Human immunodeficiency virus type 1 induces persistent changes in mucosal and blood γδ T cells despite suppressive therapy

Journal of Virology

Volumn 77, Issue 19, 2003, Pages 10456-10467

  Poles, Michael A ^a,b   Barsoum, Shady ^a,b   Yu, Wenjie ^b   Yu, Jian ^b   Sun, Patricia ^a   Daly, Jeanine ^a   He, Tian ^b   Mehandru, Saurabh ^a,b   Talal, Andrew ^c   Markowitz, Martin ^b   Hurley, Arlene ^b   Ho, David ^b   Zhang, Linqi ^b  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b AARON DIAMOND AIDS RESEARCH CENTER   (United States)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR CCR9; COMMON ACUTE LYMPHOBLASTIC LEUKEMIA ANTIGEN; PROTEINASE INHIBITOR; RNA DIRECTED DNA POLYMERASE INHIBITOR; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BLOOD; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; GAMMA DELTA T CELL; GASTROINTESTINAL MUCOSA; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HOST RESISTANCE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE SUBPOPULATION;

ACQUIRED IMMUNODEFICIENCY SYNDROME; ADULT; AGED; AGED, 80 AND OVER; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; COMPLEMENTARITY DETERMINING REGIONS; FEMALE; HIV-1; HUMANS; IMMUNITY, MUCOSAL; MALE; MIDDLE AGED; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; RECEPTORS, CHEMOKINE; T-LYMPHOCYTES;

EID: 0141632773     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.77.19.10456-10467.2003     Document Type: Article

References (50)

1. Agostini, C., R. Zambello, L. Trentin, A. Cerutti, P. Bulian, C. Crivellaro, A. Cipriani, and G. Semenzato. 1994. Gamma delta T cell receptor subsets in the lung of patients with HIV-1 infection. Cell. Immunol. 153:194-205.
2. + lymphocyte subsets during HIV infection. Clin. Exp. Immunol. 75:206-210.
3. Battistini, L., M. Salvetti, G. Ristori, M. Falcone, C. S. Raine, and C. F. Brosnan. 1995. Gamma delta T cell receptor analysis supports a role for HSP 70 selection of lymphocytes in multiple sclerosis lesions. Mol. Med. 1:554-562.
4. Behr, C., R. Poupot, M. A. Peyrat, Y. Poquet, P. Constant, P. Dubois, M. Bonneville, and J. J. Fournie. 1996. Plasmodium falciparum stimuli for human γδ T cells are related to phosphorylated antigens of mycobacteria. Infect. Immun. 64:2892-2896.
5. + T cell expansion in the peripheral blood of HIV-infected persons. J. Immunol. 154:1418-1431.
6. Boullier, S., G. Dadaglio, A. Lafeuillade, T. Debord, and M. L. Gougeon. 1997. V delta 1 T cells expanded in the blood throughout HIV infection display a cytotoxic activity and are primed for TNF-alpha and IFN-gamma production but are not selected in lymph nodes. J. Immunol. 159:3629-3637.
7. Carding, S. R., and P. J. Egan. 2002. γδ T cells: functional plasticity and heterogeneity. Nat. Rev. Immunol. 2:336-345.
8. Ciccone, E., O. Viale, C. Bottino, D. Pende, N. Migone, G. Casorati, G. Tambussi, A. Moretta, and L. Moretta. 1988. Antigen recognition by human T cell receptor gamma-positive lymphocytes. Specific lysis of allogeneic cells after activation in mixed lymphocyte culture. J. Exp. Med. 167:1517-1522.
9. Cipriani, B., G. Borsellino, F. Poccia, R. Placido, D. Tramonti, S. Bach, L. Battistini, and C. F. Brosnan. 2000. Activation of C-C beta-chemokines in human peripheral blood γδ T cells by isopentenyl pyrophosphate and regulation by cytokines. Blood 95:39-47.
10. Cosman, D., J. Mullberg, C. L. Sutherland, W. Chin, R. Armitage, W. Fanslow, M. Kubin, and N. J. Chalupny. 2001. ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor. Immunity 14:123-133.
11. De Rosa, S. C., D. K. Mitra, N. Watanabe, L. A. Herzenberg, L. A. Herzenberg, and M. Roederer. 2001. Vδ1 and Vδ2 γδ T cells express distinct surface markers and might be developmentally distinct lineages. J. Leukoc. Biol. 70:518-526.
12. + cells expressing the Jγ1.2 segment. AIDS Res. Hum. Retrovir. 19:21-29.
13. Ferrick, D. A., M. D. Schrenzel, T. Mulvania, B. Hsieh, W. G. Ferlin, and H. Lepper. 1995. Differential production of interferon-gamma and interleukin-4 in response to Th1- and Th2-stimulating pathogens by gamma delta T cells in vivo. Nature 373:255-257.
14. Fisch, P., M. Malkovsky, S. Kovats, E. Sturm, E. Braakman, B. S. Klein, S. D. Voss, L. W. Morrissey, R. DeMars, W. J. Welch, et al. 1990. Recognition by human V gamma 9/V delta 2 T cells of a GroEL homolog on Daudi Burkitt's lymphoma cells. Science 250:1269-1273.
15. Fujihashi, K., J. R. McGhee, M. Yamamoto, T. Hiroi, and H. Kiyono. 1996. Role of gamma delta T cells in the regulation of mucosal IgA response and oral tolerance. Ann. N. Y. Acad. Sci. 778:55-63.
16. Giacomelli, R., I. Parzanese, G. Frieri, A. Passacantando, F. Pizzuto, T. Pimpo, P. Cipriani, A. Viscido, R. Caprilli, and G. Tonietti. 1994. Increase of circulating gamma/delta T lymphocytes in the peripheral blood of patients affected by active inflammatory bowel disease. Clin. Exp. Immunol. 98:83-88.
17. Gougeon, M. L., S. Boullier, V. Colizzi, and F. Poccia. 1999. NKR-mediated control of γδ T-cell immunity to viruses. Microbes Infect. 1:219-226.
18. Groh, V., A. Steinle, S. Bauer, and T. Spies. 1998. Recognition of stress-induced MHC molecules by intestinal epithelial γδ T cells. Science 279:1737-1740.
19. + thymocytes express HIV-1 in the SCID-hu mouse, potentially contributing to immune dysfunction in HIV infection. J. Immunol. 169:5338-5346.
20. + subset of human gamma delta T cells responds to ligands expressed by EBV-infected Burkitt lymphoma cells and transformed B lymphocytes. J. Immunol. 149:3984-3989.
21. Hata, S., M. Clabby, P. Devlin, H. Spits, J. E. De Vries, and M. S. Krangel. 1989. Diversity and organization of human T cell receptor delta variable gene segments. J. Exp. Med. 169:41-57.
22. Hayday, A. C. 2000. γδ cells: a right time and a right place for a conserved third way of protection. Annu. Rev. Immunol. 18:975-1026.
23. Hinz, T., D. Wesch, K. Friese, A. Reckziegel, B. Arden, and D. Kabelitz. 1994. T cell receptor gamma delta repertoire in HIV-1-infected individuals. Eur. J. Immunol. 24:3044-3049.
24. Holtmeier, W., Y. Chowers, A. Lumeng, E. Morzycka-Wroblewska, and M. F. Kagnoff. 1995. The delta T cell receptor repertoire in human colon and peripheral blood is oligoclonal irrespective of V region usage. J. Clin. Investig. 96:1108-1117.
25. Imlach, S., C. Leen, J. E. Bell, and P. Simmonds. 2003. Phenotypic analysis of peripheral blood γδ T lymphocytes and their targeting by human immunodeficiency virus type 1 in vivo. Virology 305:415-427.
26. James, S. P., C. Fiocchi, A. S. Graeff, and W. Strober. 1986. Phenotypic analysis of lamina propria lymphocytes. Predominance of helper-inducer and cytolytic T-cell phenotypes and deficiency of suppressor-inducer phenotypes in Crohn's disease and control patients. Gastroenterology 91:1483-1489.
27. Komano, H., Y. Fujiura, M. Kawaguchi, S. Matsumoto, Y. Hashimoto, S. Obana, P. Mombaerts, S. Tonegawa, H. Yamamoto, S. Itohara, et al. 1995. Homeostatic regulation of intestinal epithelia by intraepithelial gamma delta T cells. Proc. Natl. Acad. Sci. USA 92:6147-6151.
28. Kunkel, E. J., J. J. Campbell, G. Haraldsen, J. Pan, J. Boisvert, A. I. Roberts, E. C. Ebert, M. A. Vierra, S. B. Goodman, M. C. Genovese, A. J. Wardlaw, H. B. Greenberg, C. M. Parker, E. C. Butcher, D. P. Andrew, and W. W. Agace. 2000. Lymphocyte CC chemokine receptor 9 and epithelial thymus-expressed chemokine (TECK) expression distinguish the small intestinal immune compartment: epithelial expression of tissue-specific chemokines as an organizing principle in regional immunity. J. Exp. Med. 192:761-768.
29. Lehner, T., E. Mitchell, L. Bergmeier, M. Singh, R. Spallek, M. Cranage, G. Hall, M. Dennis, F. Villinger, and Y. Wang. 2000. The role of γδ T cells in generating antiviral factors and beta-chemokines in protection against mucosal simian immunodeficiency virus infection. Eur. J. Immunol. 30:2245-2256.
30. Maccario, R., P. Comoli, E. Percivalle, D. Montagna, F. Locatelli, and G. Gerna. 1995. Herpes simplex virus-specific human cytotoxic T-cell colonies expressing either gamma delta or alpha beta T-cell receptor: role of accessory molecules on HLA-unrestricted killing of virus-infected targets. Immunology 85:49-56.
31. Martini, F., F. Poccia, D. Goletti, S. Carrara, D. Vincenti, G. D'Offizi, C. Agrati, G. Ippolito, V. Colizzi, L. P. Pucillo, and C. Montesano. 2002. Acute human immunodeficiency virus replication causes a rapid and persistent impairment of Vγ9Vδ2 T cells in chronically infected patients undergoing structured treatment interruption. J. Infect. Dis. 186:847-850.
32. Martini, F., R. Urso, C. Gioia, A. De Felici, P. Narciso, A. Amendola, M. G. Paglia, V. Colizzi, and F. Poccia. 2000. γδ T-cell anergy in human immunodeficiency virus-infected persons with opportunistic infections and recovery after highly active antiretroviral therapy. Immunology 100:481-486.
33. Miyagawa, F., Y. Tanaka, S. Yamashita, B. Mikami, K. Danno, M. Uehara, and N. Minato. 2001. Essential contribution of germline-encoded lysine residues in Jγ1.2 segment to the recognition of nonpeptide antigens by human γδ T cells. J. Immunol. 167:6773-6779.
34. Nilssen, D. E., F. Müller, O. Øktedalen, S. S. Frøland, O. Fausa, T. S. Halstensen, and P. Brandtzaeg. 1996. Intraepithelial γ/δ T cells in duodenal mucosa are related to the immune state and survival time in AIDS. J. Virol. 70:3545-3550.
35. Olsson, J., M. Poles, A. L. Spetz, J. Elliott, L. Hultin, J. Giorgi, J. Andersson, and P. Anton. 2000. Human immunodeficiency virus type 1 infection is associated with significant mucosal inflammation characterized by increased expression of CCR5, CXCR4, and beta-chemokines. J. Infect. Dis. 182:1625-1635.
36. Papadakis, K. A., J. Prehn, V. Nelson, L. Cheng, S. W. Binder, P. D. Ponath, D. P. Andrew, and S. R. Targan. 2000. The role of thymus-expressed chemokine and its receptor CCR9 on lymphocytes in the regional specialization of the mucosal immune system. J. Immunol. 165:5069-5076.
37. Poccia, F., L. Battistini, B. Cipriani, G. Mancino, F. Martini, M. L. Gougeon, and V. Colizzi. 1999. Phosphoantigen-reactive Vγ9Vδ2 T lymphocytes suppress in vitro human immunodeficiency virus type 1 replication by cell-released antiviral factors including CC chemokines. J. Infect. Dis. 180:858-861.
38. Poccia, F., S. Boullier, H. Lecoeur, M. Cochet, Y. Poquet, V. Colizzi, J. J. Fournie, and M. L. Gougeon. 1996. Peripheral V gamma 9/V delta 2 T cell deletion and anergy to nonpeptidic mycobacterial antigens in asymptomatic HIV-1-infected persons. J. Immunol. 157:449-461.
39. + mononuclear cells enhances gastrointestinal mucosal susceptibility to human immunodeficiency virus type 1 infection. J. Virol. 75:8390-8399.
40. Rossol, R., J. M. Dobmeyer, T. S. Dobmeyer, S. A. Klein, S. Rossol, D. Wesch, D. Hoelzer, D. Kabelitz, and E. B. Helm. 1998. Increase in Vδ+ γ8 T cells in the peripheral blood and bone marrow as a selective feature of HIV-1 but not other virus infections. Br. J. Haematol. 100:728-734.
41. Sciammas, R., and J. A. Bluestone. 1999. TCRγδ cells and viruses. Microbes Infect. 1:203-212.
42. Selin, L. K., S. Stewart, C. Shen, H. Q. Mao, and J. A. Wilkins. 1992. Reactivity of gamma delta T cells induced by the tumour cell line RPMI 8226: functional heterogeneity of clonal populations and role of GroEL heat shock proteins. Scand. J. Immunol. 36:107-117.
43. + T cells, and their cytocidal potential correlates with viral load. J. Virol. 77:1848-1855.
44. Targan, S. R., R. L. Deem, M. Liu, S. Wang, and A. Nel. 1995. Definition of a lamina propria T cell responsive state. Enhanced cytokine responsiveness of T cells stimulated through the CD2 pathway. J. Immunol. 154:664-675.
45. + T cell depletion and viral replication in SIV infection. Science 280:427-431.
46. Wallace, M., S. R. Bartz, W. L. Chang, D. A. Mackenzie, C. D. Pauza, and M. Malkovsky. 1996. Gamma delta T lymphocyte responses to HIV. Clin. Exp. Immunol. 103:177-184.
47. Wallace, M., M. Malkovsky, and S. R. Carding. 1995. Gamma/delta T lymphocytes in viral infections. J. Leukoc. Biol. 58:277-283.
48. Wen, L., D. F. Barber, W. Pao, F. S. Wong, M. J. Owen, and A. Hayday. 1998. Primary gamma delta cell clones can be defined phenotypically and functionally as Th1/Th2 cells and illustrate the association of CD4 with Th2 differentiation. J. Immunol. 160:1965-1974.
49. Wesch, D., T. Hinz, and D. Kabelitz. 1998. Analysis of the TCR Vγ repertoire in healthy donors and HIV-1-infected individuals. Int. Immunol. 10:1067-1075.
50. Wesch, D., D. Kabelitz, K. Friese, and K. Pechhold. 1996. Mycobacteria-reactive gamma delta T cells in HIV-infccted individuals: lack of V gamma 9 cell responsiveness is due to deficiency of antigen-specific CD4 T helper type 1 cells. Eur. J. Immunol. 26:557-562.