Skewed Th1 responses caused by excessive expression of Txk, a member of the Tec family of tyrosine kinases, in patients with Behcet's disease

Clinical Medicine and Research

Volumn 4, Issue 2, 2006, Pages 147-151

  Suzuki, Noboru ^a   Nara, Kazuhiko ^a   Suzuki, Tomoko ^a  

^a ST MARIANNA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Behcet's disease; Cytokines; Th1 cell; Txk

Indexed keywords

CHEMOKINE RECEPTOR; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 18; PROTEIN TYROSINE KINASE; TYROSINE KINASE TXK; UNCLASSIFIED DRUG;

BEHCET DISEASE; CD4+ T LYMPHOCYTE; CELL DIFFERENTIATION; CYTOKINE PRODUCTION; HUMAN; IMMUNOBLOTTING; PATHOGENESIS; PERIPHERAL LYMPHOCYTE; PROTEIN EXPRESSION; REVIEW; TH1 CELL;

BEHCET SYNDROME; CELL DIFFERENTIATION; CYTOKINES; GENE EXPRESSION REGULATION; HUMANS; INTERFERON TYPE II; INTERLEUKIN-12; INTERLEUKIN-18; INTESTINES; LYMPHOCYTES; PROTEIN-TYROSINE KINASES; RECEPTORS, CYTOKINE; SKIN; TH1 CELLS;

EID: 33745896226     PISSN: 15394182     EISSN: None     Source Type: Journal    
DOI: 10.3121/cmr.4.2.147     Document Type: Review

References (50)

1. Sakane T, Takeno M, Suzuki N, Inaba G. Behcet's disease. N Engl J Med 1999;341:1284-1291.
2. Gul A. Behcet's disease: an update on the pathogenesis. Clin Exp Rheumatol 2001;19:S6-S12.
3. Yurdakul S, Hamuryudan V, Yazici H. Behcet syndrome. Curr Opin Rheumatol 2004;16:38-42.
4. Zouboulis CC, May T. Pathogenesis of Adamantiades-Behcet's disease. Med Microbiol Immunol (Berl) 2003;192:149-155.
5. Direskeneli H. Behcet's disease: infectious aetiology, new autoantigens, and HLA-B51. Ann Rheum Dis 2001;60:996-1002.
6. Mege JL, Dilsen N, Sanguedolce V, Gul A, Bongrand P, Roux H, Ocal L, Inane M, Capo C. Overproduction of monocyte derived tumor necrosis factor alpha, interleukin (IL) 6, IL-8 and increased neutrophil superoxide generation in Behcet's disease. A comparative study with familial Mediterranean fever and healthy subjects. J Rheumatol 1993;20:1544-1549.
7. Frassanito MA, Dammacco R, Cafforio P, Dammacco F. Th1 polarization of the immune response in Behcet's disease: a putative pathogenetic role of interleukin-12. Arthritis Rheum 1999;42:1967-1974.
8. Szabo SJ, Sullivan BM, Peng SL, Glimcher LH. Molecular mechanisms regulating Th1 immune responses. Annu Rev Immunol 2003;21:713-758.
9. Murphy KM, Ouyang W, Farrar JD, Yang J, Ranganath S, Asnagli H, Afkarian M, Murphy TL. Signaling and transcription in T helper development. Annu Rev Immunol 2000;18:451-494.
10. Houman H, Hamzaoui A, Ben Ghorbal I, Khanfir M, Feki M, Hamzaoui K. Abnormal expression of chemokine receptors in Behcet's disease: relationship to intracellular Th1/Th2 cytokines and to clinical manifestations. J Autoimmun 2004;23:267-273.
11. Saruhan-Direskeneli G, Yentur SP, Akman-Demir G, Isik N, Serdaroglu P. Cytokines and chemokines in neuro-Behcet's disease compared to multiple sclerosis and other neurological diseases. J Neuroimmunol 2003;145:127-134.
12. Raziuddin S, al-Dalaan A, Bahabri S, Siraj AK, al-Sedairy S. Divergent cytokine production profile in Behcet's disease. Altered Th1/Th2 cell cytokine pattern. J Rheumatol 1998;25:329-333.
13. Houman H, Hamzaoui A, Ben Ghorbal I, Khanfir MS, Feki M, Hamzaoui K. Tc1/Tc2 ratio in the inflammatory process in patients with Behcet's disease. Mediators Inflamm 2004;13:247-253.
14. Hegab S, Al-Mutawa S. Immunopathogenesis of Behcet's disease. Clin Immunol 2000;96:174-186.
15. Kaneko S, Suzuki N, Yamashita N, Nagafuchi H, Nakajima T, Wakisaka S, Yamamoto S, Sakane T. Characterization of T cells specific for an epitope of human 60-kD heat shock protein (hsp) in patients with Behcet's disease (BD) in Japan. Clin Exp Immunol 1997;108:204-212.
16. Wakisaka S, Takeba Y, Mihara S, Takeno M, Yamamoto S, Sakane T, Suzuki N. Aberrant Fas ligand expression in lymphocytes in patients with Behcet's disease. Int Arch Allergy Immunol 2002;129:175-180.
17. Suzuki N, Kaneko S, Ichino M, Mihara S, Wakisaka S, Sakane T. In vivo mechanisms for the inhibition of T lymphocyte activation by long-term therapy with tacrolimus (FK-506): experience in patients with Behcet's disease. Arthritis Rheum 1997;40:1157-1167.
18. Kurokawa MS, Yoshikawa H, Suzuki N. Behcet's disease. Semin Respir Crit Care Med 2004;25:557-568.
19. Imamura Y, Kurokawa MS, Yoshikawa H, Nara K, Takada E, Masuda C, Tsukikawa S, Ozaki S, Matsuda T, Suzuki N. Involvement of Th1 cells and heat shock protein 60 in the pathogenesis of intestinal Behcet's disease. Clin Exp Immunol 2005;139:371-378.
20. Nagafuchi H, Takeno M, Yoshikawa H, Kurokawa MS, Nara K, Takada E, Masuda C, Mizoguchi M, Suzuki N. Excessive expression of Txk, a member of the Tec family of tyrosine kinases, contributes to excessive Th1 cytokine production by T lymphocytes in patients with Behcet's disease. Clin Exp Immunol 2005;139:363-370.
21. Suzuki Kurokawa M, Suzuki N. Behcet's disease. Clin Exp Med 2004;4:10-20.
22. Takeno M, Shimoyama Y, Kashiwakura J, Nagafuchi H, Sakane T, Suzuki N. Abnormal killer inhibitory receptor expression on natural killer cells in patients with Behcet's disease. Rheumatol Int 2004;24:212-216.
23. Wakisaka S, Takeba Y, Mihara S, Takeno M, Yamamoto S, Sakane T, Suzuki N. Aberrant Fas ligand expression in lymphocytes in patients with Behcet's disease. Int Arch Allergy Immunol 2002;129:175-180.
24. Rajendram R, Rao NA. Molecular mechanisms in Behcet's disease. Br J Ophthalmol 2003;87:1199-1200.
25. Sugi-Ikai N, Nakazawa M, Nakamura S, Ohno S, Minami M. Increased frequencies of interleukin-2- and interferon-gamma-producing T cells in patients with active Behcet's disease. Invest Ophthalmol Vis Sci 1998;39:996-1004.
26. Turan B, Gallati H, Erdi H, Gurler A, Michel BA, Villiger PM. Systemic levels of the T cell regulatory cytokines IL-10 and IL-12 in Bechcet's disease; soluble TNFR-75 as a biological marker of disease activity. J Rheumatol 1997;24:128-132.
27. Desmedt M, Rottiers P, Dooms H, Fiers W, Grooten J. Macrophages induce cellular immunity by activating Th1 cell responses and suppressing Th2 cell responses. J Immunol 1998;160:5300-5308.
28. Hamzaoui K, Ayed K, Slim A, Hamza M, Touraine J. Natural killer cell activity, interferon-gamma and antibodies to herpes viruses in patients with Behcet's disease. Clin Exp Immunol 1990;79:28-34.
29. Hamzaoui K, Hamzaoui A, Guemira F, Bessioud M, Hamza M, Ayed K. Cytokine profile in Behcet's disease patients. Relationship with disease activity. Scand J Rheumatol 2002;31:205-210.
30. Hamzaoui A, Ghrairi H, Ammar J, Zekri S, Guemira F, Hamzaoui K. IL-18 mRNA expression and IFN-gamma induction in bronchoalveolar lavage from Behcet's disease. Clin Exp Rheumatol 2003;21:S8-S14.
31. Eglin RP, Lehner T, Subak-Sharpe JH. Detection of RNA complementary to herpes-simplex virus in mononuclear cells from patients with Behcet's syndrome and recurrent oral ulcers. Lancet 1982;2:1356-1361.
32. Lehner T. The role of heat shock protein, microbial and autoimmune agents in the aetiology of Behcet's disease. Int Rev Immunol 1997;14:21-32.
33. Direskeneli H, Saruhan-Direskeneli G. The role of heat shock proteins in Behcet's disease. Clin Exp Rheumatol 2003;21:844-548.
34. Pervin K, Childerstone A, Shinnick T, Mizushima Y, van der Zee R, Hasan A, Vaughan R, Lehner T. T cell epitope expression of mycobacterial and homologous human 65-kilodalton heat shock protein peptides in short term cell lines from patients with Behcet's disease. J Immunol 1993;151:2273-2282.
35. Direskeneli H, Eksioglu-Demiralp E, Yavuz S, Ergun T, Shinnick T, Lehner T, Akoglu T. T cell responses to 60/65 kDa heat shock protein derived peptides in Turkish patients with Behcet's disease. J Rheumatol 2000;27:708-713.
36. Raziuddin S, al-Dalaan A, Bahabri S, Siraj AK, al-Sedairy S. Divergent cytokine production profile in Behcet's disease. Altered Th1/Th2 cell cytokine pattern. J Rheumatol 1998;25:329-333.
37. Mumcu G, Ergun T, Elbir Y, Eksioglu-Demiralp E, Yavuz S, Atalay T, Direskeneli H. Clinical and immunological effects of azithromycin in Behcet's disease. J Oral Pathol Med 2005;34:13-16.
38. Gul A, Esin S, Dilsen N, Konice M, Wigzell H, Biberfeld P. Immunohistology of skin pathergy reaction in Behcet's disease. Br J Dermatol 1995;132:901-907.
39. Schwartzberg PL, Finkelstein LD, Readinger JA. TEC-family kinases: regulators of T-helper-cell differentiation. Nat Rev Immunol 2005;5:284-295.
40. Berg LJ, Finkelstein LD, Lucas JA, Schwartzberg PL. Tec family kinases in T lymphocyte development and function. Annu Rev Immunol 2005;23:549-600.
41. Lindvall JM, Blomberg KE, Valiaho J, Vargas L, Heinonen JE, Berglof A, Mohamed AJ, Nore BF, Vihinen M, Smith CI. Bruton's tyrosine kinase: cell biology, sequence conservation, mutation spectrum, siRNA modifications, and expression profiling. Immunol Rev 2005;203:200-215.
42. Guo S, Ferl GZ, Deora R, Riedinger M, Yin S, Kerwin JL, Loo JA, Witte ON. A phosphorylation site in Bruton's tyrosine kinase selectively regulates B cell calcium signaling efficiency by altering phospholipase C-gamma activation. Proc Natl Acad Sci U S A 2004;101:14180-14185.
43. Miller AT, Wilcox HM, Lai Z, Berg LJ. Signaling through Itk promotes T helper 2 differentiation via negative regulation of T-bet. Immunity 2004;21:67-80.
44. Takeno M, Yoshikawa H, Kurokawa M, Takeba Y, Kashiwakura JI, Sakaguchi M, Yasueda H, Suzuki N. Th1-dominant shift of T cell cytokine production, and subsequent reduction of serum immunoglobulin E response by administration in vivo of plasmid expressing Txk/Rlk, a member of Tec family tyrosine kinases, in a mouse model. Clin Exp Allergy 2004;34:965-970.
45. Kashiwakura J, Suzuki N, Takeno M, Itoh S, Oku T, Sakane T, Nakajin S, Toyoshima S. Evidence of autophosphorylation in Txk: Y91 is an autophosphorylation site. Biol Pharm Bull 2002;25:718-721.
46. Takeba Y, Nagafuchi H, Takeno M, Kashiwakura J, Suzuki N. Txk, a member of nonreceptor tyrosine kinase of Tec family, acts as a ThI cell-specific transcription factor and regulates IFN-gamma gene transcription. J Immunol 2002;168:2365-2370.
47. Kashiwakura J, Suzuki N, Nagafuchi H, Takeno M, Takeba Y, Shimoyama Y, Sakane T. Txk, a nonreceptor tyrosine kinase of the Tec family, is expressed in T helper type 1 cells and regulates interferon gamma production in human T lymphocytes. J Exp Med 1999;190:1147-1154.
48. Li B, Yang P, Zhou H, Zhang Z, Xie C, Lin X, Huang X, Kijlstra A. T-bet expression is upregulated in active Behcet's disease. Br J Ophthalmol 2003;87:1264-1267.
49. Mackay CR. Follicular homing T helper (Th) cells and the Th1/Th2 paradigm. J Exp Med 2000;192:F31-F34.
50. Campbell JD, HayGlass KT. T cell chemokine receptor expression in human Th1- and Th2-associated diseases. Arch Immunol Ther Exp (Warsz) 2000;48:451-456.