Impaired Conditioned Fear and Enhanced Long-Term Potentiation in Fmr2 Knock-Out Mice

Journal of Neuroscience

Volumn 22, Issue 7, 2002, Pages 2753-2763

  Gu, Yanghong ^a   McIlwain, Kellie L ^a   Weeber, Edwin J ^a   Yamagata, Takanori ^a   Xu, Bisong ^a   Antalffy, Barbara A ^a   Reyes, Christine ^a   Yuva Paylor, Lisa ^a   Armstrong, Dawna ^a   Zoghbi, Huda ^a   Sweatt, J David ^a   Paylor, Richard ^a   Nelson, David L ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Behavioral test; Fmr2; FRAXE syndrome; Knock out; LTP; Memory; Mental retardation

Indexed keywords

BETA GALACTOSIDASE; FRAGILE X MENTAL RETARDATION 2 PROTEIN; FRAGILE X MENTAL RETARDATION PROTEIN; ISOPROTEIN; UNCLASSIFIED DRUG; AFF2 PROTEIN, MOUSE; NUCLEAR PROTEIN; TRANSACTIVATOR PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL; BONE; BRAIN; CARTILAGE; CELL DIFFERENTIATION; CONTROLLED STUDY; ESCHERICHIA COLI; EXON; FEAR; GENE EXPRESSION; GENE INSERTION; HAIR FOLLICLE; HIPPOCAMPUS; INTRON; KNOCKOUT MOUSE; LONG TERM POTENTIATION; LUNG; MALE; MENTAL DEFICIENCY; MOUSE; NEUROBLAST; NEUROEPITHELIUM; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; SALIVARY GLAND; TENDON; TONGUE; WILD TYPE; ANIMAL; ANIMAL BEHAVIOR; ANTIBODY SPECIFICITY; C57BL MOUSE; CHIMERA; CHROMOSOME MAP; CONDITIONED REFLEX; DISEASE MODEL; FRAGILE X SYNDROME; GENE TARGETING; GENETICS; IN VITRO STUDY; LEARNING DISORDER; MEMORY DISORDER; MOUSE MUTANT; NERVE CELL PLASTICITY; PATHOPHYSIOLOGY; PHENOTYPE; PHYSIOLOGY; SOUTHERN BLOTTING; SURVIVAL RATE;

ANIMALS; BEHAVIOR, ANIMAL; BLOTTING, SOUTHERN; CHIMERA; CHROMOSOME MAPPING; CONDITIONING, CLASSICAL; DISEASE MODELS, ANIMAL; FEAR; FRAGILE X SYNDROME; GENE EXPRESSION; GENE TARGETING; LEARNING DISORDERS; LONG-TERM POTENTIATION; MALE; MEMORY DISORDERS; MENTAL RETARDATION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEURONAL PLASTICITY; NUCLEAR PROTEINS; ORGAN SPECIFICITY; PHENOTYPE; PROMOTER REGIONS (GENETICS); SURVIVAL RATE; TRANS-ACTIVATORS;

EID: 0036549187     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.22-07-02753.2002     Document Type: Article

References (48)

1. Allingham-Hawkins DJ, Ray PN (1995) FRAXE expansion is not a common etiological factor among developmentally delayed males. Am J Hum Genet 57:72-76.
2. Berry M, Rogers AW (1965) The migration of the neuroblasts in the developing cerebral cortex. J Anat 99:691-709.
3. Bohme GA, Laville M, Ledent C, Parmentier M, Imoperato A (2000) Enhanced long-term potentiation in mice lacking cannabinoid CB1. Neuroscience 95:5-7.
4. Brown WT (1996) The FRAXE syndrome: is it time for routine screening? Am J Hum Genet 58:903-905.
5. Carbonell P, Lopez I, Gabarron J, Bernabe MJ, Lucas JM, Guitart M, Gabau E, Glover G (1996) FRAXE mutation analysis in three Spanish families. Am J Med Genet 64:434-440.
6. Chakrabarti L, Knight SJL, Flannery AV, Davies KE (1996) A candidate gene for mild mental handicap at the FRAXE fragile site. Hum Mol Genet 5:275-282.
7. Chakrabarti L, Bristulf J, Foss GS, Davies KE (1998) Expression of murine homologue of FMR2 in mouse brain and during development. Hum Mol Genet 7:441-448.
8. Chetkovich DM, Klann E, Sweatt JD (1993) Nitric oxide synthase-independent long-term potentiation in area CA1 of hippocampus. NeuroReport 4:919-922.
9. Crawley JN, Paylor R (1997) A proposed test battery and constellation of specific behavioral paradigms to investigate the behavioral phenotypes of transgenic and knockout mice. Horm Behav 31:197-211.
10. de Carlos JA, Lopez-Mascaraque L, Valverde F (1996) Dynamics of cell migration from the lateral ganglionic eminence in rat. J Neurosci 16:6146-6156.
11. Gecz J, Gedeon AK, Sutherland GR, Mulley JC (1996) Identification of the gene FMR2, associated with FRAXE mental retardation. Nat Genet 13:105-108.
12. Gecz J, Bielby S, Sutherland GR, Mulley JC (1997) Gene structure and subcellular location of FMR2, a member of a new family of putative transcriptional activators. Genomics 44:201-213.
13. Gedeon AK, Meinanen M, Ades LC, Kaariainen H, Gecz J, Baker E, Sutherland GR, Mulley JC (1995) Overlapping submicroscopic deletions in Xq28 in two unrelated boys with developmental disorders: identification of a gene near FRAXE. Am J Hum Genet 56:907-914.
14. Grant SG, O'Dell TJ, Karl KA, Stein PL, Soriano P, Kandel ER (1992) Impaired long-term potentiation, spatial learning, and hippocampus development in fyn mutant mice. Science 258:1903-1910.
15. Gu Y, Nakamura T, Alder H, Prasad R, Canaani O, Cimino G, Croce CM, Canaani E (1992) The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene. Cell 71:701-708.
16. Gu Y, Shen Y, Gibbs RA, Nelson DL (1996) Identification of FMR2, a novel gene associated with the FRAXE CCG repeat and CpG island. Nat Genet 13:109-113.
17. Hamel BC, Smits AP, de Graaff E, Smeets DF, Schoute F, Eussen BH, Knight SJ, Davies KE, Assman-Hulsmans CF, Oostra BA (1994) Segregation of FRAXE in a large family: clinical, psychometric, cytogenetic, and molecular data. Am J Hum Genet 55:923-931.
18. Irwin S (1968) Comprehensive observational assessment: 1a, A systematic, quantitative procedure for assessing the behavioral and physiologic state of the mouse. Psychopharmacologia 13:222-257.
19. Jia Z, Agopyan N, Miu P, Xiong Z, Henderson J, Gerlai R, Taverna FA, Velumian A, MacDonald J, Carlen P, Abramow-Newerly W, Roder J (1996) Enhanced LTP in mice deficient in the AMPA receptor GluR2, Neuron 17:945-956.
20. Kim JJ, Fanselow MS (1992) Modality-specific retrograde amnesia of fear. Science 256:675-677.
21. Knight SJ, Flannery AV, Hirst MC, Campbell L, Christodoulou Z, Phelps SR, Pointon J, Middleton-Price HR, Barnicoat A, Pembrey ME, Holland J, Oostra BA, Bobrow M, Davies KE (1993) Trinucleotide repeat amplification and hypermethylation of a CpG island in FRAXE mental retardation. Cell 74:127-134.
22. Knight SJ, Voelckel MA, Hirst MC, Flannery AV, Moncla A, Davies KE (1994) Triplet repeat expansion at the FRAXE locus and X-linked mild mental handicap. Am J Hum Genet 55:81-86.
23. Knight SJ, Ritchie RJ, Chakrabarti L, Cross G, Taylor GR, Mueller RF, Hurst J, Paterson J, Yates JR, Dow DJ, Davies KE (1996) A study of FRAXE in mentally retarded individuals referred for fragile X syndrome (FRAXA) testing in the United Kingdom. Am J Hum Genet 58:906-913.
24. Lavdas AA, Grigoriou M, Pachnis V, Parnavelas JG (1999) The medial ganglionic eminence gives rise to a population of early neurons in the developing cerebral cortex. J Neurosci 19:7881-7888.
25. Ma C, Staudet LM (1997) LAF-4 encodes a lymphoid Nuclear protein with transactivation potential that is homologous to AF-4, the gene fused to MLL in t(4;11) leukemias. Blood 87:734-745.
26. Manabe T, Noda Y, Mamiya T, Katagiri H, Houtani T, Nishi M, Noda T, Takahashi T, Sugimoto T, Nabeshima T, Takeshima H (1998) Facilitation of long-term potentiation and memory in mice lacking nociceptin receptors. Nature 394:577-581.
27. Mansour SL, Thomas KR, Capecchi MR (1988) Disruption of the proto-oncogene int-2 in mouse embryo-derived stem-cells: a general strategy for targeting mutations to non-selectable genes. Nature 336:348-352.
28. McIlwain KL, Merriweather MY, Yuva-Paylor LA, Paylor R (2001) The use of behavioral test batteries: effects of training history. Physiol Behav 73:705-717.
29. Migaud M, Charlesworth P, Dempster M, Webster LC, Watabe AM, Makhinson M, He Y, Ramsay MF, Morris RG, Morrison JH, O'Dell TJ, Grant SG (1998) Enhanced long-term potentiation and impaired learning in mice with mutant postsynaptic density-95 protein. Nature 396:433-439.
30. Miller WJ, Skinner JA, Foss GS, Davies KE (1999) Localization of the fragile X mental retardation 2 (FMR2) protein in mammalian brain. Eur J Neurosci 12:381-384.
31. Morris RGM (1981) Spatial localization does not depend on the presence of local cues. Learn Motivation 12:239-260.
32. Mulley JC, Yu S, Loesch DZ, Hay DA, Donnelly A, Gedeon AK, Carbonell P, Lopez I, Glover G, Gabarron I, Yu PWL, Baker E, Haan EA, Hockey A, Knight SJL, Davies KE, Richard RI, Sutherland GR (1995) FRAXE and mental retardation. J Med Genet 32:162-169.
33. Murgia A, Polli R, Vinanzi C, Salis M, Drigo P, Artifoni L, Zacchello F (1996) Amplification of the FRAXE: extreme phenotype variability? Am J Med Genet 64:158-162.
34. Nguyen PV, Abel T, Kandel ER (1994) Requirement of a critical period of transcription for induction of a late phase of LTP. Science 265:1104-1106.
35. Paylor R, Nguyen M, Crawley JN, Patrick J, Beaudet A, Orr-Urtreger A (1998) Alpha7 nicotinic receptor subunits are not necessary for hippocampal-dependent learning or sensorimotor gating: a behavioral characterization of Acra7-deficient mice. Learn Mem 5:302-316.
36. Peier AM, McIlwain KL, Kenneson A, Warren ST, Paylor R, Nelson DL (2000) (Over)correction of FMR1 deficiency with YAC transgenics: behavioral and physical features. Hum Mol Genet 9:1145-1159.
37. Phillips RG, LeDoux JE (1992) Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning. Behav Neurosci 106:274-285.
38. Rakic P (1974) Neurons on Rhesus monkey visual cortex: systematic relation between time of origin and eventual disposition. Science 183:425-427.
39. Roberson ED, Sweatt JD (1996) Transient activation of cyclic AMP-dependent protein kinase during hippocampal long-term potentiation. J Biol Chem 271:30436-30441.
40. Rogers DC, Fisher EM, Brown SD, Peters J, Hunter AJ, Martin JE (1997) Behavioral and functional analysis of mouse phenotype: SHIPRA, a proposed protocol for comprehensive phenotype assessment. Mamm Genome 8:711-713.
41. Silva AJ, Paylor R, Wehner JM, Tonegawa S (1992) Impaired spatial learning in a-calcium calmodulin kinase II mutant mice. Science 257:206-211.
42. Super H, Soriano E, Uyling HBM (1998) The functions of the preplate in development and evolution of the neocortex and hippocampus. Brain Res Brain Res Rev 27:40-64.
43. Taki T, Kano H, Taniwaki M, Sako M, Yanagisawa M, Hayashi Y (1999) AF5q31, a newly identified AF4-related gene, is fused to MLL in infant acute lymphoblastic leukemia with ins(5;11)(q31;q13q23). Proc Natl Acad Sci USA 96:14535-14540.
44. Tamamaki N, Fujimori KE, Takauji R (1997) Origin and route of tangentially migrating neurons in the developing neocortical intermediate zone. J Neurosci 17:8313-8323.
45. Tecott LH, Logue SF, Wehner JM, Kauer JA (1998) Perturbed dentate gyrus function in serotonin 5-HT2c receptor mutant mice. Proc Natl Acad Sci USA 95:15026-15031.
46. Uetani N, Kato K, Ogura H, Mizuno K, Kawano K, Mikoshiba K, Yakura H, Asano M, Iwakura Y (2000) Impaired learning with enhanced hippocampal long-term potentiation in PTPdelta-deficient mice. EMBO J 19:2775-2785.
47. Upchurch M, Wehner JM (1988) Differences between inbred strains of mice in Morris water maze performance. Behav Genet 18:55-68.
48. Zhu Y, Li H, Zhou L, Wu JY, Rao Y (1999) Cellular and molecular guidance of GABAergic neuronal migration from an extracortical origin to the neocortex, Neuron 23:473-485.