메뉴 건너뛰기




Volumn 2, Issue 4, 2011, Pages 647-653

Prognostic significance of phosphorylated signal transducer and activator of transcription 3 and suppressor of cytokine signaling 3 expression in hepatocellular carcinoma

Author keywords

Hepatocellular carcinoma; Phosphorylated signal transducer and activator of transcription 3; Prognosis; Suppressor of cytokine signaling 3

Indexed keywords

KI 67 ANTIGEN; STAT3 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 3; VASCULOTROPIN;

EID: 79958036438     PISSN: 17920981     EISSN: 17921015     Source Type: Journal    
DOI: 10.3892/etm.2011.254     Document Type: Article
Times cited : (22)

References (31)
  • 1
    • 24944542337 scopus 로고    scopus 로고
    • Major causes of death among men and women in China
    • He J, Gu D, Wu X, et al: Major causes of death among men and women in China. N Engl J Med 353: 1124-1134, 2005.
    • (2005) N Engl J Med , vol.353 , pp. 1124-1134
    • He, J.1    Gu, D.2    Wu, X.3
  • 2
    • 0034658541 scopus 로고    scopus 로고
    • Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors
    • Hirano T, Ishihara K and Hibi M: Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors. Oncogene 19: 2548-2556, 2000.
    • (2000) Oncogene , vol.19 , pp. 2548-2556
    • Hirano, T.1    Ishihara, K.2    Hibi, M.3
  • 3
    • 32144453842 scopus 로고    scopus 로고
    • JAK/STAT signal transduction: Regulators and implication in hematological malignancies
    • Valentino L and Pierre J: JAK/STAT signal transduction: regulators and implication in hematological malignancies. Biochem Pharmacol 71: 713-721, 2006.
    • (2006) Biochem Pharmacol , vol.71 , pp. 713-721
    • Valentino, L.1    Pierre, J.2
  • 4
    • 0036554816 scopus 로고    scopus 로고
    • Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention
    • Buettner R, Mora LB and Jove R: Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention. Clin Cancer Res 8: 945-954, 2002.
    • (2002) Clin Cancer Res , vol.8 , pp. 945-954
    • Buettner, R.1    Mora, L.B.2    Jove, R.3
  • 6
    • 1042302005 scopus 로고    scopus 로고
    • The STATs of cancer - new molecular targets come of age
    • Yu H and Jove R: The STATs of cancer - new molecular targets come of age. Nat Rev Cancer 4: 97-105, 2004.
    • (2004) Nat Rev Cancer , vol.4 , pp. 97-105
    • Yu, H.1    Jove, R.2
  • 7
    • 3042726888 scopus 로고    scopus 로고
    • STAT3 is constitutively activated and supports cell survival in association with survivin expression in gastric cancer cells
    • Kanda N, Seno H, Konda Y, et al: STAT3 is constitutively activated and supports cell survival in association with survivin expression in gastric cancer cells. Oncogene 23: 4921-4929, 2004.
    • (2004) Oncogene , vol.23 , pp. 4921-4929
    • Kanda, N.1    Seno, H.2    Konda, Y.3
  • 8
    • 33748364994 scopus 로고    scopus 로고
    • Phospho-Stat3 expression and correlation with VEGF, p53, and Bcl-2 in gastric carcinoma using tissue microarray
    • Choi JH, Ahn MJ, Park CK, Han HX, Kwon SJ, Lee YY and Kim IS: Phospho-Stat3 expression and correlation with VEGF, p53, and Bcl-2 in gastric carcinoma using tissue microarray. APMIS 114: 619-625, 2006.
    • (2006) APMIS , vol.114 , pp. 619-625
    • Choi, J.H.1    Ahn, M.J.2    Park, C.K.3    Han, H.X.4    Kwon, S.J.5    Lee, Y.Y.6    Kim, I.S.7
  • 9
    • 34250858888 scopus 로고    scopus 로고
    • Altered p-STAT3 (tyr705) expression is associated with histological grading and intratumour microvessel density in hepatocellular carcinoma
    • Yang SF, Wang SN, Wu CF, Yeh YT, Chai CY, Chunag SC, Sheen MC and Lee KT: Altered p-STAT3 (tyr705) expression is associated with histological grading and intratumour microvessel density in hepatocellular carcinoma. J Clin Pathol 60: 642-648, 2007.
    • (2007) J Clin Pathol , vol.60 , pp. 642-648
    • Yang, S.F.1    Wang, S.N.2    Wu, C.F.3    Yeh, Y.T.4    Chai, C.Y.5    Chunag, S.C.6    Sheen, M.C.7    Lee, K.T.8
  • 10
    • 78649412799 scopus 로고    scopus 로고
    • STAT-3 correlates with lymph node metastasis and cell survival in gastric cancer
    • Deng JY, Sun D, Liu XY, Pan Y and Liang H: STAT-3 correlates with lymph node metastasis and cell survival in gastric cancer. World J Gastroenterol 16: 5380-5387, 2010.
    • (2010) World J Gastroenterol , vol.16 , pp. 5380-5387
    • Deng, J.Y.1    Sun, D.2    Liu, X.Y.3    Pan, Y.4    Liang, H.5
  • 11
    • 76249101397 scopus 로고    scopus 로고
    • Clinical impact of phosphorylated signal transducer and activator of transcription 3, epidermal growth factor receptor, p53, and vascular endothelial growth factor receptor 1 expression in resected adenocarcinoma of lung by using tissue microarray
    • Kim HS, Park YH, Lee J, Ahn JS, Kim J, Shim YM, Kim JH, Park K, Han J and Ahn MJ: Clinical impact of phosphorylated signal transducer and activator of transcription 3, epidermal growth factor receptor, p53, and vascular endothelial growth factor receptor 1 expression in resected adenocarcinoma of lung by using tissue microarray. Cancer 116: 676-685, 2010.
    • (2010) Cancer , vol.116 , pp. 676-685
    • Kim, H.S.1    Park, Y.H.2    Lee, J.3    Ahn, J.S.4    Kim, J.5    Shim, Y.M.6    Kim, J.H.7    Park, K.8    Han, J.9    Ahn, M.J.10
  • 12
    • 71649115559 scopus 로고    scopus 로고
    • Expression of signal transducer and activator of transcription 3 and suppressor of cytokine signaling 3 in urothelial carcinoma
    • Huang WT, Yang SF, Wu CC, Chen WT, Huang YC, Su YC and Chai CY: Expression of signal transducer and activator of transcription 3 and suppressor of cytokine signaling 3 in urothelial carcinoma. Kaohsiung J Med Sci 25: 640-646, 2009.
    • (2009) Kaohsiung J Med Sci , vol.25 , pp. 640-646
    • Huang, W.T.1    Yang, S.F.2    Wu, C.C.3    Chen, W.T.4    Huang, Y.C.5    Su, Y.C.6    Chai, C.Y.7
  • 13
    • 0034775824 scopus 로고    scopus 로고
    • The suppressors of cytokine signalling (SOCS)
    • Kile BT and Alexander WS: The suppressors of cytokine signalling (SOCS). Cell Mol Life Sci 58: 1627-1635, 2001.
    • (2001) Cell Mol Life Sci , vol.58 , pp. 1627-1635
    • Kile, B.T.1    Alexander, W.S.2
  • 14
    • 33646092270 scopus 로고    scopus 로고
    • SOCS3 was induced by hypoxia and suppressed STAT3 phosphorylation in pulmonary arterial smooth muscle cells
    • Bai L, Yu Z, Qian G, Qian P, Jiang J, Wang G and Bai C: SOCS3 was induced by hypoxia and suppressed STAT3 phosphorylation in pulmonary arterial smooth muscle cells. Respir Physiol Neurobiol 152: 83-91, 2006.
    • (2006) Respir Physiol Neurobiol , vol.152 , pp. 83-91
    • Bai, L.1    Yu, Z.2    Qian, G.3    Qian, P.4    Jiang, J.5    Wang, G.6    Bai, C.7
  • 15
    • 0036233585 scopus 로고    scopus 로고
    • Cytokine signaling in 2002: New surprises in the Jak/Stat pathway
    • O'Shea JJ, Gadina M and Schreiber RD: Cytokine signaling in 2002: new surprises in the Jak/Stat pathway. Cell 109: S121- S131, 2002.
    • (2002) Cell , vol.109
    • O'Shea, J.J.1    Gadina, M.2    Schreiber, R.D.3
  • 16
    • 78651053628 scopus 로고
    • Primary carcinoma of the liver: A study of 100 cases among 48, 900 necropsies
    • Edmondson HA and Steiner PE: Primary carcinoma of the liver: a study of 100 cases among 48, 900 necropsies. Cancer 7: 462-503, 1954.
    • (1954) Cancer , vol.7 , pp. 462-503
    • Edmondson, H.A.1    Steiner, P.E.2
  • 17
    • 40749099079 scopus 로고    scopus 로고
    • Prognostic signifcance of MMP-9 and TIMP-1 serum and tissue expression in breast cancer
    • Wu ZS, Wu Q, Yang JH, Wang HQ, Ding XD, Yang F and Xu XC: Prognostic signifcance of MMP-9 and TIMP-1 serum and tissue expression in breast cancer. Int J Cancer 122: 2050-2056, 2008.
    • (2008) Int J Cancer , vol.122 , pp. 2050-2056
    • Wu, Z.S.1    Wu, Q.2    Yang, J.H.3    Wang, H.Q.4    Ding, X.D.5    Yang, F.6    Xu, X.C.7
  • 18
    • 77957560959 scopus 로고    scopus 로고
    • MiR-339-5p inhibits breast cancer cell migration and invasion in vitro and may be a potential biomarker for breast cancer prognosis
    • Wu ZS, Wu Q, Wang CQ, Wang XN, Wang Y, Zhao JJ, Mao SS, Zhang GH, Zhang N and Xu XC: MiR-339-5p inhibits breast cancer cell migration and invasion in vitro and may be a potential biomarker for breast cancer prognosis. BMC Cancer 10: 542, 2010.
    • (2010) BMC Cancer , vol.10 , pp. 542
    • Wu, Z.S.1    Wu, Q.2    Wang, C.Q.3    Wang, X.N.4    Wang, Y.5    Zhao, J.J.6    Mao, S.S.7    Zhang, G.H.8    Zhang, N.9    Xu, X.C.10
  • 19
    • 77149155643 scopus 로고    scopus 로고
    • Disease-related expression of the IL6/STAT3/SOCS3 signalling pathway in ulcerative colitis and ulcerative colitis-related carcinogenesis
    • Li Y, de Haar C, Chen M, Deuring J, Gerrits MM, Smits R, Xia B, Kuipers EJ and van der Woude CJ: Disease-related expression of the IL6/STAT3/SOCS3 signalling pathway in ulcerative colitis and ulcerative colitis-related carcinogenesis. Gut 59: 227-235, 2010.
    • (2010) Gut , vol.59 , pp. 227-235
    • Li, Y.1    de Haar, C.2    Chen, M.3    Deuring, J.4    Gerrits, M.M.5    Smits, R.6    Xia, B.7    Kuipers, E.J.8    van der Woude, C.J.9
  • 20
    • 0036153461 scopus 로고    scopus 로고
    • Ki67 protein: The immaculate deception?
    • Brown DC and Gatter KC: Ki67 protein: the immaculate deception? Histopathology 40: 2-11, 2002.
    • (2002) Histopathology , vol.40 , pp. 2-11
    • Brown, D.C.1    Gatter, K.C.2
  • 21
    • 50449106127 scopus 로고    scopus 로고
    • SOCS-3 is associated with vascular invasion and overall survival in hepatocellular carcinoma
    • Yang SF, Yeh YT, Wang SN, Hung SC, Chen WT, Huang CH and Chai CY: SOCS-3 is associated with vascular invasion and overall survival in hepatocellular carcinoma. Pathology 40: 558-563, 2008.
    • (2008) Pathology , vol.40 , pp. 558-563
    • Yang, S.F.1    Yeh, Y.T.2    Wang, S.N.3    Hung, S.C.4    Chen, W.T.5    Huang, C.H.6    Chai, C.Y.7
  • 22
    • 85047695527 scopus 로고    scopus 로고
    • Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis
    • Niu G, Wright KL, Huang M, et al: Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis. Oncogene 21: 2000-2008, 2002.
    • (2002) Oncogene , vol.21 , pp. 2000-2008
    • Niu, G.1    Wright, K.L.2    Huang, M.3
  • 23
    • 2542478996 scopus 로고    scopus 로고
    • The role of suppressors of cytokine signaling (SOCS) proteins in regulation of the immune response
    • Alexander WS and Hilton DJ: The role of suppressors of cytokine signaling (SOCS) proteins in regulation of the immune response. Annu Rev Immunol 22: 503-529, 2004.
    • (2004) Annu Rev Immunol , vol.22 , pp. 503-529
    • Alexander, W.S.1    Hilton, D.J.2
  • 24
    • 20144367654 scopus 로고    scopus 로고
    • Negative regulation of cytokine signaling and immune responses by SOCS proteins
    • Yoshimura A, Nishinakamura H, Matsumura Y and Hanada T: Negative regulation of cytokine signaling and immune responses by SOCS proteins. Arthritis Res Ther 7: 100-110, 2005.
    • (2005) Arthritis Res Ther , vol.7 , pp. 100-110
    • Yoshimura, A.1    Nishinakamura, H.2    Matsumura, Y.3    Hanada, T.4
  • 26
    • 68949199430 scopus 로고    scopus 로고
    • Restoration of SOCS3 suppresses human lung adeno-carcinoma cell growth by downregulating activation of Erk1/2, Akt apart from STAT3
    • Yu ZB, Bai L, Qian P, Xiao YB, Wang GS, Qian GS, Bai CX and Min JX: Restoration of SOCS3 suppresses human lung adeno-carcinoma cell growth by downregulating activation of Erk1/2, Akt apart from STAT3. Cell Biol Int 33: 995-1001, 2009.
    • (2009) Cell Biol Int , vol.33 , pp. 995-1001
    • Yu, Z.B.1    Bai, L.2    Qian, P.3    Xiao, Y.B.4    Wang, G.S.5    Qian, G.S.6    Bai, C.X.7    Min, J.X.8
  • 27
    • 0037938816 scopus 로고    scopus 로고
    • SOCS3 negatively regulates IL-6 signaling in vivo
    • Croker BA, Krebs DL, Zhang JG, et al: SOCS3 negatively regulates IL-6 signaling in vivo. Nat Immunol 4: 540-545, 2003.
    • (2003) Nat Immunol , vol.4 , pp. 540-545
    • Croker, B.A.1    Krebs, D.L.2    Zhang, J.G.3
  • 28
    • 77956060906 scopus 로고    scopus 로고
    • Loss of SOCS3 expression is associated with an increased risk of recurrent disease in breast carcinoma
    • Ying M, Li D, Yang L, Wang M, Wang N, Chen Y, He M and Wang Y: Loss of SOCS3 expression is associated with an increased risk of recurrent disease in breast carcinoma. J Cancer Res Clin Oncol 136: 1617-1626, 2010.
    • (2010) J Cancer Res Clin Oncol , vol.136 , pp. 1617-1626
    • Ying, M.1    Li, D.2    Yang, L.3    Wang, M.4    Wang, N.5    Chen, Y.6    He, M.7    Wang, Y.8
  • 30
    • 0037108433 scopus 로고    scopus 로고
    • Constitutive expression of SOCS3 confers resistance to IFN-alpha in chronic myelogenous leukemia cells
    • Sakai I, Takeuchi K, Yamauchi H, Narumi H and Fujita S: Constitutive expression of SOCS3 confers resistance to IFN-alpha in chronic myelogenous leukemia cells. Blood 100: 2926 -2931, 2002.
    • (2002) Blood , vol.100 , pp. 2926-2931
    • Sakai, I.1    Takeuchi, K.2    Yamauchi, H.3    Narumi, H.4    Fujita, S.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.