γδ+ T cells involvement in viral immune control of chronic human herpesvirus 8 infection

Journal of Immunology

Volumn 180, Issue 5, 2008, Pages 3417-3425

  Barcy, Serge ^a   De Rosa, Stephen C ^a   Vieira, Jeffrey ^a   Diem, Kurt ^a   Ikoma, Minako ^a   Casper, Corey ^a   Corey, Lawrence ^a,b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b Fred Hutchinson Cancer Research Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

VIRUS PROTEIN; ANTIVIRUS AGENT; GAMMA INTERFERON; LYMPHOCYTE ANTIGEN RECEPTOR;

ADAPTIVE IMMUNITY; ADULT; ALPHABETA T CELL; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL DIFFERENTIATION; CELL STIMULATION; CLINICAL ARTICLE; CONTROLLED STUDY; EFFECTOR CELL; GAMMADELTA T CELL; HUMAN; HUMAN CELL; HUMAN HERPESVIRUS 8; HUMAN IMMUNODEFICIENCY VIRUS; IMMUNOCOMPETENCE; IMMUNOREGULATION; IN VITRO STUDY; INNATE IMMUNITY; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PHENOTYPE; PRIORITY JOURNAL; SUPPRESSOR CELL; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; VIRUS INFECTION; VIRUS PARTICLE; ANIMAL; BIOSYNTHESIS; CELL CLONE; CELL LINE; CERCOPITHECUS; CHRONIC DISEASE; HERPES VIRUS INFECTION; IMMUNOLOGY; IMMUNOPHENOTYPING; METABOLISM; MIDDLE AGED; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PATHOLOGY; SECRETION; T LYMPHOCYTE SUBPOPULATION; TUMOR CELL LINE; VERO CELL; VIROLOGY;

ADULT; ANIMALS; ANTIVIRAL AGENTS; BASE SEQUENCE; CELL DIFFERENTIATION; CELL LINE, TRANSFORMED; CELL LINE, TUMOR; CERCOPITHECUS AETHIOPS; CHRONIC DISEASE; CLONE CELLS; HERPESVIRIDAE INFECTIONS; HERPESVIRUS 8, HUMAN; HUMANS; IMMUNOPHENOTYPING; INTERFERON TYPE II; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; T-LYMPHOCYTE SUBSETS; VERO CELLS;

EID: 49149112713     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.180.5.3417     Document Type: Article

References (53)

1. Schulz, T. F. 1998. Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8). J. Gen. Virol. 79: 1573-1591.
2. Pellet, C., D. Kerob, A. Dupuy, M. V. Carmagnat, S. Mourah, M. P. Podgorniak, C. Toledano, P. Morel, O. Verola, C. Dosquet, et al. 2006. Kaposi's sarcoma-associated herpesvirus viremia is associated with the progression of classic and endemic Kaposi's sarcoma. J. Invest. Dermatol. 126: 621-627.
3. Wilkinson, J., A. Cope, J. Gill, D. Bourboulia, P. Hayes, N. Imami, T. Kubo, A. Marcelin, V. Calvez, R. Weiss, et al. 2002. Identification of Kaposi's sarcoma-associated herpesvirus (KSHV)-specific cytotoxic T-lymphocyte epitopes and evaluation of reconstitution of KSHV-specific responses in human immunodeficiency virus type 1-Infected patients receiving highly active antiretroviral therapy. J. Virol. 76: 2634-2640.
4. + T-cell epitope for the glycoprotein B homolog of human herpesvirus 8. Blood 99: 3360-3366.
5. + cytotoxic T lymphocyte responses to lytic proteins of human herpes virus 8 in human immunodeficiency virus type 1-infected and -uninfected individuals. J. Infect. Dis. 182: 928-932.
6. Strickler, H. D., J. J. Goedert, F. R. Bethke, C. M. Trubey, T. R. O'Brien, J. Palefsky, J. E. Whitman, D. Ablashi, S. Zeichner, and G. M. Shearer. 1999. Human herpesvirus 8 cellular immune responses in homosexual men. J. Infect. Dis. 180: 1682-1685.
7. Stebbing, J., D. Bourboulia, M. Johnson, S. Henderson, I. Williams, N. Wilder, M. Tyrer, M. Youle, N. Imami, T. Kobu, et al. 2003. Kaposi's sarcoma-associated herpesvirus cytotoxic T lymphocytes recognize and target Darwinian positively selected autologous K1 epitopes. J. Virol. 77: 4306-4314.
8. + T cell epitopes within lytic antigens of human herpes virus 8. J. Immunol. 176: 923-930.
9. Micheletti, F., P. Monini, C. Fortini, P. Rimessi, M. Bazzaro, M. Andreoni, M. Giuliani, S. Traniello, B. Ensoli, and R. Gavioli. 2002. Identification of cytotoxic T lymphocyte epitopes of human herpesvirus 8. Immunology 106: 395-403.
10. Woodberry, T., T. J. Suscovich, L. M. Henry, J. N. Martin, S. Dollard, P. G. O'Connor, J. K. Davis, D. Osmond, T. H. Lee, D. H. Kedes, et al. 2005. Impact of Kaposi sarcoma-associated herpesvirus (KSHV) burden and HIV coinfection on the detection of T cell responses to KSHV ORF73 and ORF65 proteins. J. Infect. Dis. 192: 622-629.
11. + T-cell response to viral lytic cycle proteins. Blood 97: 2366-2373.
12. Rezaee, S. A., C. Cunningham, A. J. Davison, and D. J. Blackbourn. 2006. Kaposi's sarcoma-associated herpesvirus immune modulation: an overview. J. Gen. Virol. 87: 1781-1804.
13. Kronenberg, M. 1994. Antigens recognized by γ δ T cells. Curr. Opin. Immunol. 6: 64-71.
14. Fisch, P., E. Meuer, D. Pende, S. Rothenfusser, O. Viale, S. Kock, S. Ferrone, D. Fradelizi, G. Klein, L. Moretta, et al. 1997. Control of B cell lymphoma recognition via natural killer inhibitory receptors implies a role for human Vγ9/Vδ2 T cells in tumor immunity. Eur. J. Immunol. 27: 3368-3379.
15. Jouen-Beades, F., E. Paris, C. Dieulois, J. F. Lemeland, V. Barre-Dezelus, S. Marret, G. Humbert, J. Leroy, and F. Tron. 1997. In vivo and in vitro activation and expansion of γδ T cells during Listeria monocytogenes infection in humans. Infect. Immun. 65: 4267-4272.
16. Falini, B., L. Flenghi, S. Pileri, P. Pelicci, M. Fagioli, M. F. Martelli, L. Moretta, and E. Ciccone. 1989. Distribution of T cells bearing different forms of the T cell receptor γδ in normal and pathological human tissues. J. Immunol. 143: 2480-2488.
17. + γδ T cells in the peripheral blood and bone marrow as a selective feature of HIV-1 but not other virus infections. Br. J. Haematol. 100: 728-734.
18. Dechanet, J., P. Merville, F. Berge, G. Bone-Mane, J. L. Taupin, P. Michel, P. Joly, M. Bonneville, L. Potaux, and J. F. Moreau. 1999. Major expansion of γδ T lymphocytes following cytomegalovirus infection in kidney allograft recipients. J. Infect. Dis. 179: 1-8.
19. Oyoshi, M. K., H. Nagata, N. Kimura, Y. Zhang, A. Demachi, T. Hara, H. Kanegane, Y. Matsuo, T. Yamaguchi, T. Morio, et al. 2003. Preferential expansion of Vγ9-JγP/Vδ2-Jδ3 γδ T cells in nasal T-cell lymphoma and chronic active Epstein-Barr virus infection. Am. J. Pathol. 162: 1629-1638.
20. Verjans, G. M., R. W. Roest, A. van der Kooi, G. van Dijk, W. I. van der Meijden, and A. M. Osterhaus. 2004. Isopentenyl pyrophosphate-reactive Vγ9Vδ 2 T helper 1-like cells are the major γδ T cell subset recovered from lesions of patients with genital herpes. J. Infect. Dis. 190: 489-493.
21. Bluestone, J. A., R. Khattri, R. Sciammas, and A. I. Sperling. 1995. TCR γ δ cells: a specialized T-cell subset in the immune system. Annu. Rev. Cell. Dev. Biol. 11: 307-353.
22. Casper, C., E. Krantz, H. Taylor, J. Dalessio, D. Carrell, A. Wald, L. Corey, and R. Ashley. 2002. Assessment of a combined testing strategy for detection of antibodies to human herpesvirus 8 (HHV-8) in persons with Kaposi's sarcoma, persons with asymptomatic HHV-8 infection, and persons at low risk for HHV-8 infection. J. Clin. Microbiol. 40: 3822-3825.
23. Vieira, J., and P. M. O'Hearn. 2004. Use of the red fluorescent protein as a marker of Kaposi's sarcoma-associated herpesvirus lytic gene expression. Virology 325: 225-240.
24. Sakurada, S., H. Katano, T. Sata, H. Ohkuni, T. Watanabe, and S. Mori. 2001. Effective human herpesvirus 8 infection of human umbilical vein endothelial cells by cell-mediated transmission. J. Virol. 75: 7717-7722.
25. + cell clonotypes in infected tissues and blood. J. Infect. Dis. 191: 2012-2021.
26. Fickenscher, H., C. Bokel, A. Knappe, B. Biesinger, E. Meinl, B. Fleischer, B. Fleckenstein, and B. M. Broker. 1997. Functional phenotype of transformed human αβ and γδ T cells determined by different subgroup C strains of herpesvirus Saimiri. J. Virol. 71: 2252-2263.
27. Pon, R. A., and M. S. Freedman. 2003. Study of Herpesvirus saimiri immortalization of γδ T cells derived from peripheral blood and CSF of multiple sclerosis patients. J. Neuroimmunol. 139: 119-132.
28. Chowers, Y., W. Holtmeier, J. Harwood, E. Morzycka-Wroblewska, and M. F. Kagnoff. 1994. The V δ 1 T cell receptor repertoire in human small intestine and colon. J. Exp. Med. 180: 183-190.
29. Zhu, L., R. Wang, A. Sweat, E. Goldstein, R. Horvat, and B. Chandran. 1999. Comparison of human sera reactivities in immunoblots with recombinant human herpesvirus (HHV)-8 proteins associated with the latent (ORF73) and lytic (ORFs 65, K8.1A, and K8.1B) replicative cycles and in immunofluorescence assays with HHV-8-infected BCBL-1 cells. Virology 256: 381-392.
30. De Rosa, S. C., D. K. Mitra, N. Watanabe, L. A. Herzenberg, and M. Roederer. 2001. Vδ1 and Vδ2 γδ T cells express distinct surface markers and might be developmentally distinct lineages. J. Leukocyte Biol. 70: 518-526.
31. + T cells and their association with HIV-1-induced T cell dysfunction. J. Immunol. 175: 8415-8423.
32. + T cells. Blood 101: 2711-2720.
33. De Rosa, S. C., J. P. Andrus, S. P. Perfetto, J. J. Mantovani, L. A. Herzenberg, and M. Roederer. 2004. Ontogeny of γ δ T cells in humans. J. Immunol. 172: 1637-1645.
34. De Paoli, P., D. Gennari, P. Martelli, V. Cavarzerani, R. Comoretto, and G. Santini. 1990. γ δ T cell receptor-bearing lymphocytes during Epstein-Barr virus infection. J. Infect. Dis. 161: 1013-1016.
35. + human cytotoxic T lymphocytes. J. Immunol. 150: 1437-1445.
36. Rock, E. P., P. R. Sibbald, M. M. Davis, and Y. H. Chien. 1994. CDR3 length in antigen-specific immune receptors. J. Exp. Med. 179: 323-328.
37. Chien, Y. H., R. Jores, and M. P. Crowley. 1996. Recognition by γδ T cells. Annu. Rev. Immunol. 14: 511-532.
38. Kabelitz, D., A. Glatzel, and D. Wesch. 2000. Antigen recognition by human γδ T lymphocytes. Int. Arch. Allergy Immunol. 122: 1-7.
39. Sireci, G., E. Champagne, J. J. Fournie, F. Dieli, and A. Salerno. 1997. Patterns of phosphoantigen stimulation of human Vγ9/Vδ2 T cell clones include Th0 cytokines. Hum. Immunol. 58: 70-82.
40. Pozharskaya, V. P., L. L. Weakland, and M. K. Offermann. 2004. Inhibition of infectious human herpesvirus 8 production by γ interferon and α interferon in BCBL-1 cells. J. Gen. Virol. 85: 2779-2787.
41. + T lymphocytes during active, latent, and resolved infection and its relation with CD57. J. Immunol. 174: 6088-6094.
42. + subsets in acute Epstein-Barr virus infection: comparison with chronic human immunodeficiency virus disease. J. Infect. Dis. 177: 1083-1087.
43. Rutkowski, S., D. H. Busch, and H. I. Huppertz. 1997. Lymphocyte proliferation assay in response to Borrelia burgdorferi in patients with Lyme arthritis: analysis of lymphocyte subsets. Rheumatol. Int. 17: 151-158.
44. Dechanet, J., P. Merville, V. Pitard, X. Lafarge, and J. F. Moreau. 1999. Human γδ T cells and viruses. Microbes Infect. 1: 213-217.
45. Deusch, K., F. Luling, K. Reich, M. Classen, H. Wagner, and K. Pfeffer. 1991. A major fraction of human intraepithelial lymphocytes simultaneously expresses the γδ T cell receptor, the CD8 accessory molecule and preferentially uses the V δ 1 gene segment. Eur. J. Immunol. 21: 1053-1059.
46. Peacock, J. W., and K. L. Bost. 2000. Infection of intestinal epithelial cells and development of systemic disease following gastric instillation of murine γherpesvirus-68. J. Gen. Virol. 81: 421-429.
47. Jouen-Beades, F., F. Halary, L. Drouot, M. A. Peyrat, E. Paris, P. Joly, D. Gilbert, M. Bonneville, and F. Tron. 1999. Expansion of circulating V γ 9/V γ 1 T cells in a patient with a syndrome of recurrent fever: evidence for an unusual antigen-driven process leading to selection of recurrent motifs within TCR junctional loops of diverse lengths. Eur. J. Immunol. 29: 3338-3349.
48. + cells with restricted T cell receptor δ gene junctional repertoire in the peripheral blood of healthy donors. J. Exp. Med. 178: 121-127.
49. Tanaka, Y., S. Sano, E. Nieves, G. De Libero, D. Rosa, R. L. Modlin, M. B. Brenner, B. R. Bloom, and C. T. Morita. 1994. Nonpeptide ligands for human γ δ T cells. Proc. Natl. Acad. Sci. USA 91: 8175-8179.
50. Meeh, P. F., M. King, R. L. O'Brien, S. Muga, P. Buckhalts, R. Neuberg, and L. S. Lamb, Jr. 2006. Characterization of the γδ T cell response to acute leukemia. Cancer Immunol. Immunother. 55: 1072-1080.
51. Sciammas, R., R. M. Johnson, A. I. Sperling, W. Brady, P. S. Linsley, P. G. Spear, F. W. Fitch, and J. A. Bluestone. 1994. Unique antigen recognition by a herpesvirus-specific TCR-γ δ cell. J. Immunol. 152: 5392-5397.
52. Krug, L. T., V. P. Pozharskaya, Y. Yu, N. Inoue, and M. K. Offermann. 2004. Inhibition of infection and replication of human herpesvirus 8 in microvascular endothelial cells by α interferon and phosphonoformic acid. J. Virol. 78: 8359-8371.
53. Milligan, S., M. Robinson, E. O'Donnell, and D. J. Blackbourn. 2004. Inflammatory cytokines inhibit Kaposi's sarcoma-associated herpesvirus lytic gene transcription in in vitro-infected endothelial cells. J. Virol. 78: 2591-2596.