α-mangostin, a dietary xanthone, induces autophagic cell death by activating the AMP-activated protein kinase pathway in glioblastoma cells

Journal of Agricultural and Food Chemistry

Volumn 59, Issue 5, 2011, Pages 2086-2096

  Chao, A Ching ^a,b,c   Hsu, Ya Ling ^a   Liu, Ching Kuan ^a,b   Kuo, Po Lin ^a,b  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^c KAOHSIUNG MUNICIPAL TA TUNG HOSPITAL   (Taiwan)

Author keywords

Mangostin; AMPK; autophagy; LKB; raptor

Indexed keywords

AMP-ACTIVATED PROTEIN KINASE; AMPK; ANTICANCER EFFECTS; APOPTOSIS; AUTOPHAGIC CELLS; AUTOPHAGY; BAFILOMYCIN; CELL VIABILITY; DOWNSTREAM TARGET; GLIOBLASTOMA CELLS; GLIOBLASTOMAS; LKB; NUDE MICE; PRE-TREATMENT; RAPTOR; RIBOSOMAL PROTEINS; S6 KINASE;

CELL DEATH; CHEMICAL ACTIVATION; ENZYME ACTIVITY; GROWTH KINETICS; PHOSPHORYLATION;

ENZYMES;

ANTINEOPLASTIC AGENT; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MANGOSTIN; MTORC1 COMPLEX, HUMAN; PROTEIN; RPTOR PROTEIN, HUMAN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; XANTHONE DERIVATIVE;

ANIMAL; ARTICLE; AUTOPHAGY; CANCER TRANSPLANTATION; CELL SURVIVAL; DRUG ANTAGONISM; DRUG EFFECT; ENZYME ACTIVATION; GLIOBLASTOMA; HUMAN; METABOLISM; MOUSE; NUDE MOUSE; PATHOLOGY; PHOSPHORYLATION; TUMOR CELL LINE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; AUTOPHAGY; CELL LINE, TUMOR; CELL SURVIVAL; ENZYME ACTIVATION; GLIOBLASTOMA; HUMANS; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; PHOSPHORYLATION; PROTEINS; XANTHONES;

MUS MUSCULUS; RAPTORES;

EID: 79952170983     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf1042757     Document Type: Article

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