The expression of Akt and ERK1/2 proteins decreased in dexamethasone- induced intrauterine growth restricted rat placental development

Journal of Molecular Histology

Volumn 42, Issue 3, 2011, Pages 237-249

  Ozmen, Asli ^a   Unek, Gozde ^a   Kipmen Korgun, Dijle ^a   Korgun, Emin Turkay ^a  

^a AKDENIZ UNIVERSITY   (Turkey)

Author keywords

Akt; ERK1 2; IUGR; Placental development; Rat

Indexed keywords

ALCOHOL; DEXAMETHASONE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE B;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; DISEASE ASSOCIATION; EMBRYO; EMBRYONAL TISSUE; EMBRYOTOXICITY; ENZYME ACTIVATION; FEMALE; GESTATION PERIOD; IMMUNOHISTOCHEMISTRY; IMMUNOLOCALIZATION; INHIBITION KINETICS; INTRAUTERINE GROWTH RETARDATION; MOUSE; NONHUMAN; PLACENTA; PLACENTA DEVELOPMENT; PREGNANCY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; WESTERN BLOTTING;

ANIMALS; DEXAMETHASONE; EMBRYO, MAMMALIAN; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; PLACENTA; PLACENTATION; PREGNANCY; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, WISTAR;

RATTUS; RATTUS NORVEGICUS; RODENTIA;

EID: 79958052730     PISSN: 15672379     EISSN: 15672387     Source Type: Journal    
DOI: 10.1007/s10735-011-9328-4     Document Type: Article

References (55)

1. R Ain LN Canham MJ Soares 2005 Dexamethasone-induced intrauterine growth restriction impacts the placental prolactin family, insulin-like growth factor-II and the Akt signaling pathway J Endocrinol 185 2 253 263 15845918 10.1677/joe.1.06039 1:CAS:528:DC%2BD2MXktlylt7k%3D (Pubitemid 40691792)
2. B Baisden S Sonne RM Joshi V Ganapathy PS Shekhawat 2007 Antenatal dexamethasone treatment leads to changes in gene expression in a murine late placenta Placenta 28 10 1082 1090 17559929 10.1016/j.placenta.2007.04.002 1:CAS:528:DC%2BD2sXhtVWmsLnO (Pubitemid 47355230)
3. DJ Barker PD Gluckman KM Godfrey JE Harding JA Owens JS Robinson 1993 Fetal nutrition and cardiovascular disease in adult life Lancet 341 8850 938 941 8096277 10.1016/0140-6736(93)91224-A 1:STN:280:DyaK3s3htFaisQ%3D%3D (Pubitemid 23109122)
4. R Benediktsson RS Lindsay J Noble JR Seckl CR Edwards 1993 Glucocorticoid exposure in utero: new model for adult hypertension Lancet 341 8841 339 341 8094115 10.1016/0140-6736(93)90138-7 1:CAS:528:DyaK3sXktVWitL4%3D (Pubitemid 23039701)
5. B Binetruy L Heasley F Bost L Caron M Aouadi 2007 Concise review: regulation of embryonic stem cell lineage commitment by mitogen-activated protein kinases Stem Cells 25 5 1090 1095 17218395 10.1634/stemcells.2006-0612 1:CAS:528:DC%2BD2sXlvFyqur0%3D (Pubitemid 46684867)
6. V Bissonauth S Roy M Gravel S Guillemette J Charron 2006 Requirement for Map2k1 (Mek1) in extra-embryonic ectoderm during placentogenesis Development 133 17 3429 3440 16887817 10.1242/dev.02526 1:CAS:528:DC%2BD28XhtV2hsLbM (Pubitemid 44501845)
7. E Blair F Stanley 1990 Intrauterine growth and spastic cerebral palsy. I. Association with birth weight for gestational age Am J Obstet Gynecol 162 1 229 237 2301497 1:STN:280:DyaK3c7ksVyrsw%3D%3D (Pubitemid 20055457)
8. SL Bloom JS Sheffield DD McIntire KJ Leveno 2001 Antenatal dexamethasone and decreased birth weight Obstet Gynecol 97 4 485 490 11275014 10.1016/S0029-7844(00)01206-0 1:CAS:528:DC%2BD3MXitF2ksLc%3D
9. T Braun S Li TJ Moss JP Newnham JR Challis PD Gluckman DM Sloboda 2007 Maternal betamethasone administration reduces binucleate cell number and placental lactogen in sheep J Endocrinol 194 2 337 347 17641283 10.1677/JOE-07-0123 1:CAS:528:DC%2BD2sXpsFenu7g%3D (Pubitemid 47249672)
10. D Brodsky H Christou 2004 Current concepts in intrauterine growth restriction J Intensive Care Med 19 6 307 319 15523117 10.1177/0885066604269663 (Pubitemid 44544694)
11. G Daoud M Amyot E Rassart A Masse L Simoneau J Lafond 2005 ERK1/2 and p38 regulate trophoblasts differentiation in human term placenta J Physiol 566 Pt 2 409 423 15890698 10.1113/jphysiol.2005.089326 1:CAS:528:DC%2BD2MXntFCmsL4%3D (Pubitemid 41030549)
12. RJ Dickinson SM Keyse 2006 Diverse physiological functions for dual-specificity MAP kinase phosphatases J Cell Sci 119 Pt 22 4607 4615 17093265 10.1242/jcs.03266 1:CAS:528:DC%2BD2sXktF2m (Pubitemid 44964257)
13. K Forbes M Westwood 2008 The IGF axis and placental function a mini review Horm Res 69 3 129 137 18219215 10.1159/000112585 1:CAS:528: DC%2BD1cXhtVGlu7o%3D (Pubitemid 351161040)
14. TF Franke DR Kaplan LC Cantley 1997 PI3 K: downstream AKTion blocks apoptosis Cell 88 4 435 437 9038334 10.1016/S0092-8674(00)81883-8 1:CAS:528:DyaK2sXhtlKqs70%3D (Pubitemid 27154408)
15. Z Garcia A Kumar M Marques I Cortes AC Carrera 2006 Phosphoinositide 3-kinase controls early and late events in mammalian cell division EMBO J 25 4 655 661 16437156 10.1038/sj.emboj.7600967 1:CAS:528:DC%2BD28Xhs1ersLw%3D (Pubitemid 43292428)
16. P Georgiades AC Ferguson-Smith GJ Burton 2002 Comparative developmental anatomy of the murine and human definitive placentae Placenta 23 1 3 19 11869088 10.1053/plac.2001.0738 1:STN:280:DC%2BD387jt1Kluw%3D%3D
17. S Giroux M Tremblay D Bernard JF Cardin-Girard S Aubry L Larouche S Rousseau J Huot J Landry L Jeannotte J Charron 1999 Embryonic death of Mek1-deficient mice reveals a role for this kinase in angiogenesis in the labyrinthine region of the placenta Curr Biol 9 7 369 372 10209122 10.1016/S0960-9822(99)80164-X 1:CAS:528:DyaK1MXisF2jtLg%3D (Pubitemid 29194878)
18. PD Gluckman 2001 Editorial: nutrition, glucocorticoids, birth size, and adult disease Endocrinology 142 5 1689 1691 11316730 10.1210/en.142.5.1689 1:CAS:528:DC%2BD3MXjt1aktro%3D (Pubitemid 32405921)
19. D Hahn A Blaschitz ET Korgun I Lang G Desoye G Skofitsch G Dohr 2001 From maternal glucose to fetal glycogen: expression of key regulators in the human placenta Mol Hum Reprod 7 12 1173 1178 11719595 10.1093/molehr/7.12.1173 1:CAS:528:DC%2BD38XisFOitw%3D%3D (Pubitemid 33150213)
20. E Hajduch GJ Litherland HS Hundal 2001 Protein kinase B (PKB/Akt)-a key regulator of glucose transport? FEBS Lett 492 3 199 203 11257494 10.1016/S0014-5793(01)02242-6 1:CAS:528:DC%2BD3MXhvVantL4%3D (Pubitemid 32217828)
21. CN Hales M Desai SE Ozanne NJ Crowther 1996 Fishing in the stream of diabetes: from measuring insulin to the control of fetal organogenesis Biochem Soc Trans 24 2 341 350 8736760 1:CAS:528:DyaK28XjtlKrsLk%3D (Pubitemid 26165502)
22. N Hatano Y Mori M Oh-hora A Kosugi T Fujikawa N Nakai H Niwa J Miyazaki T Hamaoka M Ogata 2003 Essential role for ERK2 mitogen-activated protein kinase in placental development Genes Cells 8 11 847 856 14622137 10.1046/j.1365-2443. 2003.00680.x 1:CAS:528:DC%2BD3sXpsV2it7c%3D (Pubitemid 37428014)
23. DP Hewitt PJ Mark BJ Waddell 2006 Glucocorticoids prevent the normal increase in placental vascular endothelial growth factor expression and placental vascularity during late pregnancy in the rat Endocrinology 147 12 5568 5574 16959835 10.1210/en.2006-0825 1:CAS:528:DC%2BD28Xht1yqtr7M (Pubitemid 44833473)
24. BH Jiang LZ Liu 2008 PI3 K/PTEN signaling in tumorigenesis and angiogenesis Biochim Biophys Acta 1784 1 150 158 17964232 1:CAS:528: DC%2BD1cXptlertQ%3D%3D
25. ED Johnstone M Mackova S Das SG Payne B Lowen CP Sibley G Chan LJ Guilbert 2005 Multiple anti-apoptotic pathways stimulated by EGF in cytotrophoblasts Placenta 26 7 548 555 15993704 10.1016/j.placenta.2004.08.012 1:CAS:528:DC%2BD2MXlvFKlsrc%3D (Pubitemid 40916307)
26. D Kim J Chung 2002 Akt: versatile mediator of cell survival and beyond J Biochem Mol Biol 35 1 106 115 16248975 10.5483/BMBRep.2002.35.1.106 1:CAS:528:DC%2BD38XhtlWmu78%3D (Pubitemid 35216586)
27. W Kolch 2000 Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions Biochem J 351 Pt 2 289 305 11023813 10.1042/0264-6021:3510289 1:CAS:528:DC%2BD3cXnvFSqt78%3D
28. ET Korgun G Dohr G Desoye R Demir UA Kayisli T Hahn 2003 Expression of insulin, insulin-like growth factor I and glucocorticoid receptor in rat uterus and embryo during decidualization, implantation and organogenesis Reproduction 125 1 75 84 12622698 10.1530/rep.0.1250075 1:CAS:528:DC%2BD3sXhvFGls7k%3D (Pubitemid 36231212)
29. L Laviola S Perrini G Belsanti A Natalicchio C Montrone A Leonardini A Vimercati M Scioscia L Selvaggi R Giorgino P Greco F Giorgino 2005 Intrauterine growth restriction in humans is associated with abnormalities in placental insulin-like growth factor signaling Endocrinology 146 3 1498 1505 15564321 10.1210/en.2004-1332 1:CAS:528:DC%2BD2MXitlehtbg%3D (Pubitemid 40289340)
30. NS Levitt RS Lindsay MC Holmes JR Seckl 1996 Dexamethasone in the last week of pregnancy attenuates hippocampal glucocorticoid receptor gene expression and elevates blood pressure in the adult offspring in the rat Neuroendocrinology 64 6 412 418 8990073 10.1159/000127146 1:CAS:528: DyaK2sXisF2lsg%3D%3D (Pubitemid 27007194)
31. J Liang JM Slingerland 2003 Multiple roles of the PI3 K/PKB (Akt) pathway in cell cycle progression Cell Cycle 2 4 339 345 12851486 10.4161/cc.2.4.433 1:CAS:528:DC%2BD3sXnvVyjsLY%3D
32. OH Lowry NJ Rosebrough AL Farr RJ Randall 1951 Protein measurement with the Folin phenol reagent J Biol Chem 193 1 265 275 14907713 1:CAS:528: DyaG38XhsVyrsw%3D%3D
33. LM Luttrell 2003 'Location, location, location': activation and targeting of MAP kinases by G protein-coupled receptors J Mol Endocrinol 30 2 117 126 12683936 10.1677/jme.0.0300117 1:CAS:528:DC%2BD3sXjs1eju7s%3D (Pubitemid 36592506)
34. JP Martins JC Monteiro AD Paixao 2003 Renal function in adult rats subjected to prenatal dexamethasone Clin Exp Pharmacol Physiol 30 1-2 32 37 12542450 10.1046/j.1440-1681.2003.03787.x 1:CAS:528:DC%2BD3sXhtlGit7s%3D (Pubitemid 36232740)
35. TJ McDonald KL Franko JM Brown SL Jenkins PW Nathanielsz MJ Nijland 2003 Betamethasone in the last week of pregnancy causes fetal growth retardation but not adult hypertension in rats J Soc Gynecol Investig 10 8 469 473 14662159 10.1016/S1071-5576(03)00151-5 1:CAS:528:DC%2BD3sXps1Oltrg%3D (Pubitemid 37510005)
36. S Meloche FD Vella L Voisin SL Ang M Saba-El-Leil 2004 Erk2 signaling and early embryo stem cell self-renewal Cell Cycle 3 3 241 243 14726711 10.4161/cc.3.3.674 1:CAS:528:DC%2BD2cXltFKrsb4%3D (Pubitemid 41359061)
37. M Mikula M Schreiber Z Husak L Kucerova J Ruth R Wieser K Zatloukal H Beug EF Wagner M Baccarini 2001 Embryonic lethality and fetal liver apoptosis in mice lacking the c-raf-1 gene EMBO J 20 8 1952 1962 11296228 10.1093/emboj/20.8.1952 1:CAS:528:DC%2BD3MXjt12qtb8%3D (Pubitemid 32397397)
38. CS Mitsiades N Mitsiades M Koutsilieris 2004 The Akt pathway: molecular targets for anti-cancer drug development Curr Cancer Drug Targets 4 3 235 256 15134532 10.2174/1568009043333032 1:CAS:528:DC%2BD2cXjs1Gnu78%3D (Pubitemid 38560073)
39. V Nadeau S Guillemette LF Belanger O Jacob S Roy J Charron 2009 Map2k1 and Map2k2 genes contribute to the normal development of syncytiotrophoblasts during placentation Development 136 8 1363 1374 19304888 10.1242/dev.031872 1:CAS:528:DC%2BD1MXmtVakuro%3D
40. A Navarrete Santos S Tonack M Kirstein M Pantaleon P Kaye B Fischer 2004 Insulin acts via mitogen-activated protein kinase phosphorylation in rabbit blastocysts Reproduction 128 5 517 526 15509697 10.1530/rep.1.00204 (Pubitemid 40124282)
41. LM Neri P Borgatti S Capitani AM Martelli 2002 The nuclear phosphoinositide 3-kinase/AKT pathway: a new second messenger system Biochim Biophys Acta 1584 2-3 73 80 12385889 1:CAS:528:DC%2BD38XnvVKmur4%3D (Pubitemid 35217879)
42. T Pawson 2002 Regulation and targets of receptor tyrosine kinases Eur J Cancer 38 Suppl 5 S3 10 12528767 10.1016/S0959-8049(02)80597-4
43. J Pollheimer M Knofler 2005 Signalling pathways regulating the invasive differentiation of human trophoblasts: a review Placenta 26 Suppl 1 S21 30 15837062 10.1016/j.placenta.2004.11.013
44. J Prast L Saleh H Husslein S Sonderegger H Helmer M Knofler 2008 Human chorionic gonadotropin stimulates trophoblast invasion through extracellularly regulated kinase and AKT signaling Endocrinology 149 3 979 987 18063683 10.1210/en.2007-1282 1:CAS:528:DC%2BD1cXisVaqsb0%3D (Pubitemid 351397960)
45. X Qian L Esteban WC Vass C Upadhyaya AG Papageorge K Yienger JM Ward DR Lowy E Santos 2000 The Sos1 and Sos2 Ras-specific exchange factors: differences in placental expression and signaling properties EMBO J 19 4 642 654 10675333 10.1093/emboj/19.4.642 1:CAS:528:DC%2BD3cXhsFKms70%3D (Pubitemid 30093737)
46. JK Riley MO Carayannopoulos AH Wyman M Chi CK Ratajczak KH Moley 2005 The PI3 K/Akt pathway is present and functional in the preimplantation mouse embryo Dev Biol 284 2 377 386 16005454 10.1016/j.ydbio.2005.05.033 1:CAS:528:DC%2BD2MXpt1eksrY%3D (Pubitemid 41199813)
47. Romeis B (1989) Mikroskopische Technik, 17th edn. Urban and Schwarzenberg, Munich
48. J Rossant JC Cross 2001 Placental development: lessons from mouse mutants Nat Rev Genet 2 7 538 548 11433360 10.1038/35080570 1:CAS:528: DC%2BD3MXltVCksLc%3D (Pubitemid 33674027)
49. MK Saba-El-Leil FD Vella B Vernay L Voisin L Chen N Labrecque SL Ang S Meloche 2003 An essential function of the mitogen-activated protein kinase Erk2 in mouse trophoblast development EMBO Rep 4 10 964 968 14502223 10.1038/sj.embor.embor939 1:CAS:528:DC%2BD3sXnslaqt78%3D (Pubitemid 37407464)
50. JR Seckl 1994 Glucocorticoids and small babies Q J Med 87 5 259 262 7938405 1:STN:280:DyaK2M%2FisVGrsA%3D%3D (Pubitemid 24145545)
51. MC Sugden ML Langdown MJ Munns MJ Holness 2001 Maternal glucocorticoid treatment modulates placental leptin and leptin receptor expression and materno-fetal leptin physiology during late pregnancy, and elicits hypertension associated with hyperleptinaemia in the early-growth-retarded adult offspring Eur J Endocrinol 145 4 529 539 11581014 10.1530/eje.0.1450529 1:CAS:528:DC%2BD3MXns1Gisrs%3D (Pubitemid 32927083)
52. Unek G, Ozmen A, Kipmen-Korgun D, Korgun ET (2011) Immunolocalization of PCNA, Ki67, p27 and p57 in normal and dexamethasone-induced intrauterine growth restriction placental development in rat. Acta Histochem. doi: 10.1016/j.acthis.2011.02.002
53. BJ Waddell S Hisheh AM Dharmarajan PJ Burton 2000 Apoptosis in rat placenta is zone-dependent and stimulated by glucocorticoids Biol Reprod 63 6 1913 1917 11090465 10.1095/biolreprod63.6.1913 1:CAS:528:DC%2BD3cXosVKhtbs%3D
54. ED Watson JC Cross 2005 Development of structures and transport functions in the mouse placenta Physiology (Bethesda) 20 180 193 1:CAS:528: DC%2BD2MXls1GgtrY%3D (Pubitemid 40807056)
55. ZZ Yang O Tschopp M Hemmings-Mieszczak J Feng D Brodbeck E Perentes BA Hemmings 2003 Protein kinase B alpha/Akt1 regulates placental development and fetal growth J Biol Chem 278 34 32124 32131 12783884 10.1074/jbc.M302847200 1:CAS:528:DC%2BD3sXmsVOms7g%3D (Pubitemid 37048402)