Vitamin D analogs induce lipoxygenase mRNA expression and activity as well as reactive oxygen species (ROS) production in human bone cells

Journal of Steroid Biochemistry and Molecular Biology

Volumn 121, Issue 1-2, 2010, Pages 265-267

  Somjen, D ^a   Katzburg, S ^a   Knoll, E ^a   Sharon, O ^a   Posner, G H ^b   Stern, N ^a  

^a TEL AVIV UNIVERSITY   (Israel)

^b JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

DNA synthesis; HETE; Lipoxygenase; Osteoblasts; Vitamin D analogs

Indexed keywords

BAICALEIN; DNA; HYDROXYICOSATETRAENOIC ACID; LIPOXYGENASE; MESSENGER RNA; REACTIVE OXYGEN METABOLITE; VITAMIN D DERIVATIVE; 12 HYDROXYICOSATETRAENOIC ACID; 15-HYDROXY-5,8,11,13-EICOSATETRAENOIC ACID; VITAMIN D;

ARTICLE; BONE CELL; DNA SYNTHESIS; ENZYME ACTIVITY; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; LIPID OXIDATION; MALE; OXIDATIVE STRESS; ANALOGS AND DERIVATIVES; BIOLOGICAL MODEL; BONE; CELL PROLIFERATION; CHEMISTRY; GENE EXPRESSION REGULATION; METABOLISM; TUMOR CELL LINE;

12-HYDROXY-5,8,10,14-EICOSATETRAENOIC ACID; BONE AND BONES; CELL LINE, TUMOR; CELL PROLIFERATION; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; HYDROXYEICOSATETRAENOIC ACIDS; LIPOXYGENASE; MALE; MODELS, BIOLOGICAL; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; RNA, MESSENGER; VITAMIN D;

EID: 77954718678     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2010.03.047     Document Type: Article

References (18)

1. Shen Q., Christakos S. The vitamin D receptor, RUNX2 and the notch-signalling pathway cooperate in the transcriptional regulation of osteopontin. J. Biol. Chem. 2005, 280:40589-40598.
2. 2D3 enhancement of mouse secreted phosphoprotein 1 (SPP-1 or osteopontin) gene expression. Proc. Natl. Acad. Sci. U.S.A. 1990, 87:9995-9999.
3. 2D3 and analogs through the ligand binding domain of the vitamin D receptor in osteoblasts and osteocytes. Mediation by Src, phosphatidylinositol 3-, and JNK kinases. J. Biol. Chem. 2005, 280:14130-14137.
4. Tanaka H., Seino Y. Vitamin D metabolites and bone. Vitamin D 1997, 305-311. Academic Press, San Diego. D. Feldman, F.H. Glorieux, J.W. Pike (Eds.).
5. Holick M.F. The vitamin D epidemic and its health consequences. J. Nutr. 2005, 135:2739S-2748S.
6. Gallagher J.C. Drug therapy of osteoporosis: calcium, estrogen and vitamin D. Osteoporosis: Etiology, Diagnosis and Management 1988, vol. 1:389-401. Raven Press, New York.
7. Holick M.F. Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. Am. J. Clin. Nutr. 2004, 80(suppl.):1678S-1688S.
8. 2D3 (JKF) up regulates the induction of creatine kinase B by 17β estradiol in osteoblast-like ROS 17/2.8 cells and in rat diaphysis. J. Steroid Biochem. Mol. Biol. 2001, 77:205-212.
9. Somjen D., Katzburg S., Sharon O., Kaye A.M., Gayer B., Kohen F., Hendel D., Posner G.H. Modulation of response to estrogens in human female bone cells by a non-calcemic vitamin D analog: changes in nuclear and membranal binding. J. Steroid Biochem. Mol. Biol. 2004, 89-90:393-395.
10. Somjen D., Posner G.H., Weisman Y., Kaye A.M. Less-calcemic vitamin D analogs enhance creatine kinase specific activity and modulate responsiveness to gonadal steroids in the rat skeletal tissues. J. Endocrinol. Invest. 2007, 30:91-96.
11. Somjen D., Tordjman K., Katzburg S., Knoll E., Sharon O., Limor R., Naidich M., Naor Z., Hendel D., Stern N. Lipoxygenase metabolites are mediators of PTH-dependent human osteoblast growth. Bone 2008, 42:491-497.
12. Tong W.G., Ding X.Z., Adrian T.E. The mechanisms of lipoxygenase inhibitor-induced apoptosis in human breast cancer cells. Biochem. Biophys. Res. Commun. 2002, 296:942-948.
13. 2D3: synthesis and preliminary biological evaluation. Bioorg. Med. Chem. 2005, 13:2959-2966.
14. Somjen D., Kohen F., Katzburg S., Knoll E., Stern N. Estradiol-17β and phytoestrogens and selective estrogen receptor modulators (SERM) induce reactive oxygen species (ROS) production in human vascular smooth muscle (VSMC) and endothelial cells (ECV 304). Abstract Amer. Endo 2009.
15. Kim H.J., Chang E.J., Kim H.M., Lee S.B., Kim H.D., Su Kim G., Kim H.H. Antioxidant α-lipoic acid inhibits osteoclast differentiation by reducing nuclear factor-κB DNA binding and prevents in vivo bone resorption induced by receptor activator of nuclear factor-κB ligand and tumor necrosis factor-α. Free Radic. Biol. Med. 2006, 40:1483-1493.
16. Mody N., Parhami F., Sarafian T.A., Demer L.L. Oxidative stress modulates osteoblastic differentiation of vascular and bone cells. Free Radic. Biol. Med. 2001, 31:509-519.
17. Klein R.F., Allard J., Avnur Z., Nikolcheva T., Rotstein D., Carlo A.S., Shea M., Waters R.V., Belknap J.K., Peltz G., Orwoll E.S. Regulation of bone mass in mice by the lipoxygenase gene ALOx15. Science 2004, 303:229-232.
18. Ichikawa S., Koller D.L., Johnson M.L., Lai D., Xuei X., Edenberg H.J., Klein R.F., Orwoll E.S., Hui S.L., Foroud T.M., Peacock M., Econs M.J. Human ALOX12, but not ALOX15, is associated with BMD in white men and women. J. Bone Miner. Res. 2006, 21:556-564.