Association between peripheral γδ T-cell profile and disease progression in individuals infected with HIV-1 or HIV-2 in West Africa

Journal of Acquired Immune Deficiency Syndromes

Volumn 57, Issue 2, 2011, Pages 92-100

  Zheng, Natalie N ^a,b   McElrath, M Juliana ^a,b   Sow, Papa Salif ^c   Mesher, Andrew ^a   Hawes, Stephen E ^d   Stern, Joshua ^a   Gottlieb, Geoffrey S ^a   De Rosa, Stephen C ^a,b   Kiviat, Nancy B ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b USA   (United States)

^c UNIVERSITÉ CHEIKH ANTA DIOP   (Senegal)

^d UNIVERSITY OF WASHINGTON   (United States)

Author keywords

activation; Africa; gammadelta T cell; HIV 1; HIV 2; memory and effector phenotypes

Indexed keywords

CD27 ANTIGEN; CD28 ANTIGEN; CD38 ANTIGEN; CD45RO ANTIGEN; HLA DR ANTIGEN; VIRUS RNA;

ADOLESCENT; ADULT; ARTICLE; CD4 LYMPHOCYTE COUNT; CD8+ T LYMPHOCYTE; CELL EXPANSION; DISEASE COURSE; FEMALE; FLOW CYTOMETRY; GAMMA DELTA T LYMPHOCYTE; GAMMA DELTA1 T LYMPHOCYTE; GAMMA DELTA2 T LYMPHOCYTE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; HUMAN IMMUNODEFICIENCY VIRUS 2 INFECTION; MAJOR CLINICAL STUDY; MALE; MEMORY T LYMPHOCYTE; PHENOTYPE; PRIORITY JOURNAL; SENEGAL; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; VIRUS LOAD;

ADAPTIVE IMMUNITY; ADULT; BIOLOGICAL MARKERS; DISEASE PROGRESSION; FEMALE; HIV INFECTIONS; HIV-1; HIV-2; HUMANS; IMMUNITY, INNATE; IMMUNOLOGIC MEMORY; IMMUNOPHENOTYPING; LONGITUDINAL STUDIES; LYMPHOCYTE ACTIVATION; LYMPHOCYTE COUNT; MALE; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; RNA, VIRAL; SENEGAL; T-LYMPHOCYTE SUBSETS; VIRAL LOAD;

EID: 79957965070     PISSN: 15254135     EISSN: 10779450     Source Type: Journal    
DOI: 10.1097/QAI.0b013e318215a877     Document Type: Article

References (45)

1. Gottlieb GS, Sow PS, Hawes SE, et al. Equal plasma viral loads predict a similar rate of CD4+ T cell decline in human immunodeficiency virus (HIV) type 1-and HIV-2-infected individuals from Senegal, West Africa. J Infect Dis. 2002;185:905-914. (Pubitemid 34274433)
2. Kanki PJ, Travers KU, MBoup S, et al. Slower heterosexual spread of HIV-2 than HIV-1. Lancet. 1994;343:943-946. (Pubitemid 24117229)
3. Marlink R, Kanki P, Thior I, et al. Reduced rate of disease development after HIV-2 infection as compared to HIV-1. Science. 1994;265: 1587-1590. (Pubitemid 24308975)
4. Popper SJ, Sarr AD, Travers KU, et al. Lower human immunodeficiency virus (HIV) type 2 viral load reflects the difference in pathogenicity of HIV-1 and HIV-2. J Infect Dis. 1999;180:1116-1121. (Pubitemid 30070194)
5. Alfano M, Poli G. Role of cytokines and chemokines in the regulation of innate immunity and HIV infection. Mol Immunol. 2005;42:161-182. (Pubitemid 39361447)
6. Brandes M, Willimann K, Moser B. Professional antigen-presentation function by human gammadelta T Cells. Science. 2005;309:264-268. (Pubitemid 40967855)
7. Chen ZW, Letvin NL. Vgamma2Vdelta2+ T cells and anti-microbial immune responses. Microbes Infect. 2003;5:491-498. (Pubitemid 36575464)
8. Poccia F, Gougeon ML, Agrati C, et al. Innate T-cell immunity in HIV infection: the role of Vgamma9Vdelta2 T lymphocytes. Curr Mol Med. 2002;2:769-781. (Pubitemid 35390312)
9. Autran B, Triebel F, Katlama C, et al. T cell receptor gamma/delta+ lymphocyte subsets during HIV infection. Clin Expl Immunol. 1989;75: 206-210. (Pubitemid 19074247)
10. Deusch K, Luling F, Reich K, et al. A major fraction of human intraepithelial lymphocytes simultaneously expresses the gamma/delta T cell receptor, the CD8 accessory molecule and preferentially uses the V delta 1 gene segment. Eur J Immunol. 1991;21:1053-1059.
11. Poles MA, Barsoum S, YuW, et al. Human immunodeficiency virus type 1 induces persistent changes in mucosal and blood gammadelta T cells despite suppressive therapy. J Virol. 2003;77:10456-10467. (Pubitemid 37129690)
12. O'Brien RL, Roark CL, Jin N, et al. gammadelta T-cell receptors: functional correlations. Immunol Rev. 2007;215:77-88. (Pubitemid 46212231)
13. Glatzel A, Wesch D, Schiemann F, et al. Patterns of chemokine receptor expression on peripheral blood gamma delta T lymphocytes: strong expression of CCR5 is a selective feature of V delta 2/V gamma 9 gamma delta T cells. J Immunol. 2002;168:4920-4929. (Pubitemid 34498305)
14. Bonneville M, O'Brien RL, Born WK. Gammadelta T cell effector functions: a blend of innate programming and acquired plasticity. Nat Rev. 2010;10:467-478.
15. Kress E, Hedges JF, Jutila MA. Distinct gene expression in human Vdelta1 and Vdelta2 gammadelta T cells following non-TCR agonist stimulation. Mol Immunol. 2006;43:2002-2011.
16. De Paoli P, Gennari D, Martelli P, et al. A subset of gamma delta lymphocytes is increased during HIV-1 infection. Clin Exp Immunol. 1991;83:187-191.
17. Hinz T,Wesch D, Friese K, et al. T cell receptor gamma delta repertoire in HIV-1-infected individuals. Eur J Immunol. 1994;24:3044-3049.
18. Boullier S, Cochet M, Poccia F, et al. CDR3-independent gamma delta V delta 1+ T cell expansion in the peripheral blood of HIV-infected persons. J Immunol. 1995;154:1418-1431.
19. Harris LD, Klatt NR, Vinton C, et al. Mechanisms underlying {gamma}{delta} T cell subset perturbations in SIV-infected Asian rhesus macaques. Blood. 2010;116:4148-4157.
20. Sindhu ST, Ahmad R, Morisset R, et al. Peripheral blood cytotoxic gammadelta T lymphocytes from patients with human immunodeficiency virus type 1 infection and AIDS lyse uninfected CD4+ T cells, and their cytocidal potential correlates with viral load. J Virol. 2003;77:1848-1855. (Pubitemid 36109997)
21. Poccia F, Battistini L, Cipriani B, et al. Phosphoantigen-reactive Vgamma9Vdelta2 T lymphocytes suppress in vitro human immunodeficiency virus type 1 replication by cell-released antiviral factors including CC chemokines. J Infect Dis. 1999;180:858-861. (Pubitemid 29411378)
22. Imlach S, Leen C, Bell JE, et al. Phenotypic analysis of peripheral blood gammadelta T lymphocytes and their targeting by human immunodeficiency virus type 1 in vivo. Virology. 2003;305:415-427. (Pubitemid 36259676)
23. Poccia F, Boullier S, Lecoeur H, et al. Peripheral V gamma 9/V delta 2 T cell deletion and anergy to nonpeptidic mycobacterial antigens in asymptomatic HIV-1-infected persons. J Immunol. 1996;157:449-461. (Pubitemid 26190580)
24. Gioia C, Agrati C, Casetti R, et al. Lack of CD27-CD45RA-V gamma 9V delta 2+ T cell effectors in immunocompromised hosts and during active pulmonary tuberculosis. J Immunol. 2002;168:1484-1489. (Pubitemid 34094523)
25. Zheng NN, Kiviat NB, Sow PS, et al. Comparison of human immunodeficiency virus (HIV)-specific T-cell responses in HIV-1-and HIV-2-infected individuals in Senegal. J Virol. 2004;78:13934-13942. (Pubitemid 39612790)
26. Zheng NN, McElrath MJ, Sow PS, et al. Role of human immunodeficiency virus (HIV)-specific T-cell immunity in control of dual HIV-1 and HIV-2 infection. J Virol. 2007;81:9061-9071. (Pubitemid 47311449)
27. Gottlieb GS, Badiane NM, Hawes SE, et al. Emergence of multiclass drug-resistance in HIV-2 in antiretroviral-treated individuals in Senegal: implications for HIV-2 treatment in resouce-limited West Africa. Clin Infect Dis. 2009;48:476-483.
28. Hayday AC, Roberts S, Ramsburg E. gammadelta cells and the regulation of mucosal immune responses. Am J Respir Crit Care Med. 2000;162(4 Pt 2): S161-S163.
29. Boullier S, Dadaglio G, Lafeuillade A, et al. V delta 1 T cells expanded in the blood throughout HIV infection display a cytotoxic activity and are primed for TNF-alpha and IFN-gamma production but are not selected in lymph nodes. J Immunol. 1997;159:3629-3637. (Pubitemid 127482123)
30. Jouen-Beades F, Gilbert D, Ramzaoui S, et al. Similarity of expression of activation markers and CD28 on gamma delta and alpha betareceptor T cells in HIV infection. Clin Immunol Immunopathol. 1996; 79:189-193. (Pubitemid 26151413)
31. De Rosa SC, Mitra DK, Watanabe N, et al. Vdelta1 and Vdelta2 gammadelta T cells express distinct surface markers and might be developmentally distinct lineages. J Leukoc Biol. 2001;70:518-526. (Pubitemid 32954762)
32. Nazli A, Chan O, Dobson-Belaire WN, et al. Exposure to HIV-1 directly impairs mucosal epithelial barrier integrity allowing microbial translocation. PLoS Pathog. 2010;6:e1000852.
33. Brenchley JM, Price DA, Schacker TW, et al. Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nat Med. 2006;12:1365-1371. (Pubitemid 44924494)
34. Cassol E, Malfeld S, Mahasha P, et al. Persistent microbial translocation and immune activation in HIV-1-infected South Africans receiving combination antiretroviral therapy. J Infect Dis. 2010;202:723-733.
35. Nowroozalizadeh S, Mansson F, da Silva Z, et al. Microbial translocation correlates with the severity of both HIV-1 and HIV-2 infections. J Infect Dis. 2010;201:1150-1154.
36. Arien KK, Abraha A, Quinones-Mateu ME, et al. The replicative fitness of primary human immunodeficiency virus type 1 (HIV-1) group M, HIV-1 group O, and HIV-2 isolates. J Virol. 2005;79:8979-8990. (Pubitemid 40934809)
37. Gillespie GM, Pinheiro S, Sayeid-Al-Jamee M, et al. CD8+ T cell responses to human immunodeficiency viruses type 2 (HIV-2) and type 1 (HIV-1) gag proteins are distinguishable by magnitude and breadth but not cellular phenotype. Eur J Immunol. 2005;35:1445-1453. (Pubitemid 40691426)
38. Sarr AD, Lu Y, Sankale JL, et al. Robust HIV type 2 cellular immune response measured by a modified anthrax toxin-based enzyme-linked immunospot assay. AIDS Res Hum Retroviruses. 2001;17:1257-1264. (Pubitemid 32911629)
39. Duvall MG, Jaye A, Dong T, et al. Maintenance of HIV-specific CD4+ T cell help distinguishes HIV-2 from HIV-1 infection. J Immunol. 2006; 176:6973-6981. (Pubitemid 43787877)
40. Duvall MG, Precopio ML, Ambrozak DA, et al. Polyfunctional T cell responses are a hallmark of HIV-2 infection. Eur J Immunol. 2008;38: 350-363.
41. Cavaleiro R, Baptista AP, Soares RS, et al. Major depletion of plasmacytoid dendritic cells in HIV-2 infection, an attenuated form of HIV disease. PLoS Pathog. 2009;5:e1000667.
42. Beaumier CM, Harris LD, Goldstein S, et al. CD4 downregulation by memory CD4+ T cells in vivo renders African green monkeys resistant to progressive SIVagm infection. Nat Med. 2009;15:879-885.
43. Barcy S, De Rosa SC, Vieira J, et al. {gamma}{delta}+ T Cells Involvement in Viral Immune Control of Chronic Human Herpesvirus 8 Infection. J Immunol. 2008;180:3417-3425.
44. Hviid L, Akanmori BD, Loizon S, et al. High frequency of circulating gamma delta T cells with dominance of the v(delta)1 subset in a healthy population. Int Immunol. 2000;12:797-805. (Pubitemid 30410452)
45. Hviid L, Kurtzhals JA, Dodoo D, et al. The gamma/delta T-cell response to Plasmodium falciparum malaria in a population in which malaria is endemic. Infect Immun. 1996;64:4359-4362. (Pubitemid 26318166)