Glucocorticoid-induced TNF receptor expression by T cells is reciprocally regulated by NF-κB and NFAT

Journal of Immunology

Volumn 181, Issue 8, 2008, Pages 5405-5413

  Zhan, Yifan ^a   Gerondakis, Steve ^a,b   Coghill, Elise ^a   Bourges, Dorothee ^a,c   Xu, Yuekang ^a   Brady, Jamie L ^a   Lew, Andrew M ^a  

^a WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b MACFARLANE BURNET INSTITUTE FOR MEDICAL RESEARCH AND PUBLIC HEALTH   (Australia)

^c UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

3 (4 METHYLPHENYLSULFONYL) 2 PROPENENITRILE; CYCLOSPORIN A; GLUCOCORTICOID INDUCED TUMOR NECROSIS FACTOR RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIGAND; LITHIUM CHLORIDE; NUCLEAR FACTOR KAPPA B 1; NUCLEIC ACID BINDING PROTEIN; T LYMPHOCYTE RECEPTOR; TACROLIMUS; TRANSCRIPTION FACTOR NFAT; TRANSCRIPTION FACTOR REL; TRANSCRIPTION FACTOR RELA; UNCLASSIFIED DRUG; 3-(4-METHYLPHENYLSULFONYL)-2-PROPENENITRILE; CORTICOSTEROID; CYCLOSPORIN; IMMUNOLOGICAL ADJUVANT; IMMUNOSUPPRESSIVE AGENT; LYMPHOCYTE ANTIGEN RECEPTOR; NITRILE; SULFONE; TUMOR NECROSIS FACTOR RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL MATURATION; CELL PROTECTION; CELL SURVIVAL; CONTROLLED STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; T LYMPHOCYTE; TRANSCRIPTION REGULATION; UPREGULATION; ANIMAL; BIOSYNTHESIS; DRUG ANTAGONISM; DRUG EFFECT; GENETIC TRANSCRIPTION; GENETICS; IMMUNOLOGY; METABOLISM; REGULATORY T LYMPHOCYTE; TRANSGENIC MOUSE;

ADJUVANTS, IMMUNOLOGIC; ADRENAL CORTEX HORMONES; ANIMALS; APOPTOSIS; CELL SURVIVAL; CYCLOSPORINE; IMMUNOSUPPRESSIVE AGENTS; LITHIUM CHLORIDE; MICE; MICE, TRANSGENIC; NF-KAPPA B; NFATC TRANSCRIPTION FACTORS; NITRILES; RECEPTORS, ANTIGEN, T-CELL; RECEPTORS, TUMOR NECROSIS FACTOR; SULFONES; T-LYMPHOCYTES, REGULATORY; TACROLIMUS; TRANSCRIPTION, GENETIC; UP-REGULATION;

EID: 54049122946     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.181.8.5405     Document Type: Article

References (41)

1. Shevach, E. M., and G. L. Stephens. 2006. The GITR-GITRL interaction: costimulation or contrasuppression of regulatory activity? Nat. Rev. Immunol. 6: 613-618.
2. Nocentini, G., L. Giunchi, S. Ronchetti, L. T. Krausz, A. Bartoli, R. Moraca, G. Migliorati, and C. Riccardi. 1997. A new member of the tumor necrosis factor/ nerve growth factor receptor family inhibits T cell receptor-induced apoptosis. Proc. Natl. Acad. Sci. USA 94: 6216-6221. (Pubitemid 27270664)
3. Gurney, A. L., S. A. Marsters, R. M. Huang, R. M. Pitti, D. T. Mark, D. T. Baldwin, A. M. Gray, A. D. Dowd, A. D. Brush, A. D. Heldens, et al. 1999. Identification of a new member of the tumor necrosis factor family and its receptor, a human ortholog of mouse GITR. Curr. Biol. 9: 215-218.
4. Zhan, Y., D. P. Funda, A. L. Every, P. Fundova, J. F. Purton, D. R. Liddicoat, T. J. Cole, D. I. Godfrey, J. L. Brady, S. I. Mannering, et al. 2004. TCR-mediated activation promotes GITR upregulation in T cells and resistance to glucocorticoid- induced death. Int. Immunol. 16: 1315-1321. (Pubitemid 39220430)
5. + immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor. Immunity 16: 311-323.
6. + regulatory T cells through GITR breaks immunological self-tolerance. Nat. Immunol. 3: 135-142.
7. Tone, M., Y. Tone, E. Adams, S. F. Yates, M. R. Frewin, S. P. Cobbold, and H. Waldmann. 2003. Mouse glucocorticoid-induced tumor necrosis factor receptor ligand is costimulatory for T cells. Proc. Natl. Acad. Sci. USA 100: 15059-15064.
8. + T cells. J. Immunol. 173: 5008-5020.
9. Ronchetti, S., O. Zollo, S. Bruscoli, M. Agostini, R. Bianchini, G. Nocentini, E. Ayroldi, and C. Riccardi. 2004. GITR, a member of the TNF receptor superfamily, is costimulatory to mouse T lymphocyte subpopulations. Eur. J. Immunol. 34: 613-622. (Pubitemid 39255908)
10. + T cells. J. Immunol. 172: 7306-7314.
11. Esparza, E. M., and R. H. Arch. 2005. Glucocorticoid-induced TNF receptor functions as a costimulatory receptor that promotes survival in early phases of T cell activation. J. Immunol. 174: 7869-7874.
12. Esparza, E. M., and R. H. Arch. 2005. Glucocorticoid-induced TNF receptor, a costimulatory receptor on naive and activated T cells, uses TNF receptor-associated factor 2 in a novel fashion as an inhibitor of NF-κB activation. J. Immunol. 174: 7875-7882.
13. Wu, Y., M. Borde, V. Heissmeyer, M. Feuerer, A. D. Lapan, J. C. Stroud, D. L. Bates, L. Guo, A. Han, S. F. Ziegler, et al. 2006. FOXP3 controls regulatory T cell function through cooperation with NFAT. Cell 126: 375-387. (Pubitemid 44092960)
14. Koniaras, C., F. R. Carbone, W. R. Heath, and A. M. Lew. 1999. Inhibition of naive class I-restricted T cells by altered peptide ligands. Immunol Cell Biol. 77: 318-323. (Pubitemid 29370102)
15. Grossmann, M., L. A. O'Reilly, R. Gugasyan, A. Strasser, J. M. Adams, and S. Gerondakis. 2000. The anti-apoptotic activities of Rel and RelA required during B-cell maturation involve the regulation of Bcl-2 expression. EMBO J. 19: 6351-6360.
16. Grumont, R. J., A. Strasser, and S. Gerondakis. 2002. B cell growth is controlled by phosphatidylinositol 3-kinase-dependent induction of Rel/NF-κB regulated c-myc transcription. Mol. Cell. 10: 1283-1294.
17. Huntington, N. D., H. Puthalakath, P. Gunn, E. Naik, E. M. Michalak, M. J. Smyth, H. Tabarias, M. A. Degli-Esposti, G. Dewson, S. N. Willis, et al. 2007. Interleukin 15-mediated survival of natural killer cells is determined by interactions among Bim, Noxa, and Mcl-1. Nat. Immunol. 8: 856-863.
18. Zhumabekov, T., P. Corbella, M. Tolaini, and D. Kioussis. 1995. Improved version of a human CD2 minigene based vector for T cell-specific expression in transgenic mice. J. Immunol. Methods 185: 133-140.
19. Jameson, S. C., and M. J. Bevan. 1992. Dissection of major histocompatibility complex (MHC) and T cell receptor contact residues in a Kb-restricted ovalbumin peptide and an assessment of the predictive power of MHC-binding motifs. Eur. J. Immunol. 22: 2663-2667.
20. Roge, R., J. Thorsen, C. Torring, A. Ozbay, B. K. Moller, and J. Carstens. 2007. Commonly used reference genes are actively regulated in in vitro stimulated lymphocytes. Scand. J. Immunol. 65: 202-209. (Pubitemid 46174929)
21. Grumont, R. J., and S. Gerondakis. 1994. The subunit composition of NF-κB complexes changes during B-cell development. Cell Growth Differ. 5: 1321-1331.
22. Crossley, M., E. Whitelaw, A. Perkins, G. Williams, Y. Fujiwara, and S. H. Orkin. 1996. Isolation and characterization of the cDNA encoding BKLF/ TEF-2, a major CACCC-box-binding protein in erythroid cells and selected other cells. Mol. Cell. Biol. 16: 1695-1705. (Pubitemid 26095642)
23. Pierce, J. W., R. Schoenleber, G. Jesmok, J. Best, S. A. Moore, T. Collins, and M. E. Gerritsen. 1997. Novel inhibitors of cytokine-induced IκBα phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo. J. Biol. Chem. 272: 21096-21103.
24. Loh, C., K. T. Shaw, J. Carew, J. P. Viola, C. Luo, B. A. Perrino, and A. Rao. 1996. Calcineurin binds the transcription factor NFAT1 and reversibly regulates its activity. J. Biol. Chem. 271: 10884-10891. (Pubitemid 26145827)
25. Schreiber, S. L., and G. R. Crabtree. 1992. The mechanism of action of cyclosporin A and FK506. Immunol. Today 13: 136-142.
26. Feske, S., R. Draeger, H. H. Peter, and A. Rao. 2000. Impaired NFAT regulation and its role in a severe combined immunodeficiency. Immunobiology 202: 134-150. (Pubitemid 30639245)
27. Ohteki, T., M. Parsons, A. Zakarian, R. G. Jones, L. T. Nguyen, J. R. Woodgett, and P. S. Ohashi. 2000. Negative regulation of T cell proliferation and interleukin 2 production by the serine threonine kinase GSK-3. J. Exp. Med. 192: 99-104. (Pubitemid 30470810)
28. Bennett, B. L., D. T. Sasaki, B. W. Murray, E. C. O'Leary, S. T. Sakata, W. Xu, J. C. Leisten, A. Motiwala, S. Pierce, Y. Satoh, et al. 2001. SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase. Proc. Natl. Acad. Sci. USA 98: 13681-13686.
29. Nocentini, G., and C. Riccardi. 2005. GITR: a multifaceted regulator of immunity belonging to the tumor necrosis factor receptor superfamily. Eur. J. Immunol. 35: 1016-1022. (Pubitemid 40542207)
30. Nocentini, G., A. Bartoli, S. Ronchetti, L. Giunchi, A. Cupelli, D. Delfino, G. Migliorati, and C. Riccardi. 2000. Gene structure and chromosomal assignment of mouse GITR, a member of the tumor necrosis factor/nerve growth factor receptor family. DNA Cell Biol. 19: 205-217. (Pubitemid 30228439)
31. Nolz, J. C., M. E. Fernandez-Zapico, and D. D. Billadeau. 2007. TCR/CD28- stimulated actin dynamics are required for NFAT1-mediated transcription of c- Rel leading to CD28 response element activation. J. Immunol. 179: 1104-1112.
32. Fontenot, J. D., J. P. Rasmussen, L. M. Williams, J. L. Dooley, A. G. Farr, and A. Y. Rudensky. 2005. Regulatory T cell lineage specification by the forkhead transcription factor foxp3. Immunity 22: 329-341. (Pubitemid 40387475)
33. Macian, F., and A. Rao. 1999. Reciprocal modulatory interaction between human immunodeficiency virus type 1 Tat and transcription factor NFAT1. Mol. Cell. Biol. 19: 3645-3653. (Pubitemid 29193824)
34. Casolaro, V., S. N. Georas, Z. Song, I. D. Zubkoff, S. A. Abdulkadir, D. Thanos, and S. J. Ono. 1995. Inhibition of NF-AT-dependent transcription by NF-κB: implications for differential gene expression in T helper cell subsets. Proc. Natl. Acad. Sci. USA 92: 11623-11627. (Pubitemid 26014165)
35. Garcia-Rodriguez, C., and A. Rao. 1998. Nuclear factor of activated T cells (NFAT)-dependent transactivation regulated by the coactivators p300/CREB-binding protein (CBP). J. Exp. Med. 187: 2031-2036. (Pubitemid 28285572)
36. Hottiger, M. O., L. K. Felzien, and G. J. Nabel. 1998. Modulation of cytokine-induced HIV gene expression by competitive binding of transcription factors to the coactivator p300. EMBO J. 17: 3124-3134.
37. Schubert, L. A., G. King, R. Q. Cron, D. B. Lewis, A. Aruffo, and D. Hollenbaugh. 1995. The human gp39 promoter. Two distinct nuclear factors of activated T cell protein-binding elements contribute independently to transcriptional activation. J. Biol. Chem. 270: 29624-29627.
38. Tsytsykova, A. V., E. N. Tsitsikov, and R. S. Geha. 1996. The CD40L promoter contains nuclear factor of activated T cells-binding motifs which require AP-1 binding for activation of transcription. J. Biol. Chem. 271: 3763-3770.
39. +- independent T cell-mediated cytotoxicity. J. Exp. Med. 177: 195-200.
40. Brunner, T., N. J. Yoo, D. LaFace, C. F. Ware, and D. R. Green. 1996. Activation- induced cell death in murine T cell hybridomas: differential regulation of Fas (CD95) versus Fas ligand expression by cyclosporin A and FK506. Int. Immunol. 8: 1017-1026. (Pubitemid 26235705)
41. Combadiere, B., C. Reis e Sousa, R. N. Germain, and M. J. Lenardo. 1998. Selective induction of apoptosis in mature T lymphocytes by variant T cell receptor ligands. J. Exp. Med. 187: 349-355.