Anti-diabetic effects of aqueous ethanolic extract of Hibiscus rosasinensis L. on streptozotocin-induced diabetic rats and the possible morphologic changes in the liver and kidney

International Journal of Pharmacology

Volumn 7, Issue 3, 2011, Pages 363-369

  Mandade, Rajesh ^a   Sreenivas, S A ^b  

^a SN Institute of Pharmacy   (India)

^b Guru Nanak Institute of Pharmacy   (India)

Author keywords

Blood glucose; Diabetes complications; H. rosasinensis; Insulin; Rats; Streptozotocin

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ALKALINE PHOSPHATASE; ANTIDIABETIC AGENT; ASPARTATE AMINOTRANSFERASE; C PEPTIDE; CREATININE; GAMMA GLUTAMYLTRANSFERASE; GLUCOSE; HIBISCUS ROSASINENSIS EXTRACT; INSULIN; UNCLASSIFIED DRUG; UREA; URIC ACID;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALBUMIN BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDIABETIC ACTIVITY; AQUEOUS SOLUTION; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DIABETES MELLITUS; DRUG ACTIVITY; DRUG EFFICACY; ENZYME ACTIVITY; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; GLUCOSE BLOOD LEVEL; HIBISCUS; HIBISCUS ROSASINENSI; HISTOLOGY; INSULIN BLOOD LEVEL; NONHUMAN; PROTEIN BLOOD LEVEL; RAT; STREPTOZOCIN DIABETES; UREA BLOOD LEVEL; URIC ACID BLOOD LEVEL;

EID: 79957871538     PISSN: 18117775     EISSN: 18125700     Source Type: Journal    
DOI: 10.3923/ijp.2011.363.369     Document Type: Article

References (48)

1. Adhirajan, N., T.R. Kumar, N. Shanmugasundaram and M. Babu, 2003. In vivo and in vitro evaluation of hair growth potential of Hibiscus rosasinensis Linn. J. Ethnopharmacol., 88: 235-239.
2. Al-Attar, A.M. and T.A. Zari, 2007. Modulatory effects of ginger and clove oils on physiological responses in streptozotocin-induced diabetic rats. Int. I. Pharmacol, 3: 34-40.
3. Ahyu, R., A.H. Adebayo, D. Gatsing and I.H. Garba, 2007. The effects of ethanolic leaf extract of Commiphora africana (Burseraceae) on rat liver and kidney functions. I. Pharmacol. Toxicol., 2: 373-379.
4. Almdal, I.P. and H. Vilstrup, 1988. Strict insulin therapy normalizes organ nitrogen contents and capacity of urea nitrogen synthesis in experimental diabetes in rats. Diabetlogia, 31: 114-118.
5. Asgary, S., G.A. Naderi, N. Sarrafzadegan and M. Ghasemi, 1999. Antioxidant effect of flavonoids on hemoglobin glycosylation. Phar. Acta Helv., 73: 223-226.
6. Asgary, S., G.A. Naderi, S.N. Zadegan and R. Vakili, 2002. The inhibitory effects of pure flavonoids on in vitro protein glycosylation. I. Herbal Pharmacother., 2: 47-55.
7. Atangwho, I.J., P.E. Ebong, M.U. Eteng, E.U. Eyong and A.U. Obi, 2007. Effect of Vernonia amygdalina del leaf on kidney function of diabetic rats. Int. I. Pharmacol, 3: 143-148.
8. Aurell, M. and S. Bjorck, 1992. Determination of progressive renal disease in diabetes mellitus. Kidney Intl., 41: 38-42.
9. Bakris, G.L., 1997. Diabetic nephropathy. What you need to know to preserve kidney function. Postgrad. Med., 93: 89-100.
10. Begum, N. and K.R. Shanmugasundaram, 1978. Transaminases in experimental diabetes. Arogya I. Health Sci., 4: 116-122.
11. Brownlee, M., 2001. Biochemistry and molecular cell biology of diabetic complications. Nature, 414: 813-820.
12. Dandu, A.M. and N.M. Inamdar, 2008. Protective effects of And rographis paniculata against endothelial dysfunction in diabetic wistar rats. I. Pharmacol. Toxicol, 3: 311-317.
13. Dubey, G.P., S.P. Dixit and S. Aide, 1994. Alloxan-mduced diabetes in rabbits and effect of herbal formulation D-400. Indian J. Pharmacol, 26: 225-226.
14. Gilani, A.H., S. Bashir, K.H. lanbaz and A.J. Shah, 2005. Presence of cholinergic and calcium channel blocking activities explains the traditional use of Hibiscus rosasinensis in constipation and diarrhoea. J. Ethnopharmacol, 102: 289-294.
15. Gupta, V., P. Bansal, A. Garg and A.K. Meena, 2009. Pharmacopoeial stand ardization of Hibiscus rosa sinensis Linn. Int. J. Pharmaceut. Clin. Res., 1: 124-126.
16. Jadhav, V.M., R.M. Thorat, V.J. Kadam and N.S. Sathe, 2009. Traditional medicinal uses of Hibiscus rosasinensis. J. Pharmacy Res., 2: 1220-1222.
17. Jorda, A., M. Gomez, J. Cabo and S. Grisoha, 1982. Effect of streptozotocin diabetes on some urea cycle enzymes. Biochem. Biophys. Res. Commun., 106: 37-43.
18. Kasture, V.S., C.T. Chopde and V.K. Deshmukh, 2000. Anticonvulsive activity of Albizzia lebbeck, Hibiscus rosa sinensis and Butea monosperma in experimental animals. J. Ethnopharmacol, 71: 65-75.
19. Kikkawa, R., D. Koya and M. Haneda, 2003. Progress of diabetic neuropathy. Am. J Kidney Dis., 41: 19-21.
20. King, K.J. and A.L. Armstrong, 1988. Calcium, Phosphorus and Phosphatase. In: Practical Clinical Biochemistry, Varley, H. (Ed.). 4th Edn., CBS Publishers, New Delhi, pp: 457-461.
21. Krishnakumar, K., K.T. Augustii and P.L. Vijayammal, 1999. Hypoglycaemic and anti-oxidant activity of Salacia oblonga Wall. extract in streptozotocin-induced diabetic rats. Indian J. Physiol. Pharmacol, 43: 510-514.
22. Lowry, O.H., N.J. Rosebrough, A.L. Fair and R.J. Randall, 1951. Protein measurement with the folin phenol reagent. J. Biol. Chem., 193: 265-275.
23. Mansour, H.A. and A.A. Newairy, 2000. Amelioration of impaired renal function associated with diabetes by Balanites aegyptiaca fruits in streptozotocin-induced diabetic rats. J. Med. Res. Inst, 21: 115-125.
24. Mauer, S.M., M.W. Steffes and D.M. Brown, 1981. The kidney in diabetes. Am. Med., 70: 603-612.
25. McLennan, S.V., S. Heffernan and L. Wright 1991. Change in hepatic glutathione metabolism in diabetes. Diabetes, 40: 344-348.
26. Prince, P.S.M., V.P. Menon and L. Pari, 1997. Effect of Syzigium cumini extracts on hepatic hexokinase and glucose-6-phosphatase in experimental diabetes. Phytother. Res., 2: 529-531.
27. Pullaiah, T., 2002. Medicinal Plants in And hra Pradesh. Regency Publication, New Delhi, India, pp: 143-144, 288.
28. Rahman, M.W., M. Mostofa, S.A. Sardar, M.R. Sultana, M.M. Haque and M.E. Choudhury, 2005. Investigation of comparative hypoglycemic effect of neem (Azadirachta indicd), karala (Momordica charantea) and nayantara (Cathranthus roseus) with glibenclamide on rat. Int. J. Pharmacol., 1: 257-260.
29. Rao, B.K. and C.H. Rao, 2001. Hypoglycemic and antihyperglycemic activity oiSyzygium alternifolium (Wt.) Walp. seed extracts in normal and diabetic rats. Phytomedicme, 8: 88-93.
30. Rao, G.M., L.O. Morghmom, M.N. Kabur, B.M. Ben Mohamed and K. Ashibani, 1989. Serum Glutamic Oxaloacetic Transaminase (GOT) and Glutamic Pyruvic Transaminase (GPT) levels in diabetes mellitus. Indian J. Med. Sci., 43: 118-121.
31. Rathi, A., Ch.V. Rao, S. Khatoon and S. Mehrotra, 2003. Ethnopharmacological evaluation of Peristrophe bicalyculata Nees for anti-inflammatory and analgesic activity. Nat. Prod. Sci., 9: 195-199.
32. Reinhold, J., 1980. Determination of Serum Total Protein, Albumin and Globulin Fractions by the Biuret Method. In: Practical Clinical Biochemistry, Varley, H, AH. Gowen Lock and M. Bell (Eds.). 5th Edn., William Heinemann Medical Book Ltd., London, pp: 545-547.
33. Rosalki, S.B. and D. Rau, 1972. Serum-glutamyl transpeptidase activity in alcoholism. Clin. Chim. Acta., 39: 41-47.
34. Ross, R., 1999. Atherosclerosis an inflammatory disease. New Engl. J. Med., 340: 115-126.
35. Saeed, A., N. Ibrahim, S. Bashandy and S. El-Gengaihi, 1995. Saponin of Balanites aegyptiacaDel fruits and biological evaluation. Bull. Facl. Pharm., 33: 105-109.
36. Safiyeh, S., F. Fathallah, N. Vahid, S.S. Habib and N. Nabat, 2007. Effect of Equisetum arvense L. (Equisetaceae) in microalbuminuria and creatinine excretion in streptozotocin-induced diabetes in male rats. Int. J. Pharmacol., 3: 155-159.
37. Saravanan, G. and L. Pari, 2008. Hypoglycaemic and antihyperglycaemic effect of Syzygium cumini bark in streptozotocin-induced diabetic rats. J. Pharmacol. Toxicol., 3: 1-10.
38. Saxena, A. and N.K. Vikram, 2004. Role of selected Indian plants in management of type 2 diabetes: A review. J. Alter. Complement Med., 10: 369-378.
39. Schwartz, S.L., 2006. Diabetes and dyslipidemias. Diabetes Obes. Metab., 8: 355-364.
40. Sethi, N., D. Nath and R.K. Singh, 1986. Teratological study of an indigenous antifertility medicine, Hibiscus rosasinensis in rats. Arogya J. Health Sci., 12: 86-88.
41. Sharma, S., M. Anjanevulu, S.K. Kulkarni and K. Chopra, 2006. Resveratrol a polyphenolic phytoalexin, attenuates diabetic nephropathy in rats. Pharmacology, 76: 172-178.
42. Shmde, U.A. and R.K. Goyal, 2003. Effect of chromium picolinate on histopathological alterations in STZ and neonatal STZ diabetic rats. J. Cell. Mol. Med., 7: 322-329.
43. Thirunavukkarasu, V., C.V. Anuradha and P. Viswanathan, 2003. Protective effect of fenugreek (Trigonella foenum graecum) seeds in experimental ethanol toxicity. Phytother. Res., 17: 737-743.
44. Tuvemo, T., U. Evald, M. Kobbah and L.A. Proos, 1997. Serum magnesium and protein concentration during the 1st five years of insulin dependent diabetes in children. ActaPaed. Suppl, 418: 7-10.
45. Udoh, A.E., N. Iya, E. Okon and N. Mary, 2007. Red cell catalase activity in diabetics. Pak. J.Nutr.,6: 511-515.
46. Virella-Lopes, M.F. and G. Virella, 2003. The role of immune and inflammatory processes in the development of macrovascular disease in diabetes. Fron. Biosci., 8: 750-768.
47. WHO, 1999. Definition Diagnosis and Classification of Diabetes Mellitus and its Complications. Part 1: Diagnosis and Classification of Diabetes. WHO/NCD/NCS 99, 2, Geneva, pp: 1-58.
48. Zanna, H, S. Adeniji, B.B. Shehu, S. Modu and G.M. Ishaq, 2008. Effects of aqueous suspension of the root of Hyphaene thebaica (L.) mart on some indicators of liver and kidney function in rats. J. Pharmacol. Toxicol., 3: 330-334.g