-
1
-
-
29544432432
-
The “black box” warning and allergy drugs
-
Aaronson D.W. (2006) The “black box” warning and allergy drugs. J Allergy Clin Immunol 117: 40–44.
-
(2006)
J Allergy Clin Immunol
, vol.117
, pp. 40-44
-
-
Aaronson, D.W.1
-
5
-
-
20044368243
-
The effect of treatment with omalizumab, an anti-IgE antibody, on asthma exacerbations and emergency medical visits in patients with severe persistent asthma
-
Bousquet J. Cabrera P. Berkman N. Buhl R. Holgate S. Wenzel S. (2005) The effect of treatment with omalizumab, an anti-IgE antibody, on asthma exacerbations and emergency medical visits in patients with severe persistent asthma. Allergy 60: 302–308.
-
(2005)
Allergy
, vol.60
, pp. 302-308
-
-
Bousquet, J.1
Cabrera, P.2
Berkman, N.3
Buhl, R.4
Holgate, S.5
Wenzel, S.6
-
6
-
-
77953195601
-
Antibodies specific for a segment of human membrane IgE deplete IgE-producing B cells in humanized mice
-
Brightbill H.D. Jeet S. Lin Z. Yan D. Zhou M. Tan M. (2010) Antibodies specific for a segment of human membrane IgE deplete IgE-producing B cells in humanized mice. J Clin Invest 120: 2218–2229.
-
(2010)
J Clin Invest
, vol.120
, pp. 2218-2229
-
-
Brightbill, H.D.1
Jeet, S.2
Lin, Z.3
Yan, D.4
Zhou, M.5
Tan, M.6
-
7
-
-
38149091442
-
Targeting TNF-alpha: a novel therapeutic approach for asthma
-
quiz 11-12
-
Brightling C. Berry M. Amrani Y. (2008) Targeting TNF-alpha: a novel therapeutic approach for asthma. J Allergy Clin Immunol 121: 5–10, quiz 11-12.
-
(2008)
J Allergy Clin Immunol
, vol.121
, pp. 5-10
-
-
Brightling, C.1
Berry, M.2
Amrani, Y.3
-
8
-
-
0034907372
-
Omalizumab, anti-IgE recombinant humanized monoclonal antibody, for the treatment of severe allergic asthma
-
Busse W. Corren J. Lanier B.Q. McAlary M. Fowler-Taylor A. Cioppa G.D. (2001) Omalizumab, anti-IgE recombinant humanized monoclonal antibody, for the treatment of severe allergic asthma. J Allergy Clin Immunol 108: 184–190.
-
(2001)
J Allergy Clin Immunol
, vol.108
, pp. 184-190
-
-
Busse, W.1
Corren, J.2
Lanier, B.Q.3
McAlary, M.4
Fowler-Taylor, A.5
Cioppa, G.D.6
-
9
-
-
57349179165
-
Daclizumab improves asthma control in patients with moderate to severe persistent asthma: a randomized, controlled trial
-
Busse W.W. Israel E. Nelson H.S. Baker J.W. Charous B.L. Young D.Y. (2008) Daclizumab improves asthma control in patients with moderate to severe persistent asthma: a randomized, controlled trial. Am J Respir Crit Care Med 178: 1002–1008.
-
(2008)
Am J Respir Crit Care Med
, vol.178
, pp. 1002-1008
-
-
Busse, W.W.1
Israel, E.2
Nelson, H.S.3
Baker, J.W.4
Charous, B.L.5
Young, D.Y.6
-
10
-
-
77952683218
-
Safety profile, pharmacokinetics, and biologic activity of MEDI-563, an anti-IL-5 receptor alpha antibody, in a phase I study of subjects with mild asthma
-
Busse W.W. Katial R. Gossage D. Sari S. Wang B. Kolbeck R. (2010) Safety profile, pharmacokinetics, and biologic activity of MEDI-563, an anti-IL-5 receptor alpha antibody, in a phase I study of subjects with mild asthma. J Allergy Clin Immunol 125: 1237–1244 e1232.
-
(2010)
J Allergy Clin Immunol
, vol.125
, pp. 1237-1244 e1232
-
-
Busse, W.W.1
Katial, R.2
Gossage, D.3
Sari, S.4
Wang, B.5
Kolbeck, R.6
-
12
-
-
0000898623
-
The pharmacological basis of anti-IgE therapy
-
Chang T.W. (2000) The pharmacological basis of anti-IgE therapy. Nat Biotechnol 18: 157–162.
-
(2000)
Nat Biotechnol
, vol.18
, pp. 157-162
-
-
Chang, T.W.1
-
13
-
-
77953039047
-
A randomized, controlled, phase 2 study of AMG 317, an IL-4Ralpha antagonist, in patients with asthma
-
Corren J. Busse W. Meltzer E.O. Mansfield L. Bensch G. Fahrenholz J. (2010) A randomized, controlled, phase 2 study of AMG 317, an IL-4Ralpha antagonist, in patients with asthma. Am J Respir Crit Care Med 181: 788–796.
-
(2010)
Am J Respir Crit Care Med
, vol.181
, pp. 788-796
-
-
Corren, J.1
Busse, W.2
Meltzer, E.O.3
Mansfield, L.4
Bensch, G.5
Fahrenholz, J.6
-
14
-
-
33846464598
-
Safety of anti-immunoglobulin E therapy with omalizumab in allergic patients at risk of geohelminth infection
-
Cruz A.A. Lima F. Sarinho E. Ayre G. Martin C. Fox H. (2007) Safety of anti-immunoglobulin E therapy with omalizumab in allergic patients at risk of geohelminth infection. Clin Exp Allergy 37: 197–207.
-
(2007)
Clin Exp Allergy
, vol.37
, pp. 197-207
-
-
Cruz, A.A.1
Lima, F.2
Sarinho, E.3
Ayre, G.4
Martin, C.5
Fox, H.6
-
15
-
-
0020606965
-
Blockade of the interleukin-2 receptor by anti-Tac antibody: inhibition of human lymphocyte activation
-
Depper J.M. Leonard W.J. Robb R.J. Waldmann T.A. Greene W.C. (1983) Blockade of the interleukin-2 receptor by anti-Tac antibody: inhibition of human lymphocyte activation. J Immunol 131: 690–696.
-
(1983)
J Immunol
, vol.131
, pp. 690-696
-
-
Depper, J.M.1
Leonard, W.J.2
Robb, R.J.3
Waldmann, T.A.4
Greene, W.C.5
-
16
-
-
36849070537
-
Cytokines and growth factors in airway remodeling in asthma
-
Doherty T. Broide D. (2007) Cytokines and growth factors in airway remodeling in asthma. Curr Opin Immunol 19: 676–680.
-
(2007)
Curr Opin Immunol
, vol.19
, pp. 676-680
-
-
Doherty, T.1
Broide, D.2
-
18
-
-
32644459549
-
Inhibition of tumor necrosis factor alpha for refractory asthma
-
Erzurum S.C. (2006) Inhibition of tumor necrosis factor alpha for refractory asthma. N Engl J Med 354: 754–758.
-
(2006)
N Engl J Med
, vol.354
, pp. 754-758
-
-
Erzurum, S.C.1
-
19
-
-
85047693849
-
Anti-IL-5 treatment reduces deposition of ECM proteins in the bronchial subepithelial basement membrane of mild atopic asthmatics
-
Flood-Page P. Menzies-Gow A. Phipps S. Ying S. Wangoo A. Ludwig M.S. (2003) Anti-IL-5 treatment reduces deposition of ECM proteins in the bronchial subepithelial basement membrane of mild atopic asthmatics. J Clin Invest 112: 1029–1036.
-
(2003)
J Clin Invest
, vol.112
, pp. 1029-1036
-
-
Flood-Page, P.1
Menzies-Gow, A.2
Phipps, S.3
Ying, S.4
Wangoo, A.5
Ludwig, M.S.6
-
25
-
-
0036379740
-
Preclinical efficacy and safety of pascolizumab (SB 240683): a humanized anti-interleukin-4 antibody with therapeutic potential in asthma
-
Hart T.K. Blackburn M.N. Brigham-Burke M. Dede K. Al-Mahdi N. Zia-Amirhosseini P. (2002) Preclinical efficacy and safety of pascolizumab (SB 240683): a humanized anti-interleukin-4 antibody with therapeutic potential in asthma. Clin Exp Immunol 130: 93–100.
-
(2002)
Clin Exp Immunol
, vol.130
, pp. 93-100
-
-
Hart, T.K.1
Blackburn, M.N.2
Brigham-Burke, M.3
Dede, K.4
Al-Mahdi, N.5
Zia-Amirhosseini, P.6
-
26
-
-
0141570710
-
Pharmacodynamics of omalizumab: implications for optimised dosing strategies and clinical efficacy in the treatment of allergic asthma
-
Hochhaus G. Brookman L. Fox H. Johnson C. Matthews J. Ren S. (2003) Pharmacodynamics of omalizumab: implications for optimised dosing strategies and clinical efficacy in the treatment of allergic asthma. Curr Med Res Opin 19: 491–498.
-
(2003)
Curr Med Res Opin
, vol.19
, pp. 491-498
-
-
Hochhaus, G.1
Brookman, L.2
Fox, H.3
Johnson, C.4
Matthews, J.5
Ren, S.6
-
27
-
-
28244479315
-
Tumour necrosis factor (TNFalpha) as a novel therapeutic target in symptomatic corticosteroid dependent asthma
-
Howarth P.H. Babu K.S. Arshad H.S. Lau L. Buckley M. McConnell W. (2005) Tumour necrosis factor (TNFalpha) as a novel therapeutic target in symptomatic corticosteroid dependent asthma. Thorax 60: 1012–1018.
-
(2005)
Thorax
, vol.60
, pp. 1012-1018
-
-
Howarth, P.H.1
Babu, K.S.2
Arshad, H.S.3
Lau, L.4
Buckley, M.5
McConnell, W.6
-
28
-
-
20044362008
-
Benefits of omalizumab as add-on therapy in patients with severe persistent asthma who are inadequately controlled despite best available therapy (GINA 2002 step 4 treatment): INNOVATE
-
Humbert M. Beasley R. Ayres J. Slavin R. Hebert J. Bousquet J. (2005) Benefits of omalizumab as add-on therapy in patients with severe persistent asthma who are inadequately controlled despite best available therapy (GINA 2002 step 4 treatment): INNOVATE. Allergy 60: 309–316.
-
(2005)
Allergy
, vol.60
, pp. 309-316
-
-
Humbert, M.1
Beasley, R.2
Ayres, J.3
Slavin, R.4
Hebert, J.5
Bousquet, J.6
-
29
-
-
0025270366
-
Anti-Tac-H, a humanized antibody to the interleukin 2 receptor with new features for immunotherapy in malignant and immune disorders
-
Junghans R.P. Waldmann T.A. Landolfi N.F. Avdalovic N.M. Schneider W.P. Queen C. (1990) Anti-Tac-H, a humanized antibody to the interleukin 2 receptor with new features for immunotherapy in malignant and immune disorders. Cancer Res 50: 1495–1502.
-
(1990)
Cancer Res
, vol.50
, pp. 1495-1502
-
-
Junghans, R.P.1
Waldmann, T.A.2
Landolfi, N.F.3
Avdalovic, N.M.4
Schneider, W.P.5
Queen, C.6
-
30
-
-
0038643527
-
Effect of SCH55700, a humanized anti-human interleukin-5 antibody, in severe persistent asthma: a pilot study
-
Kips J.C. O'Connor B.J. Langley S.J. Woodcock A. Kerstjens H.A. Postma D.S. (2003) Effect of SCH55700, a humanized anti-human interleukin-5 antibody, in severe persistent asthma: a pilot study. Am J Respir Crit Care Med 167: 1655–1659.
-
(2003)
Am J Respir Crit Care Med
, vol.167
, pp. 1655-1659
-
-
Kips, J.C.1
O'Connor, B.J.2
Langley, S.J.3
Woodcock, A.4
Kerstjens, H.A.5
Postma, D.S.6
-
31
-
-
67249158818
-
Establishment of humanized anti-interleukin-5 receptor alpha chain monoclonal antibodies having a potent neutralizing activity
-
Koike M. Nakamura K. Furuya A. Iida A. Anazawa H. Takatsu K. (2009) Establishment of humanized anti-interleukin-5 receptor alpha chain monoclonal antibodies having a potent neutralizing activity. Hum Antibodies 18: 17–27.
-
(2009)
Hum Antibodies
, vol.18
, pp. 17-27
-
-
Koike, M.1
Nakamura, K.2
Furuya, A.3
Iida, A.4
Anazawa, H.5
Takatsu, K.6
-
32
-
-
77952733788
-
MEDI-563, a humanized anti-IL-5 receptor alpha mAb with enhanced antibody-dependent cell-mediated cytotoxicity function
-
Kolbeck R. Kozhich A. Koike M. Peng L. Andersson C.K. Damschroder M.M. (2010) MEDI-563, a humanized anti-IL-5 receptor alpha mAb with enhanced antibody-dependent cell-mediated cytotoxicity function. J Allergy Clin Immunol 125: 1344–1353 e1342.
-
(2010)
J Allergy Clin Immunol
, vol.125
, pp. 1344-1353 e1342
-
-
Kolbeck, R.1
Kozhich, A.2
Koike, M.3
Peng, L.4
Andersson, C.K.5
Damschroder, M.M.6
-
33
-
-
0032480574
-
Randomised, dose-ranging, placebo-controlled study of chimeric antibody to CD4 (keliximab) in chronic severe asthma
-
Kon O.M. Sihra B.S. Compton C.H. Leonard T.B. Kay A.B. Barnes N.C. (1998) Randomised, dose-ranging, placebo-controlled study of chimeric antibody to CD4 (keliximab) in chronic severe asthma. Lancet 352: 1109–1113.
-
(1998)
Lancet
, vol.352
, pp. 1109-1113
-
-
Kon, O.M.1
Sihra, B.S.2
Compton, C.H.3
Leonard, T.B.4
Kay, A.B.5
Barnes, N.C.6
-
34
-
-
70349542893
-
Omalizumab in patients with severe persistent allergic asthma in a real-life setting in Germany
-
Korn S. Thielen A. Seyfried S. Taube C. Kornmann O. Buhl R. (2009) Omalizumab in patients with severe persistent allergic asthma in a real-life setting in Germany. Respir Med 103: 1725–1731.
-
(2009)
Respir Med
, vol.103
, pp. 1725-1731
-
-
Korn, S.1
Thielen, A.2
Seyfried, S.3
Taube, C.4
Kornmann, O.5
Buhl, R.6
-
35
-
-
6644229440
-
Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response
-
Leckie M.J. ten Brinke A. Khan J. Diamant Z. O'Connor B.J. Walls C.M. (2000) Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response. Lancet 356: 2144–2148.
-
(2000)
Lancet
, vol.356
, pp. 2144-2148
-
-
Leckie, M.J.1
ten Brinke, A.2
Khan, J.3
Diamant, Z.4
O'Connor, B.J.5
Walls, C.M.6
-
36
-
-
76749136238
-
Immunomodulator therapy: monoclonal antibodies, fusion proteins, cytokines, and immunoglobulins
-
Lee S.J. Chinen J. Kavanaugh A. (2010) Immunomodulator therapy: monoclonal antibodies, fusion proteins, cytokines, and immunoglobulins. J Allergy Clin Immunol 125(2 Suppl.2): S314's323.
-
(2010)
J Allergy Clin Immunol
, vol.125
, Issue.2
, pp. S314-S323
-
-
Lee, S.J.1
Chinen, J.2
Kavanaugh, A.3
-
37
-
-
36749043895
-
Delayed onset and protracted progression of anaphylaxis after omalizumab administration in patients with asthma
-
Limb S.L. Starke P.R. Lee C.E. Chowdhury B.A. (2007) Delayed onset and protracted progression of anaphylaxis after omalizumab administration in patients with asthma. J Allergy Clin Immunol 120: 1378–1381.
-
(2007)
J Allergy Clin Immunol
, vol.120
, pp. 1378-1381
-
-
Limb, S.L.1
Starke, P.R.2
Lee, C.E.3
Chowdhury, B.A.4
-
39
-
-
67650434286
-
Immunomodulators in the treatment of asthma
-
Long A.A. (2009a) Immunomodulators in the treatment of asthma. Allergy Asthma Proc 30: 109–119.
-
(2009)
Allergy Asthma Proc
, vol.30
, pp. 109-119
-
-
Long, A.A.1
-
40
-
-
77951535660
-
Monoclonal antibodies and other biologic agents in the treatment of asthma
-
Long A.A. (2009b) Monoclonal antibodies and other biologic agents in the treatment of asthma. MAbs 1: 237–246.
-
(2009)
MAbs
, vol.1
, pp. 237-246
-
-
Long, A.A.1
-
41
-
-
34548762411
-
Monoclonal antibodies in Pediatrics: use in prevention and treatment
-
Martin-Mateos M. (2007) Monoclonal antibodies in Pediatrics: use in prevention and treatment. Allergologia Immunopathologia 35: 145–150.
-
(2007)
Allergologia Immunopathologia
, vol.35
, pp. 145-150
-
-
Martin-Mateos, M.1
-
42
-
-
0036721711
-
IL-2 receptor blockade inhibits late, but not early, IFN-gamma and CD40 ligand expression in human T cells: disruption of both IL-12-dependent and -independent pathways of IFN-gamma production
-
McDyer J.F. Li Z. John S. Yu X. Wu C.Y. Ragheb J.A. (2002) IL-2 receptor blockade inhibits late, but not early, IFN-gamma and CD40 ligand expression in human T cells: disruption of both IL-12-dependent and -independent pathways of IFN-gamma production. J Immunol 169: 2736–2746.
-
(2002)
J Immunol
, vol.169
, pp. 2736-2746
-
-
McDyer, J.F.1
Li, Z.2
John, S.3
Yu, X.4
Wu, C.Y.5
Ragheb, J.A.6
-
45
-
-
47049130758
-
The role of a soluble TNFalpha receptor fusion protein (etanercept) in corticosteroid refractory asthma: a double blind, randomised, placebo controlled trial
-
Morjaria J.B. Chauhan A.J. Babu K.S. Polosa R. Davies D.E. Holgate S.T. (2008) The role of a soluble TNFalpha receptor fusion protein (etanercept) in corticosteroid refractory asthma: a double blind, randomised, placebo controlled trial. Thorax 63: 584–591.
-
(2008)
Thorax
, vol.63
, pp. 584-591
-
-
Morjaria, J.B.1
Chauhan, A.J.2
Babu, K.S.3
Polosa, R.4
Davies, D.E.5
Holgate, S.T.6
-
48
-
-
25844461664
-
Anti-CD23 monoclonal antibody, lumiliximab, inhibited allergen-induced responses in antigen-presenting cells and T cells from atopic subjects
-
Poole J.A. Meng J. Reff M. Spellman M.C. Rosenwasser L.J. (2005) Anti-CD23 monoclonal antibody, lumiliximab, inhibited allergen-induced responses in antigen-presenting cells and T cells from atopic subjects. J Allergy Clin Immunol 116: 780–788.
-
(2005)
J Allergy Clin Immunol
, vol.116
, pp. 780-788
-
-
Poole, J.A.1
Meng, J.2
Reff, M.3
Spellman, M.C.4
Rosenwasser, L.J.5
-
51
-
-
0028144786
-
IL-4: a key cytokine in atopy
-
Ricci M. (1994) IL-4: a key cytokine in atopy. Clin Exp Allergy 24: 801–812.
-
(1994)
Clin Exp Allergy
, vol.24
, pp. 801-812
-
-
Ricci, M.1
-
52
-
-
0033136728
-
Down-regulation of human basophil IgE and FC epsilon RI alpha surface densities and mediator release by anti-IgE-infusions is reversible in vitro and in vivo
-
Saini S.S. MacGlashan D.W. Jr Sterbinsky S.A. Togias A. Adelman D.C. Lichtenstein L.M. (1999) Down-regulation of human basophil IgE and FC epsilon RI alpha surface densities and mediator release by anti-IgE-infusions is reversible in vitro and in vivo. J Immunol 162: 5624–5630.
-
(1999)
J Immunol
, vol.162
, pp. 5624-5630
-
-
Saini, S.S.1
MacGlashan, D.W.2
Sterbinsky, S.A.3
Togias, A.4
Adelman, D.C.5
Lichtenstein, L.M.6
-
53
-
-
4944230274
-
The safety and pharmacokinetics of SB240683 anti-Il-4 humanized monoclonal antibody) in patients with mild to moderate asthma
-
Shames R.S. Vexler V. Lane N.M. McClellan M. Shi J. Keller S. (2001) The safety and pharmacokinetics of SB240683 anti-Il-4 humanized monoclonal antibody) in patients with mild to moderate asthma. J Allergy Clin Immunol 107: S316's316.
-
(2001)
J Allergy Clin Immunol
, vol.107
, pp. S316-S316
-
-
Shames, R.S.1
Vexler, V.2
Lane, N.M.3
McClellan, M.4
Shi, J.5
Keller, S.6
-
54
-
-
38449109458
-
Anti-IgE and other antibody targets in asthma
-
Singh J. Kraft M. (2008) Anti-IgE and other antibody targets in asthma. Handb Exp Pharmacol 181: 257–288.
-
(2008)
Handb Exp Pharmacol
, vol.181
, pp. 257-288
-
-
Singh, J.1
Kraft, M.2
-
55
-
-
0034881877
-
The anti-IgE antibody omalizumab reduces exacerbations and steroid requirement in allergic asthmatics
-
Soler M. Matz J. Townley R. Buhl R. O'Brien J. Fox H. (2001) The anti-IgE antibody omalizumab reduces exacerbations and steroid requirement in allergic asthmatics. Eur Respir J 18: 254–261.
-
(2001)
Eur Respir J
, vol.18
, pp. 254-261
-
-
Soler, M.1
Matz, J.2
Townley, R.3
Buhl, R.4
O'Brien, J.5
Fox, H.6
-
57
-
-
77951614830
-
Monoclonal antibodies: versatile platforms for cancer immunotherapy
-
Weiner L.M. Surana R. Wang S. (2010) Monoclonal antibodies: versatile platforms for cancer immunotherapy. Nat Rev Immunol 10: 317–327.
-
(2010)
Nat Rev Immunol
, vol.10
, pp. 317-327
-
-
Weiner, L.M.1
Surana, R.2
Wang, S.3
-
58
-
-
62549084077
-
A randomized, double-blind, placebo-controlled study of tumor necrosis factor-alpha blockade in severe persistent asthma
-
Wenzel S.E. Barnes P.J. Bleecker E.R. Bousquet J. Busse W. Dahlen S.E. (2009) A randomized, double-blind, placebo-controlled study of tumor necrosis factor-alpha blockade in severe persistent asthma. Am J Respir Crit Care Med 179: 549–558.
-
(2009)
Am J Respir Crit Care Med
, vol.179
, pp. 549-558
-
-
Wenzel, S.E.1
Barnes, P.J.2
Bleecker, E.R.3
Bousquet, J.4
Busse, W.5
Dahlen, S.E.6
|