Ultraviolet A exposure induces reversible disruption of gap junction intercellular communication in lens epithelial cells

International Journal of Molecular Medicine

Volumn 28, Issue 2, 2011, Pages 239-245

  Wu, Dayang ^a   Zhao, Jiangyue ^a   Wu, Di ^a   Zhang, Jinsong ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

Connexin 43; Gap junction intercellular communication; Lens epithelial cells; p38; Ultraviolet A

Indexed keywords

CONNEXIN 43; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN KINASE C; REACTIVE OXYGEN METABOLITE;

ARTICLE; CELL COMMUNICATION; CELL FUNCTION; CELL VIABILITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; GAP JUNCTION; HUMAN; HUMAN CELL; LENS EPITHELIUM; LIPID PEROXIDATION; PRIORITY JOURNAL; RADIATION DOSE; RADIATION EXPOSURE; SIGNAL TRANSDUCTION; ULTRAVIOLET A RADIATION;

CELL COMMUNICATION; CELL LINE; CONNEXIN 43; ENZYME ACTIVATION; EPITHELIAL CELLS; GAP JUNCTIONS; GENE EXPRESSION REGULATION; HUMANS; LENS, CRYSTALLINE; LIPID PEROXIDATION; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN KINASE C; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; ULTRAVIOLET RAYS;

EID: 79958094428     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2011.665     Document Type: Article

References (32)

1. Balasubramanian D: Ultraviolet radiation and cataract. J Ocul Pharmacol Ther 16: 285-297, 2000.
2. Mukesh BN, Le A, Dimitrov PN, Ahmed S, Taylor HR and McCarty CA: Development of cataract and associated risk factors: the Visual Impairment Project. Arch Ophthalmol 124: 79-85, 2006. (Pubitemid 43063892)
3. West SK and Valmadrid CT: Epidemiology of risk factors for age-related cataract. Surv Ophthalmol 39: 323-334, 1995.
4. Li WC and Spector A: Lens epithelial cell apoptosis is an early event in the development of UVB-induced cataract. Free Radic Biol Med 20: 301-311, 1996.
5. Spector A, Kuszak JR, Ma W, Wing RR, Ho Y and Yang Y: The effect of photochemical stress upon the lenses of normal and glutathione peroxidase-1 knockout mice. Exp Eye Res 67: 457-471, 1998. (Pubitemid 28552968)
6. Spector A, Wang GM, Wang RR, Li WC and Kuszak JR: A brief photochemically induced oxidative insult causes irreversible lens damage and cataract. I. Transparency and epithelial cell layer. Exp Eye Res 60: 471-481, 1995.
7. De Maio A, Vega VL and Contreras JE: Gap junctions, homeostasis, and injury. J Cell Physiol 191: 269-282, 2002. (Pubitemid 34462477)
8. Alexander DB and Goldberg GS: Transfer of biologically important molecules between cells through gap junction channels. Curr Med Chem 10: 2045-2058, 2003. (Pubitemid 37139061)
9. Evans WH and Martin PE: Gap junctions: structure and function (Review). Mol Membr Biol 19: 121-136, 2002. (Pubitemid 34753316)
10. Boswell BA, VanSlyke JK and Musil LS: Regulation of lens gap junctions by transforming growth factor beta. Mol Biol Cell 21: 1686-1697, 2010.
11. Goodenough DA, Goliger JA and Paul DL: Connexins, connexons, and intercellular communication. Annu Rev Biochem 65: 475-502, 1996.
12. Yao J, Oite T and Kitamura M: Gap junctional intercellular communication in the juxtaglomerular apparatus. Am J Physiol Renal Physiol 296: F939-F946, 2009.
13. Kumar NM and Gilula NB: The gap junction communication channel. Cell 84: 381-388, 1996.
14. Eckert R, Adams B, Kistler J and Donaldson P: Quantitative determination of gap junctional permeability in the lens cortex. J Membr Biol 169: 91-102, 1999. (Pubitemid 29239241)
15. Baruch A, Greenbaum D, Levy ET, et al: Defining a link between gap junction communication, proteolysis, and cataract formation. J Biol Chem 276: 28999-29006, 2001.
16. Kistler J, Lin JS, Bond J, et al: Connexins in the lens: are they to blame in diabetic cataractogenesis? Novartis Found Symp 219: 97-112, 1999.
17. Krysko DV, Mussche S, Leybaert L and D'Herde K: Gap junctional communication and connexin43 expression in relation to apoptotic cell death and survival of granulosa cells. J Histochem Cytochem 52: 1199-1207, 2004. (Pubitemid 39097187)
18. Girao H and Pereira P: Phosphorylation of connexin 43 acts as a stimuli for proteasome-dependent degradation of the protein in lens epithelial cells. Mol Vis 9: 24-30, 2003. (Pubitemid 38097563)
19. Bellei B, Mastrofrancesco A, Briganti S, et al: Ultraviolet A induced modulation of gap junctional intercellular communication by P38 MAPK activation in human keratinocytes. Exp Dermatol 17: 115-124, 2008.
20. Provost N, Moreau M, Leturque A and Nizard C: Ultraviolet A radiation transiently disrupts gap junctional communication in human keratinocytes. Am J Physiol Cell Physiol 284: C51-C59, 2003. (Pubitemid 35470625)
21. Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25: 402-408, 2001. (Pubitemid 34164012)
22. Li AF and Roy S: High glucose-induced down-regulation of connexin 43 expression promotes apoptosis in microvascular endothelial cells. Invest Ophthalmol Vis Sci 50: 1400-1407, 2009.
23. Sato T, Haimovici R, Kao R, Li AF and Roy S: Down-regulation of connexin 43 expression by high glucose reduces gap junction activity in microvascular endothelial cells. Diabetes 51: 1565-1571, 2002. (Pubitemid 34826626)
24. Kyriakis JM and Avruch J: Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol Rev 81: 807-869, 2001. (Pubitemid 32267078)
25. Lampe PD and Lau AF: Regulation of gap junctions by phosphorylation of connexins. Arch Biochem Biophys 384: 205-215, 2000. (Pubitemid 32012794)
26. Lin D, Boyle DL and Takemoto DJ: IGF-I-induced phosphorylation of connexin 43 by PKCgamma: regulation of gap junctions in rabbit lens epithelial cells. Invest Ophthalmol Vis Sci 44: 1160-1168, 2003. (Pubitemid 36297836)
27. Ruch RJ and Klaunig JE: Inhibition of mouse hepatocyte intercellular communication by paraquat-generated oxygen free radicals. Toxicol Appl Pharmacol 94: 427-436, 1988.
28. Hu J, Speisky H and Cotgreave IA: The inhibitory effects of boldine, glaucine, and probucol on TPA-induced down regulation of gap junction function. Relationships to intracellular peroxides, protein kinase C translocation, and connexin 43 phosphorylation. Biochem Pharmacol 50: 1635-1643, 1995.
29. Warn-Cramer BJ, Lampe PD, Kurata WE, et al: Characterization of the mitogen-activated protein kinase phosphorylation sites on the connexin-43 gap junction protein. J Biol Chem 271: 3779-3786, 1996. (Pubitemid 26065698)
30. Cuadrado A and Nebreda AR: Mechanisms and functions of p38 MAPK signalling. Biochem J 429: 403-417, 2010.
31. Kim AL, Zhu Y, Zhu H, et al: Resveratrol inhibits proliferation of human epidermoid carcinoma A431 cells by modulating MEK1 and AP-1 signalling pathways. Exp Dermatol 15: 538-546, 2006. (Pubitemid 43834489)
32. Harper SJ and LoGrasso P: Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38. Cell Signal 13: 299-310, 2001. (Pubitemid 32448947)