Overexpression of Toll-like receptor 2/4 on monocytes modulates the activities of CD4+CD25+ regulatory T cells in chronic hepatitis B virus infection

Virology

Volumn 397, Issue 1, 2010, Pages 34-42

  Zhang, Ye ^a   Lian, Jian Qi ^a   Huang, Chang Xing ^a   Wang, Jiu Ping ^a   Wei, Xin ^a   Nan, Xue Ping ^a   Yu, Hai Tao ^a   Jiang, Li Li ^a   Wang, Xiao Qin ^a   Zhuang, Yan ^a   Li, Xin Hong ^a   Li, Yu ^a   Wang, Ping Zhong ^a   Robek, Michael D ^b   Bai, Xue Fan ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Hepatitis B virus; immunoregulation; innate immune; Regulatory T cells; Toll like receptors

Indexed keywords

CD27 ANTIGEN; CD4 ANTIGEN; HEPATITIS B CORE ANTIGEN; HEPATITIS B(E) ANTIGEN; INTERLEUKIN 2 RECEPTOR ALPHA; LIPOPOLYSACCHARIDE; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4;

ADULT; ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CONTROLLED STUDY; FEMALE; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; HUMAN CELL; IMMUNOLOGICAL TOLERANCE; IMMUNOMODULATION; LYMPHOCYTE FUNCTION; MAJOR CLINICAL STUDY; MALE; MONOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; UPREGULATION; VIRUS CARRIER;

ADULT; ANTIGENS, CD14; ANTIGENS, CD4; FEMALE; FLOW CYTOMETRY; HEPATITIS B VIRUS; HEPATITIS B, CHRONIC; HUMANS; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; INTERLEUKIN-7 RECEPTOR ALPHA SUBUNIT; MALE; MONOCYTES; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, REGULATORY; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4; YOUNG ADULT;

HEPATITIS B VIRUS;

EID: 73949089928     PISSN: 00426822     EISSN: 10960341     Source Type: Journal    
DOI: 10.1016/j.virol.2009.11.007     Document Type: Article

References (38)

1. Akira S., and Takeda K. Toll-like receptor signalling. Nat. Rev. Immunol. 4 7 (2004) 499-511
2. Barboza L., Salmen S., Goncalves L., Colmenares M., Peterson D., Montes H., Cartagirone R., Gutierrez Mdel C., and Berrueta L. Antigen-induced regulatory T cells in HBV chronically infected patients. Virology 368 1 (2007) 41-49
3. Boettler T., Spangenberg H.C., Neumann-Haefelin C., Panther E., Urbani S., Ferrari C., Blum H.E., von Weizsacker F., and Thimme R. T cells with a CD4+CD25+ regulatory phenotype suppress in vitro proliferation of virus-specific CD8+ T cells during chronic hepatitis C virus infection. J. Virol. 79 12 (2005) 7860-7867
4. Cao D., Malmstrom V., Baecher-Allan C., Hafler D., Klareskog L., and Trollmo C. Isolation and functional characterization of regulatory CD25brightCD4+ T cells from the target organ of patients with rheumatoid arthritis. Eur. J. Immunol. 33 1 (2003) 215-223
5. Caramalho I., Lopes-Carvalho T., Ostler D., Zelenay S., Haury M., and Demengeot J. Regulatory T cells selectively express toll-like receptors and are activated by lipopolysaccharide. J. Exp. Med. 197 4 (2003) 403-411
6. Chen Z., Cheng Y., Xu Y., Liao J., Zhang X., Hu Y., Zhang Q., Wang J., Zhang Z., Shen F., and Yuan Z. Expression profiles and function of Toll-like receptors 2 and 4 in peripheral blood mononuclear cells of chronic hepatitis B patients. Clin. Immunol. 128 3 (2008) 400-408
7. Chisari F.V., and Ferrari C. Hepatitis B virus immunopathogenesis. Annu. Rev. Immunol. 13 (1995) 29-60
8. Dunham R.M., Cervasi B., Brenchley J.M., Albrecht H., Weintrob A., Sumpter B., Engram J., Gordon S., Klatt N.R., Frank I., Sodora D.L., Douek D.C., Paiardini M., and Silvestri G. CD127 and CD25 expression defines CD4+ T cell subsets that are differentially depleted during HIV infection. J. Immunol. 180 8 (2008) 5582-5592
9. Franzese O., Kennedy P.T., Gehring A.J., Gotto J., Williams R., Maini M.K., and Bertoletti A. Modulation of the CD8+-T-cell response by CD4+ CD25+ regulatory T cells in patients with hepatitis B virus infection. J. Virol. 79 6 (2005) 3322-3328
10. Guo Y.W., Wei X.Q., and Yang S.J. [A close relationship between viral hepatitis B and Toll-like receptor 2]. Zhonghua Gan Zang Bing Za Zhi 15 7 (2007) 485-488
11. Hartigan-O'Connor D.J., Poon C., Sinclair E., and McCune J.M. Human CD4+ regulatory T cells express lower levels of the IL-7 receptor alpha chain (CD127), allowing consistent identification and sorting of live cells. J. Immunol. Methods 319 1-2 (2007) 41-52
12. Heeg M.H., Ulsenheimer A., Gruner N.H., Zachoval R., Jung M.C., Gerlach J.T., Raziorrouh B., Schraut W., Horster S., Kauke T., Spannagl M., and Diepolder H.M. FOXP3 expression in hepatitis C virus-specific CD4+ T cells during acute hepatitis C. Gastroenterology 137 4 (2009) 1280-1288 e1-6
13. Hoofnagle J.H., Doo E., Liang T.J., Fleischer R., and Lok A.S. Management of hepatitis B: summary of a clinical research workshop. Hepatology 45 4 (2007) 1056-1075
14. Kinter A.L., Hennessey M., Bell A., Kern S., Lin Y., Daucher M., Planta M., McGlaughlin M., Jackson R., Ziegler S.F., and Fauci A.S. CD25(+)CD4(+) regulatory T cells from the peripheral blood of asymptomatic HIV-infected individuals regulate CD4(+) and CD8(+) HIV-specific T cell immune responses in vitro and are associated with favorable clinical markers of disease status. J. Exp. Med. 200 3 (2004) 331-343
15. Kondo Y., Kobayashi K., Ueno Y., Shiina M., Niitsuma H., Kanno N., Kobayashi T., and Shimosegawa T. Mechanism of T cell hyporesponsiveness to HBcAg is associated with regulatory T cells in chronic hepatitis B. World J. Gastroenterol. 12 27 (2006) 4310-4317
16. Liu G., and Zhao Y. Toll-like receptors and immune regulation: their direct and indirect modulation on regulatory CD4+ CD25+ T cells. Immunology 122 2 (2007) 149-156
17. Liu H., Komai-Koma M., Xu D., and Liew F.Y. Toll-like receptor 2 signaling modulates the functions of CD4+ CD25+ regulatory T cells. Proc. Natl. Acad. Sci. U.S.A. 103 18 (2006) 7048-7053
18. Liu W., Putnam A.L., Xu-Yu Z., Szot G.L., Lee M.R., Zhu S., Gottlieb P.A., Kapranov P., Gingeras T.R., Fazekas de St Groth B., Clayberger C., Soper D.M., Ziegler S.F., and Bluestone J.A. CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. J. Exp. Med. 203 7 (2006) 1701-1711
19. Lok A.S., and McMahon B.J. Chronic hepatitis B. Hepatology 34 6 (2001) 1225-1241
20. Longhi M.S., Mitry R.R., Samyn M., Scalori A., Hussain M.J., Quaglia A., Mieli-Vergani G., Ma Y., and Vergani D. Vigorous activation of monocytes in juvenile autoimmune liver disease escapes the control of regulatory T-cells. Hepatology 50 1 (2009) 130-142
21. Medzhitov R., Preston-Hurlburt P., and Janeway Jr. C.A. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 388 6640 (1997) 394-397
22. Naito H., Hayashi S., and Abe K. Rapid and specific genotyping system for hepatitis B virus corresponding to six major genotypes by PCR using type-specific primers. J. Clin. Microbiol. 39 1 (2001) 362-364
23. Pasare C., and Medzhitov R. Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells. Science 299 5609 (2003) 1033-1036
24. Peng G., Guo Z., Kiniwa Y., Voo K.S., Peng W., Fu T., Wang D.Y., Li Y., Wang H.Y., and Wang R.F. Toll-like receptor 8-mediated reversal of CD4+ regulatory T cell function. Science 309 5739 (2005) 1380-1384
25. Peng G., Li S., Wu W., Sun Z., Chen Y., and Chen Z. Circulating CD4+ CD25+ regulatory T cells correlate with chronic hepatitis B infection. Immunology 123 1 (2008) 57-65
26. Riordan S.M., Skinner N., Kurtovic J., Locarnini S., and Visvanathan K. Reduced expression of toll-like receptor 2 on peripheral monocytes in patients with chronic hepatitis B. Clin. Vaccine Immunol. 13 8 (2006) 972-974
27. Shen L.S., Wang J., Shen D.F., Yuan X.L., Dong P., Li M.X., Xue J., Zhang F.M., Ge H.L., and Xu D. CD4(+)CD25(+)CD127(low/-) regulatory T cells express Foxp3 and suppress effector T cell proliferation and contribute to gastric cancers progression. Clin. Immunol. 131 1 (2009) 109-118
28. Stoop J.N., van der Molen R.G., Baan C.C., van der Laan L.J., Kuipers E.J., Kusters J.G., and Janssen H.L. Regulatory T cells contribute to the impaired immune response in patients with chronic hepatitis B virus infection. Hepatology 41 4 (2005) 771-778
29. Sutmuller R.P., den Brok M.H., Kramer M., Bennink E.J., Toonen L.W., Kullberg B.J., Joosten L.A., Akira S., Netea M.G., and Adema G.J. Toll-like receptor 2 controls expansion and function of regulatory T cells. J. Clin. Invest. 116 2 (2006) 485-494
30. Visvanathan K., Skinner N.A., Thompson A.J., Riordan S.M., Sozzi V., Edwards R., Rodgers S., Kurtovic J., Chang J., Lewin S., Desmond P., and Locarnini S. Regulation of Toll-like receptor-2 expression in chronic hepatitis B by the precore protein. Hepatology 45 1 (2007) 102-110
31. Webster G.J., Reignat S., Brown D., Ogg G.S., Jones L., Seneviratne S.L., Williams R., Dusheiko G., and Bertoletti A. Longitudinal analysis of CD8+ T cells specific for structural and nonstructural hepatitis B virus proteins in patients with chronic hepatitis B: implications for immunotherapy. J. Virol. 78 11 (2004) 5707-5719
32. Wei X.Q., Guo Y.W., Liu J.J., Wen Z.F., Yang S.J., and Yao J.L. The significance of Toll-like receptor 4 (TLR4) expression in patients with chronic hepatitis B. Clin. Invest. Med. 31 3 (2008) E123-E130
33. Wu J., Lu M., Meng Z., Trippler M., Broering R., Szczeponek A., Krux F., Dittmer U., Roggendorf M., Gerken G., and Schlaak J.F. Toll-like receptor-mediated control of HBV replication by nonparenchymal liver cells in mice. Hepatology 46 6 (2007) 1769-1778
34. Xu D., Fu J., Jin L., Zhang H., Zhou C., Zou Z., Zhao J.M., Zhang B., Shi M., Ding X., Tang Z., Fu Y.X., and Wang F.S. Circulating and liver resident CD4+CD25+ regulatory T cells actively influence the antiviral immune response and disease progression in patients with hepatitis B. J. Immunol. 177 1 (2006) 739-747
35. Yamazaki S., Iyoda T., Tarbell K., Olson K., Velinzon K., Inaba K., and Steinman R.M. Direct expansion of functional CD25+ CD4+ regulatory T cells by antigen-processing dendritic cells. J. Exp. Med. 198 2 (2003) 235-247
36. Yang G., Liu A., Xie Q., Guo T.B., Wan B., Zhou B., and Zhang J.Z. Association of CD4+CD25+Foxp3+ regulatory T cells with chronic activity and viral clearance in patients with hepatitis B. Int. Immunol. 19 2 (2007) 133-140
37. Yu X.L., Cheng Y.M., Shi B.S., Qian F.X., Wang F.B., Liu X.N., Yang H.Y., Xu Q.N., Qi T.K., Zha L.J., Yuan Z.H., and Ghildyal R. Measles virus infection in adults induces production of IL-10 and is associated with increased CD4+ CD25+ regulatory T cells. J. Immunol. 181 10 (2008) 7356-7366
38. Yuh C.H., Chang Y.L., and Ting L.P. Transcriptional regulation of precore and pregenomic RNAs of hepatitis B virus. J. Virol. 66 7 (1992) 4073-4084