CD39+ Regulatory T cells suppress generation and differentiation of Th17 cells in human malignant pleural effusion via a LAP-dependent mechanism

Respiratory Research

Volumn 12, Issue 1, 2011, Pages

  Ye, Zhi Jian ^a   Zhou, Qiong ^a   Zhang, Jian Chu ^a   Li, Xiao ^a   Wu, Cong ^b   Qin, Shou Ming ^b   Xin, Jian Bao ^a   Shi, Huan Zhong ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b GUANGXI MEDICAL UNIVERSITY   (China)

Author keywords

Latency associated peptide; Malignant pleural effusion; Regulatory T cells Th17 cells; Transfer growth factor

Indexed keywords

INTERLEUKIN 1BETA; INTERLEUKIN 6; LATENCY ASSOCIATED PEPTIDE; TRANSFORMING GROWTH FACTOR BETA1; APYRASE; CD39 ANTIGEN; IL6 PROTEIN, HUMAN; LATENCY ASSOCIATED PROPEPTIDE, TGF BETA; LATENCY-ASSOCIATED PROPEPTIDE, TGF-BETA; LEUKOCYTE ANTIGEN; PEPTIDE; PROTEIN PRECURSOR; TGFB1 PROTEIN, HUMAN; TRANSFORMING GROWTH FACTOR BETA;

ADULT; AGED; ARTICLE; CD39+ REGULATORY T LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME INHIBITION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN TISSUE; INFORMED CONSENT; LUNG CANCER; LYMPHOCYTE DIFFERENTIATION; MALIGNANT PLEURA EFFUSION; PATHOPHYSIOLOGY; PLEURA BIOPSY; PROTEIN BLOOD LEVEL; REGULATORY T LYMPHOCYTE; TH17 CELL; CELL CULTURE; CELL DIFFERENTIATION; CELL PROLIFERATION; COCULTURE; IMMUNOLOGY; IMMUNOPHENOTYPING; LUNG TUMOR; METABOLISM; MIDDLE AGED; PLEURA EFFUSION; SIGNAL TRANSDUCTION;

ADULT; AGED; ANTIGENS, CD; APYRASE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; COCULTURE TECHNIQUES; FLOW CYTOMETRY; HUMANS; IMMUNOPHENOTYPING; INTERLEUKIN-1BETA; INTERLEUKIN-6; LUNG NEOPLASMS; MIDDLE AGED; PEPTIDES; PLEURAL EFFUSION, MALIGNANT; PROTEIN PRECURSORS; SIGNAL TRANSDUCTION; T-LYMPHOCYTES, REGULATORY; TH17 CELLS; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1;

EID: 79958155356     PISSN: 14659921     EISSN: 1465993X     Source Type: Journal    
DOI: 10.1186/1465-9921-12-77     Document Type: Article

References (40)

1. Light RW: Clinical practice. Pleural effusion. N Engl J Med 2002, 346:1971-1977.
2. Lucivero G, Pierucci G, Bonomo L: Lymphocyte subsets in peripheral blood and pleural fluid. Eur Respir J 1988, 1:337-340.
3. Ikeda H, Chamoto K, Tsuji T, Suzuki Y, Wakita D, Takeshima T, Nishimura T: The critical role of type-1 innate and acquired immunity in tumor immunotherapy. Cancer Sci 2004, 95:697-703.
4. Atanackovic D, Block A, de WA, Faltz C, Hossfeld DK, Hegewisch-Becker S: Characterization of effusion-infiltrating T cells: benign versus malignant effusions. Clin Cancer Res 2004, 10:2600-2608.
5. Hori S, Nomura T, Sakaguchi S: Control of regulatory T cell development by the transcription factor Foxp3. Science 2003, 299:1057-1061.
6. + regulatory T cells. Nat Immunol 2003, 4:330-336.
7. Mills KH: Induction, function and regulation of IL-17-producing T cells. Eur J Immunol 2008, 38:2636-2649.
8. Reg cell lineages: a (co-)evolutionary perspective. Nat Rev Immunol 2009, 9:883-889.
9. + regulatory T lymphocytes in malignant pleural effusion. Am J Respir Crit Care Med 2005, 172:1434-1439.
10. Qin XJ, Shi HZ, Liang QL, Liu GN, Jiang J, Qin SM, Deng JM, Ye ZJ: CCL22 recruits CD4-positive CD25-positive regulatory T cells into malignant pleural effusion. Clin Cancer Res 2009, 15:2231-2237.
11. + T cells in malignant pleural effusion. J Immunol 2010, 185:6348-6354.
12. pos regulatory T cells differentiate into IL-17-producing cells. Blood 2008, 112:2340-2352.
13. Gleizes PE, Munger JS, Nunes I, Harpel JG, Mazzieri R, Noguera I, Rifkin DB: TGF-beta latency: biological significance and mechanisms of activation. Stem Cells 1997, 15:190-197.
14. Lawrence DA: Latent-TGF-beta: an overview. Mol Cell Biochem 2001, 219:163-170.
15. H -17 responses. Nat Immunol 2008, 9:650-657.
16. H 17 cells. Nature 2008, 454:350-352.
17. Acosta-Rodriguez EV, Napolitani G, Lanzavecchia A, Sallusto F: Interleukins 1β and 6 but not transforming growth factor-β are essential for the differentiation of interleukin 17-producing human T helper cells. Nat Immunol 2007, 8:942-949.
18. + IL-17-producing T cells in ovarian cancer. Proc Natl Acad Sci USA 2008, 105:15505-15510.
19. + regulatory T cells. J Mol Cell Biol 2010, 2:30-36.
20. + regulatory T cells is mediated by cell surface-bound transforming growth factor beta. J Exp Med 2001, 194:629-644.
21. + T cells is facilitated by CTLA-4 signaling. J Immunol 2006, 177:2331-2339.
22. Beriou G, Costantino CM, Ashley CW, Yang L, Kuchroo VK, Baecher-Allan C, Hafler DA: IL-17-producing human peripheral regulatory T cells retain suppressive function. Blood 2009, 113:4240-4249.
23. + regulatory T cells in humans. Proc Natl Acad Sci USA 2009, 106:4793-4798.
24. H 17 lineage-specific transcription factor RORγt. Proc Natl Acad Sci USA 2009, 106:8635-8640.
25. H 17 and regulatory T cells. Nature 2006, 441:235-238.
26. Veldhoen M, Hocking RJ, Atkins CJ, Locksley RM, Stockinger B: TGF-β in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 2006, 24:179-189.
27. + T cells or are self-induced to become Th17 cells in the absence of exogenous TGF-β. J Immunol 2007, 178:6725-6729.
28. H 17 cells. Clin Immunol 2009, 131:298-307.
29. Osorio F, LeibundGut-Landmann S, Lochner M, Lahl K, Sparwasser T, Eberl G, Reis e Sousa C: DC activated via dectin-1 convert Treg into IL-17 producers. Eur J Immunol 2008, 38:3274-3281.
30. + antigen-specific autoimmune effectors in vitro and in vivo. J Immunol 2008, 181:3137-3147.
31. Curiel TJ, Coukos G, Zou L, Alvarez X, Cheng P, Mottram P, Evdemon-Hogan M, Conejo-Garcia JR, Zhang L, Burow M, Zhu Y, Wei S, Kryczek I, Daniel B, Gordon A, Myers L, Lackner A, Disis ML, Knutson KL, Chen L, Zou W: Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat Med 2004, 10:942-949.
32. Kryczek I, Banerjee M, Cheng P, Vatan L, Szeliga W, Wei S, Huang E, Finlayson E, Simeone D, Welling TH, Chang A, Coukos G, Liu R, Zou W: Phenotype, distribution, generation, and functional and clinical relevance of Th17 cells in the human tumor environments. Blood 2009, 114:1141-1149.
33. + T reg cells. J Exp Med 2006, 203:1701-1711.
34. + T regulatory cells in humans. Hum Immunol 2005, 66:13-20.
35. + Treg cells: hydrolysis of extracellular ATP and immune suppression. Blood 2007, 110:1225-1232.
36. Deaglio S, Dwyer KM, Gao W, Friedman D, Usheva A, Erat A, Chen JF, Enjyoji K, Linden J, Oukka M, Kuchroo VK, Strom TB, Robson SC: Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression. J Exp Med 2007, 204:1257-1265.
37. Mandapathil M, Lang S, Gorelik E, Whiteside TL: Isolation of functional human regulatory T cells (Treg) from the peripheral blood based on the CD39 expression. J Immunol Methods 2009, 346:55-63.
38. Robson SC, Sévigny J, Zimmermann H: The E-NTPDase family of ectonucleotidases: Structure function relationships and pathophysiological significance. Purinergic Signal 2006, 2:409-430.
39. H 17 responses in a Stat3-dependent manner. Science 2009, 326:986-991.
40. + regulatory T Cells suppress pathogenic Th17 cells and are impaired in multiple sclerosis. J Immunol 2009, 183:7602-7610.