Endothelium-derived hyperpolarizing factor determines resting and stimulated forearm vasodilator tone in health and in disease

Circulation

Volumn 123, Issue 20, 2011, Pages 2244-2253

  Ozkor, Muhiddin A ^a   Murrow, Jonathan R ^a   Rahman, Ayaz M ^a   Kavtaradze, Nino ^a   Lin, Ji ^b   Manatunga, Amita ^b   Quyyumi, Arshed A ^a,c  

^a EMORY UNIVERSITY   (United States)

^b EMORY UNIVERSITY   (United States)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

endothelium; endothelium derived vasoconstrictor factors; nitric oxide; vasodilation

Indexed keywords

ACETYLCHOLINE; BRADYKININ; CALCIUM ACTIVATED POTASSIUM CHANNEL; CYTOCHROME P450 2C9; ENDOTHELIUM DERIVED HYPERPOLARIZING FACTOR; EPOXYICOSATRIENOIC ACID; FLUCONAZOLE; GLUCOSE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; N(G) METHYLARGININE; NITRIC OXIDE; NITROPRUSSIDE SODIUM; TETRYLAMMONIUM CHLORIDE;

ADULT; ARTICLE; BLOOD VESSEL REACTIVITY; BLOOD VESSEL TONE; CARDIOVASCULAR RISK; CLINICAL ARTICLE; CONTROLLED STUDY; ENDOTHELIAL DYSFUNCTION; FEMALE; FOREARM BLOOD FLOW; HUMAN; HYPERCHOLESTEROLEMIA; MALE; MICROCIRCULATION; PLETHYSMOGRAPHY; PRIORITY JOURNAL; SYSTOLIC BLOOD PRESSURE; VASOCONSTRICTION;

ACETYLCHOLINE; ADULT; BIOLOGICAL FACTORS; BRADYKININ; CYTOCHROME P-450 ENZYME SYSTEM; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; FEMALE; FOREARM; HUMANS; HYPERCHOLESTEROLEMIA; MALE; MIDDLE AGED; NITRIC OXIDE; OMEGA-N-METHYLARGININE; PLETHYSMOGRAPHY; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; REGIONAL BLOOD FLOW; RISK FACTORS; TETRAETHYLAMMONIUM; VASODILATION; YOUNG ADULT;

EID: 79958135867     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.110.990317     Document Type: Article

References (38)

1. Quyyumi AA, Dakak N, Andrews NP, Gilligan DM, Panza JA, Cannon RO 3rd. Contribution of nitric oxide to metabolic coronary vasodilation in the human heart. Circulation. 1995;92:320-326.
2. Gilligan DM, Guetta V, Panza JA, Garcia CE, Quyyumi AA, Cannon RO 3 rd. Selective loss of microvascular endothelial function in human hypercholesterolemia. Circulation. 1994;90:35-41. (Pubitemid 24203660)
3. Joannides R, Richard V, Haefeli WE, Linder L, Luscher TF, Thuillez C. Role of basal and stimulated release of nitric oxide in the regulation of radial artery caliber in humans. Hypertension. 1995;26:327-331.
4. Mullen MJ, Kharbanda RK, Cross J, Donald AE, Taylor M, Vallance P, Deanfield JE, MacAllister RJ. Heterogenous nature of flow-mediated dilatation in human conduit arteries in vivo: relevance to endothelial dysfunction in hypercholesterolemia. Circ Res. 2001;88:145-151. (Pubitemid 32147301)
5. Bellien J, Joannides R, Iacob M, Arnaud P, Thuillez C. Calcium-activated potassium channels and NO regulate human peripheral conduit artery mechanics. Hypertension. 2005;46:210-216. (Pubitemid 40946516)
6. Inokuchi K, Hirooka Y, Shimokawa H, Sakai K, Kishi T, Ito K, Kimura Y, Takeshita A. Role of endothelium-derived hyperpolarizing factor in human forearm circulation. Hypertension. 2003;42:919-924. (Pubitemid 37413731)
7. Panza JA, Casino PR, Kilcoyne CM, Quyyumi AA. Role of endotheliumderived nitric oxide in the abnormal endothelium-dependent vascular relaxation of patients with essential hypertension. Circulation. 1993;87: 1468-1474. (Pubitemid 23133089)
8. Panza JA, Garcia CE, Kilcoyne CM, Quyyumi AA, Cannon RO 3rd. Impaired endothelium-dependent vasodilation in patients with essential hypertension: evidence that nitric oxide abnormality is not localized to a single signal transduction pathway. Circulation. 1995;91:1732-1738.
9. Quyyumi AA, Dakak N, Mulcahy D, Andrews NP, Husain S, Panza JA, Cannon RO 3rd. Nitric oxide activity in the atherosclerotic human coronary circulation. J Am Coll Cardiol. 1997;29:308-317. (Pubitemid 27059959)
10. Taddei S, Galetta F, Virdis A, Ghiadoni L, Salvetti G, Franzoni F, Giusti C, Salvetti A. Physical activity prevents age-related impairment in nitric oxide availability in elderly athletes. Circulation. 2000;101:2896-2901. (Pubitemid 30415878)
11. Bellien J, Joannides R, Iacob M, Arnaud P, Thuillez C. Evidence for a basal release of a cytochrome-related endothelium-derived hyperpolarizing factor in the radial artery in humans. Am J Physiol Heart Circ Physiol. 2006;290:H1347-H1352.
12. Honing ML, Smits P, Morrison PJ, Rabelink TJ. Bradykinin-induced vasodilation of human forearm resistance vessels is primarily mediated by endothelium-dependent hyperpolarization. Hypertension. 2000;35: 1314-1318. (Pubitemid 30413670)
13. Miura H, Wachtel RE, Liu Y, Loberiza FR Jr, Saito T, Miura M, Gutterman DD. Flow-induced dilation of human coronary arterioles: important role of Ca(2+)-activated K(+) channels. Circulation. 2001; 103:1992-1998.
14. Miura H, Gutterman DD. Human coronary arteriolar dilation to arachidonic acid depends on cytochrome P-450 monooxygenase and Ca2+-activated K+ channels. Circ Res. 1998;83:501-507. (Pubitemid 28411051)
15. Busse R, Edwards G, Feletou M, Fleming I, Vanhoutte PM, Weston AH. EDHF: bringing the concepts together. Trends Pharmacol Sci. 2002;23: 374-380.
16. Feletou M, Vanhoutte PM. Endothelium-derived hyperpolarizing factor: where are we now? Arterioscler Thromb Vasc Biol. 2006;26:1215-1225. (Pubitemid 44305364)
17. Fleming I, Busse R. Endothelium-derived epoxyeicosatrienoic acids and vascular function. Hypertension. 2006;47:629-633. (Pubitemid 43740225)
18. Feletou M, Vanhoutte PM. Endothelium-dependent hyperpolarizations: past beliefs and present facts. Ann Med. 2007;39:495-516. (Pubitemid 350041557)
19. Stanfield PR. Tetraethylammonium ions and the potassium permeability of excitable cells. Rev Physiol Biochem Pharmacol. 1983;97:1-67.
20. Langton PD, Nelson MT, Huang Y, Standen NB. Block of calcium-activated potassium channels in mammalian arterial myocytes by tetraethylammonium ions. Am J Physiol. 1991;260:H927-H934.
21. Halcox JPJ, Narayanan S, Cramer-Joyce L, Mincemoyer R, Quyyumi AA. Characterization of endothelium-derived hyperpolarizing factor in the human forearm microcirculation. Am J Physiol Heart Circ Physiol. 2001;280:H2470-H2477.
22. Heavey DJ, Barrow SE, Hickling NE, Ritter JM. Aspirin causes short-lived inhibition of bradykinin-stimulated prostacyclin production in man. Nature. 1985;318:186-188. (Pubitemid 16192588)
23. Casino PR, Kilcoyne CM, Quyyumi AA, Hoeg JM, Panza JA. The role of nitric oxide in endothelium-dependent vasodilation of hypercholesterolemic patients. Circulation. 1993;88:2541-2547. (Pubitemid 23360178)
24. Quyyumi AA, Dakak N, Andrews NP, Husain S, Arora S, Gilligan DM, Panza JA, Cannon RO 3rd. Nitric oxide activity in the human coronary circulation: impact of risk factors for coronary atherosclerosis. J Clin Invest. 1995;95:1747-1755.
25. Brandes RP, Behra A, Lebherz C, Boger RH, Bode-Boger SM, Phivthong-Ngam L, Mugge A. N(G)-nitro-L-arginine-and indomethacinresistant endothelium- dependent relaxation in the rabbit renal artery: effect of hypercholesterolemia. Atherosclerosis. 1997;135:49-55. (Pubitemid 27469695)
26. Campbell WB, Gebremedhin D, Pratt PF, Harder DR. Identification of epoxyeicosatrienoic acids as endothelium-derived hyperpolarizing factors. Circ Res. 1996;78:415-423. (Pubitemid 26072547)
27. Fisslthaler B, Popp R, Kiss L, Potente M, Harder DR, Fleming I, Busse R. Cytochrome P450 2C is an EDHF synthase in coronary arteries. Nature. 1999;401:493-497. (Pubitemid 29470209)
28. Weston AH, Feletou M, Vanhoutte PM, Falck JR, Campbell WB, Edwards G. Bradykinin-induced, endothelium-dependent responses in porcine coronary arteries: involvement of potassium channel activation and epoxyeicosatrienoic acids. Br J Pharmacol. 2005;145:775-784. (Pubitemid 41076284)
29. Fichtlscherer S, Dimmeler S, Breuer S, Busse R, Zeiher AM, Fleming I. Inhibition of cytochrome P450 2C9 improves endothelium-dependent, nitric oxide-mediated vasodilatation in patients with coronary artery disease. Circulation. 2004;109:178-183. (Pubitemid 38114136)
30. Passauer J, Bussemaker E, Lassig G, Pistrosch F, Fauler J, Gross P, Fleming I. Baseline blood flow and bradykinin-induced vasodilator responses in the human forearm are insensitive to the cytochrome P450 2C9 (CYP2C9) inhibitor sulphaphenazole. Clin Sci (Lond). 2003;105: 513-518. (Pubitemid 37249179)
31. Archer SL, Gragasin FS, Wu X, Wang S, McMurtry S, Kim DH, Platonov M, Koshal A, Hashimoto K, Campbell WB, Falck JR, Michelakis ED. Endothelium-derived hyperpolarizing factor in human internal mammary artery is 11,12- epoxyeicosatrienoic acid and causes relaxation by activating smooth muscle BK(Ca) channels. Circulation. 2003;107:769-776. (Pubitemid 36222608)
32. Hillig T, Krustrup P, Fleming I, Osada T, Saltin B, Hellsten Y. Cytochrome P450 2C9 plays an important role in the regulation of exerciseinduced skeletal muscle blood flow and oxygen uptake in humans. J Physiol. 2003;546:307-314. (Pubitemid 36104990)
33. Weintraub NL, Fang X, Kaduce TL, VanRollins M, Chatterjee P, Spector AA. Potentiation of endothelium-dependent relaxation by epoxyeicosatrienoic acids. Circ Res. 1997;81:258-267. (Pubitemid 27342493)
34. Selemidis S, Cocks TM. Endothelium-dependent hyperpolarization as a remote anti-atherogenic mechanism. Trends Pharmacol Sci. 2002;23: 213-220. (Pubitemid 34465540)
35. Casino PR, Kilcoyne CM, Quyyumi AA, Hoeg JM, Panza JA. Investigation of decreased availability of nitric oxide precursor as the mechanism responsible for impaired endothelium-dependent vasodilation in hypercholesterolemic patients. J Am Coll Cardiol. 1994;23: 844-850. (Pubitemid 24090868)
36. Campia U, Choucair WK, Bryant MB, Quyyumi AA, Cardillo C, Panza JA. Role of cyclooxygenase products in the regulation of vascular tone and in the endothelial vasodilator function of normal, hypertensive, and hypercholesterolemic humans. Am J Cardiol. 2002;89:286-290. (Pubitemid 34113790)
37. Taddei S, Versari D, Cipriano A, Ghiadoni L, Galetta F, Franzoni F, Magagna A, Virdis A, Salvetti A. Identification of a cytochrome P450 2C9-derived endothelium-derived hyperpolarizing factor in essential hypertensive patients. J Am Coll Cardiol. 2006;48:508-515. (Pubitemid 44093964)
38. Urakami-Harasawa L, Shimokawa H, Nakashima M, Egashira K, Takeshita A. Importance of endothelium-derived hyperpolarizing factor in human arteries. J Clin Invest. 1997;100:2793-2799. (Pubitemid 28007548)