Differential effect of FR122047, a selective cyclo-oxygenase-1 inhibitor, in rat chronic models of arthritis

British Journal of Pharmacology

Volumn 135, Issue 3, 2002, Pages 782-788

  Ochi, Takehiro ^a   Goto, Toshio ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

Anti inflammation; Cyclo oxygenase 1; FR122047; Prostaglandin formation; Type II collagen arthritis

Indexed keywords

1 [[4,5 BIS(4 METHOXYPHENYL) 2 THIAZOYL]CARBONYL] 4 METHYLPIPERAZINE; COLLAGEN TYPE 1; CYCLOOXYGENASE 1; CYCLOOXYGENASE 1 INHIBITOR; CYCLOOXYGENASE 2; FR 122047; INDOMETACIN; LIPOPOLYSACCHARIDE; PROSTAGLANDIN E2; THROMBOXANE B2; UNCLASSIFIED DRUG;

ADJUVANT ARTHRITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARACHIDONIC ACID METABOLISM; ARTICLE; ASSAY; CHRONIC ARTHRITIS; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; DRUG SELECTIVITY; ENZYME INHIBITION; FEMALE; NONHUMAN; PAW EDEMA; PRIORITY JOURNAL; RAT; STOMACH ULCER; TREATMENT OUTCOME;

EID: 0036176669     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704511     Document Type: Article

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