Improved short-term spatial memory but impaired reversal learning following the dopamine D2 agonist bromocriptine in human volunteers

Psychopharmacology

Volumn 159, Issue 1, 2001, Pages 10-20

  Mehta, Mitul A ^a,c,d   Swainson, Rachel ^b,c,d   Ogilvie, Alan D ^a,c,d   Sahakian, Barbara ^a,c,d   Robbins, Trevor W ^b,c,d  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UK   (United Kingdom)

^c HAMMERSMITH HOSPITAL   (United Kingdom)

^d UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

Bromocriptine; Cognition; Dopamine; Learning; Parkinson's disease; Working memory

Indexed keywords

BROMOCRIPTINE; DOPAMINE 2 RECEPTOR STIMULATING AGENT;

ADULT; ARTICLE; CLINICAL TRIAL; COGNITION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DEPTH PERCEPTION; DIASTOLIC BLOOD PRESSURE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; HEART RATE; HUMAN; LATENT PERIOD; LEARNING; MALE; MOOD; MOTIVATION; NEUROPSYCHOLOGICAL TEST; NORMAL HUMAN; PATTERN RECOGNITION; PLANNING; PRIORITY JOURNAL; SHORT TERM MEMORY; SPATIAL MEMORY; SYSTOLIC BLOOD PRESSURE; TASK PERFORMANCE;

EID: 0036136489     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002130100851     Document Type: Article

References (48)

1. Biochemistry of Parkinson's disease 28 years later: A critical review
2. Parallel organization of functionally segregated circuits linking the basal ganglia and cortex
3. 2 receptor mechanisms contribute to age-related cognitive decline: The effects of quinpirole on memory and motor performance in monkeys
4. Neural systems engaged by planning: A PET study of the Tower of London task
5. The use of analogue scales in rating subjective feelings
6. Experimental designs, 2nd edn
7. The dependence of span and delayed-response performance on prefrontal cortex
8. Dissociation in prefrontal cortex of affective and attentional shifts
9. Effects of methylphenidate on spatial working memory and planning in healthy young adults
10. Effects of caffeine on vigilance and other performance tests in normal volunteers
11. Novelty-induced increase in dopamine release in the rat prefrontal cortex in vivo: Inhibition by diazepam
12. "Frontal" cognitive function in patients with Parkinson's disease "on" and "off" levodopa
13. The two-period cross-over clinical trial
14. Limbic lesions and the problem of stimulus-reinforcement associations
15. Spatial working memory in humans as revealed by PET
16. Effects of bromocriptine on human subjects depends on working memory capacity
17. Uneven pattern of dopamine loss in the striatum of patients with idiopathic Parkinson's disease. Pathophysiologic and clinical implications
18. Acute effects of levodopa on neuropsychological performance in stable and fluctuating Parkinson's disease patients at different levodopa plasma levels
19. L-Dopa withdrawal in Parkinson's disease selectively impairs cognitive performance in tests sensitive to frontal lobe dysfunction
20. Discrimination, reversal, and shift learning in Huntington's disease: Mechanisms of impaired response selection
21. Dopaminergic modulation of working memory for spatial but not object cues in normal volunteers
22. 2 dopamine receptor agonist
23. 82Br]bromocriptine
24. Differential effect of a dopaminergic agonist on prefrontal function in traumatic brain injury patients
25. Pharmacology of bromocriptine in health and disease
26. Systemic sulpiride in young adult volunteers simulates the profile of cognitive deficits in Parkinson's disease
27. Comparative psychopharmacology of methylphenidate and related drugs in human volunteers, patients with AD/HD and experimental animals
28. Interhemispheric differences in the localization of psychological processes in man
29. 2-receptor modulation of visuospatial working memory in humans
30. Planning and spatial working memory following frontal lobe lesions in man
31. Fronto-striatal cognitive deficits at different stages of Parkinson's disease
32. Dopamine-dependent fronto-striatal planning deficits in early Parkinson's disease
33. Double dissociations of memory and executive functions in working memory tasks following frontal lobe excisions, temporal lobe excisions or amygdalo-hippocampectomy in man
34. Spatial and non-spatial working memory at different stages of Parkinson's disease
35. Motivational deficits after brain injury: Effects of bromocriptine in 11 patients
36. Specific cognitive deficits in mild frontal variant frontotemporal dementia
37. Methods for measuring spontaneous motor activity
38. Cholinergic drugs and human cognitive performance
39. A comparative study of visuospatial memory and learning in Alzheimer-type dementia and Parkinson's disease
40. 1 dopamine receptors in prefrontal cortex: Involvement in working memory
41. 1-dopamine receptor in working memory: Local injections of dopamine antagonists into the prefrontal cortex of rhesus monkeys performing an oculomotor delayed-response task
42. A neural substrate of prediction and reward
43. CANTAB parallel battery: A suitable tool for investigating drug effects on cognition?
44. Specific impairments in planning
45. Probabilistic learning and reversal deficits in patients with Parkinson's disease or frontal or temporal lobe lesions: Possible adverse effects of dopaminergic medication
46. 1 dopamine receptors in the rodent prefrontal cortex impairs spatial working memory performance