A HIF-1 Target, ATIA, Protects Cells from Apoptosis by Modulating the Mitochondrial Thioredoxin, TRX2

Molecular Cell

Volumn 42, Issue 5, 2011, Pages 597-609

  Choksi, Swati ^a   Lin, Yong ^a,b   Pobezinskaya, Yelena ^a   Chen, Li ^a   Park, Chung ^a   Morgan, Michael ^a   Li, Tao ^a   Jitkaew, Siriporn ^a   Cao, Xiumei ^a   Kim, You Sun ^a   Kim, Hong Sug ^a   Levitt, Peter ^a   Shih, Grace ^a   Birre, Michael ^a   Deng, Chu Xia ^c   Liu, Zheng gang ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b LOVELACE RESPIRATORY RESEARCH INSTITUTE   (United States)

^c NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOHEXIMIDE; HYPOXIA INDUCIBLE FACTOR 1; REACTIVE OXYGEN METABOLITE; THIOREDOXIN 2; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR INHIBITOR;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; GLIOBLASTOMA; HUMAN; KNOCKOUT MOUSE; MITOCHONDRION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATION; OXIDATION REDUCTION REACTION; PROTEIN LOCALIZATION; PROTEIN TARGETING;

ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CARRIER PROTEINS; CELL HYPOXIA; CELL LINE, TUMOR; CELL MEMBRANE; GLIOBLASTOMA; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1; MEMBRANE PROTEINS; MICE; MITOCHONDRIA; OXIDATION-REDUCTION; THIOREDOXINS;

MUS;

EID: 79958038846     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2011.03.030     Document Type: Article

References (31)

1. Baud V., Karin M. Signal transduction by tumor necrosis factor and its relatives. Trends Cell Biol. 2001, 11:372-377.
2. Circu M.L., Aw T.Y. Reactive oxygen species, cellular redox systems, and apoptosis. Free Radic. Biol. Med. 2010, 48:749-762.
3. Damdimopoulos A.E., Miranda-Vizuete A., Pelto-Huikko M., Gustafsson J.A., Spyrou G. Human mitochondrial thioredoxin. Involvement in mitochondrial membrane potential and cell death. J. Biol. Chem. 2002, 277:33249-33257.
4. Decker K., Keppler D. Galactosamine hepatitis: key role of the nucleotide deficiency period in the pathogenesis of cell injury and cell death. Rev. Physiol. Biochem. Pharmacol. 1974, 1974:77-106.
5. Fadeel B., Orrenius S. Apoptosis: a basic biological phenomenon with wide-ranging implications in human disease. J. Intern. Med. 2005, 258:479-517.
6. Fukuda R., Zhang H., Kim J.W., Shimoda L., Dang C.V., Semenza G.L. HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells. Cell 2007, 129:111-122.
7. Halvey P.J., Watson W.H., Hansen J.M., Go Y.M., Samali A., Jones D.P. Compartmental oxidation of thiol-disulphide redox couples during epidermal growth factor signalling. Biochem. J. 2005, 386:215-219.
8. Hamanaka R.B., Chandel N.S. Mitochondrial reactive oxygen species regulate hypoxic signaling. Curr. Opin. Cell Biol. 2009, 21:894-899.
9. Hamanaka R.B., Chandel N.S. Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes. Trends Biochem. Sci. 2010, 35:505-513.
10. Hansen J.M., Zhang H., Jones D.P. Mitochondrial thioredoxin-2 has a key role in determining tumor necrosis factor-alpha-induced reactive oxygen species generation, NF-kappaB activation, and apoptosis. Toxicol. Sci. 2006, 91:643-650.
11. Henson P.M., Hume D.A. Apoptotic cell removal in development and tissue homeostasis. Trends Immunol. 2006, 27:244-250.
12. Holmgren A., Lu J. Thioredoxin and thioredoxin reductase: current research with special reference to human disease. Biochem. Biophys. Res. Commun. 2010, 396:120-124.
13. Ikeda Y., Imai Y., Kumagai H., Nosaka T., Morikawa Y., Hisaoka T., Manabe I., Maemura K., Nakaoka T., Imamura T., et al. Vasorin, a transforming growth factor beta-binding protein expressed in vascular smooth muscle cells, modulates the arterial response to injury in vivo. Proc. Natl. Acad. Sci. USA 2004, 101:10732-10737.
14. Kelliher M.A., Grimm S., Ishida Y., Kuo F., Stanger B.Z., Leder P. The death domain kinase RIP mediates the TNF-induced NF-kappaB signal. Immunity 1998, 8:297-303.
15. Kim Y.S., Morgan M.J., Choksi S., Liu Z.G. TNF-induced activation of the Nox1 NADPH oxidase and its role in the induction of necrotic cell death. Mol. Cell 2007, 26:675-687.
16. Lin Y., Ryan J., Lewis J., Wani M.A., Lingrel J.B., Liu Z.G. TRAF2 exerts its antiapoptotic effect by regulating the expression of Krüppel-like factor LKLF. Mol. Cell. Biol. 2003, 23:5849-5856.
17. Lin Y., Choksi S., Shen H.M., Yang Q.F., Hur G.M., Kim Y.S., Tran J.H., Nedospasov S.A., Liu Z.G. Tumor necrosis factor-induced nonapoptotic cell death requires receptor-interacting protein-mediated cellular reactive oxygen species accumulation. J. Biol. Chem. 2004, 279:10822-10828.
18. Loor G., Schumacker P.T. Role of hypoxia-inducible factor in cell survival during myocardial ischemia-reperfusion. Cell Death Differ. 2008, 15:686-690.
19. Morgan M.J., Kim Y.S., Liu Z.G. TNFalpha and reactive oxygen species in necrotic cell death. Cell Res. 2008, 18:343-349.
20. Nakayama K. Cellular signal transduction of the hypoxia response. J. Biochem. 2009, 146:757-765.
21. Nonn L., Williams R.R., Erickson R.P., Powis G. The absence of mitochondrial thioredoxin 2 causes massive apoptosis, exencephaly, and early embryonic lethality in homozygous mice. Mol. Cell. Biol. 2003, 23:916-922.
22. Paul S.A., Simons J.W., Mabjeesh N.J. HIF at the crossroads between ischemia and carcinogenesis. J. Cell. Physiol. 2004, 200:20-30.
23. Semenza G.L. HIF-1: upstream and downstream of cancer metabolism. Curr. Opin. Genet. Dev. 2010, 20:51-56.
24. Shen H.M., Pervaiz S. TNF receptor superfamily-induced cell death: redox-dependent execution. FASEB J. 2006, 20:1589-1598.
25. Tanaka T., Hosoi F., Yamaguchi-Iwai Y., Nakamura H., Masutani H., Ueda S., Nishiyama A., Takeda S., Wada H., Spyrou G., Yodoi J. Thioredoxin-2 (TRX-2) is an essential gene regulating mitochondria-dependent apoptosis. EMBO J. 2002, 21:1695-1703.
26. Thannickal V.J., Fanburg B.L. Reactive oxygen species in cell signaling. Am. J. Physiol. Lung Cell. Mol. Physiol. 2000, 279:L1005-L1028.
27. Tiegs G., Wolter M., Wendel A. Tumor necrosis factor is a terminal mediator in galactosamine/endotoxin-induced hepatitis in mice. Biochem. Pharmacol. 1989, 38:627-631.
28. Ventura J.J., Cogswell P., Flavell R.A., Baldwin A.S., Davis R.J. JNK potentiates TNF-stimulated necrosis by increasing the production of cytotoxic reactive oxygen species. Genes Dev. 2004, 18:2905-2915.
29. Wajant H. Death receptors. Essays Biochem. 2003, 39:53-71.
30. Wajant H., Pfizenmaier K., Scheurich P. Tumor necrosis factor signaling. Cell Death Differ. 2003, 10:45-65.
31. Yeh W.C., Shahinian A., Speiser D., Kraunus J., Billia F., Wakeham A., de la Pompa J.L., Ferrick D., Hum B., Iscove N., et al. Early lethality, functional NF-kappaB activation, and increased sensitivity to TNF-induced cell death in TRAF2-deficient mice. Immunity 1997, 7:715-725.