUPPL. 2
    • Stern, Y.1
  • 139
    • 70349423605 scopus 로고    scopus 로고
    • Cognitive reserve moderates the negative effect of brain atrophy on cognitive effi ciency in multiple sclerosis
    • Sumowski, J. F., Chiaravalloti, N., Wylie, G. & Deluca, J. Cognitive reserve moderates the negative effect of brain atrophy on cognitive effi ciency in multiple sclerosis. J. Int. Neuropsychol. Soc. 15, 606-612 (2009).
    • (2009) J. Int. Neuropsychol. Soc. , vol.15 , pp. 606-612
    • Sumowski, J.F.1    Chiaravalloti, N.2    Wylie, G.3    Deluca, J.4
  • 140
    • 78049520409 scopus 로고    scopus 로고
    • Premorbid cognitive leisure independently contributes to cognitive reserve in multiple sclerosis
    • Sumowski, J. F., Wylie, G. R., Gonnella, A., Chiaravalloti, N. & Deluca, J. Premorbid cognitive leisure independently contributes to cognitive reserve in multiple sclerosis. Neurology 75, 14281431 (2010).
    • (2010) Neurology , vol.75 , pp. 1428-1431
    • Sumowski, J.F.1    Wylie, G.R.2    Gonnella, A.3    Chiaravalloti, N.4    Deluca, J.5
  • 141
    • 77249142048 scopus 로고    scopus 로고
    • Intellectual enrichment is linked to cerebral efficiency in multiple sclerosis: Functional magnetic resonance imaging evidence for cognitive reserve
    • Sumowski, J. F., Wylie, G. R., Deluca, J. & Chiaravalloti, N. Intellectual enrichment is linked to cerebral efficiency in multiple sclerosis: functional magnetic resonance imaging evidence for cognitive reserve. Brain 133, 362374 (2010).
    • (2010) Brain , vol.133 , pp. 362-374
    • Sumowski, J.F.1    Wylie, G.R.2    Deluca, J.3    Chiaravalloti, N.4
  • 142
    • 40949090163 scopus 로고    scopus 로고
    • Evidenced-based cognitive rehabilitation for persons with multiple sclerosis: A review of the literature
    • DOI 10.1016/j.apmr.2007.10.019, PII S0003999308000038
    • OBrien, A. R., Chiaravalloti, N., Goverover, Y. & Deluca, J. Evidenced-based cognitive rehabilitation for persons with multiple sclerosis: a review of the literature. Arch. Phys. Med. Rehabil. 89, 761-769 (2008). (Pubitemid 351406321)
    • (2008) Archives of Physical Medicine and Rehabilitation , vol.89 , Issue.4 , pp. 761-769
    • O'Brien, A.R.1    Chiaravalloti, N.2    Goverover, Y.3    DeLuca, J.4
  • 143
    • 13844309632 scopus 로고    scopus 로고
    • Treating learning impairments improves memory performance in multiple sclerosis: A randomized clinical trial
    • DOI 10.1191/1352458505ms1118oa
    • Chiaravalloti, N. D., DeLuca, J., Moore, N. B. & Ricker, J. H. Treating learning impairments improves memory performance in multiple sclerosis: a randomized clinical trial. Mult. Scler. 11, 58-68 (2005). (Pubitemid 40259976)
    • (2005) Multiple Sclerosis , vol.11 , Issue.1 , pp. 58-68
    • Chiaravalloti, N.D.1    DeLuca, J.2    Moore, N.B.3    Ricker, J.H.4
  • 144
    • 0020489848 scopus 로고
    • Membranes myelin, and the pathophysiology of multiple sclerosis
    • Waxman, S. G. Membranes, myelin, and the pathophysiology of multiple sclerosis. N. Engl. J. Med. 306, 1529-1533 (1982).
    • (1982) N. Engl. J. Med. , vol.306 , pp. 1529-1533
    • Waxman, S.G.1
  • 145
    • 10544237271 scopus 로고    scopus 로고
    • Treatment with oral 3, 4 diaminopyridine improves leg strength in multiple sclerosis patients: Results of a randomized, double-blind, placebo-controlled, crossover trial
    • Bever, C. T. Jr, et al. Treatment with oral 3, 4 diaminopyridine improves leg strength in multiple sclerosis patients: results of a randomized, double-blind, placebo-controlled, crossover trial. Neurology 47, 1457-1462 (1996).
    • (1996) Neurology , vol.47 , pp. 1457-1462
    • Bever Jr., C.T.1
  • 146
    • 0028245456 scopus 로고
    • The effects of 4-aminopyridine in multiple sclerosis patients: Results of a randomized, placebo-controlled, double-blind, concentration-controlled, crossover trial
    • Bever, C. T. Jr, et al. The effects of 4-aminopyridine in multiple sclerosis patients: results of a randomized, placebo-controlled, double-blind, concentration-controlled, crossover trial. Neurology 44, 1054-1059 (1994).
    • (1994) Neurology , vol.44 , pp. 1054-1059
    • Bever Jr., C.T.1
  • 149
    • 72949121422 scopus 로고    scopus 로고
    • Treatment of multiple sclerosis related cognitive problems with adjunctive modafinil: Rationale and preliminary supportive data
    • Wilken, J. A., et al. Treatment of multiple sclerosis related cognitive problems with adjunctive modafinil: Rationale and preliminary supportive data. Int. J. MS Care 10, 1-10 (2008).
    • (2008) Int. J. MS Care , vol.10 , pp. 1-10
    • Wilken, J.A.1
  • 150
    • 58149148227 scopus 로고    scopus 로고
    • Single dose of methylphenidate improves cognitive performance in multiple sclerosis patients with impaired attention process
    • Harel, Y., Appleboim, N., Lavie, M. & Achiron, A. Single dose of methylphenidate improves cognitive performance in multiple sclerosis patients with impaired attention process. J. Neurol. Sci. 276, 38-40 (2009).
    • (2009) J. Neurol. Sci. , vol.276 , pp. 38-40
    • Harel, Y.1    Appleboim, N.2    Lavie, M.3    Achiron, A.4
  • 151
    • 50049122115 scopus 로고    scopus 로고
    • Effects of l-amphetamine sulfate on cognitive function in multiple sclerosis patients
    • Benedict, R. H., et al. Effects of l-amphetamine sulfate on cognitive function in multiple sclerosis patients. J. Neurol. 255, 848-852 (2008).
    • (2008) J. Neurol. , vol.255 , pp. 848-852
    • Benedict, R.H.1
  • 152
    • 67650458525 scopus 로고    scopus 로고
    • The effects of l-amphetamine sulfate on cognition in MS patients: Results of a randomized controlled trial
    • Morrow, S. A., et al. The effects of l-amphetamine sulfate on cognition in MS patients: results of a randomized controlled trial. J. Neurol. 256, 1095-1102 (2009).
    • (2009) J. Neurol. , vol.256 , pp. 1095-1102
    • Morrow, S.A.1
  • 154
    • 79955502336 scopus 로고    scopus 로고
    • A multi-center randomized clinical trial of donepezil for memory impairment in multiple sclerosis
    • in press
    • Krupp, L., et al. A multi-center randomized clinical trial of donepezil for memory impairment in multiple sclerosis. Neurology (in press).
    • Neurology
    • Krupp, L.1
  • 156
    • 84860413311 scopus 로고    scopus 로고
    • L-amphetamine improves memory in MS patients with objective memory impairment
    • in press
    • Sumoski, J. F., et al. l-amphetamine improves memory in MS patients with objective memory impairment. Mult. Scler. (in press).
    • Mult. Scler.
    • Sumoski, J.F.1
  • 158
    • 36349028564 scopus 로고    scopus 로고
    • The distressed personality type: Replicability and general health associations
    • Chapman, B. P., Duberstein, P. & Lyness, J. M. The distressed personality type: replicability and general health associations. Eur. J. Personality (2007).
    • (2007) Eur. J. Personality
    • Chapman, B.P.1    Duberstein, P.2    Lyness, J.M.3


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