The path to epigenetic treatment of memory disorders

Neurobiology of Learning and Memory

Volumn 96, Issue 1, 2011, Pages 13-18

  Mikaelsson, Mikael A ^a   Miller, Courtney A ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Acetylation; Alzheimer's disease; Chromatin; Epigenetics; Histone; Learning; Memory; Methylation

Indexed keywords

BETA SECRETASE INHIBITOR; CHOLINESTERASE INHIBITOR; DNA METHYLTRANSFERASE INHIBITOR; HISTONE; HISTONE DEACETYLASE INHIBITOR; MEMANTINE; VORINOSTAT;

AGING; ALZHEIMER DISEASE; ARTICLE; CHROMATIN; COGNITION; DEGENERATIVE DISEASE; DNA METHYLATION; DNA MODIFICATION; DRUG EFFICACY; DRUG MECHANISM; EPIGENETICS; HISTONE MODIFICATION; HUMAN; LEARNING; MEMORY DISORDER; NONHUMAN; RISK FACTOR;

BRAIN; CHROMATIN; DNA METHYLATION; EPIGENESIS, GENETIC; EPIGENOMICS; HUMANS; MEMORY; MEMORY DISORDERS;

EID: 79957983741     PISSN: 10747427     EISSN: 10959564     Source Type: Journal    
DOI: 10.1016/j.nlm.2011.02.003     Document Type: Article

References (51)

1. Alarcón J.M., Malleret G., Touzani K., Vronskaya S., Ishii S., Kandel E.R., et al. Chromatin acetylation, memory, LTP are impaired in CBP+/- mice: A model for cognitive deficit in Rubinstein-Taybi syndrome and its amelioration. Neuron 2004, 42:947-957.
2. Anekonda T.S. Resveratrol-A boon for treating Alzheimer's disease. Brain Research Reviews 2006, 52:316-326.
3. Bachmann I.M., Halvorsen O.J., Collett K., Stefansson I.M., Straumer O., Haukaas S.A., et al. EZH2 expression is associated with high proliferation rate and aggressive tumor subgroups in cutaneous melanoma and cancers of the endometrium, prostate, and breast. Journal of Clinical Oncology 2006, 24:268-273.
4. Balasubramanian S., Verner E., Buggy J.J. Isoform-specific histone deacetylase inhibitors: The next step. Cancer Letters 2009, 280:211-221.
5. Bhattacharya S.K., Ramchandani S., Cervoni N., Szyf M. A mammalian protein with specific demethylase activity for mCpG DNA. Nature 1999, 397:579-583.
6. Cao X., Südhof T.C. A transcriptively active complex of APP with Fe65 and histone acetyltransferase Tip60. Science 2001, 293:115-120.
7. Chwang W.B., O'Riordan K.J., Levenson J.M., Sweatt J.D. ERK/MAPK regulates hippocampal histone phosphorylation following contextual fear conditioning. Learning and Memory 2006, 13:322-328.
8. Drake J., Petroze R., Castegna A., Ding Q., Keller J.N., Markesbery W.R., et al. 4-Hydroxynonenal oxidatively modifies histones: Implications for Alzheimer's disease. Neuroscience Letters 2004, 356:155-158.
9. Ellinger J., Kahl P., von der Gathen J., Rogenhofer S., Heukamp L.C., Gütgemann I., et al. Global levels of histone modifications predict prostate cancer recurrence. Prostate 2010, 70:61-69.
10. Feng J., Zhou Y., Campell S.L., Le T., Li E., Sweatt J.D., et al. Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons. Nature Neuroscience 2010, 13:423-430.
11. Fischer A., Sananbenesi F., Wang X., Dobbin M., Tsai L.H. Recovery of learning and memory is associated with chromatin remodeling. Nature 2007, 447:178-182.
12. Gräff J., Mansuy I.M. Epigenetic code in cognition and behaviour. Behavioural Brain Research 2008, 192:70-87.
13. Guan J.S., Haggarty S.J., Giacometti E., Dannenberg J.H., Joseph J., Gao J., et al. HDAC2 negatively regulates memory formation and synaptic plasticity. Nature 2009, 459:55-60.
14. Gupta S., Kim S.Y., Artis S., Molfese D.L., Schumacher A., Sweatt J.D., et al. Histone methylation regulates memory formation. Journal of Neuroscience 2010, 30:3589-3599.
15. Jones P.A., Baylin S.B. The epigenomics of cancer. Cell 2007, 128:683-692.
16. Kangaspeska S., Stride B., Metivier R., Polycarpou-Schwarz M., Ibberson D., Carmouche R.P., et al. Transient cyclical methylation of promoter DNA. Nature 2008, 452:112-115.
17. Katzman R., Terry R., DeTeresa R., Brown T., Davies P., Fuld P., et al. Clinical, pathological, and neurochemical changes in dementia: A subgroup with preserved mental status and numerous neocortical plaques. Annals of Neurology 1988, 23:138-144.
18. Kelly T.K., De Carvalho D.D., Jones P.A. Epigenetic modifications as therapeutic targets. Nature Biotechnology 2010, 28:1069-1078.
19. Kilgore M., Miller C.A., Fass D.M., Hennig K.M., Haggarty S.J., Sweatt J.D., et al. Inhibitors of class 1 histone deacetylases reverse contextual memory deficits in a mouse model of Alzheimer's disease. Neuropsychopharmacology 2010, 35:870-880.
20. Kim M.S., Kondo T., Takada I., Youn M.Y., Yamamoto Y., Takahashi S., et al. DNA demethylation in hormone-induced transcriptional derepression. Nature 2009, 461:1007-1012.
21. Korzus E., Rosenfeld M.G., Mayford M. CBP histone acetyltransferase activity is a critical component of memory consolidation. Neuron 2004, 42:961-972.
22. Koshibu K., Gräff J., Beullens M., Heitz F.D., Berchtold D., Russig H., et al. Protein phosphatase 1 regulates the histone code for long-term memory. Journal of Neuroscience 2009, 29:13079-13089.
23. Levenson J.M., O'Riordan K.J., Brown K.D., Trinh M.A., Molfese D.L., Sweatt J.D. Regulation of histone acetylation during memory formation in the hippocampus. The Journal of Biological Chemistry 2004, 279:405450-405459.
24. Levenson J.M., Roth T.L., Lubin F.D., Miller C.A., Huang I.C., Desai P., et al. Evidence that DNA (cytosine-5) methyltransferase regulates synaptic plasticity in the hippocampus. Journal of Biological Chemistry 2006, 281:15763-17773.
25. Lubin F.D., Roth T.L., Sweatt J.D. Epigenetic regulation of BDNF gene transcription in the consolidation of fear memory. Journal of Neuroscience 2008, 28:10576-10586.
26. Ma D.K., Jang M.H., Guo J.U., Kitabatake Y., Chang M.L., Pow-Anpongkul N., et al. Neuronal activity-induced Gadd45b promotes epigenetic DNA demethylation and adult neurogenesis. Science 2009, 323:1074-1077.
27. Marambaud P., Wen P.H., Dutt A., Shioi J., Takashima A., Siman R., et al. A CBP binding transcriptional repressor produced by the PS1/epsilon-cleavage of N-cadherin is inhibited by PS1 FAD mutation. Cell 2003, 114:635-645.
28. Mastroeni D., Grover A., Delvaux E., Whiteside C., Coleman P.D., Rogers J. Epigenetic changes in Alzheimer's disease: Decrements in DNA methylation. Neurobiology of Aging 2010, 31:2025-2037.
29. Metivier R., Gallais R., Tiffoche C., Le Peron C., Jurkowska R.Z., Carmouche R.P., et al. Cyclical DNA methylation of a transcriptionally active promoter. Nature 2008, 452:45-50.
30. Miller C.A., Campbell S.L., Sweatt J.D. DNA methylation and histone acetylation work in concert to regulate memory formation and synaptic plasticity. Neurobiology of Learning and Memory 2008, 89:599-603.
31. Miller C.A., Gavin C.F., White J.A., Parrish R.R., Honasoge A., Yancey C.R., et al. Cortical DNA methylation maintains remote memory. Nature Neuroscience 2010, 13:664-666.
32. Miller C.A., Sweatt J.D. Covalent modification of DNA regulates memory function. Neuron 2007, 53:857-869.
33. Min S.W., Cho S.H., Zhou Y., Schroeder S., Haroutunian V., Seeley W.W., et al. Acetylation of Tau inhibits its degradation and contributes to Tauopathy. Neuron 2010, 67:953-966.
34. Myung N.H., Zhu X., Kruman I.I., Castellani R.J., Petersen R.B., Siedlak S.L., et al. Evidence of DNA damage in Alzheimers disease: Phosphorylation of histone H2AX in astroctyes. Age 2008, 30:209-215.
35. Oliveira A.M., Wood M.A., McDonough C.B., Abel T. Transgenic mice expressing an inhibitory truncated form of p300 exhibit long-term memory deficit. Learning and Memory 2007, 14:564-572.
36. Outeiro T.F., Marques O., Kazantsev A. Therapeutic role of sirtuins in neurodegenerative disease. Biochimica et Biophysica Acta 2008, 1782:363-369.
37. Peleg S., Sananbenesi F., Zovoilis A., Burkhardt S., Bahari-Javan S., Agis-Balboa R.C., et al. Altered histone acetylation is associated with age-dependent memory impairment in mice. Science 2010, 328:753-756.
38. Ricobaraza A., Cuadrado-Tejedor M., Pérez-Mediavilla A., Frechilla D., Del Río J., García-Osta A. Phenylbutyrate ameliorates cognitive deficit and reduces tau pathology in an Alzheimer's disease mouse model. Neuropsychopharmacology 2009, 34:1721-1732.
39. Roe C.M., Mintun M.A., D'Angelo G., Xiong C., Grant E.A., Morris J.C. Alzheimer disease and cognitive reserve: Variation of education effect with carbon 11-labeled Pittsburgh Compound B uptake. Archives of Neurology 2008, 65:1467-1471.
40. Saura C.A., Choi S.Y., Beglopoulos V., Malkani S., Zhang D., Shankaranarayana Rao B.S., et al. Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration. Neuron 2004, 42:23-36.
41. Scarpa S., Fuso A., D'Anselmi F., Cavallaro R.A. Presenilin 1 gene silencing by S-adenosylmethionine: A treatment for Alzheimer disease?. FEBS letters 2003, 541:145-148.
42. Stefanko D.P., Barrett R.M., Ly A.R., Reolon G.K., Wood M.A. Modulation of long-term memory for object recognition via HDAC inhibition. Proceedings of the National Academy of Sciences 2009, 106:9447-9452.
43. Swank M.W., Sweatt J.D. Increased histone acetyltransferase and lysine acetyltransferase activity and biphasic activation of the ERK/RSK cascasde in insular cortex during novel taste learning. Journal of Neuroscience 2001, 21:3383-3391.
44. Tohgi H., Utsugisawa K., Nagane Y., Yoshimura M., Genda Y., Ukitsu M. Reduction with age in methylcytosine in the promoter region -224 approximately -101 of the amyloid precursor protein gene in autopsy human cortex. Molecular Brain Research 1999, 70:288-292.
45. Vecsey C.G., Hawk J.D., Lattal K.M., Stein J.M., Fabian S.A., Attner M.A., et al. Histone deacetylase inhibitors enhance memory and synaptic plasticity via CREB: CBP-dependent transcriptional activation. Journal of Neuroscience 2007, 27:6128-6140.
46. Wang J., Fivecoat H., Ho L., Pan Y., Ling E., Pasinetti G.M. The role of Sirt1: At the crossroad between promotion of longevity and protection against Alzheimer's disease neuropathology. Biochimica et Biophysica Acta 2010, 1804:1690-1694.
47. Wenk G.L. Neuropathologic changes in Alzheimer's disease. Journal of Clinical Psychiatry 2003, 64:7-10.
48. West R.L., Lee J.M., Maroun L.E. Hypomethylation of the amyloid precursor protein gene in the brain of an Alzheimer's disease patient. Journal of Molecular Neuroscience 1995, 6:141-146.
49. Wilson R.S., Herbert L.E., Scherr P.A., Barnes L.L., Mendes de Leon C.F., Evans D.A. Educational attainment and cognitive decline in old age. Neurology 2009, 72:460-465.
50. Wood M.A., Attner M.A., Oliveira A.M., Brindle P.K., Abel T. A transcription factor-binding domain of the coactivator CBP is essential for long-term memory and the expression of specific target genes. Learning and Memory 2006, 13:609-617.
51. Wood M.A., Kaplan M.P., Park A., Blanchard E.J., Oliveira A.M., Lombardi T.L., et al. Transgenic mice expressing a truncated form of CREB-binding protein (CBP) exhibit deficits in hippocampal synaptic plasticity and memory storage. Learning and Memory 2005, 12:111-119.