Enhanced long-term depression and impaired reversal learning in phosphodiesterase 4B-knockout (PDE4B -/-) mice

Neuropharmacology

Volumn 61, Issue 1-2, 2011, Pages 138-147

  Rutten, Kris ^a,b,c   Wallace, Tanya L ^a   Works, Melissa ^a   Prickaerts, Jos ^b   Blokland, Arjan ^b   Novak, Thomas J ^a   Santarelli, Luca ^a   Misner, Dinah L ^a  

^a ROCHE BIOSCIENCE   (United States)

^b MAASTRICHT UNIVERSITY   (Netherlands)

^c GRÜNENTHAL GMBH   (Germany)

Author keywords

cAMP; Fear conditioning; Gene knockout; LTD; LTP; Memory; Mouse; PDE4; Reversal learning; Water maze

Indexed keywords

PHOSPHODIESTERASE IV; PHOSPHODIESTERASE IVB; UNCLASSIFIED DRUG;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ELECTROPHYSIOLOGY; BRAIN REGION; COGNITION; CONTROLLED STUDY; DEPRESSION; GENE EXPRESSION; GENE FUNCTION; GENE LOCATION; GENOTYPE; HIPPOCAMPUS; KNOCKOUT MOUSE; LEARNING DISORDER; MALE; MAZE TEST; MOUSE; NERVE CELL PLASTICITY; NONHUMAN; PDE4B GENE; POSTSYNAPTIC POTENTIAL; PRIORITY JOURNAL; STIMULUS RESPONSE; SYNAPTIC TRANSMISSION; TASK PERFORMANCE; WILD TYPE;

ANIMALS; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 4; LONG-TERM SYNAPTIC DEPRESSION; MALE; MICE; MICE, 129 STRAIN; MICE, INBRED C57BL; MICE, KNOCKOUT; NEURONAL PLASTICITY; REVERSAL LEARNING;

EID: 79957873259     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2011.03.020     Document Type: Article

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