T-cell activation triggers death receptor-6 expression in a NF-κB and NF-AT dependent manner

Molecular Immunology

Volumn 48, Issue 12-13, 2011, Pages 1439-1447

  Klíma, Martin ^a   Broučková, Adéla ^a   Koc, Michal ^a   Anděra, Ladislav ^a  

^a INSTITUTE OF MOLECULAR GENETICS   (Czech Republic)

Author keywords

DR6; Jurkat; NF kappaB; T cells; TNFRSF21

Indexed keywords

DEATH RECEPTOR; DEATH RECEPTOR 6; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TRANSCRIPTION FACTOR NFAT; UNCLASSIFIED DRUG;

ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE ACTIVATION;

ANIMALS; ANTIGENS, CD3; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL MOVEMENT; HUMANS; INTERLEUKINS; JURKAT CELLS; LYMPHOCYTE ACTIVATION; MICE; MICE, TRANSGENIC; NF-KAPPA B; NFATC TRANSCRIPTION FACTORS; POLYMERASE CHAIN REACTION; PROMOTER REGIONS, GENETIC; RECEPTORS, ANTIGEN, T-CELL; RECEPTORS, TUMOR NECROSIS FACTOR; SIGNAL TRANSDUCTION; TH2 CELLS; UP-REGULATION;

MURINAE;

EID: 79957842617     PISSN: 01615890     EISSN: 18729142     Source Type: Journal    
DOI: 10.1016/j.molimm.2011.03.021     Document Type: Article

References (37)

1. Abraham R.T., Weiss A. Jurkat T cells and development of the T-cell receptor signalling paradigm. Nat. Rev. Immunol. 2004, 4:301-308.
2. Aggarwal B.B. Signalling pathways of the TNF superfamily: a double-edged sword. Nat. Rev. Immunol. 2003, 3:745-756.
3. Aggarwal B.B., Eessalu T.E., Hass P.E. Characterization of receptors for human tumour necrosis factor and their regulation by gamma-interferon. Nature 1985, 318:665-667.
4. Baum P.R., Gayle R.B., Ramsdell F., Srinivasan S., Sorensen R.A., Watson M.L., Seldin M.F., Baker E., Sutherland G.R., Clifford K.N., et al. Molecular characterization of murine and human OX40/OX40 ligand systems: identification of a human OX40 ligand as the HTLV-1-regulated protein gp34. EMBO J. 1994, 13:3992-4001.
5. Benschop R., Wei T., Na S. Tumor necrosis factor receptor superfamily member 21: TNFR-related death receptor-6 DR6. Adv. Exp. Med. Biol. 2009, 647:186-194.
6. Bridgham J.T., Bobe J., Goetz F.W., Johnson A.L. Conservation of death receptor-6 in avian and piscine vertebrates. Biochem. Biophys. Res. Commun. 2001, 284:1109-1115.
7. Cannons J.L., Lau P., Ghumman B., DeBenedette M.A., Yagita H., Okumura K., Watts T.H. 4-1BB ligand induces cell division, sustains survival, and enhances effector function of CD4 and CD8 T cells with similar efficacy. J. Immunol. 2001, 167:1313-1324.
8. Cartharius K., Frech K., Grote K., Klocke B., Haltmeier M., Klingenhoff A., Frisch M., Bayerlein M., Werner T. MatInspector and beyond: promoter analysis based on transcription factor binding sites. Bioinformatics 2005, 21:2933-2942.
9. Gaur U., Aggarwal B.B. Regulation of proliferation, survival and apoptosis by members of the TNF superfamily. Biochem. Pharmacol. 2003, 66:1403-1408.
10. Chinnaiyan A.M., O'Rourke K., Yu G.L., Lyons R.H., Garg M., Duan D.R., Xing L., Gentz R., Ni J., Dixit V.M. Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95. Science 1996, 274:990-992.
11. Itoh N., Yonehara S., Ishii A., Yonehara M., Mizushima S., Sameshima M., Hase A., Seto Y., Nagata S. The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis. Cell 1991, 66:233-243.
12. Jones G.W., Stumhofer J.S., Foster T., Twohig J.P., Hertzog P., Topley N., Williams A.S., Hunter C.A., Jenkins B.J., Wang E.C., Jones S.A. Naive and activated T cells display differential responsiveness to TL1A that affects Th17 generation, maintenance, and proliferation. FASEB J. 2011, 25:409-419.
13. Kane L.P., Shapiro V.S., Stokoe D., Weiss A. Induction of NF-kappaB by the Akt/PKB kinase. Curr. Biol. 1999, 9:601-604.
14. Kasof G.M., Lu J.J., Liu D., Speer B., Mongan K.N., Gomes B.C., Lorenzi M.V. Tumor necrosis factor-alpha induces the expression of DR6, a member of the TNF receptor family, through activation of NF-kappaB. Oncogene 2001, 20:7965-7975.
15. Klima M., Zajedova J., Doubravska L., Andera L. Functional analysis of the posttranslational modifications of the death receptor 6. Biochim. Biophys. Acta 2009, 1793:1579-1587.
16. Kopf M., Ruedl C., Schmitz N., Gallimore A., Lefrang K., Ecabert B., Odermatt B., Bachmann M.F. OX40-deficient mice are defective in Th cell proliferation but are competent in generating B cell and CTL Responses after virus infection. Immunity 1999, 11:699-708.
17. Kordes U., Krappmann D., Heissmeyer V., Ludwig W.D., Scheidereit C. Transcription factor NF-kappaB is constitutively activated in acute lymphoblastic leukemia cells. Leukemia 2000, 14:399-402.
18. Liu J., Heuer J.G., Na S., Galbreath E., Zhang T., Yang D.D., Glasebrook A., Song H.Y. Accelerated onset and increased severity of acute graft-versus-host disease following adoptive transfer of DR6-deficient T cells. J. Immunol. 2002, 169:3993-3998.
19. Liu J., Na S., Glasebrook A., Fox N., Solenberg P.J., Zhang Q., Song H.Y., Yang D.D. Enhanced CD4+ T cell proliferation and Th2 cytokine production in DR6-deficient mice. Immunity 2001, 15:23-34.
20. Meylan F., Davidson T.S., Kahle E., Kinder M., Acharya K., Jankovic D., Bundoc V., Hodges M., Shevach E.M., Keane-Myers A., Wang E.C., Siegel R.M. The TNF-family receptor DR3 is essential for diverse T cell-mediated inflammatory diseases. Immunity 2008, 29:79-89.
21. Morel Y., Schiano de Colella J.M., Harrop J., Deen K.C., Holmes S.D., Wattam T.A., Khandekar S.S., Truneh A., Sweet R.W., Gastaut J.A., Olive D., Costello R.T. Reciprocal expression of the TNF family receptor herpes virus entry mediator and its ligand LIGHT on activated T cells: LIGHT down-regulates its own receptor. J. Immunol. 2000, 165:4397-4404.
22. Nikolaev A., McLaughlin T., O'Leary D.D., Tessier-Lavigne M. APP binds DR6 to trigger axon pruning and neuron death via distinct caspases. Nature 2009, 457:981-989.
23. Oehm A., Behrmann I., Falk W., Pawlita M., Maier G., Klas C., Li-Weber M., Richards S., Dhein J., Trauth B.C., et al. Purification and molecular cloning of the APO-1 cell surface antigen, a member of the tumor necrosis factor/nerve growth factor receptor superfamily Sequence identity with the Fas antigen. J. Biol. Chem. 1992, 267:10709-10715.
24. Pan G., Bauer J.H., Haridas V., Wang S., Liu D., Yu G., Vincenz C., Aggarwal B.B., Ni J., Dixit V.M. Identification and functional characterization of DR6, a novel death domain-containing TNF receptor. FEBS Lett. 1998, 431:351-356.
25. Pan G., O'Rourke K., Chinnaiyan A.M., Gentz R., Ebner R., Ni J., Dixit V.M. The receptor for the cytotoxic ligand TRAIL. Science 1997, 276:111-113.
26. Pichler K., Kattan T., Gentzsch J., Kress A.K., Taylor G.P., Bangham C.R., Grassmann R. Strong induction of 4-1BB, a growth and survival promoting costimulatory receptor, in HTLV-1-infected cultured and patients' T cells by the viral Tax oncoprotein. Blood 2008, 111:4741-4751.
27. Pippig S.D., Pena-Rossi C., Long J., Godfrey W.R., Fowell D.J., Reiner S.L., Birkeland M.L., Locksley R.M., Barclay A.N., Killeen N. Robust B cell immunity but impaired T cell proliferation in the absence of CD134 (OX40). J. Immunol. 1999, 163:6520-6529.
28. Rothe J., Lesslauer W., Lotscher H., Lang Y., Koebel P., Kontgen F., Althage A., Zinkernagel R., Steinmetz M., Bluethmann H. Mice lacking the tumour necrosis factor receptor 1 are resistant to TNF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes. Nature 1993, 364:798-802.
29. Shan X., Czar M.J., Bunnell S.C., Liu P., Liu Y., Schwartzberg P.L., Wange R.L. Deficiency of PTEN in Jurkat T cells causes constitutive localization of Itk to the plasma membrane and hyperresponsiveness to CD3 stimulation. Mol. Cell Biol. 2000, 20:6945-6957.
30. Schmidt C.S., Liu J., Zhang T., Song H.Y., Sandusky G., Mintze K., Benschop R.J., Glasebrook A., Yang D.D., Na S. Enhanced B cell expansion, survival, and humoral responses by targeting death receptor 6. J. Exp. Med. 2003, 197:51-62.
31. Schmidt C.S., Zhao J., Chain J., Hepburn D., Gitter B., Sandusky G., Chintalacharuvu S., Glasebrook A., Na S. Resistance to myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis by death receptor 6-deficient mice. J. Immunol. 2005, 175:2286-2292.
32. Tone Y., Kojima Y., Furuuchi K., Brady M., Yashiro-Ohtani Y., Tykocinski M.L., Tone M. OX40 gene expression is up-regulated by chromatin remodeling in its promoter region containing Sp1/Sp3 YY1, and NF-kappa B binding sites. J. Immunol. 2007, 179:1760-1767.
33. Venkataraman C., Justen K., Zhao J., Galbreath E., Na S. Death receptor-6 regulates the development of pulmonary eosinophilia and airway inflammation in a mouse model of asthma. Immunol. Lett. 2006, 106:42-47.
34. Walczak H., Degli-Esposti M.A., Johnson R.S., Smolak P.J., Waugh J.Y., Boiani N., Timour M.S., Gerhart M.J., Schooley K.A., Smith C.A., Goodwin R.G., Rauch C.T. TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL. EMBO J. 1997, 16:5386-5397.
35. Weinberg A.D., Bourdette D.N., Sullivan T.J., Lemon M., Wallin J.J., Maziarz R., Davey M., Palida F., Godfrey W., Engleman E., Fulton R.J., Offner H., Vandenbark A.A. Selective depletion of myelin-reactive T cells with the anti-OX-40 antibody ameliorates autoimmune encephalomyelitis. Nat. Med. 1996, 2:183-189.
36. Zhan Y., Gerondakis S., Coghill E., Bourges D., Xu Y., Brady J.L., Lew A.M. Glucocorticoid-induced TNF receptor expression by T cells is reciprocally regulated by NF-kappaB and NFAT. J. Immunol. 2008, 181:5405-5413.
37. Zhao H., Yan M., Wang H., Erickson S., Grewal I.S., Dixit V.M. Impaired c-Jun amino terminal kinase activity and T cell differentiation in death receptor 6-deficient mice. J. Exp. Med. 2001, 194:1441-1448.