Sex specific response of cultured human bone cells to ERα and ERβ specific agonists by modulation of cell proliferation and creatine kinase specific activity

Journal of Steroid Biochemistry and Molecular Biology

Volumn 125, Issue 3-5, 2011, Pages 226-230

  Somjen, Dalia ^a   Katzburg, Sara ^a   Sharon, Orli ^a   Knoll, Esther ^a   Hendel, David ^b   Stern, Naftali ^a  

^a TEL AVIV UNIVERSITY   (Israel)

^b SHAARE ZEDEK MEDICAL CENTER   (Israel)

Author keywords

CK; DNA; DPN; HETE; Lipoxygenase; Osteoblasts; PPT

Indexed keywords

2,3 BIS (4 HYDROXYPHENYL) PROPIONITRILE; 4,4',4'''[4'PROPYL' (1H) PYRAZOL 1,3,5 TRIYL] TRIS PHENOL; AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; BAICALEIN; CREATINE KINASE; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; LIPOXYGENASE; MESSENGER RNA; RALOXIFENE; UNCLASSIFIED DRUG;

ARTICLE; CELL CULTURE; CELL PROLIFERATION; CONTROLLED STUDY; DNA SYNTHESIS; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN CELL; MALE; OSTEOBLAST; POSTMENOPAUSE; PREMENOPAUSE; REAL TIME POLYMERASE CHAIN REACTION; SEX DIFFERENTIATION;

BONE AND BONES; CELL PROLIFERATION; CELLS, CULTURED; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CREATINE KINASE; ENZYME ACTIVATION; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; HUMANS; NITRILES; PYRAZOLES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 79957873732     PISSN: 09600760     EISSN: 18791220     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2011.03.006     Document Type: Article

References (25)

1. D. Somjen, Y. Weisman, Z. Mor, A. Harell, A.M. Kaye, Regulation of proliferation of rat cartilage and bone by sex steroid hormones, J. Steroid Biochem.Mol. Biol. 40 (1991) 717-723.
2. A.M. Kaye, Y. Weisman, A. Harell, D. Somjen, Hormonal stimulation of bone cell proliferation, J. Steroid Biochem. Mol. Biol. 37 (1990) 431-435.
3. B. Fournier, S. Haring, A.M. Kaye, D. Somjen, Stimulation of creatine kinase specific activity in human osteoblast and endometrial cells by estrogens and anti-estrogens and its modulation by calciotropic hormones, J. Endocrinol. 150 (1996) 275-285. (Pubitemid 26295622)
4. S. Katzburg, A. Ornoy, D. Hendel, M. Lieberherr, A.M. Kaye, D. Somjen, Age and gender specific stimulation of creatine kinase specific activity by gonadal steroids in human bone-derived cells in culture, J. Endocrinol. Invest. 24 (2001) 166-172.
5. D. Somjen, Y. Weisman, A. Harell, E. Berger, A.M. Kaye, Direct and sex specific stimulation by sex steroids of creatine kinase activity and DNA synthesis in rat bone, Proc. Natl. Acad. Sci. U.S.A. 86 (1989) 3361-3363.
6. J.C. Gallagher, Drug therapy of osteoporosis: calcium, estrogen and vitamin D, in: B.L. Riggs, L.J. Melton III (Eds.), Osteoporosis: Etiology, Diagnosis and Management, vol. 1, Raven Press, New York, 1988, pp. 389-401.
7. S.C. Manolagas, S. Kousteni, R.L. Jilka, Sex steroids and bone, Recent Progr. Horm. Res. 57 (2002) 385-409.
8. P.D. Delmas, Treatment of postmenopausal osteoporosis, Lancet 359 (2000) 2018-2026. (Pubitemid 34663722)
9. Effects of menopause and estrogen replacement therapy or hormone replacementtherapy inwomenwith diabetes mellitus: consensus opinion of The North American Menopause Society, Menopause 7 (2000) 87-95.
10. D. Somjen, K. Tordjman, S. Katzburg, E. Knoll, O. Sharon, R. Limor, M. Naidich, Z. Naor, D. Hendel, N. Stern, Lipoxygenase metabolites are mediators of PTH-dependent human osteoblast growth, Bone 42 (2008) 491-497.
11. D. Somjen, S. Katzburg, M. Grafi-Cohen, E. Knoll, O. Sharon, G.H. Posner, Vitamin D metabolites and analogs induce lipoxygenase mRNA expression and activity as well as reactive oxygen species (ROS) production in human bone cell line, J. Steroid Biochem. Mol. Biol., 123 (2011) 85-89.
12. D. Somjen, S. Katzburg, O. Sharon, M. Grafi-Cohen, E. Knoll, N. Stern, The effects of estrogen receptors α and β specific agonists and antagonists on cell proliferation and energy metabolism in human bone cell line, J. Cell. Biochem., 112 (2011) 625-632.
13. W.G. Tong, X.Z. Ding, T.E. Adrian, The mechanisms of lipoxygenase inhibitorinduced apoptosis in human breast cancer cells, Biochem. Biophys. Res. Commun. 296 (2002) 942-948.
14. H.J. Kim, E.J. Chang, H.M. Kim, S.B. Lee, H.D. Kim,G. SuKim, H.H. Kim, Antioxidant α-lipoic acid inhibits osteoclast differentiation by reducing nuclear factor-κB DNA binding and prevents in vivo bone resorption induced by receptor activator of nuclear factor-κB ligand and tumor necrosis factor-α, Free Radic. Biol. Med. 40 (2006) 1483-1493.
15. R.F. Klein, J. Allard, Z. Avnur, T. Nikolcheva, D. Rotstein, A.S. Carlo, M. Shea, R.V. Waters, J.K. Belknap, G. Peltz, E.S. Orwoll, Regulation of bone mass in mice by the lipoxygenase gene ALOx15, Science 303 (2004) 229-232. (Pubitemid 38057572)
16. N. Mody, F. Parhami, T.A. Sarafian, L.L. Demer, Oxidative stress modulates osteoblastic differentiation of vascular and bone cells, Free Radic. Biol. Med. 31 (2001) 509-519. (Pubitemid 32728438)
17. S. Katzburg, M. Lieberherr, A. Ornoy, B.Y. Klein, D. Hendel, D. Somjen, Isolation and hormonal responsiveness of primary cultures ofhumanbone-derived cells: gender and age differences, Bone 25 (1999) 667-673. (Pubitemid 29525432)
18. D. Somjen, Y. Zaltsman, B. Gayer, T. Kulik, E. Knoll, N. Stern, L.J.W. Lu, L. Toldo, F. Kohen, 6-Carboxymethyl genistein: a novel selective oestrogen receptor modulator (SERM) with unique differential effects on the vasculature, bone and uterus, J. Endocrinol. 173 (2002) 415-427. (Pubitemid 34704713)
19. D. Somjen, F. Kohen,.M. Lieberherr, B. Gayer, E. Schejter, S. Katzburg, R. Limor, O. Sharon, E. Knoll, G.H. Posner, A.M. Kaye, N. Stern, Membranal effects of phytoestrogens and carboxy derivatives of phytoestrogens on human vascular and bone cells: new insights based on studies with carboxy-biochanin A, J. Steroid Biochem. Mol. Biol. 93 (2005) 293-303. (Pubitemid 40602503)
20. D. Somjen, S. Katzburg, E. Knoll, O. Sharon, G.H. Posner, N. Stern, Vitamin D analogs induce lipoxygenase mRNA expression and activity as well as reactive oxygen species (ROS) production in human bone cells, J. Steroid Biochem.Mol. Biol. 121 (2010) 265-267.
21. D. Somjen, S. Katzburg, M. Lieberherr, D. Hendel, I. Yoles, DT56a stimulates gender-specific human cultured bone cells in vitro, J. Steroid Biochem. Mol. Biol. 98 (2006) 90-96. (Pubitemid 43113249)
22. S. Ichikawa, D.L. Koller, M.L. Johnson, D. Lai, X. Xuei, R.F. Edenberg, E.S. Klein, E.S. Orwoll, S.L. Hui, T.M. Foroud, M. Peacock, M.J. Ecsons, Human ALOX12, but not ALOX15, is associated with BMD in white men and women, J. Bone Miner. Res. 21 (2006) 556-564.
23. B. Fournier, S. Häring, A.M. Kaye, D. Sömjen, Stimulation of creatine kinase specific activity in human osteoblast and endometrial cells by estrogens and anti-estrogens and its modulation by calciotropic hormones, J. Endocrinol. 150 (1996) 275-285. (Pubitemid 26295622)
24. D. Somjen, S. Katzburg, O. Sharon, A.M. Kaye, B. Gayer, F. Kohen, D. Hendel, G.H. Posner, Modulation of response to estrogens in cultured human female bone cells by a non-calcemic vitamin D analog: changes in nuclear and membranal binding, J. Steroid Biochem. Mol. Biol. 89-90 (2004) 393-395. (Pubitemid 38844317)
25. F. Callewaert, M. Sinneseael, E. Gielen, S. Boonen, D. Vanderscueren, Skeletal sexual dimorphism: relative contribution of sex steroids, GH-IGF1, and mechanical loading, J. Endocrinol. 207 (2010) 127-134.