Nitric oxide activity in the atherosclerotic human coronary circulation

Journal of the American College of Cardiology

Volumn 29, Issue 2, 1997, Pages 308-317

  Quyyumi, Arshed A ^a,b   Dakak, Nader ^a   Mulcahy, David ^a   Andrews, Neil P ^a   Husain, Syed ^a   Panza, Julio A ^a   Cannon III, Richard O ^a  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; ARGININE; N(G) METHYLARGININE; NITRIC OXIDE;

ADULT; ARTICLE; ATHEROSCLEROSIS; CLINICAL ARTICLE; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; CORONARY VASCULAR RESISTANCE; FEMALE; HUMAN; INTRACARDIAC DRUG ADMINISTRATION; MALE; PRIORITY JOURNAL; VASOCONSTRICTION; VASODILATATION;

ACETYLCHOLINE; AGE FACTORS; AGED; CORONARY ARTERIOSCLEROSIS; CORONARY VESSELS; ENDOTHELIUM, VASCULAR; FEMALE; HUMANS; MALE; MIDDLE AGED; NITRIC OXIDE; OMEGA-N-METHYLARGININE; REGIONAL BLOOD FLOW; SEX FACTORS; VASCULAR RESISTANCE; VASODILATION;

EID: 0031037968     PISSN: 07351097     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0735-1097(96)00472-X     Document Type: Article

References (45)

1. Furchgott RF, Zawadzki JV. The obligatory role of the endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 1980;288: 373-6.
2. Vanhoutte PM. The endothelium. Modulator of vascular smooth muscle tone. N Engl J Med 1988;319:512-3.
3. Feletou M, Vanhoutte PM. Endothelium-dependent hyperpolarization of canine coronary smooth muscle. Br J Pharmacol 1988;93:515-24.
4. Palmer RM, Ferrige AG, Moncada S. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature 1987;327: 524-6.
5. De Mey JG, Claeys M, Vanhoutte PM. Endothelium-dependent inhibitory effects of acetylcholine, adenosine triphosphate, thrombin and arachidonic acid in the canine femoral artery. J Pharmacol Exp Ther 1982;222:166-73.
6. Ludmer PL, Selwyn AP, Shook TL, et al. Paradoxical vasoconstriction induced by acetylcholine in atherosclerotic coronary arteries. N Engl J Med 1986;315:1046-51.
7. Zeiher AM, Drexler H, Wollschläger H, Just H. Modulation of coronary vasomotor tone in humans. Progressive endothelial dysfunction with different early stages of coronary atherosclerosis. Circulation 1991;83:391-401.
8. Hodgson JM, Marshall JJ. Direct vasoconstriction and endothelium-dependent vasodilation: mechanism of acetylcholine effects on coronary flow and arterial diameter in patients with non-stenotic coronary arteries. Circulation 1989;79:1043-51.
9. Newman CM, Maseri A, Hackett DR, El-Tamimi HM, Davies GJ. Responses of angiographically normal and atherosclerotic left anterior descending coronary arteries to acetylcholine. Am J Cardiol 1990;66:1070-6.
10. Zieher AM, Schächinger V, Hohnloser SH, Saurbier B, Just H. Coronary atherosclerotic wall thickening and vascular reactivity in humans: elevated high-density lipoprotein levels ameliorate abnormal vasoconstriction in early atherosclerosis. Circulation 1994;89:2525-32.
11. Quyyumi AA, Mulcahy D, Andrews NP, Husain S, Panza JA, Cannon RO III. Coronary vascular nitric oxide activity in hypertension and hypercholesterolemia: comparison of acetylcholine and substance P. Circulation. In press.
12. Crossman DC, Larkin SW, Dashwood MR, Davies GJ, Yacoub M, Maseri A. Responses of atherosclerotic human coronary arteries in vivo to endothelium-dependent vasodilator substance P. Circulation 1991;85:2001-10.
13. Egashira K, Inou T, Yamada A, et al. Heterogeneous effects of the endothelium-dependent vasodilation acetylcholine and substance P on the coronary circulation of patients with angiographically normal coronary arteries. Coron Artery Dis 1992;3:945-52.
14. Yang Z, Luscher TF. Endothelium-dependent responses in human blood vessels in health and cardiovascular disease. Coron Artery Dis 1991;2:338-48.
15. Katusic ZS, Shepherd JT, Vanhoutte PM. Endothelium-dependent contractions to calcium inophore A23187, arachidonic acid and acetylcholine in canine basilar arteries. Stroke 1988;19:476-9.
16. 2. J Pharmacol Exp Ther 1986;236:535-41.
17. Lefroy DC, Crake T, Uren NG, Davies GJ, Maseri A. Effect of inhibition of nitric oxide synthesis on epicardial coronary artery caliber and coronary blood flow in humans. Circulation 1993;88:43-54.
18. Chu A, Chambers DE, Lin C, et al. Effects of inhibition of nitric oxide formation on basal vasomotion and endothelium-dependent responses of the coronary arteries in awake dogs. J Clin Invest 1991;87:1964-8.
19. Quyyumi AA, Dakak N, Andrews NP, et al. Nitric oxide activity in the human coronary circulation: impact of risk factors for coronary atherosclerosis. J Clin Invest 1995;95:1747-55.
20. Doucette JW, Corl D, Payne HM, et al. Validation of a Doppler guide wire for intravascular measurement of coronary artery flow velocity. Circulation 1992;85:1899-1911.
21. Rees DD, Palmer RM, Hodson HF, Moncada S. A specific inhibitor of nitric oxide formation from L-arginine attenuates endothelium-dependent relaxation. Br J Pharmacol 1989;96:418-24.
22. Gilligan DM, Quyyumi AA, Cannon RO III. Effects of physiological levels of estrogen on coronary vasomotor function in postmenopausal women. Circulation 1994;89:2545-51.
23. Glantz SA, Slinker BK. Repeated measures. In: Glantz SA, Slinker BK, editors. Primer of Applied Regression and Analysis of Variance. New York: McGraw-Hill, 1990:381-463.
24. Cox DA, Vita JA, Treasure CB, et al. Atherosclerosis impairs flow-mediated dilatation of coronary arteries in humans. Circulation 1989;80:458-65.
25. Drexler H, Zeiher AM, Wollschlager H, Meinertz T, Just H, Bonzel T. Flow-dependent coronary artery dilation in humans. Circulation 1989;80: 466-74.
26. Nabel EG, Selwyn AP, Ganz P. Paradoxical narrowing of atherosclerotic arteries induced by increases in heart rate. Circulation 1990;81:850-9.
27. Gordon JB, Ganz P, Nabel E, et al. Atherosclerosis influences the vasomotor response of epicardial coronary arteries to exercise. J Clin Invest 1989;83: 1946-52.
28. Yeung AC, Vekshtein VI, Krantz DS, et al. The effect of atherosclerosis on the vasomotor response of coronary arteries to mental stress. N Engl J Med 1991;325:1551-6.
29. Egashira K, Inou T, Hirooka Y, et al. Impaired coronary blood flow response to acetylcholine in patients with coronary risk factors and proximal atherosclerotic lesions. J Clin Invest 1993;91:29-37.
30. Yamamoto H, Bossaller C, Cartwright J, Henry PD. Video-microscopic demonstration of defective cholinergic arteriolar vasodilation in atherosclerotic rabbit. J Clin Invest 1988;81:1752-8.
31. Osborne JA, Siegman MJ, Sedar AW, Mooers SU, Lefer AM. Lack of endothelium-dependent relaxation in coronary resistance arteries of atherosclerotic rabbit. Am J Physiol 1989;256:C591-7.
32. Sellke FW, Armstrong ML, Harrison DG. Endothelium-dependent vascular relaxation is abnormal in the coronary microcirculation of atherosclerotic primates. Circulation 1990;81:1586-93.
33. Chilian WM, Dellsperger KC, Layne SM, et al. Effects of atherosclerosis on the coronary microcirculation. Am J Physiol 1990;258:H529-39.
34. Drexler H, Zeiher AM, Meinertz T, Just H. Correction of endothelial dysfunction in coronary microcirculation of hypercholesterolemic patients by L-arginine. Lancet 1991;338:1546-50.
35. Creager MA, Girerd XJ, Gallagher SH, Coleman S, Dzau VJ, Cooke JP. L-Arginine improves endothelium-dependent vasodilation in hypercholesterolemic humans. J Clin Invest 1992;90:1248-53.
36. Ohara Y, Peterson TE, Harrison D. Hypercholesterolemia increases super-oxide anion production by the endothelium [abstract]. Circulation 1992;86 Suppl I:I-222.
37. Minor RL, Myers PR, Guerra R Jr, Bates JN, Harrison DG. Diet-induced atherosclerosis increases the release of nitrogen oxides from rabbit aorta. J Clin Invest 1990;86:2109-16.
38. Zeiher AM, Drexler H, Wollschläger H, Just H. Endothelial dysfunction of the coronary microvasculature is associated with impaired coronary blood flow regulation in patients with early atherosclerosis. Circulation 1991;84: 1984-1992.
39. Vita JA, Treasure CB, Nabel EG, et al. Coronary vasomotor response to acetylcholine relates to risk factors for coronary artery disease. Circulation 1990;81:491-7.
40. Schachinger V, Zeiher AM. Quantitative assessment of coronary vasoreactivity in humans in vivo. Circulation 1995;92:2087-94.
41. Heistad DD, Armstrong ML, Marcus ML, Piegors DJ, Mark AL. Augmented responses to vasoconstrictor stimuli in hypercholesterolemic and atherosclerotic monkeys. Circ Res 1984;54:711-8.
42. Vita JA, Treasure CB, Yeung A, et al. Patients with evidence of coronary endothelial dysfunction as assessed by acetylcholine infusion demonstrate marked increase in sensitivity to constrictor effects of catecholamines. Circulation 1992;85:1390-7.
43. Zeiher AM, Drexler H, Wollschlaeger H, Saurbier B, Just H. Coronary vasomotion in response to sympathetic stimulation in humans: importance of the functional integrity of the endothelium. J Am Coll Cardiol 1989;14:1181-90.
44. Yasue H, Matsuyama K, Matsuyama K, Okumura K, Morikami Y, Ogawa H. Responses of angiographically normal human coronary arteries to intracoronary injection of acetylcholine by age and segment: possible role of early coronary atherosclerosis. Circulation 1990;81:482-90.
45. Egashira K, Inou T, Hirooka Y, et al. Effects of age on endothelium-dependent vasodilation of resistance coronary arteries by acetylcholine in humans. Circulation 1993;88:77-81.