Polymorphism in 3'-untranslated region of toll-like receptor 4 gene is associated with protection from hepatitis B virus recurrence after liver transplantation

Transplant Infectious Disease

Volumn 13, Issue 3, 2011, Pages 250-258

  Zhou, L ^a,b   Wei, B ^a,b   Xing, C ^a,b   Xie, H ^a,b   Yu, X ^a,b   Wu, L ^a,b   Zheng, Shusen ^a,b  

^a ZHEJIANG UNIVERSITY   (China)

^b ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

HBV recurrence; Liver transplantation; Single nucleotide polymorphism; Toll like receptor

Indexed keywords

ADEFOVIR; CYCLOSPORIN; GENOMIC DNA; HEPATITIS B ANTIBODY; HEPATITIS B SURFACE ANTIGEN; LAMIVUDINE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISONE; RAPAMYCIN; TACROLIMUS; TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 10; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 5; TOLL LIKE RECEPTOR 6; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8; TOLL LIKE RECEPTOR 9; VIRUS DNA;

3' UNTRANSLATED REGION; ADULT; AGED; ANTIVIRAL THERAPY; ARTICLE; CHINESE; CONTROLLED STUDY; DRUG DOSE REDUCTION; DRUG MEGADOSE; DRUG SUBSTITUTION; DRUG WITHDRAWAL; FEMALE; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENOTYPE; HAPLOTYPE; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; INFECTION PREVENTION; LIVER GRAFT REJECTION; LIVER TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; NONHUMAN; POLYMERASE CHAIN REACTION; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; PROTEIN FUNCTION; RECURRENCE RISK; RECURRENT VIRUS INFECTION; RISK REDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; TREATMENT INDICATION; VIRUS IMMUNITY;

3' UNTRANSLATED REGIONS; ADULT; AGED; ASIAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HEPATITIS B; HEPATITIS B VIRUS; HUMANS; LIVER TRANSPLANTATION; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RECURRENCE; TOLL-LIKE RECEPTOR 4; YOUNG ADULT;

EID: 79957972183     PISSN: 13982273     EISSN: 13993062     Source Type: Journal    
DOI: 10.1111/j.1399-3062.2010.00574.x     Document Type: Article

References (36)

1. World Health Organization/Hepatitis B, 2002. Available at
2. Ministry of Health, China/Seroepidemiological survey of hepatitis B, 2008. Available at
3. Papatheodoridis GV, Cholongitas E, Archimandritis AJ, et al. Current management of hepatitis B virus infection before and after liver transplantation. Liver Int 2009; 29 (9): 1294-1305.
4. Kiyici M, Yilmaz M, Akyildiz M, et al. Association between hepatitis B and hepatocellular carcinoma recurrence in patients undergoing liver transplantation. Transplant Proc 2008; 40 (5): 1511-1517.
5. Limquiaco JL, Wong J, Wong VW, et al. Lamivudine monoprophylaxis and adefovir salvage for liver transplantation in chronic hepatitis B: a seven-year follow-up study. J Med Virol 2009; 81 (2): 224-229.
6. Uematsu S, Akira S. Toll-like receptors and innate immunity. J Mol Med 2006; 84 (9): 712-725.
7. Bochud PY, Sinsimer D, Aderem A, et al. Polymorphisms in Toll-like receptor 4 (TLR4) are associated with protection against leprosy. Eur J Clin Microbiol Infect Dis 2009; 28 (9): 1055-1065.
8. Davila S, Hibberd ML, Hari DR, et al. Genetic association and expression studies indicate a role of toll-like receptor 8 in pulmonary tuberculosis. PLoS Genet 2008; 4 (10): e1000218.
9. Agnese DM, Calvano JE, Hahm SJ, et al. Human toll-like receptor 4 mutations but not CD14 polymorphisms are associated with an increased risk of gram-negative infections. J Infect Dis 2002; 186 (10): 1522-1525.
10. Eid AJ, Brown RA, Paya CV, et al. Association between toll-like receptor polymorphisms and the outcome of liver transplantation for chronic hepatitis C virus. Transplantation 2007; 84 (4): 511-516.
11. Kijpittayarit S, Eid AJ, Brown RA, et al. Relationship between toll-like receptor 2 polymorphism and cytomegalovirus disease after liver transplantation. Clin Infect Dis 2007; 44 (10): 1315-1320.
12. Isogawa M, Robek MD, Furuichi Y, et al. Toll-like receptor signaling inhibits hepatitis B virus replication in vivo. J Virol 2005; 79 (11): 7269-7272.
13. Xia C, Lu M, Zhang Z, et al. TLRs antiviral effect on hepatitis B virus in HepG2 cells. J Appl Microbiol 2008; 105 (5): 1720-1727.
14. Shimazu R, Akashi S, Ogata H, et al. MD-2, a molecule that confers lipopolysaccharide responsiveness on toll-like receptor 4. J Exp Med 1999; 189 (11): 1777-1782.
15. Kurt-Jones EA, Popova L, Kwinn L, et al. Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus. Nat Immunol 2000; 1 (5): 398-401.
16. Haynes LM, Moore DD, Kurt-Jones EA, et al. Involvement of toll-like receptor 4 in innate immunity to respiratory syncytial virus. J Virol 2001; 75 (22): 10730-10737.
17. Bochud PY, Chien JW, Marr KA, et al. Toll-like receptor 4 polymorphisms and aspergillosis in stem-cell transplantation. N Engl J Med 2008; 359 (17): 1766-1777.
18. Hwang YH, Ro H, Choi I, et al. Impact of polymorphisms of TLR4/CD14 and TLR3 on acute rejection in kidney transplantation. Transplantation 2009; 88 (5): 699-705.
19. Zheng SL, Augustsson-Balter K, Chang B, et al. Sequence variants of toll-like receptor 4 are associated with prostate cancer risk: results from the Cancer Prostate in Sweden study. Cancer Res 2004; 64 (8): 2918-2922.
20. Fukusaki T, Ohara N, Hara Y, et al. Evidence for association between a toll-like receptor 4 gene polymorphism and moderate/severe periodontitis in the Japanese population. J Periodontal Res 2007; 42 (6): 541-545.
21. Hishida A, Matsuo K, Goto Y, et al. Toll-like receptor 4+3725 G/C polymorphism, Helicobacter pylori seropositivity, and the risk of gastric atrophy and gastric cancer in Japanese. Helicobacter 2009; 14 (1): 47-53.
22. Di Paola R, Frittitta L, Miscio G, et al. A variation in 3' UTR of hPTP1B increases specific gene expression and associates with insulin resistance. Am J Hum Genet 2002; 70 (3): 806-812.
23. Cok SJ, Morrison AR. The 3'-untranslated region of murine cyclooxygenase-2 contains multiple regulatory elements that alter message stability and translational efficiency. J Biol Chem 2001; 276 (25): 23179-23185.
24. Reddy KK, Oitomen FM, Patel GP, et al. Perinuclear localization of slow troponin C mRNA in muscle cells is controlled by a cis-element located at its 3' untranslated region. Rna 2005; 11 (3): 294-307.
25. Thio GL, Ray RP, Barcelo G, et al. Localization of gurken RNA in Drosophila oogenesis requires elements in the 5' and 3' regions of the transcript. Dev Biol 2000; 221 (2): 435-446.
26. Tanguay RL, Gallie DR. Translational efficiency is regulated by the length of the 3' untranslated region. Mol Cell Biol 1996; 16 (1): 146-156.
27. Duan ZX, Zhu PF, Dong H, et al. Functional significance of the TLR4/11367 polymorphism identified in Chinese Han population. Shock 2007; 28 (2): 160-164.
28. Chen Z, Cheng YM, Xu YF, et al. Expression profiles and function of Toll-like receptors 2 and 4 in peripheral blood mononuclear cells of chronic hepatitis B patients. Clin Immunol 2008; 128 (3): 400-408.
29. Lian JQ, Wang XQ, Zhang Y, et al. Correlation of Circulating TLR2/4 Expression with CD3(+)/4(+)/8(+) T Cells and Treg cells in HBV-Related Liver Cirrhosis. Viral Immunol 2009; 22 (5): 301-308.
30. Zhang Y, Lian JQ, Huang CX, et al. Overexpression of Toll-like receptor 2/4 on monocytes modulates the activities of CD4(+)CD25(+) regulatory T cells in chronic hepatitis B virus infection. Virology 2010; 397 (1): 34-42.
31. Chuang TH, Ulevitch RJ. Cloning and characterization of a sub-family of human Toll-like receptors: hTLR7, hTLR8 and hTLR9. Eur Cytokine Netw 2000; 11 (3): 372-378.
32. Du X, Poltorak A, Wei Y, et al. Three novel mammalian toll-like receptors: gene structure, expression, and evolution. Eur Cytokine Netw 2000; 11 (3): 362-371.
33. Thomas A, Laxton C, Rodman J, et al. Investigating Toll-like receptor agonists for potential to treat hepatitis C virus infection. Antimicrob Agents Chemother 2007; 51 (8): 2969-2978.
34. Oh DY, Taube S, Hamouda O, et al. A functional toll-like receptor 8 variant is associated with HIV disease restriction. J Infect Dis 2008; 198 (5): 701-709.
35. Moller-Larsen S, Nyegaard M, Haagerup A, et al. Association analysis identifies TLR7 and TLR8 as novel risk genes in asthma and related disorders. Thorax 2008; 63 (12): 1064-1069.
36. Faria LC, Gigou M, Roque-Afonso AM, et al. Hepatocellular carcinoma is associated with an increased risk of hepatitis B virus recurrence after liver transplantation. Gastroenterology 2008; 134 (7): 1890-1899, 2155.