-
1
-
-
38949141609
-
Immunomodulators: A brave new world
-
Ballas ZK. Immunomodulators: a brave new world. J Allergy Clin Immunol 2008; 121:331-333.
-
(2008)
J Allergy Clin Immunol
, vol.121
, pp. 331-333
-
-
Ballas, Z.K.1
-
2
-
-
52049113214
-
New targets for drug development in asthma
-
Adcock IM, Caramori G, Chung KF. New targets for drug development in asthma. Lancet 2008; 372:1073-1087.
-
(2008)
Lancet
, vol.372
, pp. 1073-1087
-
-
Adcock, I.M.1
Caramori, G.2
Chung, K.F.3
-
3
-
-
33749321597
-
Management of asthma with antiimmunoglobulin E: A review of clinical trials of omalizumab
-
Nowak D. Management of asthma with antiimmunoglobulin E: a review of clinical trials of omalizumab. Respir Med 2006; 100:1907-1917.
-
(2006)
Respir Med
, vol.100
, pp. 1907-1917
-
-
Nowak, D.1
-
4
-
-
33845334892
-
Biologic immune modifiers: Trials and tribulations: Are we there yet?
-
Ballow M. Biologic immune modifiers: trials and tribulations: are we there yet? J Allergy Clin Immunol 2006; 118:1209-1215.
-
(2006)
J Allergy Clin Immunol
, vol.118
, pp. 1209-1215
-
-
Ballow, M.1
-
5
-
-
67649366101
-
The use of omalizumab in the treatment of severe allergic asthma: A clinical experience update
-
Holgate S, Buhl R, Bousquet J, et al. The use of omalizumab in the treatment of severe allergic asthma: a clinical experience update. Respir Med 2009; 103:1098-1113.
-
(2009)
Respir Med
, vol.103
, pp. 1098-1113
-
-
Holgate, S.1
Buhl, R.2
Bousquet, J.3
-
6
-
-
45349094683
-
The use of omalizumab in asthma
-
Price D. The use of omalizumab in asthma. Prim Care Respir J 2008; 17:62-72.
-
(2008)
Prim Care Respir J
, vol.17
, pp. 62-72
-
-
Price, D.1
-
7
-
-
0034907372
-
Omalizumab, anti-IgE recombinant humanized monoclonal antibody, for the treatment of severe allergic asthma
-
Busse WW, Corren J, Lanier BQ, et al. Omalizumab, anti-IgE recombinant humanized monoclonal antibody, for the treatment of severe allergic asthma. J Allergy Clin Immunol 2001; 108:184-190.
-
(2001)
J Allergy Clin Immunol
, vol.108
, pp. 184-190
-
-
Busse, W.W.1
Corren, J.2
Lanier, B.Q.3
-
8
-
-
70349542893
-
Omalizumab in patients with severe persistent allergic asthma in a real-life setting in Germany
-
doi:10.1016/j.rmed.2009.05.002
-
Korn S, Thielen A, Seyfried S, et al. Omalizumab in patients with severe persistent allergic asthma in a real-life setting in Germany. Respir Med 2009; doi: 10.1016/j.rmed.2009.05.002.
-
(2009)
Respir Med
-
-
Korn, S.1
Thielen, A.2
Seyfried, S.3
-
9
-
-
58849143492
-
Combination of omalizumab and specific immunotherapy is superior to immunotherapy in patients with seasonal allergic rhinoconjunctivitis and co-morbid seasonal allergic asthma
-
Koop MV, Hamelmann E, Zielen S, et al. Combination of omalizumab and specific immunotherapy is superior to immunotherapy in patients with seasonal allergic rhinoconjunctivitis and co-morbid seasonal allergic asthma. Clin Exp Allergy 2008; 39:271-279.
-
(2008)
Clin Exp Allergy
, vol.39
, pp. 271-279
-
-
Koop, M.V.1
Hamelmann, E.2
Zielen, S.3
-
10
-
-
58149119978
-
Omalizumab therapy: Patients who achieve greatest benefit for their asthma experience greatest benefit for rhinitis
-
Humbert M, Boulet LP, Niven RM, et al. Omalizumab therapy: patients who achieve greatest benefit for their asthma experience greatest benefit for rhinitis. Allergy 2009; 64:81-84.
-
(2009)
Allergy
, vol.64
, pp. 81-84
-
-
Humbert, M.1
Boulet, L.P.2
Niven, R.M.3
-
12
-
-
44649103777
-
Anti-IL-5 (mepolizumab) therapy reduces eosinophil activation ex vivo and increases IL-5 and IL-5 receptor levels
-
Stein ML, Villanueva JM, Buckmeier BK, et al. Anti-IL-5 (mepolizumab) therapy reduces eosinophil activation ex vivo and increases IL-5 and IL-5 receptor levels. J Allergy Clin Immunol 2008; 121:1473-1483.
-
(2008)
J Allergy Clin Immunol
, vol.121
, pp. 1473-1483
-
-
Stein, M.L.1
Villanueva, J.M.2
Buckmeier, B.K.3
-
13
-
-
0037438409
-
Eosinophil's role remains uncertain as antiinterleukin-5 only partially depletes numbers in asthmatic airway
-
Flood-Page PT, Menzies-Gow AN, Kay AB, et al. Eosinophil's role remains uncertain as antiinterleukin-5 only partially depletes numbers in asthmatic airway. Am J Respir Crit Care Med 2003; 167:199-204.
-
(2003)
Am J Respir Crit Care Med
, vol.167
, pp. 199-204
-
-
Flood-Page, P.T.1
Menzies-Gow, A.N.2
Kay, A.B.3
-
14
-
-
36749065556
-
A study to evaluate safety and efficacy of mepolizumab in patients with moderate persistent asthma
-
Flood-Page P, Swenson C, Faiferman I, et al. A study to evaluate safety and efficacy of mepolizumab in patients with moderate persistent asthma. Am J Respir Crit Care Med 2007; 176:1062-1071.
-
(2007)
Am J Respir Crit Care Med
, vol.176
, pp. 1062-1071
-
-
Flood-Page, P.1
Swenson, C.2
Faiferman, I.3
-
15
-
-
61849086181
-
Mepolizumab and exacerbations of refractory eosinophilic asthma
-
Haldar P, Brightling CE, Hargadon B, et al. Mepolizumab and exacerbations of refractory eosinophilic asthma. N Engl J Med 2009; 360:973-984.
-
(2009)
N Engl J Med
, vol.360
, pp. 973-984
-
-
Haldar, P.1
Brightling, C.E.2
Hargadon, B.3
-
16
-
-
61849155730
-
Mepolizumab for prednisonedependent asthma with sputum eosinophilia
-
Nair P, Pizzichini MM, Kjarsgaard M, et al. Mepolizumab for prednisonedependent asthma with sputum eosinophilia. N Engl J Med 2009; 360: 985-993.
-
(2009)
N Engl J Med
, vol.360
, pp. 985-993
-
-
Nair, P.1
Pizzichini, M.M.2
Kjarsgaard, M.3
-
17
-
-
32644490529
-
Evidence of a role of tumor necrosis factor a in refractory asthma
-
Berry MA, Hargadon B, Shelley M, et al. Evidence of a role of tumor necrosis factor a in refractory asthma. N Engl J Med 2006; 354:697-708.
-
(2006)
N Engl J Med
, vol.354
, pp. 697-708
-
-
Berry, M.A.1
Hargadon, B.2
Shelley, M.3
-
18
-
-
32644459549
-
Inhibition of tumor necrosis factor alpha for refractory asthma
-
Erzurum SC. Inhibition of tumor necrosis factor alpha for refractory asthma. N Engl J Med 2006; 354:754-758.
-
(2006)
N Engl J Med
, vol.354
, pp. 754-758
-
-
Erzurum, S.C.1
-
19
-
-
28244479315
-
Tumour necrosis factor (TNFa) as a novel therapeutic target in symptomatic corticosteroid dependent asthma
-
Howarth PH, Babu KS, Arshad HS, et al. Tumour necrosis factor (TNFa) as a novel therapeutic target in symptomatic corticosteroid dependent asthma. Thorax 2005; 60:1012-1018.
-
(2005)
Thorax
, vol.60
, pp. 1012-1018
-
-
Howarth, P.H.1
Babu, K.S.2
Arshad, H.S.3
-
20
-
-
33749438560
-
The effects of a monoclonal antibody directed against tumor necrosis factor-a in asthma
-
Erin EM, Leaker BR, Nicholson GC, et al. The effects of a monoclonal antibody directed against tumor necrosis factor-a in asthma. Am J Respir Crit Care Med 2006; 174:753-762.
-
(2006)
Am J Respir Crit Care Med
, vol.174
, pp. 753-762
-
-
Erin, E.M.1
Leaker, B.R.2
Nicholson, G.C.3
-
21
-
-
62549084077
-
A randomized, double-blind, placebo-controlled study of tumor necrosis factor-a blockade in severe persistent asthma
-
Wenzel SE, Barnes PJ, Bleecker ER, et al. A randomized, double-blind, placebo-controlled study of tumor necrosis factor-a blockade in severe persistent asthma. Am J Respir Crit Care Med 2009; 179:549-558.
-
(2009)
Am J Respir Crit Care Med
, vol.179
, pp. 549-558
-
-
Wenzel, S.E.1
Barnes, P.J.2
Bleecker, E.R.3
-
22
-
-
0034995872
-
Efficacy of soluble IL-4 receptor for the treatment of adults with asthma
-
Borish LC, Nelson HS, Corren J, et al. Efficacy of soluble IL-4 receptor for the treatment of adults with asthma. J Allergy Clin Immunol 2001; 107:963-970.
-
(2001)
J Allergy Clin Immunol
, vol.107
, pp. 963-970
-
-
Borish, L.C.1
Nelson, H.S.2
Corren, J.3
-
25
-
-
4944230274
-
The safety and pharmacokinetics of SB240683 (anti-IL-4 humanized monoclonal antibody) in patients with mild to moderate asthma
-
Shames RS, Vexler V, Lane N, et al. The safety and pharmacokinetics of SB240683 (anti-IL-4 humanized monoclonal antibody) in patients with mild to moderate asthma. J Allergy Clin Immunol 2001; 107:S317.
-
(2001)
J Allergy Clin Immunol
, vol.107
-
-
Shames, R.S.1
Vexler, V.2
Lane, N.3
-
26
-
-
0034906753
-
The effects of an anti-CD4 monoclonal antibody, keliximab, on peripheral blood CD4+ T-cells in asthma
-
Kon OM, Sihra BS, Loh LC, et al. The effects of an anti-CD4 monoclonal antibody, keliximab, on peripheral blood CD4+ T-cells in asthma. Eur Respir J 2001; 18:45-52.
-
(2001)
Eur Respir J
, vol.18
, pp. 45-52
-
-
Kon, O.M.1
Sihra, B.S.2
Loh, L.C.3
-
27
-
-
35348909044
-
Effect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: Results of two phase 2a studies
-
Wenzel S, Wilbraham D, Fuller R, et al. Effect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: results of two phase 2a studies. Lancet 2007; 370:1422-1431.
-
(2007)
Lancet
, vol.370
, pp. 1422-1431
-
-
Wenzel, S.1
Wilbraham, D.2
Fuller, R.3
-
28
-
-
61749098024
-
Immunotherapeutic applications of CpG oligodeoxynucleotide TLR9 agonists
-
Vollmer J, Krieg AM. Immunotherapeutic applications of CpG oligodeoxynucleotide TLR9 agonists. Adv Drug Deliv Rev 2009; 61:195-204.
-
(2009)
Adv Drug Deliv Rev
, vol.61
, pp. 195-204
-
-
Vollmer, J.1
Krieg, A.M.2
-
29
-
-
38949201705
-
Immunomodulators for allergic respiratory disorders
-
Casale TB, Stokes JR. Immunomodulators for allergic respiratory disorders. J Allergy Clin Immunol 2008; 121:288-296.
-
(2008)
J Allergy Clin Immunol
, vol.121
, pp. 288-296
-
-
Casale, T.B.1
Stokes, J.R.2
-
30
-
-
36849070537
-
Cytokines and growth factors in airway remodeling in asthma
-
Doherty T, Broide D. Cytokines and growth factors in airway remodeling in asthma. Curr Opin Immunol 2007; 19:676-680.
-
(2007)
Curr Opin Immunol
, vol.19
, pp. 676-680
-
-
Doherty, T.1
Broide, D.2
-
31
-
-
40949121542
-
The airway epithelium is central to the pathogenesis of asthma
-
Holgate ST. The airway epithelium is central to the pathogenesis of asthma. Allergol Int 2008; 57:1-10.
-
(2008)
Allergol Int
, vol.57
, pp. 1-10
-
-
Holgate, S.T.1
-
32
-
-
67650434286
-
Immunomodulators in the treatment of asthma
-
Long AA. Immunomodulators in the treatment of asthma. Allergy Asthma Proc 2009; 30:109-119.
-
(2009)
Allergy Asthma Proc
, vol.30
, pp. 109-119
-
-
Long, A.A.1
-
33
-
-
57349179165
-
Daclizumab improves asthma control in patients with moderate to severe persistent asthma: A randomized, controlled trial
-
Busse WW, Israel E, Nelson HS, et al. Daclizumab improves asthma control in patients with moderate to severe persistent asthma: a randomized, controlled trial. Am J Respir Crit Care Med 2008; 178:1002-1008.
-
(2008)
Am J Respir Crit Care Med
, vol.178
, pp. 1002-1008
-
-
Busse, W.W.1
Israel, E.2
Nelson, H.S.3
-
34
-
-
74549121557
-
Incidence of asthma exacerbations by season and the effects of treatment with fluticasone propionate/salmeterol (FSC) or fluticasone propionate (FP) compared with montelukast [abstract]
-
Nelson H, Yancey S, Emmett A, et al. Incidence of asthma exacerbations by season and the effects of treatment with fluticasone propionate/salmeterol (FSC) or fluticasone propionate (FP) compared with montelukast [abstract]. J Allergy Clin Immunol 2005; 115:S2.
-
(2005)
J Allergy Clin Immunol
, vol.115
-
-
Nelson, H.1
Yancey, S.2
Emmett, A.3
-
35
-
-
25844510667
-
Preliminary safety and efficacy of daclizumab in the treatment of patients with moderate to severe chronic persistent asthma [abstract]
-
Busse WW, Baker JW, Charous BL, et al. Preliminary safety and efficacy of daclizumab in the treatment of patients with moderate to severe chronic persistent asthma [abstract]. J Allergy Clin Immunol 2004; 113:S286-S287.
-
(2004)
J Allergy Clin Immunol
, vol.113
-
-
Busse, W.W.1
Baker, J.W.2
Charous, B.L.3
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