SASPase regulates stratum corneum hydration through profilaggrin-to-filaggrin processing

EMBO Molecular Medicine

Volumn 3, Issue 6, 2011, Pages 320-333

  Matsui, Takeshi ^a,e   Miyamoto, Kenichi ^b   Kubo, Akiharu ^b   Kawasaki, Hiroshi ^b   Ebihara, Tamotsu ^b   Hata, Kazuya ^c   Tanahashi, Shinya ^c   Ichinose, Shizuko ^a   Imoto, Issei ^a,d   Inazawa, Johji ^a   Kudoh, Jun ^b   Amagai, Masayuki ^b  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c Sunplanet Co Ltd   (Japan)

^d UNIVERSITY OF TOKUSHIMA   (Japan)

^e KYOTO UNIVERSITY   (Japan)

Author keywords

Dermatology; Epidermis; Filaggrin; Protease; Skin

Indexed keywords

ASPARTIC PROTEINASE; FILAGGRIN; PROFILAGGRIN; RECOMBINANT ENZYME; SKIN SPECIFIC RETROVIRAL LIKE ASPARTIC PROTEASE; UNCLASSIFIED DRUG;

AMINO ACID ANALYSIS; AMINO ACID COMPOSITION; ANIMAL EXPERIMENT; ARTICLE; ATOPIC DERMATITIS; CELL STRUCTURE; CONTROLLED STUDY; DRY SKIN; ENZYME ACTIVITY; ENZYME DEFICIENCY; GENE MUTATION; HAIRLESS MOUSE; HYDRATION; IN SITU HYBRIDIZATION; IN VITRO STUDY; MISSENSE MUTATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN PROCESSING; PROTEIN PURIFICATION; REGULATORY MECHANISM; STRATUM CORNEUM; WRINKLE;

AMINO ACID SUBSTITUTION; ANIMALS; ASPARTIC ACID ENDOPEPTIDASES; DERMATITIS, ATOPIC; EPIDERMIS; HUMANS; INTERMEDIATE FILAMENT PROTEINS; MICE; MICE, HAIRLESS; MUTATION, MISSENSE; PROTEIN PRECURSORS; RECOMBINANT PROTEINS; WATER;

EID: 79957895462     PISSN: 17574676     EISSN: 17574684     Source Type: Journal    
DOI: 10.1002/emmm.201100140     Document Type: Article

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