메뉴 건너뛰기




Volumn 3 E, Issue 1, 2011, Pages 137-157

Aberrant methylation as a main mechanism of TSGs silencing in PTC

Author keywords

Bisulfite specific PCR; Fractional allele loss; Gene expression; Imprinted region; Loss of heterozygosity; Methylation index; Methylation pattern; Methylation specific PCR; Microsatellite instability; Nodular goitre; Non imprinted region; Papillary thyroid carcinoma; Realtime PCR; Tumour suppressor gene

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 2A; GENOMIC DNA; POTASSIUM CHANNEL KCNQ1; RAS ASSOCIATION DOMAIN FAMILY PROTEIN 1A; TUMOR SUPPRESSOR PROTEIN; UVOMORULIN; VON HIPPEL LINDAU PROTEIN; BISULFITE; MICROSATELLITE DNA; PRIMER DNA; SULFITE;

EID: 79957922852     PISSN: 19450494     EISSN: 19450508     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (14)

References (63)
  • 1
    • 0037425748 scopus 로고    scopus 로고
    • Thyroid carcinoma
    • Sherma, S.I.: Thyroid carcinoma. Lancet 361, 501-511 (2003)
    • (2003) Lancet , vol.361 , pp. 501-511
    • Sherma, S.I.1
  • 2
    • 0037379904 scopus 로고    scopus 로고
    • High prevalence of BRAF mutations in thyroid cancer: Genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma
    • Kimura, E.T., M.N. Nikiforova, Z. Zhu, J.A. Knauf, Y.E. Nikiforov & J.A. Fagin: High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma. Cancer Res 63, 1454-1457 (2003) (Pubitemid 36373628)
    • (2003) Cancer Research , vol.63 , Issue.7 , pp. 1454-1457
    • Kimura, E.T.1    Nikiforova, M.N.2    Zhu, Z.3    Knauf, J.A.4    Nikiforov, Y.E.5    Fagin, J.A.6
  • 4
    • 30944445020 scopus 로고    scopus 로고
    • BRAF mediates RET/PTC-induced mitogen-activated protein kinase activation in thyroid cells: Functional support for requirement of the RET/PTC-RAS-BRAF pathway in papillary thyroid carcinogenesis
    • DOI 10.1210/en.2005-0280
    • Mitsutake, N., M. Miyagishi, S. Mitsutake, N. Akeno, C. Mesa, Jr., J.A. Knauf, L. Zhang, K. Taira & J.A. Fagin: BRAF mediates RET/PTC-induced mitogen-activated protein kinase activation in thyroid cells: functional support for requirement of the RET/PTC-RAS-BRAF pathway in papillary thyroid carcinogenesis. Endocrinology 147, 1014- 1019 (2006) (Pubitemid 43113021)
    • (2006) Endocrinology , vol.147 , Issue.2 , pp. 1014-1019
    • Mitsutake, N.1    Miyagishi, M.2    Mitsutake, S.3    Akeno, N.4    Mesa Jr., C.5    Knauf, J.A.6    Zhang, L.7    Taira, K.8    Fagin, J.A.9
  • 5
    • 21244457181 scopus 로고    scopus 로고
    • BRAF mutation in thyroid cancer
    • DOI 10.1677/erc.1.0978
    • Xing, M.: BRAF mutation in thyroid cancer. Endocr Relat Cancer 12, 245-262 (2005) (Pubitemid 40896444)
    • (2005) Endocrine-Related Cancer , vol.12 , Issue.2 , pp. 245-262
    • Xing, M.1
  • 8
    • 33644947163 scopus 로고    scopus 로고
    • Genotyping of an Italian papillary thyroid carcinoma cohort revealed high prevalence of BRAF mutations, absence of RAS mutations and allowed the detection of a new mutation of BRAF oncoprotein (BRAF(V599lns))
    • Carta, C., S. Moretti, L. Passeri, F. Barbi, N. Avenia, A. Cavaliere, M. Monacelli, A. Macchiarulo, F. Santeusanio, M. Tartaglia & E. Puxeddu: Genotyping of an Italian papillary thyroid carcinoma cohort revealed high prevalence of BRAF mutations, absence of RAS mutations and allowed the detection of a new mutation of BRAF oncoprotein (BRAF(V599lns)). Clin Endocrinol (Oxf) 64, 105-109 (2006)
    • (2006) Clin Endocrinol (Oxf) , vol.64 , pp. 105-109
    • Carta, C.1    Moretti, S.2    Passeri, L.3    Barbi, F.4    Avenia, N.5    Cavaliere, A.6    Monacelli, M.7    Macchiarulo, A.8    Santeusanio, F.9    Tartaglia, M.10    Puxeddu, E.11
  • 10
    • 0035986363 scopus 로고    scopus 로고
    • RET/PTC rearrangement in thyroid tumors
    • Nikiforov, Y.E.: RET/PTC rearrangement in thyroid tumors. Endocr Pathol 13, 3-16 (2002) (Pubitemid 34665111)
    • (2002) Endocrine Pathology , vol.13 , Issue.1 , pp. 3-16
    • Nikiforov, Y.E.1
  • 13
    • 33644846509 scopus 로고    scopus 로고
    • Epigenetic gene silencing in cancer - A mechanism for early oncogenic pathway addiction?
    • DOI 10.1038/nrc1799, PII N1799
    • Baylin, S.B. & J.E. Ohm: Epigenetic gene silencing in cancer - a mechanism for early oncogenic pathway addiction? Nat Rev Cancer 6, 107-116 (2006) (Pubitemid 43361543)
    • (2006) Nature Reviews Cancer , vol.6 , Issue.2 , pp. 107-116
    • Baylin, S.B.1    Ohm, J.E.2
  • 14
    • 33845417885 scopus 로고    scopus 로고
    • The cancer epigenome-components and functional correlates
    • Ting, A.H., K.M. McGarvey & S.B. Baylin: The cancer epigenome-components and functional correlates. Genes Dev 20, 3215-3231 (2006)
    • (2006) Genes Dev , vol.20 , pp. 3215-3231
    • Ting, A.H.1    McGarvey, K.M.2    Baylin, S.B.3
  • 15
    • 22844457491 scopus 로고    scopus 로고
    • DNA methylation and human disease
    • DOI 10.1038/nrg1655
    • Robertson, K.D.: DNA methylation and human disease. Nat Rev Genet 6, 597-610 (2001) (Pubitemid 41044297)
    • (2005) Nature Reviews Genetics , vol.6 , Issue.8 , pp. 597-610
    • Robertson, K.D.1
  • 16
    • 0036144048 scopus 로고    scopus 로고
    • DNA methylation patterns and epigenetic memory
    • DOI 10.1101/gad.947102
    • Bird, A.: DNA methylation patterns and epigenetic memory. Genes Dev 16, 6-21 (2002) (Pubitemid 34049633)
    • (2002) Genes and Development , vol.16 , Issue.1 , pp. 6-21
    • Bird, A.1
  • 17
    • 0345357773 scopus 로고    scopus 로고
    • Gene silencing in cancer in association with promoter hypermethylation
    • DOI 10.1056/NEJMra023075
    • Herman, J.G. & S.B. Baylin: Gene silencing in cancer in association with promoter hypermethylation. N Engl J Med 349, 2042-2054 (2003) (Pubitemid 37448928)
    • (2003) New England Journal of Medicine , vol.349 , Issue.21 , pp. 2042-2054
    • Herman, J.G.1    Baylin, S.B.2
  • 18
    • 0036644895 scopus 로고    scopus 로고
    • Frequent epigenetic silencing of the CpG island promoter of RASSF1A in thyroid carcinoma
    • Schagdarsurengin, U., O. Gimm, C. Hoang-Vu, H. Dralle, G.P. Pfeifer & R. Dammann: Frequent epigenetic silencing of the CpG island promoter of RASSF1A in thyroid carcinoma. Cancer Res 62, 3698-3701 (2002) (Pubitemid 34728849)
    • (2002) Cancer Research , vol.62 , Issue.13 , pp. 3698-3701
    • Schagdarsurengin, U.1    Gimm, O.2    Hoang-Vu, C.3    Dralle, H.4    Pfeifer, G.P.5    Dammann, R.6
  • 19
    • 1642272931 scopus 로고    scopus 로고
    • Early occurrence of RASSF1A hypermethylation and its mutual exclusion with BRAF mutation in thyroid tumorigenesis
    • DOI 10.1158/0008-5472.CAN-03-3242
    • Xing, M., Y. Cohen, E. Mambo, G. Tallini, R. Udelsman, P.W. Ladenson & D. Sidransky: Early occurrence of RASSF1A hypermethylation and its mutual exclusion with BRAF mutation in thyroid tumorigenesis. Cancer Res 64, 1664-1668 (2004) (Pubitemid 38428687)
    • (2004) Cancer Research , vol.64 , Issue.5 , pp. 1664-1668
    • Xing, M.1    Cohen, Y.2    Mambo, E.3    Tallini, G.4    Udelsman, R.5    Ladenson, P.W.6    Sidransky, D.7
  • 23
    • 33847073463 scopus 로고    scopus 로고
    • Gene methylation in thyroid tumorigenesis
    • Xing, M.: Gene methylation in thyroid tumorigenesis. Endocrinology 148, 948-953 (2007)
    • (2007) Endocrinology , vol.148 , pp. 948-953
    • Xing, M.1
  • 24
    • 0038375053 scopus 로고    scopus 로고
    • Hypermethylation of the Pendred syndrome gene SLC26A4 is an early event in thyroid tumorigenesis
    • Xing, M., Y. Tokumaru, G. Wu, W.B. Westra, P.W. Ladenson & D. Sidransky: Hypermethylation of the Pendred syndrome gene SLC26A4 is an early event in thyroid tumorigenesis. Cancer Res 63, 2312-2315 (2003) (Pubitemid 36538642)
    • (2003) Cancer Research , vol.63 , Issue.9 , pp. 2312-2315
    • Xing, M.1    Tokumaru, Y.2    Wu, G.3    Westra, W.B.4    Ladenson, P.W.5    Sidransky, D.6
  • 25
    • 0034025873 scopus 로고    scopus 로고
    • Association of allelic loss on 1q, 4p, 7q, 9p, 9q, and 16q with postoperative death in papillary thyroid carcinoma
    • Kitamura, Y., K. Shimizu, S. Tanaka, K. Ito & M. Emi: Association of allelic loss on 1q, 4p, 7q, 9p, 9q, and 16q with postoperative death in papillary thyroid carcinoma. Clin Cancer Res 6, 1819-1825 (2000) (Pubitemid 30305077)
    • (2000) Clinical Cancer Research , vol.6 , Issue.5 , pp. 1819-1825
    • Kitamura, Y.1    Shimizu, K.2    Tanaka, S.3    Ito, K.4    Emi, M.5
  • 27
    • 2442679266 scopus 로고    scopus 로고
    • Microsatellite instability and its correlation with clinicopathological features in a series of thyroid tumors prevalent in iodine deficient areas
    • Vaish, M., A. Mishra, M. Kaushal, S.K. Mishra & B. Mittal: Microsatellite instability and its correlation with clinicopathological features in a series of thyroid tumors prevalent in iodine deficient areas. Exp Mol Med 36, 122-129 (2004) (Pubitemid 38667920)
    • (2004) Experimental and Molecular Medicine , vol.36 , Issue.2 , pp. 122-129
    • Vaish, M.1    Mishra, A.2    Kaushal, M.3    Mishra, S.K.4    Mittal, B.5
  • 28
    • 0037308570 scopus 로고    scopus 로고
    • Loss of heterozygosity in follicular and papillary thyroid carcinomas
    • DOI 10.1016/S0165-4608(02)00686-6, PII S0165460802006866
    • Rodrigues-Serpa, A., A. Catarino & J. Soares: Loss of heterozygosity in follicular and papillary thyroid carcinomas. Cancer Genet Cytogenet 141, 26-31 (2003) (Pubitemid 36165193)
    • (2003) Cancer Genetics and Cytogenetics , vol.141 , Issue.1 , pp. 26-31
    • Rodrigues-Serpa, A.1    Catarino, A.2    Soares, J.3
  • 29
    • 55749103843 scopus 로고    scopus 로고
    • Molecular analysis of multifocal papillary thyroid carcinoma
    • Lin, X., S.D. Finkelstein, B. Zhu & J. F. Silverman: Molecular analysis of multifocal papillary thyroid carcinoma. J Mol Endocrinol 41, 195-203 (2008)
    • (2008) J Mol Endocrinol , vol.41 , pp. 195-203
    • Lin, X.1    Finkelstein, S.D.2    Zhu, B.3    Silverman, J.F.4
  • 31
    • 30344441509 scopus 로고    scopus 로고
    • High frequency of loss of heterozygosity in imprinted, compared with nonimprinted, genomic regions in follicular thyroid carcinomas and atypical adenomas
    • DOI 10.1210/jc.2005-1880
    • Sarquis, M.S., F. Weber, L. Shen, C.E. Broelsch, S.M. Jhiang, J. Zedenius, A. Frilling & C. Eng: High frequency of loss of heterozygosity in imprinted, compared with nonimprinted, genomic regions in follicular thyroid carcinomas and atypical adenomas. J Clin Endocrinol Metab 91, 262-269 (2006) (Pubitemid 43069147)
    • (2006) Journal of Clinical Endocrinology and Metabolism , vol.91 , Issue.1 , pp. 262-269
    • Sarquis, M.S.1    Weber, F.2    Shen, L.3    Broelsch, C.E.4    Jhiang, S.M.5    Zedenius, J.6    Frilling, A.7    Eng, C.8
  • 34
    • 0035172139 scopus 로고    scopus 로고
    • MethDB - A public database for DNA methylation data
    • Grunau, C., E. Renault, A. Rosenthal & G. Roizes: MethDB - a public database for DNA methylation data. Nucleic Acids Res 29, 270-274 (2001) (Pubitemid 32054465)
    • (2001) Nucleic Acids Research , vol.29 , Issue.1 , pp. 270-274
    • Grunau, C.1    Renault, E.2    Rosenthal, A.3    Roizes, G.4
  • 35
    • 0036774406 scopus 로고    scopus 로고
    • High resolution loss of heterozygosity mapping of 17p13 in thyroid cancer: Hurthle cell carcinomas exhibit a small 411-kilobase common region of allelic imbalance, probably containing a novel tumor suppressor gene
    • DOI 10.1210/jc.2002-020708
    • Farrand, K., B. Delahunt, X.L. Wang, B. McIver, I.D. Hay, J.R. Goellner, N.L. Eberhardt & S.K. Grebe: High resolution loss of heterozygosity mapping of 17p13 in thyroid cancer: Hurthle cell carcinomas exhibit a small 411-kilobase common region of allelic imbalance, probably containing a novel tumor suppressor gene. J Clin Endocrinol Metab 87, 4715-4721 (2002) (Pubitemid 35247066)
    • (2002) Journal of Clinical Endocrinology and Metabolism , vol.87 , Issue.10 , pp. 4715-4721
    • Farrand, K.1    Delahunt, B.2    Wang, X.-L.3    McIver, B.4    Hay, I.D.5    Goellner, J.R.6    Eberhardt, N.L.7    Grebe, S.K.G.8
  • 37
    • 0345859249 scopus 로고    scopus 로고
    • AJCC thyroid
    • 6th. edition, Eds: F.L. Greene, D.L. Page, I.D. Fleming, A.F. Fritz, C.M. Balch, D.G. Haller, M. Morrow. Springer-Verlag, New York, NY
    • Greene, L.F., D.L. Page, A.M. Fritz, C.M. Balch, D.G. Haller, M. Morrow. AJCC, Thyroid. In: AJCC Cancer Staging Manual, 6th. edition, Eds: F.L. Greene, D.L. Page, I.D. Fleming, A.F. Fritz, C.M. Balch, D.G. Haller, M. Morrow. Springer-Verlag, New York, NY, 77-87 (2002)
    • (2002) AJCC Cancer Staging Manual , pp. 77-87
    • Greene, L.F.1    Page, D.L.2    Fritz, A.M.3    Balch, C.M.4    Haller, D.G.5    Morrow, M.6
  • 38
    • 34248578373 scopus 로고    scopus 로고
    • Genetic background of carcinogenesis in the thyroid gland
    • Lewinski, A. & K. Wojciechowska: Genetic background of carcinogenesis in the thyroid gland. Neuro Endocrinol Lett 28, 77-105 (2007) (Pubitemid 46744779)
    • (2007) Neuroendocrinology Letters , vol.28 , Issue.2 , pp. 77-105
    • Lewinski, A.1    Wojciechowska, K.2
  • 40
  • 42
    • 37249077105 scopus 로고    scopus 로고
    • DNA hypermethylation status of multiple genes in papillary thyroid carcinomas
    • DOI 10.1159/000110028
    • Ishida, E., M. Nakamura, K. Shimada, T. Higuchi, K. Takatsu, K. Yane & N. Konishi: DNA hypermethylation status of multiple genes in papillary thyroid carcinomas. Pathobiology 74, 344-352 (2007) (Pubitemid 350273706)
    • (2007) Pathobiology , vol.74 , Issue.6 , pp. 344-352
    • Ishida, E.1    Nakamura, M.2    Shimada, K.3    Higuchi, T.4    Takatsu, K.5    Yane, K.6    Konishi, N.7
  • 43
    • 33747367221 scopus 로고    scopus 로고
    • CpG island methylation of tumorrelated promoters occurs preferentially in undifferentiated carcinoma
    • Schagdarsurengin, U., O. Gimm, H. Dralle, C. Hoang- Vu & R. Dammann: CpG island methylation of tumorrelated promoters occurs preferentially in undifferentiated carcinoma. Thyroid 16, 633-642 (2006)
    • (2006) Thyroid , vol.16 , pp. 633-642
    • Schagdarsurengin, U.1    Gimm, O.2    Dralle, H.3    Hoang- Vu, C.4    Dammann, R.5
  • 44
    • 15144350589 scopus 로고    scopus 로고
    • Distinct patterns of E-cadherin CpG island methylation in papillary, follicular, hurthle's cell, and poorly differentiated human thyroid carcinoma
    • Graff, J.R., V.E. Greenberg, J.G. Herman, W.H. Westra, E.R. Boghaert, K.B. Ain, M. Saji, M.A. Zeiger, S.G. Zimmer & S.B. Baylin: Distinct patterns of E-cadherin CpG island methylation in papillary, follicular, Hurthle's cell, and poorly differentiated human thyroid carcinoma. Cancer Res 58, 2063-2066 (1998) (Pubitemid 28232884)
    • (1998) Cancer Research , vol.58 , Issue.10 , pp. 2063-2066
    • Graff, J.R.1    Greenberg, V.E.2    Herman, J.G.3    Westra, W.H.4    Boghaert, E.R.5    Ain, K.B.6    Saji, M.7    Zeiger, M.A.8    Zimmer, S.G.9    Baylin, S.B.10
  • 45
    • 0034938692 scopus 로고    scopus 로고
    • Abnormalities of the E-cadherin/catenin adhesion complex in classical papillary thyroid carcinoma and in its diffuse sclerosing variant
    • DOI 10.1002/path.905
    • Rocha, A.S., P. Soares, R. Seruca, V. Maximo, X. Matias-Guiu, J. Cameselle-Teijeiro & M. Sobrinho-Simoes: Abnormalities of the E-cadherin/catenin adhesion complex in classical papillary thyroid carcinoma and in its diffuse sclerosing variant. J Pathol 194, 358-366 (2001) (Pubitemid 32624563)
    • (2001) Journal of Pathology , vol.194 , Issue.3 , pp. 358-366
    • Rocha, A.S.1    Soares, P.2    Seruca, R.3    Maximo, V.4    Matias-Guiu, X.5    Cameselle-Teijeiro, J.6    Sobrinho-Simoes, M.7
  • 46
    • 10744223629 scopus 로고    scopus 로고
    • Reactivation of the silenced and imprinted alleles of ARHI is associated with increased histone H3 acetylation and decreased histone H3 lysine 9 methylation
    • DOI 10.1093/hmg/ddg204
    • Fujii, S., R.Z. Luo, J. Yuan, M. Kadota, M. Oshimura, S.R. Dent, Y. Kondo, J.P. Issa, R.C. Bast, Jr. & Y. Yu: Reactivation of the silenced and imprinted alleles of ARHI is associated with increased histone H3 acetylation and decreased histone H3 lysine 9 methylation. Hum Mol Genet 12, 1791-1800 (2003) (Pubitemid 36944134)
    • (2003) Human Molecular Genetics , vol.12 , Issue.15 , pp. 1791-1800
    • Fujii, S.1    Luo, R.Z.2    Yuan, J.3    Kadota, M.4    Oshimura, M.5    Dent, S.R.6    Kondo, Y.7    Issa, J.-P.J.8    Bast Jr., R.C.9    Yu, Y.10
  • 49
    • 1042301960 scopus 로고    scopus 로고
    • Ubiquitous aberrant RASSF1A promoter methylation in childhood neoplasia
    • DOI 10.1158/1078-0432.CCR-0378-3
    • Wong, I.H., J. Chan, J. Wong & P.K. Tam: Ubiquitous aberrant RASSF1A promoter methylation in childhood neoplasia. Clin Cancer Res 10, 994-1002 (2004) (Pubitemid 38198901)
    • (2004) Clinical Cancer Research , vol.10 , Issue.3 , pp. 994-1002
    • Wong, I.H.N.1    Chan, J.2    Wong, J.3    Tam, P.K.H.4
  • 51
    • 0033856270 scopus 로고    scopus 로고
    • Expression of the von hippel-lindau tumor suppressor gene in nonneoplastic and neoplastic lesions of the thyroid
    • Hinze, R., C. Boltze, A. Meye, H.J. Holzhausen, H. Dralle & F.W. Rath: Expression of the von Hippel-Lindau tumor suppressor gene in nonneoplastic and neoplastic lesions of the thyroid. Endocr Pathol 11, 145-155 (2000) (Pubitemid 30610124)
    • (2000) Endocrine Pathology , vol.11 , Issue.2 , pp. 145-155
    • Hinze, R.1    Boltze, C.2    Meye, A.3    Holzhausen, H.-J.4    Dralle, H.5    Rath, F.-W.6
  • 54
    • 0035870248 scopus 로고    scopus 로고
    • A gene hypermethylation profile of human cancer
    • Esteller, M., P.G. Corn, S.B. Baylin & J.G. Herman: A gene hypermethylation profile of human cancer. Cancer Res 61, 3225-3229 (2001) (Pubitemid 32695003)
    • (2001) Cancer Research , vol.61 , Issue.8 , pp. 3225-3229
    • Esteller, M.1    Corn, P.G.2    Baylin, S.B.3    Herman, J.G.4
  • 55
    • 0032533645 scopus 로고    scopus 로고
    • Genetic and epigenetic alterations of the cyclin-dependent kinase inhibitors p15(INK4b) and p16(INK4a) in human thyroid carcinoma cell lines and primary thyroid carcinomas
    • DOI 10.1002/(SICI)1097-0142(19981115)83:10<2185::AID-CNCR18>3.0. CO;2-4
    • Elisei, R., M. Shiohara, H.P. Koeffler & J.A. Fagin: Genetic and epigenetic alterations of the cyclin-dependent kinase inhibitors p15INK4b and p16INK4a in human thyroid carcinoma cell lines and primary thyroid carcinomas. Cancer 83, 2185-2193 (1998) (Pubitemid 28525401)
    • (1998) Cancer , vol.83 , Issue.10 , pp. 2185-2193
    • Elisei, R.1    Shiohara, M.2    Koeffler, H.P.3    Fagin, J.A.4
  • 56
    • 0002051541 scopus 로고    scopus 로고
    • Genomic imprinting and cancer
    • Eds: B. Vogelstein, K.W. Kinzler. McGraw Hill Medical Publishing, NY
    • Feinberg, A.P.: Genomic imprinting and cancer. In: The Genetic Basis of Human Cancer. Eds: B. Vogelstein, K.W. Kinzler. McGraw Hill Medical Publishing, NY (1998), 95- 107
    • (1998) The Genetic Basis of Human Cancer , pp. 95-107
    • Feinberg, A.P.1
  • 57
    • 0034899454 scopus 로고    scopus 로고
    • Gain of 1q and loss of 9q21.3-q32 are associated with a less favorable prognosis in papillary thyroid carcinoma
    • DOI 10.1002/gcc.1165
    • Kjellman, P., S. Lagercrantz, A. Hoog, G. Wallin, C. Larsson & J. Zedenius: Gain of 1q and loss of 9q21.3-q32 are associated with a less favorable prognosis in papillary thyroid carcinoma. Genes Chromosomes Cancer 32, 43-49 (2001) (Pubitemid 32737783)
    • (2001) Genes Chromosomes and Cancer , vol.32 , Issue.1 , pp. 43-49
    • Kjellman, P.1    Lagercrantz, S.2    Hoog, A.3    Wallin, G.4    Larsson, C.5    Zedenius, J.6
  • 59
    • 45849102747 scopus 로고    scopus 로고
    • Changes in genomic imprinting and gene expression associated with transformation in a model of human osteosarcoma
    • Li, Y., G. Meng & Q.N. Guo: Changes in genomic imprinting and gene expression associated with transformation in a model of human osteosarcoma. Exp Mol Pathol 84, 234-239 (2008)
    • (2008) Exp Mol Pathol , vol.84 , pp. 234-239
    • Li, Y.1    Meng, G.2    Guo, Q.N.3
  • 63
    • 0033863556 scopus 로고    scopus 로고
    • Genetic changes in chromosomes 1p and 17p in thyroicl cancer progression
    • Kleer, C.G., B.R. Bryant, T.J. Giordano, M. Sobel & M.J. Merino: Genetic Changes in Chromosomes 1p and 17p in Thyroid Cancer Progression. Endocr Pathol 11, 137- 143 (2000) (Pubitemid 30610123)
    • (2000) Endocrine Pathology , vol.11 , Issue.2 , pp. 137-143
    • Kleer, C.G.1    Bryant, B.R.2    Giordano, T.J.3    Sobel, M.4    Merino, M.J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.