Intrathecal PKA-selective siRNA treatment blocks sustained morphine-mediated pain sensitization and antinociceptive tolerance in rats

Journal of Neuroscience Methods

Volumn 199, Issue 1, 2011, Pages 62-68

  Tumati, S ^a   Roeske, W R ^a,b   Largent Milnes, T M ^a   Vanderah, T W ^a,c   Varga, E V ^a,b,c  

^a UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

^c UNIVERSITY OF ARIZONA   (United States)

Author keywords

Allodynia; Analgesic tolerance; Hyperalgesia; Opioid; PKA

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE; CYCLIC AMP DEPENDENT PROTEIN KINASE; MORPHINE; SMALL INTERFERING RNA;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; CATHETERIZATION; CONTINUOUS INFUSION; ENZYME ACTIVITY; HYPERALGESIA; IMMUNOREACTIVITY; MALE; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; SPINAL GANGLION;

ANIMALS; CALCITONIN GENE-RELATED PEPTIDE; CAPSAICIN; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; GENE THERAPY; HOT TEMPERATURE; HYPERALGESIA; INJECTIONS, SPINAL; MALE; MORPHINE; NARCOTICS; POSTERIOR HORN CELLS; PRESYNAPTIC TERMINALS; RATS; RATS, SPRAGUE-DAWLEY; RNA INTERFERENCE; RNA, SMALL INTERFERING; SECOND MESSENGER SYSTEMS; SPINAL CORD; STRESS, MECHANICAL;

EID: 79958126295     PISSN: 01650270     EISSN: 1872678X     Source Type: Journal    
DOI: 10.1016/j.jneumeth.2011.04.036     Document Type: Article

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